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Pradeep Mammen, M.D.
Pradeep Mammen, M.D.

Pradeep Mammen, M.D.

  • Alfred W. Harris, M.D., Professorship in Cardiology
  • Internal Medicine - Cardiology
  • Cardiomyopathies
  • Heart Failure & Cardiac Support

Biography

Pradeep Mammen, M.D., is an Associate Professor in the Department of Internal Medicine’s Division of Cardiology at UT Southwestern Medical Center.

Dr. Mammen’s clinical and investigative focus is heart failure/heart transplantation, and he serves as Medical Director of the Neuromuscular Cardiomyopathy Clinic, as well as Director of Translational Research for the Advanced Heart Failure and Transplant Cardiology Program.

He is also a member of the UT Southwestern Hamon Center for Regenerative Science & Medicine and runs a molecular laboratory that is funded through grants from the National Institutes of Health and the American Heart Association. Dr. Mammen’s scientific interests revolve around the molecular mechanisms underlying heart failure and he oversees a laboratory dedicated to better understanding this disease entity. The goal is to eventually develop new, targeted heart failure therapies.

After earning his medical degree at the University of Wisconsin School of Medicine, he completed an internal medicine internship and residency at the University of Iowa Hospitals and Clinics, followed by fellowships in cardiology, heart failure/cardiac transplantation, and molecular cardiology at UT Southwestern.

A Fellow of both the American Heart Association and the American College of Cardiology, Dr. Mammen is board certified in internal medicine and cardiovascular medicine. He is one of only 500 U.S. cardiologists board certified in advanced heart failure/transplant cardiology.

Dr. Mammen has published more than 40 journal articles and delivered a number of invited lectures. He has served as a reviewer for publications that include the American Heart Journal, American Journal of Cardiology, American Journal of PhysiologyHeart and Circulatory Physiology, Circulation: Heart Failure, Journal of the American College of Cardiology, and the Journal of Cardiac Failure. In addition, Dr. Mammen serves on the Scientific Review Committee for various study sections for the National Institutes of Health and the American Heart Association.

He is a member of professional organizations that include the American College of Cardiology (Heart Failure/VAD/Heart Transplantation Section), American Heart Association (Council on Basic Cardiovascular Sciences as well as the Council on Clinical Cardiology), Heart Failure Society of America, International Society of Heart and Lung Transplantation, and American College of Physicians.

Dr. Mammen also serves as a member of UT Southwestern’s Class of 2013 LEAD Program. He was among 30 faculty members identified as having leadership potential and chosen by the Dean’s Office to take part in a leadership-training program for junior faculty members.

Personal Note

Dr. Mammen and his wife have a son and a daughter.

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Meet Dr. Mammen

Heart Failure Specialist

Pradeep Mammen, M.D., finds great satisfaction in his dual role as a clinician-scientist at UT Southwestern Medical Center: As a clinician, he contributes directly to his patients’ health in the clinic, and as a scientist, he pioneers new treatments in the research lab.

Dr. Mammen is an expert in advanced heart failure, ventricular assist devices (VADs), and heart transplantation. He has a special interest in neuromuscular cardiomyopathy – heart failure caused by neuromuscular disorders – and he serves as the Medical Director of UT Southwestern’s dedicated Neuromuscular Cardiomyopathy Clinic, which he founded in 2010. It remains one of only a handful of dedicated neuromuscular cardiomyopathy clinics in the United States.

Meanwhile, Dr. Mammen is one of only 500 cardiologists in the nation who is board certified in advanced heart failure/transplant cardiology. He also performs cardiopulmonary stress testing – a specialized test for advanced heart failure – as well as procedures such as heart biopsies and cardiac catheterizations.

On the research side, Dr. Mammen is the Director of Translational Research for the Advanced Heart Failure Program and investigates the molecular mechanisms underlying heart failure. The goal of his molecular cardiology laboratory is to develop novel therapeutic approaches for the treatment of patients with heart failure. Dr. Mammen’s laboratory is funded through grants from the National Institute of Health and the American Heart Association.

He is optimistic about the future of heart-failure treatment.

“Heart failure, ventricular assist devices, and cardiac transplantation are some of the fastest-growing subspecialties within cardiology,” he says. “And fields like regenerative biology and stem-cell transplantation are enabling us to look at ways to regenerate heart tissue – which helps damaged hearts repair themselves.”

Dr. Mammen is also proud to belong to UT Southwestern’s group of experienced and skilled specialists, a team that includes physicians and surgeons as well as clinicians such as nurse coordinators and practitioners.

“Everything the heart failure/transplant team does, we do as a team – not as individuals – and our patients really benefit from that,” Dr. Mammen says. “UT Southwestern wouldn’t have the excellent heart transplantation survival rates it does if it weren’t for this well-oiled machine, and I’m proud that as a group, we’re able to give these very sick patients another chance at life.”

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Education & Training
  • Fellowship - UT Southwestern Medical Center (2003-2004), Heart Failure/cardiac Transplant
  • Fellowship - UT Southwestern Medical Center (2000-2004), Molecular Cardiology
  • Fellowship - UT Southwestern Medical Center (1998-2001), Cardiology
  • Residency - University of Iowa Hospitals and Clinics (1996-1998), Internal Medicine
  • Internship - University of Iowa Hospitals and Clinics (1995-1996), Internal Medicine
  • Medical School - University of Wisconsin School of Medicine (1990-1995)
Professional Associations & Affiliations
  • Texas Medical Association (2004), Member
  • International Society of Heart and Lung Transplantation (2004), Member
  • Heart Failure Society of America (2004), Member
  • Dallas County Medical Society (2004), Member
  • American Heart Association (2004), Fellow
  • American College of Physicians (2004), Member
  • American College of Cardiology (2004), Fellow
  • Central Society for Clinical Research (2008), Member
  • American Society for Biochemistry and Molecular Biology (2008), Member
Honors & Awards
  • Ernest O. Theilen Award 1998, Outstanding Cardiac Care Unit Resident of the Year (U. of Iowa Hospitals & Clinics)
  • Diplomate in Internal Medicine (American Board of Internal Medicine) 1998
  • Above and Beyond the Call of Duty Award 1998, Recognition for compassionate care (U. of Iowa Hospitals & Clinics)
  • Diplomate in Cardiovascular Medicine (American Board of Internal Medicine) 2002
  • 3rd Place: Basic Science Research at the Young Investigators Molecular Cardiovascular Forum: Pathways to Cardiac Development and Regeneration (Sponsored by UT Southwestern Medical Center) 2003
  • Recipient of the Dr. Madhukar Deshmukh Award (Sponsored by the American Association of Cardiologists of Indian Origin) 2004
  • Finalist: AstraZeneca Cardiovascular Young Investigators’ Forum 2004
  • Recipient of a NIH Clinician Scientist Development Award 2005-2011
  • Induction as a Fellow into the American College of Cardiology 2005
  • GlaxoSmithKline Competitive Grant Award for Young Investigators 2005, One of four cardiovascular investigators in the nation to receive this competitive grant.
  • Finalist: Northwestern University Feinberg School of Medicine Cardiovascular Young Investigators’ Forum 2005, Outstanding research as a cardiology fellow
  • 2nd Place, Northwestern University Feinberg School of Medicine Cardiovascular Young Investigators’ Forum 2006, Outstanding research as a junior faculty member
  • Recipient of a AHA Grant-in-Aid Award 2009-2012
  • Mentor to Sarvjeet Singh PhD, recipient of an AHA Postdoctoral Research Award 2009-2012
  • Postdoctoral Mentor to Sarvjeet Singh, PhD, a Finalist for the Louis N. and Arnold M. Katz Basic Science Research Award 2010, Highest basic science award given to a junior investigator. The award is sponsored by the American Heart Association
  • Diplomate in Advanced Heart Failure/Transplant Cardiology (American Board of Internal Medicine) 2010
  • Mentor to Diana Canseco PhD, recipient of an AHA Postdoctoral Research Award 2011-2013
  • Induction as a Fellow into the American Heart Association (Council on Basic Cardiovascular Sciences) 2011
  • Recipient of a NIH-NHLBI R01 Research Grant 2012-2017
  • UTSW Leadership Emerging in Academic Departments (LEAD) Program (Class of 2013) 2013-2013, Only 30 out of 100 UTSW faculty members were chosen to enter the Class of 2013 based on their future leadership potential.
Books & Publications
Research
  • Regenerative Medicine
  • Oxygen and nitric oxide metabolism in the heart
  • Oxidative stress
  • Modulation of the metabolic and redox states with stressed cardiomyocytes
  • Cardiac energetics

Clinical Focus

  • Cardiomyopathies
  • Heart Failure & Cardiac Support
  • Heart Transplant Medicine

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Q&A by Dr. Mammen

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University Hospital Heart and Lung Clinic

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