-
Publications
-
Precision medicine and immunotherapeutic approaches for relapsed/refractory paediatric acute myeloid leukaemia
Smith CC, Tasian SK Current Opinion in Pharmacology 2025 Aug 83 -
Eph Receptors Activate Myeloid Checkpoint Receptor LILRB5 to Support Tumor Development
He Y, Zhang C, Tan L, Deng M, Liu X, Huang R, Yang X, Xie J, Lou Q, Fang M, Smith C, John S, Xiong W, Li X, Lewis C, Homsi J, Gupta A, Zhang N, An Z, Zhang CC Cancer Immunology Research 2025 Jun 13 821-835 -
Higher Rates of Hypersensitivity Reactions to Calaspargase Compared With Pegaspargase: A Single Center Retrospective Review
McCarty K, Smith C, Zhang S, Gao A, Patel B, Cox J, Winick N, Slone T Pediatric Blood and Cancer 2025 May 72 -
Bone-marrow-homing lipid nanoparticles for genome editing in diseased and malignant haematopoietic stem cells
Lian X, Chatterjee S, Sun Y, Dilliard SA, Moore S, Xiao Y, Bian X, Yamada K, Sung YC, Levine RM, Mayberry K, John S, Liu X, Smith C, Johnson LT, Wang X, Zhang CC, Liu DR, Newby GA, Weiss MJ, Yen JS, Siegwart DJ Nature Nanotechnology 2024 Sep 19 1409-1417 -
Anaplastic sarcoma of the kidney (DICER1-sarcoma of the kidney): A report from the International Pleuropulmonary Blastoma/DICER1 Registry
Schoettler PJ, Smith CC, Nishitani M, Harris AK, Nelson AT, Watson DA, Kamihara J, Mullen EA, Hill DA, Messinger YH, Fair DB, Kumar KA, Dehner LP, Ash S, Chen KS, Schultz KA Pediatric Blood and Cancer 2024 Aug 71 -
LILRB3 Supports Immunosuppressive Activity of Myeloid Cells and Tumor Development
Huang R, Liu X, Kim J, Deng H, Deng M, Gui X, Chen H, Wu G, Xiong W, Xie J, Lewis C, Homsi J, Yang X, Zhang C, He Y, Lou Q, Smith C, John S, Zhang N, An Z, Zhang CC Cancer Immunology Research 2024 Mar 12 350-362 -
Metachronous diagnosis of synovial sarcoma and papillary thyroid carcinoma in a child
Yang AT, Smith C, Callan A, Liu C, Stewart R, Sengupta A, Leavey PJ Pediatric Blood and Cancer 2022 Jan 69 -
The effects of sildenafil on ciliary beat frequency in patients with pulmonary non-tuberculous mycobacteria disease: phase I/II trial
Fowler C, Wu UI, Shaffer R, Smith C, Barnhart L, Bryant C, Olivier K, Holland SM BMJ Open Respiratory Research 2020 Mar 7 -
A familial syndrome of pulmonary nontuberculous mycobacteria infections
Leung JM, Fowler C, Smith C, Adjemian J, Frein C, Claypool RJ, Holland SM, Prevots RD, Olivier K American Journal of Respiratory and Critical Care Medicine 2013 Dec 188 1373-1376 -
Abnormal nasal nitric oxide production, ciliary beat frequency, and toll-like receptor response in pulmonary nontuberculous mycobacterial disease epithelium
Fowler CJ, Olivier KN, Leung JM, Smith CC, Huth AG, Root H, Kuhns DB, Logun C, Zelazny A, Frein CA, Daub J, Haney C, Shelhamer JH, Bryant CE, Holland SM American Journal of Respiratory and Critical Care Medicine 2013 Jun 187 1374-1381
-
Precision medicine and immunotherapeutic approaches for relapsed/refractory paediatric acute myeloid leukaemia
Caroline Smith, M.D.
- Pediatrics - Hematology-Oncology
Biography
Caroline Smith, M.D., joined UT Southwestern as an Instructor in the Department of Pediatrics in the Division of Hematology and Oncology in 2023. Dr. Smith earned her undergraduate degree in Human Biology with a minor in American Studies at Stanford University. She completed her medical degree at UT Southwestern and her residency training in Pediatrics at Boston Children’s Hospital and Boston Medical Center in the Boston Combined Residency Program (BCRP). Ultimately, she returned to UT Southwestern / Children’s Medical Center Dallas for her fellowship training in Pediatric Hematology and Oncology.
Dr. Smith’s clinical and research interests include leukemia and lymphoma, in particular, studying the role of novel targeted cancer therapeutics in patients with relapsed or refractory leukemia. Dr. Smith conducts her research in the Alec Zhang Lab under the co-mentorship of Dr. Samuel John, studying the role of the tumor microenvironment and a novel CAR-T cell therapy in infant leukemia and other leukemias with KMT2A rearrangements.
Education & Training
- Fellowship - UT Southwestern Medical Center (2020-2023), Pediatric Hematology/oncology
- Residency - Boston Children's Hospital (2017-2020), Pediatrics
- Medical School - UT Southwestern Medical School (2013-2017)