Brendan Kelley, M.D.

Vice Chair for Clinical Operations

Peter O'Donnell Jr. Brain Institute

Neurology
Memory Disorders
Alzheimer's Disease

Biography

Brendan Kelley, M.D., is a Professor and Clinical Vice-Chair in the Department of Neurology at UT Southwestern Medical Center. He specializes in the evaluation and study of neurological causes of impairment in memory and cognition.

Dr. Kelley earned his medical degree at The Ohio State University. He completed a residency in neurology at the Cleveland Clinic and received advanced training in behavioral neurology and multiple sclerosis through fellowships at the Mayo Clinic.

He also holds an executive M.B.A. from The Ohio State University’s Fisher College of Business and a master’s degree in physics from Cornell University.

Certified by the American Board of Psychiatry and Neurology, he joined the UT Southwestern faculty in 2017.

Dr. Kelley’s research focuses on the clinical translation of novel techniques to better identify changes in the brain and spinal fluid related to Alzheimer’s disease and other dementias. He collaborates with investigators in UT Southwestern research labs who conduct basic science research to better understand the biological processes that cause neurodegeneration and to improve our ability to detect these changes before irreversible cognitive impairments have occurred.

He also participates in clinical research trials conducted throughout the United States that are aimed at testing new compounds as potential treatments for dementia. He has authored numerous peer-reviewed scientific articles and book chapters related to Alzheimer’s disease and other dementias.

Dr. Kelley directs the UT Southwestern Behavioral Neurology and Neuropsychiatry Fellowship Program. He’s a member of the American Neurological Association and the Behavioral Neurology Section of the American Academy of Neurology.

Education & Training

Medical School - The Ohio State University College of Medicine (1998-2002)
Fellowship - Mayo Clinic College of Science and Medicine (2007-2008), Multiple Sclerosis
Fellowship - Mayo Clinic College of Medicine and Science (2006-2007), Behavioral Neurology
Residency - Cleveland Clinic Foundation (2003-2006), Neurology
Internship - Cleveland Clinic Foundation (2002-2003), Internal Medicine

Professional Associations & Affiliations

American Neurological Association
American Academy of Neurology

Honors & Awards

APP Champion of the Year 2020, UT Southwestern
Buckeye Pride Award for Patient Satisfaction 2015-2017
Columbus Monthly Top Doctors 2015-2016
Cincinnati Magazine Top Doctors 2010-2014
AAN Award for Excellence in Clinical Neurology 2002
OSU Neurology Department Award for Outstanding Performance 2002
J.D. and C.D. Smith Award 1995, The Ohio State University
Excellence in Teaching Award 1995, The Ohio State University Department of Physics
Graduated Summa Cum Laude 1995, The Ohio State University
Outstanding Scholar in the College of Humanities 1993, The Ohio State University
Phi Beta Kappa 1992, The Ohio State University

Books & Publications

Publications
- Associations Between High-Density Lipoprotein Cholesterol Efflux and Brain Grey Matter Volume
  Giacona JM, Wang J, Zhang R, Kelley B, Hajjar I, Thomas BP, Yu FF, De Lemos JA, Rohatgi AK, Vongpatanasin W Journal of Clinical Medicine 2024 Oct 13
- Preventing cognitive decline by reducing BP target (PCOT): A randomized, pragmatic, multi-health systems clinical trial
  Giacona JM, Bates BM, Sundaram V, Brinker S, Moss E, Paspula R, Kassa S, Zhang R, Ahn C, Zhang S, Basit M, Burkhalter L, Cullum CM, Carlew A, Kelley BJ, Plassman BL, Vazquez M, Vongpatanasin W Contemporary Clinical Trials 2024 Mar 138
- Prognostic relevance of gait-related cognitive functions for dementia conversion in amnestic mild cognitive impairment
  Author Collaboration TA, Tuena C, Maestri S, Serino S, Pedroli E, Stramba-Badiale M, Riva G, Silbert LC, Lind B, Crissey R, Kaye JA, Carter R, Dolen S, Quinn J, Schneider LS, Pawluczyk S, Becerra M, Teodoro L, Dagerman K, Spann BM, Brewer J, Fleisher A, Vanderswag H, Ziolkowski J, Heidebrink JL, Zbizek-Nulph L, Lord JL, Albers CS, Petersen R, Mason SS, Knopman D, Johnson K, Villanueva-Meyer J, Pavlik V, Pacini N, Lamb A, Kass JS, Doody RS, Shibley V, Chowdhury M, Rountree S, Dang M, Stern Y, Honig LS, Mintz A, Kelley B, Nguyen T, Mathews D, Quiceno M, Hajjar I, Kerwin D BMC Geriatrics 2023 Dec 23
- Circular-SWAT for deep learning based diagnostic classification of Alzheimer's disease: application to metabolome data
  Author Collaboration AD, Author Collaboration AD, Jo T, Kim J, Bice P, Huynh K, Wang T, Arnold M, Meikle PJ, Giles C, Kaddurah-Daouk R, Saykin AJ, Nho K, Kueider-Paisley A, Doraiswamy PM, Blach C, Moseley A, Thompson W, St John-Williams L, Mahmoudiandehkhordi S, Tenenbaum J, Welsh-Balmer K, Plassman B, Risacher SL, Kastenmüller G, Han X, Baillie R, Knight R, Dorrestein P, Brewer J, Mayer E, Labus J, Baldi P, Gupta A, Fiehn O, Barupal D, Meikle P, Mazmanian S, Rader D, Kling M, Shaw L, Trojanowski J, van Duijin C, Nevado-Holgado A, Bennett D, Krishnan R, Keshavarzian A, Vogt R, Kelley B, Quiceno M, Hajjar I, Kerwin D EBioMedicine 2023 Nov 97
- Regional Neuroanatomic Effects on Brain Age Inferred Using Magnetic Resonance Imaging and Ridge Regression
  Author Collaboration AD, Massett RJ, Maher AS, Imms PE, Amgalan A, Chaudhari NN, Chowdhury NF, Irimia A, Weiner MW, Aisen P, Petersen R, Jack CR, Jagust W, Trojanowki JQ, Toga AW, Beckett L, Green RC, Saykin AJ, Morris JC, Perrin RJ, Shaw LM, Khachaturian Z, Carrillo M, Potter W, Barnes L, Bernard M, González H, Ho C, Hsiao JK, Jackson J, Masliah E, Masterman D, Okonkwo O, Ryan L, Silverberg N, Fleisher A, Sacrey DT, Fockler J, Conti C, Veitch D, Neuhaus J, Jin C, Nosheny R, Ashford M, Cabrera Y, Kelley B, Nguyen T, Womack KB, Quiceno M, Hajjar I, Kerwin D Journals of Gerontology - Series A Biological Sciences and Medical Sciences 2023 Jun 78 872-881
- A predictive model using the mesoscopic architecture of the living brain to detect Alzheimer’s disease
  Author Collaboration TA, Inglese M, Patel N, Linton-Reid K, Loreto F, Win Z, Perry RJ, Carswell C, Grech-Sollars M, Crum WR, Lu H, Malhotra PA, Silbert LC, Lind B, Crissey R, Kaye JA, Carter R, Dolen S, Quinn J, Schneider LS, Pawluczyk S, Becerra M, Teodoro L, Dagerman K, Spann BM, Brewer J, Vanderswag H, Fleisher A, Ziolkowski J, Heidebrink JL, Lord JL, Zbizek-Nulph L, Petersen R, Mason SS, Albers CS, Knopman D, Johnson K, Villanueva-Meyer J, Pavlik V, Pacini N, Lamb A, Kass JS, Doody RS, Shibley V, Chowdhury M, Nguyen T, Quiceno M, Hajjar I, Kerwin D, Kelley B Communications Medicine 2022 Dec 2
- Psychotic depression in older adults following the sudden loss of a spouse during the COVID-19 pandemic: a case series
  Eichenberger AR, Carlew AR, Kelley BJ, Camp ME Journal of Gerontology and Geriatrics 2022 Dec 70 297-299
- Using RBANS to characterize cognitive treatment response in autoimmune encephalopathy
  Kelley BJ, Bratt R, Lobue C Clinical Neurology and Neurosurgery 2022 Nov 222
- Cognitive Decline in Older People with Multiple Sclerosis—A Narrative Review of the Literature
  Chiang HS, Khera A, Stopschinski BE, Stuve O, Hart J, Kelley B, Nguyen T Geriatrics (Switzerland) 2022 Jun 7
- Linking Problems Reported by Care Partners of Individuals With Alzheimer’s Disease and Lewy Body Dementia to the International Classification of Functioning Disability and Health
  Kew CL, Juengst SB, Kelley B, Osborne CL Gerontology and Geriatric Medicine 2022 Mar 8
- Diagnostic Utility of Hippocampal Volumetric Data in a Memory Disorder Clinic Setting
  Ruchinskas R, Nguyen T, Womack K, Khera A, Yu FF, Kelley BJ Cognitive and Behavioral Neurology 2022 Mar 35 66-75
- Mild Traumatic Brain Injury Is Related to Elevated Cerebrospinal Fluid Tau in Alzheimer's Disease Dementia
  Lobue C, Kelley BJ, Hart J, Helphrey J, Schaffert J, Cullum CM, Peters ME, Douglas PM Journal of Alzheimer's Disease 2022 87 1491-1496
- CSF-Derived CD4⁺T-Cell Diversity Is Reduced in Patients With Alzheimer Clinical Syndrome
  Joshi C, Sivaprakasam K, Christley S, Ireland S, Rivas J, Zhang W, Sader D, Logan R, Lambracht-Washington D, Rosenberg R, Cullum M, Hitt B, Li QZ, Barber R, Greenberg B, Cowell L, Zhang R, Stowe A, Huebinger R, Kelley B, Monson N Neurology: Neuroimmunology and NeuroInflammation 2022 Jan 9
- Staging tau pathology with tau PET in Alzheimer’s disease: a longitudinal study
  Author Collaboration Ft, Chen SD, Lu JY, Li HQ, Yang YX, Jiang JH, Cui M, Zuo CT, Tan L, Dong Q, Yu JT, Weiner MW, Aisen P, Petersen R, Jack CR, Jagust W, Trojanowki JQ, Toga AW, Beckett L, Green RC, Saykin AJ, Morris JC, Perrin RJ, Shaw LM, Carrillo M, Potter W, Barnes L, Bernard M, González H, Ho C, Hsiao JK, Jackson J, Masliah E, Masterman D, Okonkwo O, Ryan L, Silverberg N, Fleisher A, Sacrey DT, Fockler J, Conti C, Veitch D, Neuhaus J, Jin C, Cabrera Y, Kelley B, Nguyen T, Mathews D, Quiceno M, Hajjar I, Kerwin D Translational psychiatry 2021 Dec 11
- Higher CSF sTNFR1-related proteins associate with better prognosis in very early Alzheimer’s disease
  Author Collaboration AD, Hu WT, Ozturk T, Kollhoff A, Wharton W, Christina Howell J, Weiner M, Aisen P, Petersen R, Jack CR, Jagust W, Trojanowki JQ, Toga AW, Beckett L, Green RC, Saykin AJ, Morris J, Perrin RJ, Shaw LM, Kachaturian Z, Carrillo M, Potter W, Barnes L, Bernard M, González H, Ho C, Hsiao JK, Masliah E, Masterman D, Okonkwo O, Ryan L, Silverberg N, Fleisher A, Montine T, Kaye JA, Silbert LC, Schneider LS, Pawluczyk S, Becerra M, Brewer J, Heidebrink JL, Knopman D, Villanueva-Meyer J, Doody RS, Kass JS, Stern Y, Honig LS, Mintz A, Geldmacher D, Kelley B, Nguyen T Nature communications 2021 Dec 12
- Plasma phosphorylated-tau181 as a predictive biomarker for Alzheimer’s amyloid, tau and FDG PET status
  Author Collaboration AD, Shen XN, Huang YY, Chen SD, Guo Y, Tan L, Dong Q, Yu JT, Weiner MW, Aisen P, Petersen R, Jack CR, Jagust W, Trojanowki JQ, Toga AW, Beckett L, Green RC, Saykin AJ, Morris JC, Perrin RJ, Shaw LM, Carrillo M, Potter W, Barnes L, Bernard M, González H, Ho C, Hsiao JK, Jackson J, Masliah E, Masterman D, Okonkwo O, Ryan L, Silverberg N, Fleisher A, Fockler J, Conti C, Veitch D, Neuhaus J, Jin C, Nosheny R, Ashford M, Flenniken D, Kormos A, Cabrera Y, Nguyen T, Mathews D, Quiceno M, Hajjar I, Kerwin D, Kelley B Translational psychiatry 2021 Dec 11
- Bilingual problem-solving training for caregivers of adults with dementia: A randomized, factorial-design protocol for the CaDeS trial
  Juengst SB, Supnet C, Kew CL, Silva V, Vega M, Han G, Kelley B, Smith ML, Maestre G Contemporary Clinical Trials 2021 Sep 108
- Chronic Use of Aspirin and Total White Matter Lesion Volume: Results from the Women's Health Initiative Memory Study of Magnetic Resonance Imaging Study
  Holcombe A, Ammann E, Espeland MA, Kelley BJ, Manson JA, Wallace R, Robinson J Journal of Stroke and Cerebrovascular Diseases 2017 Oct 26 2128-2136
- Association of plasma neurofilament light with neurodegeneration in patients with Alzheimer disease
  Author Collaboration AD, Mattsson N, Andreasson U, Zetterberg H, Blennow K, Weiner MW, Aisen P, Toga AW, Petersen R, Jack CR, Jagust W, Trojanowki JQ, Shaw LM, Beckett L, Green RC, Saykin AJ, Morris J, Khachaturian Z, Sorensen G, Carrillo M, Kuller L, Raichle M, Holtzman D, Paul S, Davies P, Fillit H, Hefti F, Mesulam MM, Potter W, Snyder P, Lilly E, Schwartz A, Montine T, Thomas RG, Donohue M, Walter S, Gessert D, Sather T, Jiminez G, Balasubramanian AB, Mason J, Sim I, Harvey D, Bernstein M, Borowski B, Gunter J, Nguyen D, Womack K, Mathews D, Bonakdarpour B, Scharre DW JAMA neurology 2017 May 74 557-566
- Treatment of Mild Cognitive Impairment
  Kelley BJ Current Treatment Options in Neurology 2015 Sep 17
- Regular aspirin use does not reduce risk of cognitive decline
  Kelley BJ, McClure LA, Unverzagt FW, Kissela B, Kleindorfer D, Howard G, Wadley VG Journal of the American Geriatrics Society 2015 Feb 63 390-392
- Performance of the NINDS-CSN 5-Minute protocol in a national population-based sample
  Kennedy RE, Wadley VG, McClure LA, Letter AJ, Unverzagt FW, Crowe M, Nyenhius D, Kelley BJ, Kana B, Marceaux J, Kurella Tamura M, Howard V, Howard G Journal of the International Neuropsychological Society 2014 Aug 20 856-867
- Cognitive effects of statin medications
  Kelley BJ, Glasser S CNS Drugs 2014 May 28 411-419
- C9ORF72 repeat expansions in cases with previously identified pathogenic mutations
  Van Blitterswijk M, Baker MC, Hernandez M, Ghidoni R, Benussi L, Finger E, Hsiung GY, Kelley BJ, Murray ME, Rutherford NJ, Brown PE, Ravenscroft T, Mullen B, Ash PE, Bieniek KF, Hatanpaa KJ, Karydas A, Wood EM, Coppola G, Bigio EH, Lippa C, Strong MJ, Beach TG, Knopman DS, Huey ED, Mesulam M, Bird T, White CL, Kertesz A, Geschwind DH, Van Deerlin VM, Petersen RC, Binetti G, Miller BL, Petrucelli L, Wszolek ZK, Boylan KB, Graff-Radford NR, MacKenzie IR, Boeve BF, Dickson DW, Rademakers R Neurology 2013 Oct 81 1332-1341
- Report of stroke-like symptoms predicts incident cognitive impairment in a stroke-free cohort
  Kelley BJ, McClure LA, Letter AJ, Wadley VG, Unverzagt FW, Kissela BM, Kleindorfer D, Howard G Neurology 2013 Jul 81 113-118
- Dementia and Systemic Disorders
  Molano JR, Kelley BJ 2013 Jan 51-76
- Atypical motor and behavioral presentations of Alzheimer disease a case-based approach
  Duker AP, Espay AJ, Wszolek ZK, Rademakers R, Dickson DW, Kelley BJ Neurologist 2012 Sep 18 266-272
- Dopamine agonists and pathologic behaviors
  Kelley BJ, Duker AP, Chiu P Parkinson's Disease 2012
- Vascular risk factors and cognitive impairment in a stroke-free cohort
  Unverzagt FW, McClure LA, Wadley VG, Jenny NS, Go RC, Cushman M, Kissela BM, Kelley BJ, Kennedy R, Moy CS, Howard V, Howard G Neurology 2011 Nov 77 1729-1736
- Compressive myelopathy mimicking transverse myelitis
  Kelley BJ, Erickson BJ, Weinshenker BG Neurologist 2010 Mar 16 120-122
- Alzheimer disease-like phenotype associated with the c.154delA mutation in progranulin
  Kelley BJ, Haidar W, Boeve BF, Baker M, Shiung M, Knopman DS, Rademakers R, Hutton M, Adamson J, Kuntz KM, Dickson DW, Parisi JE, Smith GE, Petersen RC Archives of neurology 2010 Feb 67 171-177
- Cognitive and noncognitive neurological features of young-onset dementia
  Kelley BJ, Boeve BF, Josephs KA Dementia and Geriatric Cognitive Disorders 2009 Jul 27 564-571
- Prominent phenotypic variability associated with mutations in Progranulin
  Kelley BJ, Haidar W, Boeve BF, Baker M, Graff-Radford NR, Krefft T, Frank AR, Jack CR, Shiung M, Knopman DS, Josephs KA, Parashos SA, Rademakers R, Hutton M, Pickering-Brown S, Adamson J, Kuntz KM, Dickson DW, Parisi JE, Smith GE, Ivnik RJ, Petersen RC Neurobiology of Aging 2009 May 30 739-751
- Rapidly progressive young-onset dementia
  Robert H, Smith C, Van Buren Alzheimer's A, Kelley BJ, Boeve BF, Josephs KA Cognitive and Behavioral Neurology 2009 Mar 22 22-27
- Mild cognitive impairment
  Kelley BJ, Petersen RC 2009 Jan 172-187
- Seizures in patients with multiple sclerosis: Epidemiology, pathophysiology and management
  Kelley BJ, Rodriguez M CNS Drugs 2009 23 805-815
- Young-onset dementia: Demographic and etiologic characteristics of 235 patients
  Kelley BJ, Boeve BF, Josephs KA Archives of neurology 2008 Nov 65 1502-1508
- Alternative medicine and Alzheimer disease
  Kelley BJ, Knopman DS Neurologist 2008 Sep 14 299-306
- Novel mutations in TARDBP(TDP-43) in patients with familial amyotrophic lateral sclerosis
  Rutherford NJ, Zhang YJ, Baker M, Gass JM, Finch NC, Xu YF, Stewart H, Kelley BJ, Kuntz K, Crook RJ, Sreedharan J, Vance C, Sorenson E, Lippa C, Bigio EH, Geschwind DH, Knopman DS, Mitsumoto H, Petersen RC, Cashman NR, Hutton M, Shaw CE, Boylan KB, Boeve B, Graff-Radford NR, Wszolek ZK, Caselli RJ, Dickson DW, Mackenzie IR, Petrucelli L, Rademakers R PLoS genetics 2008 Sep 4
- PRES following administration of DHE in a patient with unsuspected pheochromocytoma
  Kelley BJ, Samples S, Kunkel R Headache 2008 Sep 48 1237-1239
- Phenotypic variability associated with progranulin haploinsufficiency in patients with the common 1477C→T (Arg493X) mutation: an international initiative
  Rademakers R, Baker M, Gass J, Adamson J, Huey ED, Momeni P, Spina S, Coppola G, Karydas AM, Stewart H, Johnson N, Hsiung GY, Kelley B, Kuntz K, Steinbart E, Wood EM, Yu CE, Josephs K, Sorenson E, Womack KB, Weintraub S, Pickering-Brown SM, Schofield PR, Brooks WS, Van Deerlin VM, Snowden J, Clark CM, Kertesz A, Boylan K, Ghetti B, Neary D, Schellenberg GD, Beach TG, Mesulam M, Mann D, Grafman J, Mackenzie IR, Feldman H, Bird T, Petersen R, Knopman D, Boeve B, Geschwind DH, Miller B, Wszolek Z, Lippa C, Bigio EH, Dickson D, Graff-Radford N, Hutton M Lancet Neurology 2007 Oct 6 857-868
- Alzheimer's Disease and Mild Cognitive Impairment
  Kelley BJ, Petersen RC Neurologic Clinics 2007 Aug 25 577-609
- The effect of propranolol on cognitive flexibility and memory in acute cocaine withdrawal
  Kelley BJ, Yeager KR, Pepper TH, Bornstein RA, Beversdorf DQ Neurocase 2007 13 320-327
- A middle-aged man with progressive neurologic deficits and bilateral leg lesions
  Kelley BJ, Samples S, Mays M Cleveland Clinic journal of medicine 2006 Mar 73 269-272
- Cognitive impairment in acute cocaine withdrawal
  Kelley BJ, Yeager KR, Pepper TH, Beversdorf DQ Cognitive and Behavioral Neurology 2005 Jun 18 108-112

Research

Mild Cognitive Impairment
Alzheimer’s Disease
Dementias
Neurodegeneration

Clinical Focus

Memory Disorders
Alzheimer's Disease
Lewy Body Dementia
Frontotemporal Dementia