- Medical School - Washington University School of Medicine
- Internship - Jewish Hospital of St. Louis (1988-1989), Internal Medicine
- Residency - Barnes-Jewish Hospital (1989-1992), Neurology
- Fellowship - Washington University in St. Louis (1992-1994), Neuromuscular Disease
Jeffrey Elliott, M.D.
- Neuromuscular Disorders
Education & Training
Professional Associations & Affiliations
- American Academy of Neurology
- American Association of Electrodiagnostic Medicine
- Society for Neuroscience
Honors & Awards
- President Research Council Distinguished Young Researcher Award 1998
Books & Publications
Selective dependence of mammalian dorsal root ganglion neurons on nerve growth factor during embryonic development.
Ruit KG, Elliott JL, Osborne PA, Yan Q, Snider WD Neuron 1992 Mar 8 3 573-87
Axotomy-induced neuronal death during development.
Snider WD, Elliott JL, Yan Q Journal of neurobiology 1992 Nov 23 9 1231-46
Influences of neurotrophins on mammalian motoneurons in vivo.
Yan Q, Elliott JL, Matheson C, Sun J, Zhang L, Mu X, Rex KL, Snider WD Journal of neurobiology 1993 Dec 24 12 1555-77
Upregulation of NMDARI mRNA induced by MK-801 is associated with massive death of axotomized motor neurones in adult rats.
Sanner C, Elliott JL, Snider WD Neurobiology of disease 1994 Dec 1 3 121-9
Progression of multifocal motor neuropathy during apparently successful treatment with human immunoglobulin.
Elliott JL, Pestronk A Neurology 1994 May 44 5 967-8
Distal lower motor neuron syndrome with high-titer serum IgM anti-GM1 antibodies: improvement following immunotherapy with monthly plasma exchange and intravenous cyclophosphamide.
Pestronk A, Lopate G, Kornberg AJ, Elliott JL, Blume G, Yee WC, Goodnough LT Neurology 1994 Nov 44 11 2027-31
Parvalbumin is a marker of ALS-resistant motor neurons.
Elliott JL, Snider WD Neuroreport 1995 Feb 6 3 449-52
Assignment of a second Charcot-Marie-Tooth type II locus to chromosome 3q.
Kwon JM, Elliott JL, Yee WC, Ivanovich J, Scavarda NJ, Moolsintong PJ, Goodfellow PJ American journal of human genetics 1995 Oct 57 4 853-8
Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury.
Reaume AG, Elliott JL, Hoffman EK, Kowall NW, Ferrante RJ, Siwek DF, Wilcox HM, Flood DG, Beal MF, Brown RH, Scott RW, Snider WD Nature genetics 1996 May 13 1 43-7
Motor neuron growth factors.
Elliott JL, Snider WD Neurology 1996 Oct 47 4 Suppl 2 S47-53
BAX is required for neuronal death after trophic factor deprivation and during development.
Deckwerth TL, Elliott JL, Knudson CM, Johnson EM, Snider WD, Korsmeyer SJ Neuron 1996 Sep 17 3 401-11
Hereditary motor and sensory neuropathy IIB: clinical and electrodiagnostic characteristics.
Elliott JL, Kwon JM, Goodfellow PJ, Yee WC Neurology 1997 Jan 48 1 23-8
A clearer view of upper motor neuron dysfunction in amyotrophic lateral sclerosis.
Elliott JL Archives of neurology 1998 Jul 55 7 910-2
Mutation analysis in Emery-Dreifuss muscular dystrophy.
Nevo Y, Al-Lozi M, Parsadanian AS, Elliott JL, Connolly AM, Pestronk A Pediatric neurology 1999 Jul 21 1 456-9
Experimental models of amyotrophic lateral sclerosis.
Elliott JL Neurobiology of disease 1999 Oct 6 5 310-20
Brachial amyotrophic diplegia: a slowly progressive motor neuron disorder.
Katz JS, Wolfe GI, Andersson PB, Saperstein DS, Elliott JL, Nations SP, Bryan WW, Barohn RJ Neurology 1999 Sep 53 5 1071-6
Restricted expression of G86R Cu/Zn superoxide dismutase in astrocytes results in astrocytosis but does not cause motoneuron degeneration.
Gong YH, Parsadanian AS, Andreeva A, Snider WD, Elliott JL The Journal of neuroscience : the official journal of the Society for Neuroscience 2000 Jan 20 2 660-5
Metallothionein expression is altered in a transgenic murine model of familial amyotrophic lateral sclerosis.
Gong YH, Elliott JL Experimental neurology 2000 Mar 162 1 27-36
Glutamate transporter EAAT2 splice variants occur not only in ALS, but also in AD and controls.
Honig LS, Chambliss DD, Bigio EH, Carroll SL, Elliott JL Neurology 2000 Oct 55 8 1082-8
Zinc and copper in the pathogenesis of amyotrophic lateral sclerosis.
Elliott JL Progress in neuro-psychopharmacology & biological psychiatry 2001 Aug 25 6 1169-85
Survival in a transgenic model of FALS is independent of iNOS expression.
Son M, Fathallah-Shaykh HM, Elliott JL Annals of neurology 2001 Aug 50 2 273
Cytokine upregulation in a murine model of familial amyotrophic lateral sclerosis.
Elliott JL Brain research. Molecular brain research 2001 Nov 95 1-2 172-8
Disease progression in a transgenic model of familial amyotrophic lateral sclerosis is dependent on both neuronal and non-neuronal zinc binding proteins.
Puttaparthi K, Gitomer WL, Krishnan U, Son M, Rajendran B, Elliott JL The Journal of neuroscience : the official journal of the Society for Neuroscience 2002 Oct 22 20 8790-6
Aggregate formation in Cu,Zn superoxide dismutase-related proteins.
Son M, Cloyd CD, Rothstein JD, Rajendran B, Elliott JL The Journal of biological chemistry 2003 Apr 278 16 14331-6
Aggregate formation in the spinal cord of mutant SOD1 transgenic mice is reversible and mediated by proteasomes.
Puttaparthi K, Wojcik C, Rajendran B, DeMartino GN, Elliott JL Journal of neurochemistry 2003 Nov 87 4 851-60
Beginning to understand hereditary spastic paraplegia atlastin.
Elliott JL Archives of neurology 2004 Dec 61 12 1842-3
Non-neuronal induction of immunoproteasome subunits in an ALS model: possible mediation by cytokines.
Puttaparthi K, Elliott JL Experimental neurology 2005 Dec 196 2 441-51
Novel mutations that enhance or repress the aggregation potential of SOD1.
Krishnan U, Son M, Rajendran B, Elliott JL Molecular and cellular biochemistry 2006 Jul 287 1-2 201-11
Overexpression of CCS in G93A-SOD1 mice leads to accelerated neurological deficits with severe mitochondrial pathology.
Son M, Puttaparthi K, Kawamata H, Rajendran B, Boyer PJ, Manfredi G, Elliott JL Proceedings of the National Academy of Sciences of the United States of America 2007 Apr 104 14 6072-7
Assessing the role of immuno-proteasomes in a mouse model of familial ALS.
Puttaparthi K, Van Kaer L, Elliott JL Experimental neurology 2007 Jul 206 1 53-8
The death domain-containing kinase RIP1 regulates p27(Kip1) levels through the PI3K-Akt-forkhead pathway.
Park S, Ramnarain DB, Hatanpaa KJ, Mickey BE, Saha D, Paulmurugan R, Madden CJ, Wright PS, Bhai S, Ali MA, Puttaparthi K, Hu W, Elliott JL, Stuve O, Habib AA EMBO reports 2008 Aug 9 8 766-73
Biological effects of CCS in the absence of SOD1 enzyme activation: implications for disease in a mouse model for ALS.
Proescher JB, Son M, Elliott JL, Culotta VC Human molecular genetics 2008 Jun 17 12 1728-37
Isolated cytochrome c oxidase deficiency in G93A SOD1 mice overexpressing CCS protein.
Son M, Leary SC, Romain N, Pierrel F, Winge DR, Haller RG, Elliott JL The Journal of biological chemistry 2008 May 283 18 12267-75
Redox susceptibility of SOD1 mutants is associated with the differential response to CCS over-expression in vivo.
Son M, Fu Q, Puttaparthi K, Matthews CM, Elliott JL Neurobiology of disease 2009 Apr 34 1 155-62
MicroRNA-206 delays ALS progression and promotes regeneration of neuromuscular synapses in mice.
Williams AH, Valdez G, Moresi V, Qi X, McAnally J, Elliott JL, Bassel-Duby R, Sanes JR, Olson EN Science (New York, N.Y.) 2009 Dec 326 5959 1549-54
Deep brain stimulation artifact in needle electromyography.
Sadeghian H, Chitnis S, Elliott JL Archives of neurology 2010 Aug 67 8 1030
Progressive motor weakness in transgenic mice expressing human TDP-43.
Stallings NR, Puttaparthi K, Luther CM, Burns DK, Elliott JL Neurobiology of disease 2010 Nov 40 2 404-14
Biochemical properties and in vivo effects of the SOD1 zinc-binding site mutant (H80G).
Son M, Srikanth U, Puttaparthi K, Luther C, Elliott JL Journal of neurochemistry 2011 Jun 891-901
Huntington chorea presenting with motor neuron disease.
Sadeghian H, O'Suilleabhain PE, Battiste J, Elliott JL, Trivedi JR Archives of neurology 2011 May 68 5 650-2
TDP-43, an ALS linked protein, regulates fat deposition and glucose homeostasis.
Stallings NR, Puttaparthi K, Dowling KJ, Luther CM, Burns DK, Davis K, Elliott JL PloS one 2013 8 8 e71793
The RNA Binding Protein TDP-43 Selectively Disrupts MicroRNA-1/206 Incorporation into the RNA-Induced Silencing Complex.
King I, Yartseva V, Salas D, Kumar A, Heidersbach A, Ando DM, Stallings NR, Elliott JL, Srivastava D, Ivey KN The Journal of biological chemistry 2014 Apr
Mitochondrial defects in transgenic mice expressing Cu,Zn superoxide dismutase mutations, the role of copper chaperone for SOD1.
Son M, Elliott JL Journal of the neurological sciences 2014 Jan 336 1-2 1-7
Gradually Progressive Spastic Ataxia in a Young Man: Steadily Unsteady.
Dubey D, Khemani P, Remster E, Elliott JL JAMA neurology 2016 Dec
Copper delivery to the CNS by CuATSM effectively treats motor neuron disease in SOD(G93A) mice co-expressing the copper-chaperone-for-SOD.
Williams JR, Trias E, Beilby PR, Lopez NI, Labut EM, Samuel Bradford C, Roberts BR, McAllum EJ, Crouch PJ, Rhoads TW, Pereira C, Son M, Elliott JL, Franco MC, Estévez AG, Barbeito L, Beckman JS Neurobiology of disease 2016 Jan
A novel heterozygous mutation in the C-terminal region of HSPB8 leads to limb-girdle rimmed vacuolar myopathy.
Nicolau S, Liewluck T, Elliott JL, Engel AG, Milone M, Neuromuscular disorders : NMD 2020 Feb
- Selective dependence of mammalian dorsal root ganglion neurons on nerve growth factor during embryonic development.
- Neuromuscular Disorders
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