- Medical School - UT Southwestern Medical School (2001-2005)
- Residency - UT Southwestern/Children's Medical Center (2005-2008), Pediatrics
- Fellowship - UT Southwestern/Children's Medical Center (2008-2011), Pediatric Gastroenterology
Edaire Cheng, M.D., received her B.S. degree from Rice University (2001) and earned her medical degree at University of Texas Southwestern Medical School (2005). She completed her residency in pediatric medicine (2008) and her fellowship in pediatric gastroenterology (2011) at University of Texas Southwestern Medical Center/Children’s Medical Center in Dallas.
Dr. Cheng’s clinical interests include eosinophilic esophagitis, gastroesophageal reflux disease, and eosinophilic gastrointestinal disease. Her research interests include understanding the mechanisms of eosinophilic infiltration and tissue remodeling in the esophagus.
In 2019, Dr. Cheng was named a Texas Monthly Super Doctor Rising Star.
- American Gastroenterological Association (2009)
- American Gastroenterological Association Women's Committee (2015)
- North American Society of Pediatric Gastroenterology and Nutrition (2008)
- Gastroenterology Research Group (2009)
- Texas Monthly Super Doctor Rising Star 2019
- SWMS Dean's Competitive Scholarship 2002-2004, UT Southwestern Medical School
- Fellowship2Leadership Gastroenterology/Hepatology Fellows' Travel Grant 2010, Travel Award
- Distinguished Achievement Award - North American Conference of Gastroenterology Fellows 2011, Abstract and Travel Award
- Gastroenterology Research Group Fellows Travel Award 2010, Abstract and Travel Award
- First Place Award - Research Poster Presentation 2012, Dallas VA Medical Center Research Week
- UTSW Alumni Scholarship Program 2001-2003, UT Southwestern
- Medical Center Woman's Club Scholarship 2001-2002, UT Southwestern Medical School
- Magna Cum Laude 2001
- NASPGHAN Foundation/AstraZeneca Award 2012, for Disorders of the Upper Gastrointestinal Tract
- Research Scholar Award 2013, American Gastroenterological Association
Relationship of Eosinophilic Esophagitis To Gastroesophageal Reflux in Eosinophilic Esophagitis, C. Liacouras, J. Markovitz, eds.
Cheng E, Winter H, Spechler S. (2011), New York, Springer
- Relationship of Eosinophilic Esophagitis To Gastroesophageal Reflux in Eosinophilic Esophagitis, C. Liacouras, J. Markovitz, eds.
In oesophageal squamous cells exposed to acidic bile salt medium, omeprazole inhibits IL-8 expression through effects on nuclear factor-?B and activator protein-1.
Huo X, Zhang X, Yu C, Zhang Q, Cheng E, Wang DH, Pham TH, Spechler SJ, Souza RF Gut 2013 Sep
Hypoxia-inducible factor-2a plays a role in mediating oesophagitis in GORD.
Huo X, Agoston AT, Dunbar KB, Cipher DJ, Zhang X, Yu C, Cheng E, Zhang Q, Pham TH, Tambar UK, Bruick RK, Wang DH, Odze RD, Spechler SJ, Souza RF Gut 2016 Sep
Eosinophilic esophagitis: current perspectives from diagnosis to management.
Moawad FJ, Cheng E, Schoepfer A, Al-Haddad S, Bellizzi AM, Dawson H, El-Zimaity H, Guindi M, Penagini R, Safrooneva E, Chehade M Annals of the New York Academy of Sciences 2016 Jul
In oesophageal squamous cells, nitric oxide causes S-nitrosylation of Akt and blocks SOX2 (sex determining region Y-box 2) expression.
Asanuma K, Huo X, Agoston A, Zhang X, Yu C, Cheng E, Zhang Q, Dunbar KB, Pham TH, Wang DH, Iijima K, Shimosegawa T, Odze RD, Spechler SJ, Souza RF Gut 2015 May
Tissue remodeling in eosinophilic esophagitis.
Cheng E, Souza RF, Spechler SJ American journal of physiology. Gastrointestinal and liver physiology 2012 Dec 303 11 G1175-87
Updated international consensus diagnostic criteria for eosinophilic esophagitis: Proceedings of the AGREE conference.
Dellon ES, Liacouras CA, Molina-Infante J, Furuta GT, Spergel JM, Zevit N, Spechler SJ, Attwood SE, Straumann A, Aceves SS, Alexander JA, Atkins D, Arva NC, Blanchard C, Bonis PA, Book WM, Capocelli KE, Chehade M, Cheng E, Collins MH, Davis CM, Dias JA, Di Lorenzo C, Dohil R, Dupont C, Falk GW, Ferreira CT, Fox A, Gonsalves NP, Gupta SK, Katzka DA, Kinoshita Y, Menard-Katcher C, Kodroff E, Metz DC, Miehlke S, Muir AB, Mukkada VA, Murch S, Nurko S, Ohtsuka Y, Orel R, Papadopoulou A, Peterson KA, Philpott H, Putnam PE, Richter JE, Rosen R, Rothenberg ME, Schoepfer A, Scott MM, Shah N, Sheikh J, Souza RF, Strobel MJ, Talley NJ, Vaezi MF, Vandenplas Y, Vieira MC, Walker MM, Wechsler JB, Wershil BK, Wen T, Yang GY, Hirano I, Bredenoord AJ Gastroenterology 2018 Jul
Eosinophilic Esophagitis: Interactions with Gastroesophageal Reflux Disease.
Cheng E, Souza RF, Spechler SJ Gastroenterology clinics of North America 2014 Jun 43 2 243-256
New Developments in Eosinophilic Gastrointestinal Diseases Presented at the CEGIR/TIGERS Symposium at the 2018 AAAAI Meeting.
Spergel JM, Aceves SS, Kliewer K, Gonsalves N, Chehade M, Wechsler JB, Groetch M, Friedlander J, Dellon ES, Book W, Hirano I, Muir AB, Cianferoni A, Spencer L, Liacouras CA, Cheng E, Kottyan L, Wen T, Platts-Mills T, Rothenberg ME The Journal of allergy and clinical immunology 2018 May
Obtaining Adequate Lamina Propria for Subepithelial Fibrosis Evaluation in Pediatric Eosinophilic Esophagitis.
Wang J, Park JY, Huang R, Souza RF, Spechler SJ, Cheng E Gastrointestinal endoscopy 2018 Jan
Aspirin prevents NF-?B activation and CDX2 expression stimulated by acid and bile salts in oesophageal squamous cells of patients with Barrett's oesophagus.
Huo X, Zhang X, Yu C, Cheng E, Zhang Q, Dunbar KB, Pham TH, Lynch JP, Wang DH, Bresalier RS, Spechler SJ, Souza RF Gut 2017 Apr
NOD-Like Receptor Protein 3 Inflammasome Priming and Activation in Barrett's Epithelial Cells.
Nadatani Y, Huo X, Zhang X, Yu C, Cheng E, Zhang Q, Dunbar KB, Theiss A, Pham TH, Wang DH, Watanabe T, Fujiwara Y, Arakawa T, Spechler SJ, Souza RF Cellular and molecular gastroenterology and hepatology 2016 Jul 2 4 439-453
Significance of Paneth Cells in Histologically Unremarkable Rectal Mucosa.
Pezhouh MK, Cheng E, Weinberg AG, Park JY The American journal of surgical pathology 2016 Feb
JAK-STAT6 Pathway Inhibitors Block Eotaxin-3 Secretion by Epithelial Cells and Fibroblasts from Esophageal Eosinophilia Patients: Promising Agents to Improve Inflammation and Prevent Fibrosis in EoE.
Cheng E, Zhang X, Wilson KS, Wang DH, Park JY, Huo X, Yu C, Zhang Q, Spechler SJ, Souza RF PloS one 2016 11 6 e0157376
Mitochondrial STAT3 Contributes to Transformation of Barrett's Epithelial Cells that Express Oncogenic Ras in a p53-Independent Fashion.
Yu C, Huo X, Agoston AT, Zhang X, Theiss AL, Cheng E, Zhang Q, Zaika A, Pham TH, Wang DH, Lobie PE, Odze RD, Spechler SJ, Souza RF American journal of physiology. Gastrointestinal and liver physiology 2015 Jun ajpgi.00462.2014
Translating New Developments in Eosinophilic Esophagitis Pathogenesis into Clinical Practice.
Cheng E Current treatment options in gastroenterology 2015 Jan
Autocrine VEGF signaling promotes proliferation of neoplastic Barrett's epithelial cells through a PLC-dependent pathway.
Zhang Q, Yu C, Peng S, Xu H, Wright E, Zhang X, Huo X, Cheng E, Pham TH, Asanuma K, Hatanpaa KJ, Rezai D, Wang DH, Sarode V, Melton S, Genta RM, Spechler SJ, Souza RF Gastroenterology 2014 Feb 146 2 461-72.e6
Proton pump inhibitors decrease eotaxin-3 expression in the proximal esophagus of children with esophageal eosinophilia.
Park JY, Zhang X, Nguyen N, Souza RF, Spechler SJ, Cheng E PloS one 2014 9 7 e101391
Omeprazole blocks eotaxin-3 expression by oesophageal squamous cells from patients with eosinophilic oesophagitis and GORD.
Cheng E, Zhang X, Huo X, Yu C, Zhang Q, Wang DH, Spechler SJ, Souza RF Gut 2013 Jun 62 6 824-32
Proton pump inhibitors for eosinophilic oesophagitis.
Cheng E Current opinion in gastroenterology 2013 Jul 29 4 416-20
Targeting the intrinsic inflammatory pathway: honokiol exerts proapoptotic effects through STAT3 inhibition in transformed Barrett's cells.
Yu C, Zhang Q, Zhang HY, Zhang X, Huo X, Cheng E, Wang DH, Arbiser JL, Spechler SJ, Souza RF American journal of physiology. Gastrointestinal and liver physiology 2012 Sep 303 5 G561-9
Omeprazole blocks STAT6 binding to the eotaxin-3 promoter in eosinophilic esophagitis cells.
Zhang X, Cheng E, Huo X, Yu C, Zhang Q, Pham TH, Wang DH, Spechler SJ, Souza RF PloS one 2012 7 11 e50037
Cancer-related inflammation and Barrett's carcinogenesis: interleukin-6 and STAT3 mediate apoptotic resistance in transformed Barrett's cells.
Zhang HY, Zhang Q, Zhang X, Yu C, Huo X, Cheng E, Wang DH, Spechler SJ, Souza RF American journal of physiology. Gastrointestinal and liver physiology 2011 Mar 300 3 G454-60
Deoxycholic acid causes DNA damage while inducing apoptotic resistance through NF-?B activation in benign Barrett's epithelial cells.
Huo X, Juergens S, Zhang X, Rezaei D, Yu C, Strauch ED, Wang JY, Cheng E, Meyer F, Wang DH, Zhang Q, Spechler SJ, Souza RF American journal of physiology. Gastrointestinal and liver physiology 2011 Aug 301 2 G278-86
In Barrett's Esophagus Patients and Barrett's Cell Lines, Ursodeoxycholic Acid Increases Antioxidant Expression and Prevents DNA Damage by Bile Acids.
Peng S, Huo X, Rezaei D, Zhang Q, Zhang X, Yu C, Asanuma K, Cheng E, Pham TH, Wang DH, Chen M, Souza RF, Spechler SJ American journal of physiology. Gastrointestinal and liver physiology 2014 May
- In oesophageal squamous cells exposed to acidic bile salt medium, omeprazole inhibits IL-8 expression through effects on nuclear factor-?B and activator protein-1.
- Tissue remodeling and fibrosis in eosinophilic esophagitis
- Therapeutic agents for eosinophilic esophagitis
- Eotaxin-3 expression in eosinophilic esophagitis and GERD