Takeshi Yokoo, M.D., Ph.D.

Medical Director, Magnetic Resonance Imaging

Harold C. Simmons Comprehensive Cancer Center

Radiology - MRI
Pancreatic Cancer Prevention
Diagnostic Radiology

Biography

Takeshi Yokoo, M.D., Ph.D., is an Associate Professor of Radiology at UT Southwestern Medical Center and a member of its Magnetic Resonance Imaging (MRI) Division. He also serves as the Lead Radiologist for Body Intervention at Parkland Hospital. His clinical interests include imaging of liver cancer, as well as image-guided biopsies and drainages.

Dr. Yokoo holds a bachelor's degree in mathematics from Williams College in Williamstown, Massachusetts. He earned his doctorate in biomathematics and his medical degree at Mount Sinai School of Medicine in New York. He then completed his residency in diagnostic radiology on a five-year research track at the University of California, San Diego Medical School before obtaining advanced training in abdominal imaging and intervention through a fellowship at Massachusetts General Hospital in Boston.

A passion for research

Dr. Yokoo focuses on researching quantitative imaging techniques in order to support radiologists in objective interpretation and standardized reporting of imaging studies. He has collaborated with MRI manufacturers to develop product sequences that are now available for routine clinical imaging use. Through his extensive research and work in technological imaging advancement, along with his research on topics such as diffuse liver disease and liver cancer, Dr. Yokoo has authored or co-authored more than 35 peer-reviewed publications, as well as more than 60 conference abstracts.

A career marked by service

In addition to serving on numerous committees for the UTSW Radiology Department, Dr. Yokoo is an active member of several national and international professional societies, including the American College of Radiology, the Society of Abdominal Radiology, the Radiological Society of North America, the American Board of Radiology, and the International Society of Magnetic Resonance in Medicine

He is an active reviewer for the Journal of Magnetic Resonance Imaging and Magnetic Resonance in Medicine; for the latter, he has been recognized as a distinguished reviewer five times. In addition, he has served as an ad hoc reviewer on a range of publications such as Abdominal Imaging, Journal of Hematology, and European Radiology. He also served as a guest editor for a special issue of BioMed Research International focused on "Advances in MR Imaging Techniques and Applications.”

Education & Training

Medical School - Mount Sinai School of Medicine (1997-2005)
Internship - North Shore-Long Island Jewish (2005-2006), Internal Medicine
Fellowship - Massachusetts General Hospital (2011-2012), F
Residency - UC San Diego (2006-2011), Diagnostic Radiology

Honors & Awards

RSNA Research Scholar Award 2016
RSNA Roentgen Resident Research Award 2011
RSNA Trainee Research Award 2009
RSNA R&E Foundation Resident Research Grant 2007
Honors in Mathematics, Williams College 1996

Books & Publications

Books
- Ch. 65: Fatty Liver in Abdominal Imaging
  Sirlin, CB, Mazhar S, Faria S, Yokoo T (2009), Maryland Heights, MO, Saunders Elsevier Publishing
- Ch. 9: Imaging of NAFLD in Non-Alcoholic Fatty Liver Disease: A Practical Guide
  Yokoo T, Tang A, and Sirlin, CB. (2012), Chichester, UK, Wiley-Blackwell Publishing
Publications
- Abbreviated-protocol screening MRI vs. complete-protocol diagnostic MRI for detection of hepatocellular carcinoma in patients with cirrhosis: An equivalence study using LI-RADS v2018.
  Khatri G, Pedrosa I, Ananthakrishnan L, de Leon AD, Fetzer DT, Leyendecker J, Singal AG, Xi Y, Yopp A, Yokoo T, Journal of magnetic resonance imaging : JMRI 2020 Feb 51 2 415-425
- Assessment of hepatocellular carcinoma treatment response with LI-RADS: a pictorial review.
  Voizard N, Cerny M, Assad A, Billiard JS, Olivié D, Perreault P, Kielar A, Do RKG, Yokoo T, Sirlin CB, Tang A, Insights into imaging 2019 Dec 10 1 121
- Magnetic resonance imaging of obesity and metabolic disorders: Summary from the 2019 ISMRM Workshop.
  Hu HH, Branca RT, Hernando D, Karampinos DC, Machann J, McKenzie CA, Wu HH, Yokoo T, Velan SS, Magnetic resonance in medicine 2019 Nov
- Prevalence and clinical significance of discordant LI-RADS^® observations on multiphase contrast-enhanced MRI in patients with cirrhosis.
  Yokoo T, Singal AG, Diaz de Leon A, Ananthakrishnan L, Fetzer DT, Pedrosa I, Khatri G, Abdominal radiology (New York) 2019 Jul
- Pelvic muscle size and myosteatosis: Relationship with age, gender, and obesity.
  Pacicco T, Ratner S, Xi Y, Yokoo T, Fetzer D, Oz OK, Rubin CD, Chhabra A, The Indian journal of radiology & imaging 2019 Apr-Jun 29 2 155-162
- Low-to-high b value DWI ratio approaches in multiparametric MRI of the prostate: feasibility, optimal combination of b values, and comparison with ADC maps for the visual presentation of prostate cancer.
  Xi Y, Liu A, Olumba F, Lawson P, Costa DN, Yuan Q, Khatri G, Yokoo T, Pedrosa I, Lenkinski RE Quantitative imaging in medicine and surgery 2018 Jul 8 6 557-567
- MR relaxometry for estimation of liver iron concentration.
  Pirasteh A, Yuan Q, Hernando D, Reeder SB, Pedrosa I, Yokoo T Magnetic resonance in medicine 2018 May
- Liver Iron Quantification with MR Imaging: A Primer for Radiologists.
  Labranche R, Gilbert G, Cerny M, Vu KN, Soulières D, Olivié D, Billiard JS, Yokoo T, Tang A Radiographics : a review publication of the Radiological Society of North America, Inc 2018 Mar-Apr 38 2 392-412
- Diagnostic Performance and Interreader Agreement of a Standardized MR Imaging Approach in the Prediction of Small Renal Mass Histology.
  Kay FU, Canvasser NE, Xi Y, Pinho DF, Costa DN, Diaz de Leon A, Khatri G, Leyendecker JR, Yokoo T, Lay AH, Kavoussi N, Koseoglu E, Cadeddu JA, Pedrosa I Radiology 2018 Feb 171557
- Liver Injury in Hemolysis, Elevated Liver Enzymes, and Low Platelets Syndrome Measured by Diffusion-Weighted Magnetic Resonance Imaging.
  Nelson DB, Khan A, Bailey A, Yokoo T, Pedrosa I, McIntire DD, Cunningham FG American journal of perinatology 2017 Dec
- Linearity, Bias, and Precision of Hepatic Proton Density Fat Fraction Measurements by Using MR Imaging: A Meta-Analysis.
  Yokoo T, Serai SD, Pirasteh A, Bashir MR, Hamilton G, Hernando D, Hu HH, Hetterich H, Kühn JP, Kukuk GM, Loomba R, Middleton MS, Obuchowski NA, Song JS, Tang A, Wu X, Reeder SB, Sirlin CB Radiology 2017 Sep 170550
- Locoregional therapies for hepatocellular carcinoma and the new LI-RADS treatment response algorithm.
  Kielar A, Fowler KJ, Lewis S, Yaghmai V, Miller FH, Yarmohammadi H, Kim C, Chernyak V, Yokoo T, Meyer J, Newton I, Do RK Abdominal radiology (New York) 2017 Aug
- Addressing metabolic heterogeneity in clear cell renal cell carcinoma with quantitative Dixon MRI.
  Zhang Y, Udayakumar D, Cai L, Hu Z, Kapur P, Kho EY, Pavía-Jiménez A, Fulkerson M, de Leon AD, Yuan Q, Dimitrov IE, Yokoo T, Ye J, Mitsche MA, Kim H, McDonald JG, Xi Y, Madhuranthakam AJ, Dwivedi DK, Lenkinski RE, Cadeddu JA, Margulis V, Brugarolas J, DeBerardinis RJ, Pedrosa I JCI insight 2017 Aug 2 15
- Population rCharacteristics and Progressive Disability in Neuofibromatosis Type 2.
  Iwatate K, Yokoo T, Iwatate E, Ichikawa M, Sato T, Fujii M, Sakuma J, Saito K World neurosurgery 2017 Jul
- Diagnostic Accuracy of Multiparametric Magnetic Resonance Imaging to Identify Clear Cell Renal Cell Carcinoma in cT1a Renal Masses.
  Canvasser NE, Kay FU, Xi Y, Pinho DF, Costa D, de Leon AD, Khatri G, Leyendecker JR, Yokoo T, Lay A, Kavoussi N, Koseoglu E, Cadeddu JA, Pedrosa I The Journal of urology 2017 Apr
- Editorial: ultrasound surveillance of hepatocellular carcinoma in the 21st century - authors' reply.
  Simmons O, Fetzer DT, Yokoo T, Marrero JA, Yopp A, Parikh N, Browning T, Singal AG Alimentary pharmacology & therapeutics 2017 Feb 45 4 562-563
- Extrahepatic metastasis risk of hepatocellular carcinoma based on a-fetoprotein and tumor staging parameters at cross-sectional imaging.
  Yokoo T, Patel AD, Lev-Cohain N, Singal AG, Yopp AC, Pedrosa I Cancer management and research 2017 9 503-511
- Predictors of adequate ultrasound quality for hepatocellular carcinoma surveillance in patients with cirrhosis.
  Simmons O, Fetzer DT, Yokoo T, Marrero JA, Yopp A, Kono Y, Parikh ND, Browning T, Singal AG Alimentary pharmacology & therapeutics 2016 Nov
- Optimization of breathing instructions and timing of late arterial phase acquisition on gadobutrol-enhanced MRI of the liver.
  Pinho DF, Lev-Cohain N, Awdeh H, Xi Y, Khatri G, Yokoo T, Pedrosa I Clinical imaging 2016 Sep 40 6 1274-1279
- Effect of steatosis on liver signal and enhancement on multiphasic contrast-enhanced magnetic resonance imaging.
  Pirasteh A, Clark HR, Sorra EA, Pedrosa I, Yokoo T Abdominal radiology (New York) 2016 Apr
- Multisite, multivendor validation of the accuracy and reproducibility of proton-density fat-fraction quantification at 1.5T and 3T using a fat-water phantom.
  Hernando D, Sharma SD, Aliyari Ghasabeh M, Alvis BD, Arora SS, Hamilton G, Pan L, Shaffer JM, Sofue K, Szeverenyi NM, Welch EB, Yuan Q, Bashir MR, Kamel IR, Rice MJ, Sirlin CB, Yokoo T, Reeder SB Magnetic resonance in medicine 2016 Apr
- Radiation-Induced Liver Injury Mimicking Metastatic Disease in a Patient With Esophageal Cancer: Correlation of Positron Emission Tomography/Computed Tomography With Magnetic Resonance Imaging and Literature Review.
  Rabe TM, Yokoo T, Meyer J, Kernstine KH, Wang D, Khatri G Journal of computer assisted tomography 2016 Mar
- Quantification of renal steatosis in type II diabetes mellitus using dixon-based MRI.
  Yokoo T, Clark HR, Pedrosa I, Yuan Q, Dimitrov I, Zhang Y, Lingvay I, Beg MS, Bobulescu IA Journal of magnetic resonance imaging : JMRI 2016 Mar
- Mechanisms of Action of Liraglutide in Patients with Type 2 Diabetes Treated with High Dose Insulin.
  Vanderheiden A, Harrison LB, Warshauer JT, Adams-Huet B, Li X, Yuan Q, Hulsey K, Dimitrov I, Yokoo T, Jaster AW, Pinho DF, Pedrosa I, Lenkinski RE, Pop LM, Lingvay I The Journal of clinical endocrinology and metabolism 2016 Feb jc20153906
- Quantitative Imaging Biomarkers of NAFLD.
  Kinner S, Reeder SB, Yokoo T Digestive diseases and sciences 2016 Feb
- Feasibility of and agreement between MR imaging and spectroscopic estimation of hepatic proton density fat fraction in children with known or suspected nonalcoholic fatty liver disease.
  Achmad E, Yokoo T, Hamilton G, Heba ER, Hooker JC, Changchien C, Schroeder M, Wolfson T, Gamst A, Schwimmer JB, Lavine JE, Sirlin CB, Middleton MS Abdominal imaging 2015 Jul
- A Phase I Dose-Escalation Trial of Single-Fraction Stereotactic Radiation Therapy for Liver Metastases.
  Meyer JJ, Foster RD, Lev-Cohain N, Yokoo T, Dong Y, Schwarz RE, Rule W, Tian J, Xie Y, Hannan R, Nedzi L, Solberg T, Timmerman R Annals of surgical oncology 2015 May
- Quantitative R2 * MRI of the liver with rician noise models for evaluation of hepatic iron overload: Simulation, phantom, and early clinical experience.
  Yokoo T, Yuan Q, Sénégas J, Wiethoff AJ, Pedrosa I Journal of magnetic resonance imaging : JMRI 2015 May
- Advances in MRI Techniques and Applications.
  Dong Z, Andrews T, Xie C, Yokoo T BioMed research international 2015 2015 139043
- Evaluation of Liver Fibrosis Using Texture Analysis on Combined-Contrast-Enhanced Magnetic Resonance Images at 3.0T.
  Yokoo T, Wolfson T, Iwaisako K, Peterson MR, Mani H, Goodman Z, Changchien C, Middleton MS, Gamst AC, Mazhar SM, Kono Y, Ho SB, Sirlin CB BioMed research international 2015 2015 387653
- Fat and iron quantification in the liver: past, present, and future.
  Yokoo T, Browning JD Topics in magnetic resonance imaging : TMRI 2014 Apr 23 2 129-50
- Establishment of a Multidisciplinary Hepatocellular Carcinoma Clinic is Associated with Improved Clinical Outcome.
  Yopp AC, Mansour JC, Beg MS, Arenas J, Trimmer C, Reddick M, Pedrosa I, Khatri G, Yakoo T, Meyer JJ, Shaw J, Marrero JA, Singal AG Annals of surgical oncology 2013 Dec
- Effect of echo-sampling strategy on the accuracy of out-of-phase and in-phase multiecho gradient-Echo MRI hepatic fat fraction estimation.
  Levin YS, Yokoo T, Wolfson T, Gamst AC, Collins J, Achmad EA, Hamilton G, Middleton MS, Loomba R, Sirlin CB Journal of magnetic resonance imaging : JMRI 2013 May
- Reproducibility of hepatic fat fraction measurement by magnetic resonance imaging.
  Mashhood A, Railkar R, Yokoo T, Levin Y, Clark L, Fox-Bosetti S, Middleton MS, Riek J, Kauh E, Dardzinski BJ, Williams D, Sirlin C, Shire NJ Journal of magnetic resonance imaging : JMRI 2012 Nov
- A multivariate, multitaper approach to detecting and estimating harmonic response in cortical optical imaging data.
  Sornborger AT, Yokoo T Journal of neuroscience methods 2012 Jan 203 1 254-63
- In vivo characterization of the liver fat ?H MR spectrum.
  Hamilton G, Yokoo T, Bydder M, Cruite I, Schroeder ME, Sirlin CB, Middleton MS NMR in biomedicine 2011 Aug 24 7 784-90
- Estimation of hepatic proton-density fat fraction by using MR imaging at 3.0 T.
  Yokoo T, Shiehmorteza M, Hamilton G, Wolfson T, Schroeder ME, Middleton MS, Bydder M, Gamst AC, Kono Y, Kuo A, Patton HM, Horgan S, Lavine JE, Schwimmer JB, Sirlin CB Radiology 2011 Mar 258 3 749-59
- Constraining the initial phase in water-fat separation.
  Bydder M, Yokoo T, Yu H, Carl M, Reeder SB, Sirlin CB Magnetic resonance imaging 2011 Feb 29 2 216-21
- Assessment of liver fat quantification in the presence of iron.
  Bydder M, Shiehmorteza M, Yokoo T, Sugay S, Middleton MS, Girard O, Schroeder ME, Wolfson T, Gamst A, Sirlin C Magnetic resonance imaging 2010 Jul 28 6 767-76
- A quantitative approach to sequence and image weighting.
  Yokoo T, Bae WC, Hamilton G, Karimi A, Borgstede JP, Bowen BC, Sirlin CB, Chung CB, Crues JV, Bradley WG, Bydder GM Journal of computer assisted tomography 2010 May-Jun 34 3 317-31
- Effect of PRESS and STEAM sequences on magnetic resonance spectroscopic liver fat quantification.
  Hamilton G, Middleton MS, Bydder M, Yokoo T, Schwimmer JB, Kono Y, Patton HM, Lavine JE, Sirlin CB Journal of magnetic resonance imaging : JMRI 2009 Jul 30 1 145-52
- Heritability of nonalcoholic fatty liver disease.
  Schwimmer JB, Celedon MA, Lavine JE, Salem R, Campbell N, Schork NJ, Shiehmorteza M, Yokoo T, Chavez A, Middleton MS, Sirlin CB Gastroenterology 2009 May 136 5 1585-92
- Nonalcoholic fatty liver disease: diagnostic and fat-grading accuracy of low-flip-angle multiecho gradient-recalled-echo MR imaging at 1.5 T.
  Yokoo T, Bydder M, Hamilton G, Middleton MS, Gamst AC, Wolfson T, Hassanein T, Patton HM, Lavine JE, Schwimmer JB, Sirlin CB Radiology 2009 Apr 251 1 67-76
- Fatty liver disease: MR imaging techniques for the detection and quantification of liver steatosis.
  Cassidy FH, Yokoo T, Aganovic L, Hanna RF, Bydder M, Middleton MS, Hamilton G, Chavez AD, Schwimmer JB, Sirlin CB Radiographics : a review publication of the Radiological Society of North America, Inc 2009 Jan-Feb 29 1 231-60
- Effects of intravenous gadolinium administration and flip angle on the assessment of liver fat signal fraction with opposed-phase and in-phase imaging.
  Yokoo T, Collins JM, Hanna RF, Bydder M, Middleton MS, Sirlin CB Journal of magnetic resonance imaging : JMRI 2008 Jul 28 1 246-51
- Optimal phased-array combination for spectroscopy.
  Bydder M, Hamilton G, Yokoo T, Sirlin CB Magnetic resonance imaging 2008 Jul 26 6 847-50
- Relaxation effects in the quantification of fat using gradient echo imaging.
  Bydder M, Yokoo T, Hamilton G, Middleton MS, Chavez AD, Schwimmer JB, Lavine JE, Sirlin CB Magnetic resonance imaging 2008 Apr 26 3 347-59
- Extraction of the average and differential dynamical response in stimulus-locked experimental data.
  Sornborger A, Yokoo T, Delorme A, Sailstad C, Sirovich L Journal of neuroscience methods 2005 Feb 141 2 223-9
- An optimization approach to signal extraction from noisy multivariate data.
  Yokoo T, Knight BW, Sirovich L NeuroImage 2001 Dec 14 6 1309-26

Research

Diffuse Liver Disease (liver fat, iron, fibrosis)
Hepatocellular Carcinoma
Image Analysis, Signal Processing
Image Computation and Quantification
Liver Imaging
Magnetic Resonance Imaging and Spectroscopy

Clinical Focus

Pancreatic Cancer Prevention
Diagnostic Radiology

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