- Medical School - Johannes Gutenberg University Mainz (1992-1999)
- Internship - Ludwig-Maximilians-Universitat Munich (1998-1999), Internal Medicine
- Residency - University Children's Hospital Erlangen-Nuremberg (1999-2000), Pediatrics
- Residency - Benjamin Franklin Childrens Hospital (2000-2001), Pediatrics
- Residency - University Children's Hospital, Freiburg Germany (2001-2002), Pediatrics
- Fellowship - University of Michigan Hospitals & Health Centers (2002-2004), Research
- Residency - University Children's Hospital, Charite, Berlin (2004-2004), Neonatal-perinatal Medicine
- Residency - University Children's Hospital Cologne Germany (2004-2006), Pediatrics
- Fellowship - University of Michigan Hospitals & Health Centers (2006-2007), Research
- Residency - UT Southwestern/Children's Medical Center (2007-2009), Pediatrics
- Fellowship - UT Southwestern/Children's Medical Center (2009-2012), Pediatric Nephrology
Dr. Matthias Wolf is a Pediatric Nephrologist at UT Southwestern and Children’s Medical Center Dallas. He was born in Germany and attended Medical School at the Johannes Gutenberg University in Mainz, where he obtained his doctoral degree. Dr. Wolf finished his medical studies at the Ludwig-Maximilians University in Munich, Germany. He completed his five-year residency program at different academic centers in Germany, including the University Children’s Hospitals in Erlangen-Nuremberg, Berlin and Cologne. He interrupted his training for two years of postdoctoral fellowship training at the University of Michigan. Here, he studied the genetics of inherited kidney disorders, including different forms of cystic kidney disease and nephrotic syndrome.
After his return to Germany, he passed the German Pediatric Board exam, and became one of the youngest assistant professors at the University Children’s Hospital in Cologne. In 2006, he returned to the United States and completed pediatric residency training at Children’s Medical Center in Dallas. He continued as a fellow in the Pediatric Nephrology program at UT Southwestern, which he successfully completed in 2012.
During his fellowship training, Dr. Wolf joined Dr. Huang’s laboratory at UT Southwestern, where he learned patch-clamp recording, protein biochemistry, and mouse genetics. Dr. Wolf joined the faculty after graduating from fellowship. He has a strong interest in clinical aspects of renal channelopathies, magnesium and calcium homeostasis, inherited kidney diseases, cystic kidney disease, nephrotic syndrome, and nephrolithiasis.
Dr. Wolf is a member of the editorial board of Pediatric Nephrology. In his laboratory, Dr. Wolf focuses on regulation of TRP (transient receptor potential) channels. He studies the regulation of TRP channels by urinary proteins and how this process contributes to common disorders such as kidney stones or type 2 diabetes mellitus.
Dr. Wolf received the Carl W. Gottschalk Research Scholar grant from the American Society of Nephrology. His scientific contribution resulted in over 34 peer-reviewed publications and seven book chapters and reviews. He is currently supported by a NIH Career Development Award and funding by the Children’s Clinical Research Advisory Committee (CCRAC).
He has been included in D Magazine's Best Doctors list.
- International Pediatric Nephrology Association (2014)
- American Board of Pediatrics, Diplomate (2010)
- American Society for Nephrology (2009)
- American Medical Association (2008)
- American Academy of Pediatrics (2007)
- Society for Pediatric Nephrology, Germany (2004)
- German Society of Pediatrics (1999)
- American Physiological Society (2015)
- American Diabetes Association (2018)
- D Magazine Best Pediatric Specialist 2020
- Carl W. Gottschalk Research Scholar Grant 2014, American Society of Nephrology
- Junior Investigator Research Award, Childrens Clinical Research Advisory Committee 2013, Children's Medical Center Dallas
- Awarded Best Oral Presentation, Third Annual Senior Fellows' Research Day 2012, UT Southwestern Medical Center
- Pediatric Resident Research Award 2007-2009, UT Southwestern Medical Center
Investigation of inherited renal disease in Barratt J, Harris K, Topham P, eds. Oxford Desk Reference: Nephrology.
Hildebrandt F, Wolf MTF. (2008), Oxford University Press; 582-585.
Potassium Homeostasis in the Fetus and Neonate in Polin RA, Abman SH, Rowitch D, Benitz WE, eds. Fetal and Neonatal Physiology. 5th ed.
Wolf MT, Benchimol C, Satlin LM, Quigley R. (2016), Philadelphia: Elsevier; 1011-1023.
Renal Tubular Acidosis in Children in Avner ED, Harmon WE, Niaudet P, Yoshikawa N, Emma F, Goldstein SL, eds. Pediatric Nephrology. 7th ed.
Quigley R, Wolf MTF. (2016), Springer; 1273-1306.
- Investigation of inherited renal disease in Barratt J, Harris K, Topham P, eds. Oxford Desk Reference: Nephrology.
Omental Arteriopathy in Primary Atypical Hemolytic Uremic Syndrome.
Ellington N, Wolf MT, Kasten J, Rakheja D International journal of surgical pathology 2017 Mar 1066896917699703
Mutations in KEOPS-complex genes cause nephrotic syndrome with primary microcephaly.
Braun DA, Rao J, Mollet G, Schapiro D, Daugeron MC, Tan W, Gribouval O, Boyer O, Revy P, Jobst-Schwan T, Schmidt JM, Lawson JA, Schanze D, Ashraf S, Ullmann JFP, Hoogstraten CA, Boddaert N, Collinet B, Martin G, Liger D, Lovric S, Furlano M, Guerrera IC, Sanchez-Ferras O, Hu JF, Boschat AC, Sanquer S, Menten B, Vergult S, De Rocker N, Airik M, Hermle T, Shril S, Widmeier E, Gee HY, Choi WI, Sadowski CE, Pabst WL, Warejko JK, Daga A, Basta T, Matejas V, Scharmann K, Kienast SD, Behnam B, Beeson B, Begtrup A, Bruce M, Ch'ng GS, Lin SP, Chang JH, Chen CH, Cho MT, Gaffney PM, Gipson PE, Hsu CH, Kari JA, Ke YY, Kiraly-Borri C, Lai WM, Lemyre E, Littlejohn RO, Masri A, Moghtaderi M, Nakamura K, Ozaltin F, Praet M, Prasad C, Prytula A, Roeder ER, Rump P, Schnur RE, Shiihara T, Sinha MD, Soliman NA, Soulami K, Sweetser DA, Tsai WH, Tsai JD, Topaloglu R, Vester U, Viskochil DH, Vatanavicharn N, Waxler JL, Wierenga KJ, Wolf MTF, Wong SN, Leidel SA, Truglio G, Dedon PC, Poduri A, Mane S, Lifton RP, Bouchard M, Kannu P, Chitayat D, Magen D, Callewaert B, van Tilbeurgh H, Zenker M, Antignac C, Hildebrandt F Nature genetics 2017 Aug
Inherited and acquired disorders of magnesium homeostasis.
Wolf MT Current opinion in pediatrics 2016 Nov
Mucin-1 Increases Renal TRPV5 Activity In Vitro, and Urinary Level Associates with Calcium Nephrolithiasis in Patients.
Nie M, Bal MS, Yang Z, Liu J, Rivera C, Wenzel A, Beck BB, Sakhaee K, Marciano DK, Wolf MT Journal of the American Society of Nephrology : JASN 2016 Apr
Autosomal dominant tubulointerstitial kidney disease: diagnosis, classification, and management-A KDIGO consensus report.
Eckardt KU, Alper SL, Antignac C, Bleyer AJ, Chauveau D, Dahan K, Deltas C, Hosking A, Kmoch S, Rampoldi L, Wiesener M, Wolf MT, Devuyst O Kidney international 2015 Mar
Nephronophthisis and related syndromes.
Wolf MT Current opinion in pediatrics 2015 Jan
Klotho upregulates renal calcium channel transient receptor potential vanilloid 5 (TRPV5) by intra- and extracellular N-glycosylation dependent mechanisms.
Wolf MT, An SW, Nie M, Bal MS, Huang CL The Journal of biological chemistry 2014 Nov
Uromodulin upregulates TRPV5 by impairing caveolin-mediated endocytosis.
Wolf MT, Wu XR, Huang CL Kidney international 2013 Mar
Autosomal dominant mutation in the signal peptide of renin in a kindred with anemia, hyperuricemia, and CKD.
Beck BB, Trachtman H, Gitman M, Miller I, Sayer JA, Pannes A, Baasner A, Hildebrandt F, Wolf MT American journal of kidney diseases : the official journal of the National Kidney Foundation 2011 Nov 58 5 821-5
Mutation analysis of 18 nephronophthisis associated ciliopathy disease genes using a DNA pooling and next generation sequencing strategy.
Otto EA, Ramaswami G, Janssen S, Chaki M, Allen SJ, Zhou W, Airik R, Hurd TW, Ghosh AK, Wolf MT, Hoppe B, Neuhaus TJ, Bockenhauer D, Milford DV, Soliman NA, Antignac C, Saunier S, Johnson CA, Hildebrandt F Journal of medical genetics 2011 Feb 48 2 105-16
Wolf MT, Hildebrandt F Pediatric nephrology (Berlin, Germany) 2011 Feb 26 2 181-94
Uromodulin is expressed in renal primary cilia and UMOD mutations result in decreased ciliary uromodulin expression.
Zaucke F, Boehnlein JM, Steffens S, Polishchuk RS, Rampoldi L, Fischer A, Pasch A, Boehm CW, Baasner A, Attanasio M, Hoppe B, Hopfer H, Beck BB, Sayer JA, Hildebrandt F, Wolf MT Human molecular genetics 2010 May 19 10 1985-97
Individuals with mutations in XPNPEP3, which encodes a mitochondrial protein, develop a nephronophthisis-like nephropathy.
O'Toole JF, Liu Y, Davis EE, Westlake CJ, Attanasio M, Otto EA, Seelow D, Nurnberg G, Becker C, Nuutinen M, Kärppä M, Ignatius J, Uusimaa J, Pakanen S, Jaakkola E, van den Heuvel LP, Fehrenbach H, Wiggins R, Goyal M, Zhou W, Wolf MT, Wise E, Helou J, Allen SJ, Murga-Zamalloa CA, Ashraf S, Chaki M, Heeringa S, Chernin G, Hoskins BE, Chaib H, Gleeson J, Kusakabe T, Suzuki T, Isaac RE, Quarmby LM, Tennant B, Fujioka H, Tuominen H, Hassinen I, Lohi H, van Houten JL, Rotig A, Sayer JA, Rolinski B, Freisinger P, Madhavan SM, Herzer M, Madignier F, Prokisch H, Nurnberg P, Jackson PK, Jackson P, Khanna H, Katsanis N, Hildebrandt F The Journal of clinical investigation 2010 Mar 120 3 791-802
Mutation analysis of the Uromodulin gene in 96 individuals with urinary tract anomalies (CAKUT).
Wolf MT, Hoskins BE, Beck BB, Hoppe B, Tasic V, Otto EA, Hildebrandt F Pediatric nephrology (Berlin, Germany) 2009 Jan 24 1 55-60
A systematic approach to mapping recessive disease genes in individuals from outbred populations.
Hildebrandt F, Heeringa SF, Rüschendorf F, Attanasio M, Nürnberg G, Becker C, Seelow D, Huebner N, Chernin G, Vlangos CN, Zhou W, O'Toole JF, Hoskins BE, Wolf MT, Hinkes BG, Chaib H, Ashraf S, Schoeb DS, Ovunc B, Allen SJ, Vega-Warner V, Wise E, Harville HM, Lyons RH, Washburn J, Macdonald J, Nürnberg P, Otto EA PLoS genetics 2009 Jan 5 1 e1000353
Mutation analysis in nephronophthisis using a combined approach of homozygosity mapping, CEL I endonuclease cleavage, and direct sequencing.
Otto EA, Helou J, Allen SJ, O'Toole JF, Wise EL, Ashraf S, Attanasio M, Zhou W, Wolf MT, Hildebrandt F Human mutation 2008 Mar 29 3 418-26
Evidence of oligogenic inheritance in nephronophthisis.
Hoefele J, Wolf MT, O'Toole JF, Otto EA, Schultheiss U, Dêschenes G, Attanasio M, Utsch B, Antignac C, Hildebrandt F Journal of the American Society of Nephrology : JASN 2007 Oct 18 10 2789-95
The ciliary gene RPGRIP1L is mutated in cerebello-oculo-renal syndrome (Joubert syndrome type B) and Meckel syndrome.
Delous M, Baala L, Salomon R, Laclef C, Vierkotten J, Tory K, Golzio C, Lacoste T, Besse L, Ozilou C, Moutkine I, Hellman NE, Anselme I, Silbermann F, Vesque C, Gerhardt C, Rattenberry E, Wolf MT, Gubler MC, Martinovic J, Encha-Razavi F, Boddaert N, Gonzales M, Macher MA, Nivet H, Champion G, Berthélémé JP, Niaudet P, McDonald F, Hildebrandt F, Johnson CA, Vekemans M, Antignac C, Rüther U, Schneider-Maunoury S, Attié-Bitach T, Saunier S Nature genetics 2007 Jul 39 7 875-81
Medullary cystic kidney disease type 1: mutational analysis in 37 genes based on haplotype sharing.
Wolf MT, Mucha BE, Hennies HC, Attanasio M, Panther F, Zalewski I, Karle SM, Otto EA, Deltas CC, Fuchshuber A, Hildebrandt F Human genetics 2006 Jul 119 6 649-58
Mapping a new suggestive gene locus for autosomal dominant nephrolithiasis to chromosome 9q33.2-q34.2 by total genome search for linkage.
Wolf MT, Zalewski I, Martin FC, Ruf R, Müller D, Hennies HC, Schwarz S, Panther F, Attanasio M, Acosta HG, Imm A, Lucke B, Utsch B, Otto E, Nurnberg P, Nieto VG, Hildebrandt F Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2005 May 20 5 909-14
Expression and phenotype analysis of the nephrocystin-1 and nephrocystin-4 homologs in Caenorhabditis elegans.
Wolf MT, Lee J, Panther F, Otto EA, Guan KL, Hildebrandt F Journal of the American Society of Nephrology : JASN 2005 Mar 16 3 676-87
Telomeric refinement of the MCKD1 locus on chromosome 1q21.
Wolf MT, van Vlem B, Hennies HC, Zalewski I, Karle SM, Puetz M, Panther F, Otto E, Fuchshuber A, Lameire N, Loeys B, Hildebrandt F Kidney international 2004 Aug 66 2 580-5
Refinement of the critical region for MCKD1 by detection of transcontinental haplotype sharing.
Wolf MT, Karle SM, Schwarz S, Anlauf M, Anlauf M, Glaeser L, Kroiss S, Burton C, Feest T, Otto E, Fuchshuber A, Hildebrandt F Kidney international 2003 Sep 64 3 788-92
Mutations of the Uromodulin gene in MCKD type 2 patients cluster in exon 4, which encodes three EGF-like domains.
Wolf MT, Mucha BE, Attanasio M, Zalewski I, Karle SM, Neumann HP, Rahman N, Bader B, Baldamus CA, Otto E, Witzgall R, Fuchshuber A, Hildebrandt F Kidney international 2003 Nov 64 5 1580-7
Pulmonary re-occurrence of post-transplant lymphoproliferative disease with hypogammaglobulinaemia.
Wolf MT, Mildenberger E, Lennert T, Anagnostopoulos I, Zinn C, Paul K, Keitzer R, Versmold H European journal of pediatrics 2003 Mar 162 3 180-3
A gene locus for steroid-resistant nephrotic syndrome with deafness maps to chromosome 14q24.2.
Ruf RG, Wolf MT, Hennies HC, Lucke B, Zinn C, Varnholt V, Lichtenberger A, Pasch A, Imm A, Briese S, Lennert T, Fuchshuber A, Nurnberg P, Hildebrandt F Journal of the American Society of Nephrology : JASN 2003 Jun 14 6 1519-22
Mutations in a novel gene, NPHP3, cause adolescent nephronophthisis, tapeto-retinal degeneration and hepatic fibrosis.
Olbrich H, Fliegauf M, Hoefele J, Kispert A, Otto E, Volz A, Wolf MT, Sasmaz G, Trauer U, Reinhardt R, Sudbrak R, Antignac C, Gretz N, Walz G, Schermer B, Benzing T, Hildebrandt F, Omran H Nature genetics 2003 Aug 34 4 455-9
Mutations in INVS encoding inversin cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determination.
Otto EA, Schermer B, Obara T, O'Toole JF, Hiller KS, Mueller AM, Ruf RG, Hoefele J, Beekmann F, Landau D, Foreman JW, Goodship JA, Strachan T, Kispert A, Wolf MT, Gagnadoux MF, Nivet H, Antignac C, Walz G, Drummond IA, Benzing T, Hildebrandt F Nature genetics 2003 Aug 34 4 413-20
A gene mutated in nephronophthisis and retinitis pigmentosa encodes a novel protein, nephroretinin, conserved in evolution.
Otto E, Hoefele J, Ruf R, Mueller AM, Hiller KS, Wolf MT, Schuermann MJ, Becker A, Birkenhäger R, Sudbrak R, Hennies HC, Nürnberg P, Hildebrandt F American journal of human genetics 2002 Nov 71 5 1161-7
Follow-up of five patients with FHHNC due to mutations in the Paracellin-1 gene.
Wolf MT, Dötsch J, Konrad M, Böswald M, Rascher W Pediatric nephrology (Berlin, Germany) 2002 Aug 17 8 602-8
Uromodulin regulates renal magnesium homeostasis through the ion channel transient receptor potential melastatin 6 (TRPM6).
Nie M, Bal MS, Liu J, Yang Z, Rivera C, Wu XR, Hoenderop JGJ, Bindels RJM, Marciano DK, Wolf MTF The Journal of biological chemistry 2018 Aug
Single molecule real time sequencing in ADTKD-MUC1 allows complete assembly of the VNTR and exact positioning of causative mutations.
Wenzel A, Altmueller J, Ekici AB, Popp B, Stueber K, Thiele H, Pannes A, Staubach S, Salido E, Nuernberg P, Reinhardt R, Reis A, Rump P, Hanisch FG, Wolf MTF, Wiesener M, Huettel B, Beck BB Scientific reports 2018 Mar 8 1 4170
Mercury Intoxication as a Rare Cause of Membranous Nephropathy in a Child.
Onwuzuligbo O, Hendricks AR, Hassler J, Domanski K, Goto C, Wolf MTF American journal of kidney diseases : the official journal of the National Kidney Foundation 2018 Jul
- Omental Arteriopathy in Primary Atypical Hemolytic Uremic Syndrome.