- Fellowship - University of Virginia Health System (1995-1997), Nephrology
- Residency - University of Virginia Health System (1991-1995), Urology
- Medical School - University of Louisville School of Medicine (1985-1989)
- Internship - University of Virginia Health System (1989-1991), General Surgery
- Fellowship - Johns Hopkins School of Medicine (1997-1999), Pediatric Urology
Linda Baker, M.D.
Director of Pediatric Urology Research
- Pediatric Urology
Dr. Baker is a NIH-funded physician scientist and Board-certified pediatric urologist specializing in the surgical reconstruction and study of complex congenital birth defects of the genitourinary tract. Dr. Baker completed her urology residency at the University of Virginia from 1989-1995 and became an American Foundation for Urological Disease Research Scholar from 1995-1997, studying the molecular basis of renal and genitourinary development. From 1997-1999, she was a Fellow in Pediatric Urology at the Johns Hopkins Medical Institution. She joined the Department of Urology at UT Southwestern in 1999 and created a thriving research program in pediatric urology. She became Director of Pediatric Urology Research in 2001 after receiving her first NIH R01 and was promoted to Professor of Urology in 2008.
Currently, she is the Director of Pediatric Urology Research at UT Southwestern and Children’s Medical Center. She holds secondary faculty appointments in the UT Southwestern McDermott Center for Human Growth and Development/Genetics, the Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, and the Southwestern Graduate School of Biomedical Sciences Genetics and Development Graduate Program.
She has served on numerous NIH study sections, several NIH planning committees, and is active in the American Urological Association Foundation Research Council and the Society for Pediatric Urology Research Advisory Council.
She is reviewer for many journals, including the New England Journal of Medicine. From 2012-2014, she served on the American Urological Association (AUA) Guidelines Panel for Cryptorchidism, co-authoring the treatment guidelines statement.
She has been faculty on several national training courses for laparoscopic or robotic surgery, has authored 120 published abstracts, 20 book chapters, 6 invited review articles, and 97 peer-reviewed publications, has a medical device patent, and has held 18 visiting professorships nationally and internationally.
She is Course Director for the annual international training course webinar, "Vaginoplasty for Birth Defects or Surgical Complications and the Oral Buccal Mucosa Technique." She has received many awards, most recently including the 2014 John W. Duckett, MD Pediatric Urology Research Excellence Award given by the AUA Urology Care Foundation.
As a board-certified pediatric urologist, she specializes in the surgical reconstruction of complex congenital birth defects of the genitourinary tract, including prune belly syndrome; disorders of sexual development; undescended testes (cryptorchidism); testicular torsion; and congenital female vaginal anomalies.
An NIH-funded investigator, Dr. Baker directs her molecular biology research program spanning basic science, translational and clinical research on pediatric genitourinary diseases and congenital defects. The major goals of this research are to understand the genetic, embryonic and molecular basis of rare and common birth defects including prune belly syndrome, female reproductive anomalies, VACTERL association, hypospadias, anorectal malformations, bladder exstrophy and epispadias, as well as to delineate hormonal and molecular mechanisms mediating cryptorchidism and testicular torsion.
She has strong translational genetic research interest in pediatric urolithiasis. Using genetically engineered mouse models, her research laboratory studies the causes of pediatric urological birth defects. With a personalized medicine approach, her research team recruits individuals with pediatric urological birth defects and disorders and performs cutting edge DNA testing using next generation sequencing technologies to discover the cause of pediatric urological disorders and birth defects, thus achieving bench-to-bedside research.
Dr. Baker was included in D Magazine's Best Doctors list for 2018.
Dr. Baker lives in Southlake, TX with her husband, Ken, and children Amanda and Andrew.
- Society for Basic Urological Research (2001)
- Society for Pediatric Urology (2001)
- American Urological Association (1997)
- Society for Fetal Urology (1997)
- Fellow, American Academy of Pediatrics, Section on Urology (2001)
- Fellow American College of Surgeons (2002)
- American Society of Human Genetics (2010)
- First Prize Research Award 2004, Engineering and Urology Society
- Best Pediatric Specialists in Dallas 2004-2014, D Magazine 2004, 2007, 2010, 2011, 2012, 2013 and 2014
- AAP Section of Urology Basic Research Prize Finalist 2002
- John W. Duckett, MD Pediatric Urology Research Excellence Award 2014, Awarded by the American Urologic Association Urology Care Foundation
- America's Top Surgeons 2012, Consumer's Research Council of America
- SWIU/SBUR Award for Excellence in Urologic Research 2011
- Texas Super Doctors 2010, Texas Monthly Magazine 2010-2014
- 2nd Place Clinical Poster Prize 2005, European Society for Pediatric Urology
- Society for Basic Urologic Research/Merck Young Investigator Award 2002
- Top Doctors 2011, US News & World Report
Hinman's Atlas of Urologic Surgery, 3rd Edition
Prieto, J.C. and Baker, L.A.(Ed.) (2011), Philadelphia, PA, Saunders
International Consultation on Urological Diseases (ICUD): International Consultation on Congenital Anomalies in Children
Grimsby, GM, LeClair, M-D, Schneck, FX, Lee, PA, Wolffenbuttel, KP, and Baker, LA.(Ed.) (2014), Société Internationale d?Urologie (SIU)
In Pediatric Endourology Techniques, 2nd edition
Yucel, S and Baker, L.A.(Ed.) (2013), P. Springer-Verlag London Ltd
Minimally Invasive Approaches to Pediatric Urology
Baker, L.A., Lorenzo, A.J., Jordan, G.H., and Docimo, S.G.(Ed.) (2005), Oxfordshire, OX, UK, Taylor & Francis
Pediatric Urology, 2nd edition
Bergu, B., Baker, L.A., and Docimo, S.G.(Ed.) (2010), Philadelphia, W. B. Saunders Company
The Kelalis-King-Belman Textbook of Clinical Pediatric Urology
Grady, R and Baker, L.A.(Ed.) (2007), Informa Healthcare
Smith's Textbook of Endourology, 2nd edition
Baker, L.A. and Jordan, G.H.(Ed.) (2006), Hamilton, Ontario, BC Decker, Inc
In Pediatric Endourology Techniques, 2nd edition
Keays, M and Baker, L.A.(Ed.) (2013), P. Blackwell Publishing
Pediatric Robotic and Reconstructive Urology
DaJusta, D. and Baker, L.A.(Ed.) (2012), Oxford, Wiley-Blackwell Publishing Limited
- Hinman's Atlas of Urologic Surgery, 3rd Edition
Single trocar laparoscopic nephrectomy using magnetic anchoring and guidance system in the porcine model.
Zeltser IS, Bergs R, Fernandez R, Baker L, Eberhart R, Cadeddu JA The Journal of urology 2007 Jul 178 1 288-91
Nephrectomy for hypertension in pediatric patients with a unilateral poorly functioning kidney: a contemporary cohort.
Schlomer BJ, Smith PJ, Barber TD, Baker LA Journal of pediatric urology 2011 Jun 7 3 373-7
Bilateral Laparoscopic Retroperitoneal Nephrectomies in a Pediatric Patient with Portal Hypertension
Holzer, M.S., Nuss, G.R., Villanueva, C. and Baker, L.A. J Ped Urol 2012
What to anticipate with experience in pediatric laparoscopic ablative renal surgery.
Yucel S, Brown B, Bush NC, Ahmad N, Baker LA The Journal of urology 2008 Feb 179 2 697-702; discussion 702
Impact and frequency of extra-genitourinary manifestations of prune belly syndrome.
Grimsby GM, Harrison SM, Granberg CF, Bernstein IH, Baker LA Journal of pediatric urology 2015 Jul
DNA Copy-Number Variations in 46,XY Disorders of Sex Development.
Harrison SM, Granberg CF, Keays M, Grimsby GM, Baker LA The Journal of urology 2014 Jun
Correlation between preoperative staging computerized tomography and pathological findings after nodal sampling in children with Wilms tumor.
Lubahn JD, Cost NG, Kwon J, Powell JA, Yang M, Granberg CF, Wickiser JE, Rakheja D, Gargollo PC, Baker LA, Margulis V The Journal of urology 2012 Oct 188 4 Suppl 1500-4
Small genomic rearrangements involving FMR1 support the importance of its gene dosage for normal neurocognitive function.
Nagamani SC, Erez A, Probst FJ, Bader P, Evans P, Baker LA, Fang P, Bertin T, Hixson P, Stankiewicz P, Nelson D, Patel A, Cheung SW Neurogenetics 2012 Nov 13 4 333-9
Wilms tumor: preoperative risk factors identified for intraoperative tumor spill.
Barber TD, Derinkuyu BE, Wickiser J, Joglar J, Koral K, Baker LA The Journal of urology 2011 Apr 185 4 1414-8
Loss of Insl3: a potential predisposing factor for testicular torsion.
Sozubir S, Barber T, Wang Y, Ahn C, Zhang S, Verma S, Lonergan D, Lorenzo AJ, Nef S, Baker LA The Journal of urology 2010 Jun 183 6 2373-9
UBE2A deficiency syndrome: Mild to severe intellectual disability accompanied by seizures, absent speech, urogenital, and skin anomalies in male patients.
de Leeuw N, Bulk S, Green A, Jaeckle-Santos L, Baker LA, Zinn AR, Kleefstra T, van der Smagt JJ, Vianne Morgante AM, de Vries BB, van Bokhoven H, de Brouwer AP American journal of medical genetics. Part A 2010 Dec 152A 12 3084-90
DELETION MAPPING OF CRITICAL REGION FOR HYPOSPADIAS, PENOSCROTAL TRANSPOSITION AND IMPERFORATE ANUS ON HUMAN CHROMOSOME 13.
Garcia NM, Allgood J, Santos LJ, Lonergan D, Batanian JR, Henkemeyer M, Bartsch O, Schultz RA, Zinn AR, Baker LA Journal of pediatric urology 2006 Aug 2 4 233-242
Autologous buccal mucosa graft for repair of recurrent rectovaginal fistula.
Grimsby GM, Fischer AC, Baker LA Pediatric surgery international 2014 May 30 5 533-5
Trocar-less instrumentation for laparoscopy: magnetic positioning of intra-abdominal camera and retractor.
Park S, Bergs RA, Eberhart R, Baker L, Fernandez R, Cadeddu JA Annals of surgery 2007 Mar 245 3 379-84
Prechemotherapy laparoscopic nephrectomy for Wilms' tumor.
Barber TD, Wickiser JE, Wilcox DT, Baker LA Journal of pediatric urology 2009 Oct 5 5 416-9
The Insulin-3(INSL3) Gene: Lack of a genetic basis for human cryptorchidism
Baker, L.A., Zhang, S., Nef, S., Nguyen, M., Pohl, H., and Parada, L.F. J Urol 2002 167(6) 2534-7
Pathological review of Wilms tumor nephrectomy specimens and potential implications for nephron sparing surgery in Wilms tumor.
Cost NG, Lubahn JD, Granberg CF, Sagalowsky AI, Wickiser JE, Gargollo PC, Baker LA, Margulis V, Rakheja D The Journal of urology 2012 Oct 188 4 Suppl 1506-10
Genetic basis of prune belly syndrome: screening for HNF1ß gene.
Granberg CF, Harrison SM, Dajusta D, Zhang S, Hajarnis S, Igarashi P, Baker LA The Journal of urology 2012 Jan 187 1 272-8
Comparative analysis of nephrolithiasis in otherwise healthy versus medically complex gastrostomy fed children.
Smith PJ, Basravi S, Schlomer BJ, Bush NC, Brown BJ, Gingrich A, Baker LA Journal of pediatric urology 2011 Jun 7 3 244-7
Hospitalizations for pediatric stone disease in United States, 2002-2007.
Bush NC, Xu L, Brown BJ, Holzer MS, Gingrich A, Schuler B, Tong L, Baker LA The Journal of urology 2010 Mar 183 3 1151-6
Mutational analyses of UPIIIA, SHH, EFNB2 and HNF1beta in persistent cloaca and associated kidney malformations.
Jenkins D, Bitner-Glindzicz M, Thomasson L, Malcolm S, Warne SA, Feather SA, Flanagan SE, Ellard S, Bingham C, Santos L, Henkemeyer M, Zinn A, Baker LA, Wilcox DT, Woolf AS Journal of pediatric urology 2007 Feb 3 1 2-9
Pediatric testicular torsion: demographics of national orchiopexy versus orchiectomy rates.
Cost NG, Bush NC, Barber TD, Huang R, Baker LA The Journal of urology 2011 Jun 185 6 Suppl 2459-63
Autologous buccal mucosa graft augmentation for foreshortened vagina.
Grimsby GM, Bradshaw K, Baker LA Obstetrics and gynecology 2014 May 123 5 947-50
Circadian variation in urine pH and uric acid nephrolithiasis risk.
Cameron MA, Baker LA, Maalouf NM, Moe OW, Sakhaee K Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2007 Aug 22 8 2375-8
Bladder Outlet Injection for Urinary Incontinence
Yucel, S. and Baker, L.A. 2013 Ch 13
Trans-scrotal Near Infrared Spectroscopy as a Diagnostic Test for Testis Torsion in Pediatric Acute Scrotum: A Prospective Comparison to Gold Standard Diagnostic Test Study.
Schlomer BJ, Keays MA, Grimsby GM, Granberg CF, DaJusta DG, Menon VS, Ostrov L, Sheth KR, Hill M, Sanchez EJ, Harrison CB, Jacobs MA, Huang R, Burgu B, Hennes H, Baker LA The Journal of urology 2017 Apr
Diagnosing Testicular Torsion before Urologic Consultation and Imaging: A Validation of the TWIST Score.
Sheth KR, Keays M, Grimsby GM, Granberg CF, Menon VS, DaJusta DG, Ostrov L, Hill M, Sanchez E, Kuppermann D, Harrison CB, Jacobs MA, Huang R, Burgu B, Hennes H, Schlomer BJ, Baker LA The Journal of urology 2016 Jan
A homozygous loss-of-function variant in MYH11 in a case with megacystis-microcolon-intestinal hypoperistalsis syndrome.
Gauthier J, Ouled Amar Bencheikh B, Hamdan FF, Harrison SM, Baker LA, Couture F, Thiffault I, Ouazzani R, Samuels ME, Mitchell GA, Rouleau GA, Michaud JL, Soucy JF European journal of human genetics : EJHG 2014 Nov
DNA copy number variations in patients with persistent cloaca.
Harrison SM, Seideman C, Baker LA The Journal of urology 2014 May 191 5 Suppl 1543-6
Evaluation and Treatment of Cryptorchidism: AUA Guideline.
Kolon TF, Anthony Herndon CD, Baker LA, Baskin LS, Baxter CG, Cheng EY, Diaz M, Lee PA, Seashore CJ, Tasian GE, Barthold JS The Journal of urology 2014 May
The use of autologous buccal mucosa grafts in vaginal reconstruction.
Grimsby GM, Baker LA Current urology reports 2014 Aug 15 8 428
Reprogramming of human fibroblasts toward a cardiac fate.
Nam YJ, Song K, Luo X, Daniel E, Lambeth K, West K, Hill JA, Dimaio JM, Baker LA, Bassel-Duby R, Olson EN Proceedings of the National Academy of Sciences of the United States of America 2013 Mar
Genetic abnormalities in FOXP1 are associated with congenital heart defects.
Chang SW, Mislankar M, Misra C, Huang N, Dajusta DG, Harrison SM, McBride KL, Baker LA, Garg V Human mutation 2013 Jun
Screening and familial characterization of copy-number variations in NR5A1 in 46,XY disorders of sex development and premature ovarian failure.
Harrison SM, Campbell IM, Keays M, Granberg CF, Villanueva C, Tannin G, Zinn AR, Castrillon DH, Shaw CA, Stankiewicz P, Baker LA American journal of medical genetics. Part A 2013 Aug
Single institution experience with tru-cut renal mass biopsy for diagnosing wilms tumor.
Cost NG, Granberg CF, Schlomer BJ, Wickiser JE, Gargollo PC, Baker LA, Rakheja D Urology journal 2013 10 1 780-3
An approach to the identification of anomalies and etiologies in neonates with identified or suspected VACTERL (Vertebral Defects, Anal Atresia, Tracheo-Esophageal Fistula with Esophageal Atresia, Cardiac Anomalies, Renal Anomalies, and Limb Anomalies) Association
Solomon BD, Baker LA, Bear KA, Cunningham BK, Giampietro PF, Hadigan C, Hadley DW, Harrison S, Levitt MA, Niforatos N, Paul SM, Raggio C, Reutter H, Warren-Mora N Journal of Pediatrics 2013 Epub ahead of print
Staged Male Urethroplasty Transferring Megalourethra Tissue as Free Graft Dorsal Inlay to Proximal Urethral Atresia in VACTERL Association.
Bagrodia A, Yucel S, Baker LA Urology 2011 May
Human balanced translocation and mouse gene inactivation implicate Basonuclin 2 in distal urethral development.
Bhoj EJ, Ramos P, Baker LA, Cost N, Nordenskjöld A, Elder FF, Bleyl SB, Bowles NE, Arrington CB, Delhomme B, Vanhoutteghem A, Djian P, Zinn AR European journal of human genetics : EJHG 2011 May 19 5 540-6
Guidelines for the Development of Comprehensive Care Centers for Congenital Adrenal Hyperplasia: Guidance from the CARES Foundation Initiative.
Auchus RJ, Witchel SF, Leight KR, Aisenberg J, Azziz R, Bachega TA, Baker LA, Baratz AB, Baskin LS, Berenbaum SA, Breault DT, Cerame BI, Conway GS, Eugster EA, Fracassa S, Gearhart JP, Geffner ME, Harris KB, Hurwitz RS, Katz AL, Kalro BN, Lee PA, Alger Lin G, Loechner KJ, Marshall I, Merke DP, Migeon CJ, Miller WL, Nenadovich TL, Oberfield SE, Pass KA, Poppas DP, Lloyd-Puryear MA, Quigley CA, Riepe FG, Rink RC, Rivkees SA, Sandberg DE, Schaeffer TL, Schlussel RN, Schneck FX, Seely EW, Snyder D, Speiser PW, Therrell BL, Vanryzin C, Vogiatzi MG, Wajnrajch MP, White PC, Zuckerman AE International journal of pediatric endocrinology 2010 2010 275213
A novel SOX9 mutation, 972delC, causes 46,XY sex-reversed campomelic dysplasia with nephrocalcinosis, urolithiasis, and dysgerminoma.
Cost NG, Ludwig AT, Wilcox DT, Rakheja D, Steinberg SJ, Baker LA Journal of pediatric surgery 2009 Feb 44 2 451-4
Autologous buccal mucosa vulvovaginoplasty for high urogenital sinus.
Samuelson ML, Baker LA Journal of pediatric urology 2006 Oct 2 5 486-8
Phenotypic expansion of the supernumerary derivative (22) chromosome syndrome: VACTERL and Hirschsprung's disease.
Prieto JC, Garcia NM, Elder FF, Zinn AR, Baker LA Journal of pediatric surgery 2007 Nov 42 11 1928-32
Bidirectional signaling mediated by ephrin-B2 and EphB2 controls urorectal development.
Dravis C, Yokoyama N, Chumley MJ, Cowan CA, Silvany RE, Shay J, Baker LA, Henkemeyer M Developmental biology 2004 Jul 271 2 272-90
Ephrin-B2 reverse signaling is required for axon pathfinding and cardiac valve formation but not early vascular development.
Cowan CA, Yokoyama N, Saxena A, Chumley MJ, Silvany RE, Baker LA, Srivastava D, Henkemeyer M Developmental biology 2004 Jul 271 2 263-71
Images in clinical medicine. True hermaphroditism.
Karam JA, Baker LA The New England journal of medicine 2004 Jan 350 4 393
TP53 codon 72 polymorphisms in favorable histology Wilms tumors.
Cost NG, Mitui M, Khokhar S, Wickiser JE, Baker LA, Rakheja D Pediatric blood & cancer 2012 Aug 59 2 326-8
Hypospadias and anorectal malformations mediated by Eph/ephrin signaling.
Yucel S, Dravis C, Garcia N, Henkemeyer M, Baker LA Journal of pediatric urology 2007 Oct 3 5 354-363
An Approach to the Identification of Anomalies and Etiologies in Neonates with Identified or Suspected VACTERL (Vertebral Defects, Anal Atresia, Tracheo-Esophageal Fistula with Esophageal Atresia, Cardiac Anomalies, Renal Anomalies, and Limb Anomalies) Association.
Solomon BD, Baker LA, Bear KA, Cunningham BK, Giampietro PF, Hadigan C, Hadley DW, Harrison S, Levitt MA, Niforatos N, Paul SM, Raggio C, Reutter H, Warren-Mora N The Journal of pediatrics 2014 Mar 164 3 451-457.e1
Pilot feasibility study of transscrotal near infrared spectroscopy in the evaluation of adult acute scrotum.
Burgu B, Aydogdu O, Huang R, Soygur T, Yaman O, Baker L The Journal of urology 2013 Jul 190 1 124-9
Oncologic outcomes of partial versus radical nephrectomy for unilateral Wilms tumor.
Cost NG, Lubahn JD, Penn HA, Granberg CF, Schlomer BJ, Wickiser JE, Rakheja D, Gargollo PC, Leonard D, Baker LA, Raj G, Margulis V Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2011 May 29 15_suppl 9561
Grady, R and Baker, L.A. In The Kelalis-King-Belman Textbook of Clinical Pediatric urology 2013
Long Term Outcomes of Bladder Neck Reconstruction without Augmentation Cystoplasty in Children.
Grimsby GM, Menon V, Schlomer BJ, Baker LA, Adams R, Gargollo PC, Jacobs MA The Journal of urology 2015 Jul
Urethral foreign body: removal of degraded magnetic spheres using hartmann ear forceps.
Chung PH, Traylor J, Baker LA Urology 2014 Nov 84 5 1214-6
General Principles of Cystourethroscopy
Keays, M. and Baker, L.A. In Pediatric Endourology Techniques, 2nd edition 2013 Ch 11
Fetal Abdominal Ascites from Intraabdominal Bladder Rupture secondary to Posterior Urethral Valves: Diagnostic Challenges
Bagrodia, A., Holzer, M.S., Mauck, R., Baker, L.A. Dialogues in Pediatric Urology 2012 Feb 33 2 3
Contemporary review of testicular torsion: New concepts, emerging technologies and potential therapeutics.
Dajusta DG, Granberg CF, Villanueva C, Baker LA Journal of pediatric urology 2012 Oct
Urolithiasis in children: surgical approach.
Granberg CF, Baker LA Pediatric clinics of North America 2012 Aug 59 4 897-908
- Single trocar laparoscopic nephrectomy using magnetic anchoring and guidance system in the porcine model.
- Causes of disorders of sexual development
- Causes of hypospadias
- Causes of undescended testes and testicular torsion
- Pediatric renal stone disease
- Inherited or familial birth defects of the genitourinary tract
- Genetic Basis of Prune Belly Syndrome
- Genetic basis of female reproductive birth defects
- Pediatric Urology