Zhikai Chi, M.D., Ph.D.

Pathology

Education & Training

Other Post Graduate Training - John Hopkins University School of Medicine
Medical School - Peking Union Medical College (1995-2003)
Fellowship - Cedars Sinai Medical Center (2017-2018), Gastrointestinal & Liver Pathology
Graduate School - Johns Hopkins University School of Medicine (2003-2009)
Fellowship - Johns Hopkins Hospital (2009-2013), Post Doctoral
Residency - Indiana University School of Medicine (2013-2017), Pathology

Books & Publications

Publications
- A critical assessment of using ChatGPT for extracting structured data from clinical notes.
  Huang J, Yang DM, Rong R, Nezafati K, Treager C, Chi Z, Wang S, Cheng X, Guo Y, Klesse LJ, Xiao G, Peterson ED, Zhan X, Xie Y, NPJ digital medicine 2024 May 7 1 106
- INSM1 is a useful neuroendocrine marker to differentiate pancreatic serous cystadenoma from pancreatic well-differentiated neuroendocrine tumors in cytology and surgical specimens.
  Chi Z, Xu J, Karamchandani DM, Peng L, Annals of diagnostic pathology 2024 Apr 71 152304
- Esophageal carcinoma with SMARCA4 mutation: a narrative review for this rare entity.
  Xu J, Chi Z, Translational gastroenterology and hepatology 2024 9 24
- Deep learning of cell spatial organizations identifies clinically relevant insights in tissue images.
  Wang S, Rong R, Zhou Q, Yang DM, Zhang X, Zhan X, Bishop J, Chi Z, Wilhelm CJ, Zhang S, Pickering CR, Kris MG, Minna J, Xie Y, Xiao G, Nature communications 2023 Dec 14 1 7872
- A Rare Case of a Pancreatic Intraductal Oncocytic Papillary Neoplasm Associated With Invasive Adenocarcinoma Presenting as a Gastric Mass.
  Younes AI, Hu X, Peng L, Chi Z, Cureus 2023 Oct 15 10 e47886
- Inhibition of phosphodiesterase 4D suppresses mTORC1 signaling and pancreatic cancer growth.
  Jeong MH, Urquhart G, Lewis C, Chi Z, Jewell JL, JCI insight 2023 Jul 8 13
- Pax8 as a useful adjunct marker to differentiate pancreatic serous cystadenoma from clear cell renal cell carcinoma in both cytologic and surgical specimens.
  Chi Z, Xu J, Karamchandani DM, Peng L, Diagnostic pathology 2023 Apr 18 1 54
- GATA3 positivity is associated with poor prognosis in patients with oesophageal squamous cell carcinoma.
  Chi Z, Balani J, Gopal P, Hammer S, Xu J, Peng L, Journal of clinical pathology 2022 Jan
- The Use of Intraoperative Frozen Sections in Guiding the Extent of Pancreatic Resections for Intraductal Papillary Mucinous Neoplasms: A Single Institution Experience and Review of the Literature.
  Chi Z, Dhall D, Mertens R, Pancreas 2022 Jan 51 1 63-74
- Characterization of Desmoglein 3 (DSG3) as a Sensitive and Specific Marker for Esophageal Squamous Cell Carcinoma.
  Chi Z, Balani J, Gopal P, Hammer S, Lewis CM, Peng L, Gastroenterology research and practice 2022 2022 2220940
- Variations of P40 and P63 Immunostains in Different Grades of Esophageal Squamous Cell Carcinoma: A Potential Diagnostic Pitfall.
  Chi Z, Balani J, Gopal P, Peng L, Hammer S, Applied immunohistochemistry & molecular morphology : AIMM 2021 May
- Noninvasive monitoring of hepatic glutathione depletion through fluorescence imaging and blood testing.
  Jiang X, Zhou Q, Du B, Li S, Huang Y, Chi Z, Lee WM, Yu M, Zheng J, Science advances 2021 Feb 7 8
- Increased Mast Cell Counts and Degranulation in Microscopic Colitis.
  Chi Z, Xu J, Saxena R, Gastroenterology research and practice 2020 2020 9089027
- Mucinous intrahepatic cholangiocarcinoma: a distinct variant.
  Chi Z, Bhalla A, Saeed O, Cheng L, Curless K, Wang HL, Patil DT, Lin J Human pathology 2018 Apr
- Multivisceral transplant is a viable treatment option for patients with non-resectable intra-abdominal fibromatosis.
  Chi Z, Mangus RS, Kubal CA, Chen S, Lin J Clinical transplantation 2018 Mar 32 3 e13186
- The AAA?+?ATPase Thorase is neuroprotective against ischemic injury.
  Zhang J, Yang J, Wang H, Sherbini O, Keuss MJ, Umanah GK, Pai EL, Chi Z, Paldanius KM, He W, Wang H, Andrabi SA, Dawson TM, Dawson VL Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2018 Jan 271678X18769770
- Cytomorphological Features Useful to Prevent Errors in the Diagnosis of Pancreatic Adenocarcinoma by Fine Needle Aspiration Cytology.
  Chi Z, Wu HH, Cramer H, Lin J, Chen S Acta cytologica 2017 61 1 7-16
- as a Key Mediator of Neuronal Cell Death.
  Zhang J, Wang H, Sherbini O, Ling-Lin Pai E, Kang SU, Kwon JS, Yang J, He W, Wang H, Eacker SM, Chi Z, Mao X, Xu J, Jiang H, Andrabi SA, Dawson TM, Dawson VL eNeuro 2016 Sep-Oct 3 5
- Cultured networks of excitatory projection neurons and inhibitory interneurons for studying human cortical neurotoxicity.
  Xu JC, Fan J, Wang X, Eacker SM, Kam TI, Chen L, Yin X, Zhu J, Chi Z, Jiang H, Chen R, Dawson TM, Dawson VL Science translational medicine 2016 Apr 8 333 333ra48
- Botch is a ?-glutamyl cyclotransferase that deglycinates and antagonizes Notch.
  Chi Z, Byrne ST, Dolinko A, Harraz MM, Kim MS, Umanah G, Zhong J, Chen R, Zhang J, Xu J, Chen L, Pandey A, Dawson TM, Dawson VL Cell reports 2014 May 7 3 681-8
- Botch promotes neurogenesis by antagonizing Notch.
  Chi Z, Zhang J, Tokunaga A, Harraz MM, Byrne ST, Dolinko A, Xu J, Blackshaw S, Gaiano N, Dawson TM, Dawson VL Developmental cell 2012 Apr 22 4 707-20
- Iduna is a poly(ADP-ribose) (PAR)-dependent E3 ubiquitin ligase that regulates DNA damage.
  Kang HC, Lee YI, Shin JH, Andrabi SA, Chi Z, Gagné JP, Lee Y, Ko HS, Lee BD, Poirier GG, Dawson VL, Dawson TM Proceedings of the National Academy of Sciences of the United States of America 2011 Aug 108 34 14103-8
- Iduna protects the brain from glutamate excitotoxicity and stroke by interfering with poly(ADP-ribose) polymer-induced cell death.
  Andrabi SA, Kang HC, Haince JF, Lee YI, Zhang J, Chi Z, West AB, Koehler RC, Poirier GG, Dawson TM, Dawson VL Nature medicine 2011 Jun 17 6 692-9
- The AAA+ ATPase Thorase regulates AMPA receptor-dependent synaptic plasticity and behavior.
  Zhang J, Wang Y, Chi Z, Keuss MJ, Pai YM, Kang HC, Shin JH, Bugayenko A, Wang H, Xiong Y, Pletnikov MV, Mattson MP, Dawson TM, Dawson VL Cell 2011 Apr 145 2 284-99
- Neonatal stroke in mice causes long-term changes in neuronal Notch-2 expression that may contribute to prolonged injury.
  Albéri L, Chi Z, Kadam SD, Mulholland JD, Dawson VL, Gaiano N, Comi AM Stroke 2010 Oct 41 10 Suppl S64-71
- BRI3 associates with SCG10 and attenuates NGF-induced neurite outgrowth in PC12 cells.
  Gong Y, Wu J, Qiang H, Liu B, Chi Z, Chen T, Yin B, Peng X, Yuan J BMB reports 2008 Apr 41 4 287-93