- Residency - Harvard Medical School/Brigham & Women's Hospital (1975-1976), Int. Medicine
- Internship - Harvard Medical School/Brigham & Women's Hospital (1974-1975), Int. Medicine
- Fellowship - National Institutes of Health-Research (1976-1980), Immunology/rheumatology
- Medical School - UT Southwestern Medical Center
Joel Taurog, M.D.
- William M. and Gay Burnett Professorship for Arthritis Research
- Internal Medicine - Rheumatology
Dr. Taurog has been a faculty member in the Division of Rheumatic Diseases at UT Southwestern since 1986. Since joining the faculty he has served as attending physician in rheumatology and internal medicine at Parkland Memorial Hospital. From 1980 to 1986 he was a faculty member in rheumatology and internal medicine at the University of Minnesota in Minneapolis.
The goal of Dr. Taurog's research has been to understand the molecular basis for the association of the rheumatic disease called ankylosing spondylitis with the major histocompatibility allele HLA-B27. This MHC class I allele is found in 7 percent of the U.S. population, but in over 90 percent of individuals with ankylosing spondylitis. Of individuals with B27, it is estimated that up to 13 percent will develop ankylosing spondylitis or a related form of spondyloarthritis.
Dr. Taurog's efforts largely involve the study of rats transgenic for HLA-B27 and its associated light chain, beta-2-microglobulin. The rats develop a spontaneous arthritis and spondylitis that in many ways mimics the spectrum of the human spondyloarthropathies.
We have used a variety of cellular, genetic, biochemical and microbiological approaches have been used to try to understand the role of the B27 molecule in the pathogenesis of this experimental disorder.
- American College of Rheumatology (1980), Fellow
- American Association of Immunologists (1980), Member
- American Society for Clinical Investigation (1991), Member
- Rheumatologist of the Year 1991, Abstract Rhumato (French Journal)
- Master of the American College of Rheumatology 2013
- Carol-Nachman Prize for Rheumatology 1992, State Capital of Wiesbaden, Germany
- Kroc Lectureship 1993, University of Michigan
- William M. & Gatha Burnett Professorship for Arthritis Research 1997, UT Southwestern Medical Center
- Glenn Clark Lectureship 2008, University of Tennessee, Memphis
Ankylosing Spondylitis and Axial Spondyloarthritis.
Taurog JD, Chhabra A, Colbert RA The New England journal of medicine 2016 Jun 374 26 2563-74
The HLA-B27 peptidome in vivo in spondyloarthritis-susceptible HLA-B27 transgenic rats and the effect of ERAP1 deletion.
Barnea E, Melamed Kadosh D, Haimovich Y, Satumtira N, Dorris ML, Nguyen MT, Hammer RE, Tran TM, Colbert RA, Taurog JD, Admon A Molecular & cellular proteomics : MCP 2017 Feb
Additional human beta2-microglobulin curbs HLA-B27 misfolding and promotes arthritis and spondylitis without colitis in male HLA-B27-transgenic rats.
Tran TM, Dorris ML, Satumtira N, Richardson JA, Hammer RE, Shang J, Taurog JD Arthritis and rheumatism 2006 Apr 54 4 1317-27
The Peptide Repertoire of HLA-B27 may include Ligands with Lysine at P2 Anchor Position.
Yair-Sabag S, Tedeschi V, Vitulano C, Barnea E, Glaser F, Melamed Kadosh D, Taurog JD, Fiorillo MT, Sorrentino R, Admon A Proteomics 2018 Feb
The Initiation, but Not the Persistence, of Experimental Spondyloarthritis Is Dependent on Interleukin-23 Signaling.
van Tok MN, Na S, Lao CR, Alvi M, Pots D, van de Sande MGH, Taurog JD, Sedgwick JD, Baeten DL, van Duivenvoorde LM Frontiers in immunology 2018 9 1550
Loss of bone strength in HLA-B27 transgenic rats is characterized by a high bone turnover and is mainly osteoclast-driven.
Rauner M, Thiele S, Fert I, Araujo LM, Layh-Schmitt G, Colbert RA, Hofbauer C, Bernhardt R, Bürki A, Schwiedrzik J, Zysset PK, Pietschmann P, Taurog JD, Breban M, Hofbauer LC Bone 2015 Mar 75 183-191
Role of PPM1A and anti-PPM1A Autoantibodies in Ankylosing Spondylitis.
Kim YG, Sohn DH, Zhao X, Sokolove J, Lindstrom TM, Yoo B, Lee CK, Reveille JD, Taurog JD, Robinson WH Arthritis & rheumatology (Hoboken, N.J.) 2014 Jun
Relationship between inflammation, bone destruction, and osteoproliferation in spondyloarthritis in HLA-B27/Huß2m transgenic rats.
van Duivenvoorde LM, Dorris ML, Satumtira N, van Tok MN, Redlich K, Tak PP, Taurog JD, Baeten DL Arthritis and rheumatism 2012 Jun
HLA-B27 and Human ß2-Microglobulin Affect the Gut Microbiota of Transgenic Rats.
Lin P, Bach M, Asquith M, Lee AY, Akileswaran L, Stauffer P, Davin S, Pan Y, Cambronne ED, Dorris M, Debelius JW, Lauber CL, Ackermann G, Baeza YV, Gill T, Knight R, Colbert RA, Taurog JD, Van Gelder RN, Rosenbaum JT PloS one 2014 9 8 e105684
Autoimmune epididymo-orchitis is essential to the pathogenesis of male-specific spondyloarthritis in HLA-B27 transgenic rats.
Taurog JD, Rival C, van Duivenvoorde LM, Satumtira N, Dorris ML, Sun M, Shelton JM, Richardson JA, Hamra FK, Hammer RE, Tung KS Arthritis and rheumatism 2012 Apr
Spondylarthritis in HLA-B27/human beta2-microglobulin-transgenic rats is not prevented by lack of CD8.
Taurog JD, Dorris ML, Satumtira N, Tran TM, Sharma R, Dressel R, van den Brandt J, Reichardt HM Arthritis and rheumatism 2009 Jul 60 7 1977-84
The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats.
Taurog JD, Richardson JA, Croft JT, Simmons WA, Zhou M, Fernández-Sueiro JL, Balish E, Hammer RE The Journal of experimental medicine 1994 Dec 180 6 2359-64
Spontaneous inflammatory disease in transgenic rats expressing HLA-B27 and human beta 2m: an animal model of HLA-B27-associated human disorders.
Hammer RE, Maika SD, Richardson JA, Tang JP, Taurog JD Cell 1990 Nov 63 5 1099-112
Reverse interferon signature is characteristic of antigen-presenting cells in human and rat spondyloarthritis.
Fert I, Cagnard N, Glatigny S, Letourneur F, Jacques S, Smith JA, Colbert RA, Taurog JD, Chiocchia G, Araujo LM, Breban M Arthritis & rheumatology (Hoboken, N.J.) 2014 Apr 66 4 841-51
IL-17A Inhibition Diminishes Inflammation and New Bone Formation In Experimental Spondyloarthritis.
van Tok MN, van Duivenvoorde LM, Kramer I, Ingold P, Pfister S, Roth L, Blijdorp IC, van de Sande MGH, Taurog JD, Kolbinger F, Baeten DL Arthritis & rheumatology (Hoboken, N.J.) 2018 Nov
Innate Immune Activation Can Trigger Experimental Spondyloarthritis in HLA-B27/Huß2m Transgenic Rats.
van Tok MN, Satumtira N, Dorris M, Pots D, Slobodin G, van de Sande MG, Taurog JD, Baeten DL, van Duivenvoorde LM Frontiers in immunology 2017 8 920
- Ankylosing Spondylitis and Axial Spondyloarthritis.
- Role of HLA-B27 in Spondyloarthritis