- Residency - UT MD Anderson Cancer Center (2006-2010), Radiation Oncology
- Internship - University of Texas MD Anderson Cancer Center (2005-2006), Internal Medicine
- Graduate School - Albert Einstein College of Medicine (1999-2005), Cell Biology
- Medical School - Albert Einstein College of Medicine (2001-2005)
Puneeth Iyengar, M.D., Ph.D.
- Radiation Oncology
- Chest Cancers
- Radiation Therapy for Esophageal Cancer
Understanding how tumors respond to radiation has been a lifelong process for Puneeth Iyengar, M.D., Ph.D., Assistant Professor of Radiation Oncology at UT Southwestern Medical Center. He began testing theories in school science fairs as an adolescent growing up in Louisiana. Studying at MIT furthered his interest in the biologic and engineering aspects of medicine, and he earned a bachelor of science degree in biology before receiving his M.D./Ph.D. degrees from Albert Einstein College of Medicine in New York in 2005. With medical school came a better understanding of cancer biology that led Dr. Iyengar to pursue an internship and residency at MD Anderson Cancer Center in Houston, where he honed his clinical skills.
Dr. Iyengar ultimately chose UT Southwestern as the academic medical center where he wanted to continue his career because, he says, “it offers the greatest opportunity to integrate clinical radiation oncology with the science behind it. The science is what enables us to push things to the forefront for optimal treatment management for patients.”
As a key member of the radiation oncology team at UT Southwestern, Dr. Iyengar has two main roles: He is an expert in treating lung cancer patients with radiation. He also leads a research lab with two missions – discovering how lung tumors become therapeutically resistant, and understanding the basic mechanisms of cancer cachexia, a wasting process of the body that’s associated with certain types of tumors, primarily lung and gastrointestinal tumors.
As a biologist, a researcher, and a physician, Dr. Iyengar is uniquely qualified to talk to patients about their disease in as much detail as they want to hear. “I try to be direct and honest with my patients while at the same time balancing their need for hope,” he says. “When patients ask me about lifespan, I honestly tell them that any patient can be the exception to the rule and every situation is different. I want them to have just as much hope for themselves as I have for them.”
Among Dr. Iyengar’s many recognitions, he received the 2016 ARRO Educator of the Year Teaching Award, a 2015 American Cancer Society Research Scholar Grant Award, a 2013 Sidney Kimmel Cancer Foundation Translational Research Award, a 2012 Distinguished Researcher Award from the UT Southwestern President’s Research Council, a 2011 Young Investigator Research Grant from the National Lung Cancer Partnership, a 2011 Lung Cancer Research Foundation grant, and the Roentgen Research Award from the Radiological Society of North America Research and Education Foundation in 2010. He was part of the National Institutes of Health Medical Scientist Training Program in 2005, and, in 2001, he received the Eastern Cooperative Oncology Group Young Investigator Award. Dr. Iyengar’s research has been published in many major journals, including Lancet Oncology, JAMA Oncology, the Journal of Clinical Oncology, Nature Medicine, the Journal of Clinical Investigation, among others.
Meet Dr. Iyengar
As a physician and research scientist, Puneeth Iyengar, M.D., Ph.D., brings unique skills to his patients and his position as Assistant Professor of Radiation Oncology at UT Southwestern Medical Center. He’s able to use what he learns from his lung cancer patients to test theories in his lab, as well as translate discoveries from his lab into better treatments for his patients. The ability to traverse both areas makes him a better caregiver and researcher, he says.
"We offer patients state-of-the-art technology in radiation therapy and the highest level of expertise solely for lung cancer patients."
Lung cancer patients at UT Southwestern have access to some of the most effective techniques in radiation treatment and the country’s top clinicians. Dr. Iyengar and three other radiation oncologists at UT Southwestern focus solely on the treatment of lung cancer and are experts in stereotactic ablative radiation therapy (SABR), a form of radiation treatment for lung cancer that’s becoming more of a first-line, curative treatment. This type of noninvasive treatment involves high-dose radiation beams entering the body through various angles and intersecting at the desired target. This allows for a concentrated dose to reach the tumor while limiting the dose to surrounding healthy tissue.
Dr. Iyengar and his colleagues are using SABR, also known as stereotactic body radiation therapy, to reduce the number of treatments for lung cancer patients while safely increasing the dosage of radiation given during each treatment. Additionally, Dr. Iyengar has been center stage of national efforts to use SABR in the management of metastatic NSCLC, a new evolving treatment paradigm meant to improve overall survival.
In the laboratory, Dr. Iyengar runs a research program studying the wasting syndrome known as cancer cachexia. This syndrome, leading to losses of adipose and muscle mass with eventual weight loss, is observed in over 50 percent of all solid tumor patients and responsible for 30 percent of all cancer-related deaths. Dr. Iyengar’s group is attempting to understand how to block cachexia development in improving the survival and quality of life of his lung cancer patients.
Being on the forefront of treatment technology and seeing how he can make a difference in the lives of lung cancer patients drew Dr. Iyengar to UT Southwestern. The challenges of the disease, the need to understand it, and the rapport he develops with his patients keep him here, along with a world-class team of health care providers focused on the same goal.
- Radiological Society of North America
- Radiation Therapy Oncology Group
- NRG Oncology
- Lung Cancer Research Foundation
- International Association for the Study of Lung Cancer
- Free to Breathe
- American Society of Therapeutic Radiology and Oncology
- American Society of Clinical Oncology
- ECOG Young Investigator Award cosponsored by Aventis 2001
- NIH Medical Scientist Training Program 2005, MD/PhD Program
- Roentgen Research Award, RSNA Research and Education Foundation 2010, Research Resident Award
- Radiological Society of North America 2011, RSNA Research Grant Award Winner
- National Lung Cancer Partnership 2011, Young Investigator Research Award
- Lung Cancer Research Foundation 2011, Research Award
- UT Southwestern Medical Center 2012, President Research Council Distinguished Research Award
- Sidney Kimmel Cancer Research Foundation 2013, Translational Research Award
- American Cancer Society 2015, Research Scholar
- ARRO 2017, Educator of the Year Teaching Award
- American Society of Therapeutic Radiation Oncology 2017, Plenary Speaker
Ribosome-initiator tRNA complex as an intermediate in translation initiation in Escherichia coli revealed by use of mutant initiator tRNAs and specialized ribosomes.
Wu XQ, Iyengar P, RajBhandary UL The EMBO journal 1996 Sep 15 17 4734-9
Constitutive and growth factor-regulated phosphorylation of caveolin-1 occurs at the same site (Tyr-14) in vivo: identification of a c-Src/Cav-1/Grb7 signaling cassette.
Lee H, Volonte D, Galbiati F, Iyengar P, Lublin DM, Bregman DB, Wilson MT, Campos-Gonzalez R, Bouzahzah B, Pestell RG, Scherer PE, Lisanti MP Molecular endocrinology (Baltimore, Md.) 2000 Nov 14 11 1750-75
Sexual differentiation, pregnancy, calorie restriction, and aging affect the adipocyte-specific secretory protein adiponectin.
Combs TP, Berg AH, Rajala MW, Klebanov S, Iyengar P, Jimenez-Chillaron JC, Patti ME, Klein SL, Weinstein RS, Scherer PE Diabetes 2003 Feb 52 2 268-76
Adiponectin/Acrp30, an adipocyte-specific secretory factor: physiological relevance during development.
Iyengar P, Scherer PE Pediatric diabetes 2003 Mar 4 1 32-7
Combined loss of INK4a and caveolin-1 synergistically enhances cell proliferation and oncogene-induced tumorigenesis: role of INK4a/CAV-1 in mammary epithelial cell hyperplasia.
Williams TM, Lee H, Cheung MW, Cohen AW, Razani B, Iyengar P, Scherer PE, Pestell RG, Lisanti MP The Journal of biological chemistry 2004 Jun 279 23 24745-56
Role of caveolin-1 in the modulation of lipolysis and lipid droplet formation.
Cohen AW, Razani B, Schubert W, Williams TM, Wang XB, Iyengar P, Brasaemle DL, Scherer PE, Lisanti MP Diabetes 2004 May 53 5 1261-70
The hyperglycemia-induced inflammatory response in adipocytes: the role of reactive oxygen species.
Lin Y, Berg AH, Iyengar P, Lam TK, Giacca A, Combs TP, Rajala MW, Du X, Rollman B, Li W, Hawkins M, Barzilai N, Rhodes CJ, Fantus IG, Brownlee M, Scherer PE The Journal of biological chemistry 2005 Feb 280 6 4617-26
Lumenal protein sorting to the constitutive secretory pathway of a regulated secretory cell.
Lara-Lemus R, Liu M, Turner MD, Scherer P, Stenbeck G, Iyengar P, Arvan P Journal of cell science 2006 May 119 Pt 9 1833-42
Outcome of patients with diffuse large B-cell lymphoma of the testis by era of treatment: the M. D. Anderson Cancer Center experience.
Mazloom A, Fowler N, Medeiros LJ, Iyengar P, Horace P, Dabaja BS Leukemia & lymphoma 2010 Jul 51 7 1217-24
Clinically apparent internal mammary nodal metastasis in patients with advanced breast cancer: incidence and local control.
Zhang YJ, Oh JL, Whitman GJ, Iyengar P, Yu TK, Tereffe W, Woodward WA, Perkins G, Buchholz TA, Strom EA International journal of radiation oncology, biology, physics 2010 Jul 77 4 1113-9
Marginal zone lymphomas: factors that affect the final outcome.
Mazloom A, Medeiros LJ, McLaughlin PW, Reed V, Cabanillas FF, Fayad LE, Pro B, Gonzalez G, Iyengar P, Urbauer DL, Dabaja BS Cancer 2010 Sep 116 18 4291-8
Radiation for Hodgkin's lymphoma in young female patients: a new technique to avoid the breasts and decrease the dose to the heart.
Dabaja BS, Rebueno NC, Mazloom A, Thorne S, Perrin KJ, Tolani N, Das P, Delclos ME, Iyengar P, Reed VK, Horace P, Salehpour MR International journal of radiation oncology, biology, physics 2011 Feb 79 2 503-7
Design of a smart biomarker for bioremediation: a machine learning approach.
Kumar PT, Vinod PT, Phoha VV, Iyengar SS, Iyengar P Computers in biology and medicine 2011 Jun 41 6 357-60
Summary of presentations from the 11th targeted therapies for lung cancer meeting: radiation oncology.
Iyengar P, Choy H Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2011 Nov 6 11 Suppl 4 S1822-4
Satraplatin and simultaneous chest radiation for non-small cell lung cancer
Iyengar P, Hodges J, Hughes R, DiMaio M, Petrone M, Yun S, Choy H Advances in Lung Cancer 2012 1 13-19
Can preoperative axillary US help exclude N2 and N3 metastatic breast cancer?
Iyengar SS, Li X, Xu Huanhuan, Mukhopadhyay Supratik, Balakrishnan N, Sawant A, Iyengar P IEEE Computer Society 2012 45 1 59-65
The value of ultrasound in detecting extra-axillary regional node involvement in patients with advanced breast cancer
Puneeth Iyengar, M.D., Ph.D, Eric A. Strom, M.D., Yu-Jing Zhang, M.D., Ph.D, Gary J. Whitman, M.D., Wendy A. Woodward, M.D., Ph.D, Tse-Kuan Yu, M.D., Ph.D, and Thomas A. Buchholz, M.D. Oncologist 2012 17 11
Stereotactic ablative radiotherapy for non-small cell lung cancer: rationale and outcomes.
Iyengar P, Timmerman RD Journal of the National Comprehensive Cancer Network : JNCCN 2012 Dec 10 12 1514-20
Isolated central nervous system progression on Crizotinib: an Achilles heel of non-small cell lung cancer with EML4-ALK translocation?
Chun SG, Choe KS, Iyengar P, Yordy JS, Timmerman RD Cancer biology & therapy 2012 Dec 13 14 1376-83
Design of an expert system for mitigating trace element toxicity in cancer risk management.
Krishna Kumar PT, Vinod PT, Phoha VV, Iyengar SS, Iyengar P Cancer informatics 2013 12 21-9
Histone modifications and DNA double-strand break repair after exposure to ionizing radiations.
Hunt CR, Ramnarain D, Horikoshi N, Iyengar P, Pandita RK, Shay JW, Pandita TK Radiation research 2013 Apr 179 4 383-92
Localization accuracy and immobilization effectiveness of a stereotactic body frame for a variety of treatment sites.
Foster R, Meyer J, Iyengar P, Pistenmaa D, Timmerman R, Choy H, Solberg T International journal of radiation oncology, biology, physics 2013 Dec 87 5 911-6
Stereotactic Ablative Radiotherapy (SABR) for Non-Small Cell Lung Cancer.
Iyengar P, Westover K, Timmerman RD Seminars in respiratory and critical care medicine 2013 Dec 34 6 845-54
The Role of Inflammatory Pathways in Cancer Associated Cachexia and Radiation Resistance.
Laine A, Iyengar P, Pandita TK Molecular cancer research : MCR 2013 Jun
Locally advanced lung cancer: an optimal setting for vaccines and other immunotherapies.
Iyengar P, Gerber DE Cancer journal (Sudbury, Mass.) 2013 May-Jun 19 3 247-62
Stereotactic ablative body radiation therapy for tumors in the lung in octogenarians: a retrospective single institution study.
Cannon NA, Iyengar P, Choy H, Timmerman R, Meyer J BMC cancer 2014 14 971
Optic Neuropathy and Blindness Associated With Crizotinib for Non-Small-Cell Lung Cancer With EML4-ALK Translocation.
Chun SG, Iyengar P, Gerber DE, Hogan RN, Timmerman RD Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2014 Mar
Neutrophil-lymphocyte and platelet-lymphocyte ratios as prognostic factors following stereotactic radiation therapy for early-stage non-small cell lung cancer.
Cannon NA, Meyer J, Iyengar P, Ahn C, Westover KD, Choy H, Timmerman R Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2014 Oct
Phase II Trial of Stereotactic Body Radiation Therapy Combined With Erlotinib for Patients With Limited but Progressive Metastatic Non-Small-Cell Lung Cancer.
Iyengar P, Kavanagh BD, Wardak Z, Smith I, Ahn C, Gerber DE, Dowell J, Hughes R, Abdulrahman R, Camidge DR, Gaspar LE, Doebele RC, Bunn PA, Choy H, Timmerman R Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2014 Oct
Employment After Radiation Oncology Residency: A Survey of the Class of 2014.
Bland RE, Hodges JC, Folkert MR, Iyengar P, Meyer JJ International journal of radiation oncology, biology, physics 2015 Aug 92 5 969-70
Standard-dose versus high-dose conformal radiotherapy with concurrent and consolidation carboplatin plus paclitaxel with or without cetuximab for patients with stage IIIA or IIIB non-small-cell lung cancer (RTOG 0617): a randomised, two-by-two factorial phase 3 study.
Bradley JD, Paulus R, Komaki R, Masters G, Blumenschein G, Schild S, Bogart J, Hu C, Forster K, Magliocco A, Kavadi V, Garces YI, Narayan S, Iyengar P, Robinson C, Wynn RB, Koprowski C, Meng J, Beitler J, Gaur R, Curran W, Choy H The Lancet. Oncology 2015 Feb 16 2 187-199
Concurrent pemetrexed and radiation therapy in the treatment of patients with inoperable stage III non-small cell lung cancer: A systematic review of completed and ongoing studies.
Choy H, Gerber DE, Bradley JD, Iyengar P, Monberg M, Treat J, Govindan R, Koustensis A, Barker S, Obasaju C Lung cancer (Amsterdam, Netherlands) 2015 Mar 87 3 232-240
SABR for aggressive local therapy of metastatic cancer: A new paradigm for metastatic non-small cell lung cancer.
Westover KD, Iyengar P, Sharma AN, Timmerman R Lung cancer (Amsterdam, Netherlands) 2015 May
Driver Missense Mutation Identification Using Feature Selection and Model Fusion.
Soliman AT, Meng T, Chen SC, Iyengar SS, Iyengar P, Yordy J, Shyu ML Journal of computational biology : a journal of computational molecular cell biology 2015 Sep
Precision Hypofractionated Radiation Therapy in Poor Performing Patients With Non-Small Cell Lung Cancer: Phase 1 Dose Escalation Trial.
Westover KD, Loo BW, Gerber DE, Iyengar P, Choy H, Diehn M, Hughes R, Schiller J, Dowell J, Wardak Z, Sher D, Christie A, Xie XJ, Corona I, Sharma A, Wadsworth ME, Timmerman R International journal of radiation oncology, biology, physics 2015 Sep 93 1 72-81
Local Therapy for Limited Metastatic Non-Small Cell Lung Cancer: What Are the Options and Is There a Benefit?
Iyengar P, Lau S, Donington JS, Suh RD American Society of Clinical Oncology educational book / ASCO. American Society of Clinical Oncology. Meeting 2016 35 e460-7
Inverse 4D conformal planning for lung SBRT using particle swarm optimization.
Modiri A, Gu X, Hagan A, Bland R, Iyengar P, Timmerman R, Sawant A Physics in medicine and biology 2016 Aug 61 16 6181-202
Obesity: Slim without the gym - the magic of chilling out.
Iyengar P, Scherer PE Nature reviews. Endocrinology 2016 Feb
Predicting distant failure in early stage NSCLC treated with SBRT using clinical parameters.
Zhou Z, Folkert M, Cannon N, Iyengar P, Westover K, Zhang Y, Choy H, Timmerman R, Yan J, Xie XJ, Jiang S, Wang J Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2016 May
Rationale and evidence to combine radiation therapy and immunotherapy for cancer treatment.
Ishihara D, Pop L, Takeshima T, Iyengar P, Hannan R Cancer immunology, immunotherapy : CII 2016 Oct
Key role for neutrophils in radiation-induced antitumor immune responses: Potentiation with G-CSF.
Takeshima T, Pop LM, Laine A, Iyengar P, Vitetta ES, Hannan R Proceedings of the National Academy of Sciences of the United States of America 2016 Sep
Application of Critical Volume Dose Constraints for SBRT in NRG Radiation Therapy Trials
Ritter T, Matuszak M, Chetty I, Mayo C, Wu J, Iyengar P, et al International Journal of Radiation Oncology, Biology, Physics 2017 98 1 34-36
A new CT reconstruction technique using adaptive deformation recovery and intensity correction (ADRIC).
Zhang Y, Ma J, Iyengar P, Zhong Y, Wang J Medical physics 2017 Apr
Impact of Intensity-Modulated Radiation Therapy Technique for Locally Advanced Non-Small-Cell Lung Cancer: A Secondary Analysis of the NRG Oncology RTOG 0617 Randomized Clinical Trial.
Chun SG, Hu C, Choy H, Komaki RU, Timmerman RD, Schild SE, Bogart JA, Dobelbower MC, Bosch W, Galvin JM, Kavadi VS, Narayan S, Iyengar P, Robinson CG, Wynn RB, Raben A, Augspurger ME, MacRae RM, Paulus R, Bradley JD Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2017 Jan 35 1 56-62
Multi-objective radiomics model for predicting distant failure in lung SBRT.
Zhou Z, Folkert M, Iyengar P, Westover K, Zhang Y, Choy H, Timmerman R, Jiang S, Wang J Physics in medicine and biology 2017 Jun 62 11 4460-4478
Randomized Phase II Study Comparing Prophylactic Cranial Irradiation Alone To Prophylactic Cranial Irradiation And Consolidative Extra-Cranial Irradiation For Extensive Disease Small Cell Lung Cancer (ED-SCLC): NRG Oncology RTOG 0937.
Gore EM, Hu C, Sun AY, Grimm DF, Ramalingam SS, Dunlap NE, Higgins KA, Werner-Wasik M, Allen AM, Iyengar P, Videtic GMM, Hales RK, McGarry RC, Urbanic JJ, Pu AT, Johnstone CA, Stieber VW, Paulus R, Bradley JD Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2017 Jun
Implications of weight loss for cancer patients receiving radiotherapy.
Lau SKM, Iyengar P Current opinion in supportive and palliative care 2017 Sep
Metabolic dysregulation and adipose tissue fibrosis: role of collagen VI
Khan T, Muise ES, Iyengar P, Wang ZV, Chandalia M, Abate N, Zhang BB, Bonaldo P, Chua S, Scherer PE Mol Cell Biol April 2009 29(6) 1575-1591
Hodgkin Lymphoma Involving Extranodal and Nodal Head and Neck Sites: Characteristics and Outcomes
P. Iyengar, A. Mazloom A. Younes, M. Fanale, F. Shihadeh, and B. Dabaja Cancer August 2010 116 16
Toxicity Associated with Post-Operative Radiation Therapy for Prostate Cancer
P Iyengar, LB Levy, S Choi, et al. American Journal of Clinical Oncology December 2011 34 6
Reduction of noise due to systematic uncertainties in 113mIn SPECT imaging using information theory
Kumar, PTK, Phoha, VV, Iyengar, SS, and Iyengar, P Computers in Biology and Medicine Fall 2009 39 482-488
Fat apoptosis through targeted activation of caspase 8: a new mouse model of inducible and reversible lipoatrophy
Pajvani UB, Trujillo ME, Combs TP, Iyengar P, Jelicks L, Roth, KA, Kitsis RN, Scherer PE Nat Med July 2005 11(7) 797-803
Metabolic dysregulation and adipose tissue fibrosis: role of collagen VI
Khan T, Muise ES, Iyengar P, Wang ZV, Chandalia M, Abate N, Zhang BB, Bonaldo P, Chua S, Scherer PE Mol Cell Biol March 2009 (6) 1575-91
Adipocyte-derived collagen VI affects early mammary tumor progression in vivo, demonstrating a critical interaction in the tumor/stroma microenvironment
Iyengar P, Espina V, Williams TW, Lin Y, Berry D, Jelicks LA, Lee H, Temple K, Graves R, Pollard J, Chopra N, Russell RG, Sasisekharan R, Trock BJ, Lippman M, Calvert VS, Petricoin Iii EF, Liotta L, Dadachova E, Pestell RG, Lisanti MP, Bonaldo P, Scherer PE J Clin Invest May 2005 115(5) 1163-1176
Adipocyte-secreted factors synergistically promote mammary tumorigenesis through induction of anti-apoptotic transcriptional programs and proto-oncogene stabilization
Iyengar P, Combs TP, Shah SJ, Gouon-Evans V, Pollard JW, Albanese C, Flanagan L, Tenniswood MP, Guha C, Lisanti MP, Pestell RG, Scherer PE Oncogene September 2003 22(41) 6408-6423
Targeting Tumors and Personalizing Individual Treatments for Radiation Therapy
P Iyengar, S Chan, and R Komaki Personalized Therapy for Cancer Winter 2010
- Ribosome-initiator tRNA complex as an intermediate in translation initiation in Escherichia coli revealed by use of mutant initiator tRNAs and specialized ribosomes.
- Pathophysiology and Biology of Cachexia
- Oligometastatic Lung Cancer and Treatment with Radiation
- Metabolic Dysregulation and Lung Cancer
- Lung Cancer Radiation Resistance
- Inflammation and Lung Cancer
- Chest Cancers
- Radiation Therapy for Esophageal Cancer
- Brain Metastases
- Radiation Therapy for Lung Cancer