Emre Turer, M.D., Ph.D.

Internal Medicine - Digestive and Liver Diseases
Inflammatory Bowel Disease
Ulcerative Colitis

Biography

Emre Turer, M.D., Ph.D., is an Associate Professor in the Center for the Genetics of Host Defense, the Department of Internal Medicine, and the Department of Immunology at UT Southwestern Medical Center. He specializes in inflammatory bowel disease, ulcerative colitis, and Crohn's disease.

Dr. Turer earned his medical degree and doctoral degree in biological sciences at the University of Chicago Pritzker School of Medicine. He completed both his residency in internal medicine and fellowship in digestive and liver diseases at UT Southwestern as part of the Physician-Scientist Training Program.

Board certified in internal medicine and gastroenterology, he joined the UT Southwestern faculty in 2015.

Dr. Turer’s research is focused on discovering new genes involved in maintaining intestinal homeostasis. He has published numerous academic articles in the area of intestinal inflammation, including articles in Nature Communications and the Proceedings of the National Academy of Sciences. He also serves as a reviewer for several scholarly journals and is a member of the American Gastroenterological Association and the Crohn’s & Colitis Foundation.

In 2020, Dr. Turer was named the Lancaster Family Chair of Gastroenterology by UT Southwestern Medical Center.

Personal Note

When he is not at work, Dr. Turer enjoys cooking, gardening, and traveling.

Education & Training

Residency - UT Southwestern Medical Center (2009-2011), Internal Medicine
Fellowship - UT Southwestern Medical Center (2011-2015), Gastroenterology
Medical School - University of Chicago Pritzker School of Medicine (2000-2009)

Professional Associations & Affiliations

American Gastroenterological Association
Crohn’s & Colitis Foundation

Honors & Awards

Lancaster Family Chair of Gastroenterology 2020, UT Southwestern Medical Center
Disease Oriented Clinical Scholar 2017, UT Southwestern Medical Center
Presidents Research Council Award 2017, UT Southwestern Medical Center
Keystone Scholar 2005, Keystone Symposium Committee

Books & Publications

Publications
- Mutual inhibition between Prkd2 and Bcl6 controls T follicular helper cell differentiation.
  Misawa T, SoRelle JA, Choi JH, Yue T, Wang KW, McAlpine W, Wang J, Liu A, Tabeta K, Turer EE, Evers B, Nair-Gill E, Poddar S, Su L, Ou F, Yu L, Russell J, Ludwig S, Zhan X, Hildebrand S, Li X, Tang M, Murray AR, Moresco EMY, Beutler B, Science immunology 2020 Jan 5 43
- Research Techniques Made Simple: Forward Genetic Screening to Uncover Genes Involved in Skin Biology.
  McAlpine W, Russell J, Murray AR, Beutler B, Turer E, The Journal of investigative dermatology 2019 09 139 9 1848-1853.e1
- Enhanced susceptibility to chemically induced colitis caused by excessive endosomal TLR signaling in LRBA-deficient mice.
  Wang KW, Zhan X, McAlpine W, Zhang Z, Choi JH, Shi H, Misawa T, Yue T, Zhang D, Wang Y, Ludwig S, Russell J, Tang M, Li X, Murray AR, Moresco EMY, Turer EE, Beutler B, Proceedings of the National Academy of Sciences of the United States of America 2019 May
- Excessive endosomal TLR signaling causes inflammatory disease in mice with defective SMCR8-WDR41-C9ORF72 complex function.
  McAlpine W, Sun L, Wang KW, Liu A, Jain R, San Miguel M, Wang J, Zhang Z, Hayse B, McAlpine SG, Choi JH, Zhong X, Ludwig S, Russell J, Zhan X, Choi M, Li X, Tang M, Moresco EMY, Beutler B, Turer E Proceedings of the National Academy of Sciences of the United States of America 2018 12 115 49 E11523-E11531
- mutation causes hyperphagic obesity, diabetes and hepatic steatosis.
  Turer EE, San Miguel M, Wang KW, McAlpine W, Ou F, Li X, Tang M, Zang Z, Wang J, Hayse B, Evers B, Zhan X, Russell J, Beutler B Disease models & mechanisms 2018 12 11 12
- The class I myosin MYO1D binds to lipid and protects against colitis.
  McAlpine W, Wang KW, Choi JH, San Miguel M, McAlpine SG, Russell J, Ludwig S, Li X, Tang M, Zhan X, Choi M, Wang T, Bu CH, Murray AR, Moresco EMY, Turer EE, Beutler B Disease models & mechanisms 2018 Sep 11 9
- Microbial Sensing by Intestinal Myeloid Cells Controls Carcinogenesis and Epithelial Differentiation.
  Miyata N, Morris LL, Chen Q, Thorne C, Singla A, Zhu W, Winter M, Melton SD, Li H, Sifuentes-Dominguez L, Llano E, Huff-Hardy K, Starokadomskyy P, Lopez A, Reese TA, Turer E, Billadeau DD, Winter SE, Burstein E Cell reports 2018 Aug 24 9 2342-2355
- Creatine maintains intestinal homeostasis and protects against colitis.
  Turer E, McAlpine W, Wang KW, Lu T, Li X, Tang M, Zhan X, Wang T, Zhan X, Bu CH, Murray AR, Beutler B Proceedings of the National Academy of Sciences of the United States of America 2017 Jan
- Insulin resistance and diabetes caused by genetic or diet-induced KBTBD2 deficiency in mice.
  Zhang Z, Turer E, Li X, Zhan X, Choi M, Tang M, Press A, Smith SR, Divoux A, Moresco EM, Beutler B Proceedings of the National Academy of Sciences of the United States of America 2016 Oct 113 42 E6418-E6426
- Real-time resolution of point mutations that cause phenovariance in mice.
  Wang T, Zhan X, Bu CH, Lyon S, Pratt D, Hildebrand S, Choi JH, Zhang Z, Zeng M, Wang KW, Turer E, Chen Z, Zhang D, Yue T, Wang Y, Shi H, Wang J, Sun L, SoRelle J, McAlpine W, Hutchins N, Zhan X, Fina M, Gobert R, Quan J, Kreutzer M, Arnett S, Hawkins K, Leach A, Tate C, Daniel C, Reyna C, Prince L, Davis S, Purrington J, Bearden R, Weatherly J, White D, Russell J, Sun Q, Tang M, Li X, Scott L, Moresco EM, McInerney GM, Karlsson Hedestam GB, Xie Y, Beutler B Proceedings of the National Academy of Sciences of the United States of America 2015 Jan
- Dimerization and ubiquitin mediated recruitment of A20, a complex deubiquitinating enzyme.
  Lu TT, Onizawa M, Hammer GE, Turer EE, Yin Q, Damko E, Agelidis A, Shifrin N, Advincula R, Barrera J, Malynn BA, Wu H, Ma A Immunity 2013 May 38 5 896-905
- A potential novel use for direct antiviral therapy.
  Turer E, Rockey DC, Singal AG Hepatology (Baltimore, Md.) 2013 Jan 57 1 414-5
- Expression of A20 by dendritic cells preserves immune homeostasis and prevents colitis and spondyloarthritis.
  Hammer GE, Turer EE, Taylor KE, Fang CJ, Advincula R, Oshima S, Barrera J, Huang EJ, Hou B, Malynn BA, Reizis B, DeFranco A, Criswell LA, Nakamura MC, Ma A Nature immunology 2011 Dec 12 12 1184-93
- The ubiquitin modifying enzyme A20 restricts B cell survival and prevents autoimmunity.
  Tavares RM, Turer EE, Liu CL, Advincula R, Scapini P, Rhee L, Barrera J, Lowell CA, Utz PJ, Malynn BA, Ma A Immunity 2010 Aug 33 2 181-91
- ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development.
  Oshima S, Turer EE, Callahan JA, Chai S, Advincula R, Barrera J, Shifrin N, Lee B, Benedict Yen TS, Yen B, Woo T, Malynn BA, Ma A Nature 2009 Feb 457 7231 906-9
- The ubiquitin-editing enzyme A20 restricts nucleotide-binding oligomerization domain containing 2-triggered signals.
  Hitotsumatsu O, Ahmad RC, Tavares R, Wang M, Philpott D, Turer EE, Lee BL, Shiffin N, Advincula R, Malynn BA, Werts C, Ma A Immunity 2008 Mar 28 3 381-90
- Homeostatic MyD88-dependent signals cause lethal inflamMation in the absence of A20.
  Turer EE, Tavares RM, Mortier E, Hitotsumatsu O, Advincula R, Lee B, Shifrin N, Malynn BA, Ma A The Journal of experimental medicine 2008 Feb 205 2 451-64
- E2 enzymes: expanding the 'ubi-verse' of immune signaling.
  Ma A, Turer E Nature immunology 2006 Sep 7 9 903-4
- The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses.
  Boone DL, Turer EE, Lee EG, Ahmad RC, Wheeler MT, Tsui C, Hurley P, Chien M, Chai S, Hitotsumatsu O, McNally E, Pickart C, Ma A Nature immunology 2004 Oct 5 10 1052-60

Research

Mucosal immunology
Intestinal epithelial cell biology
Inflammatory bowel disease
Apoptotic and inflammatory signaling
Glycosylation
Intracellular trafficking

Clinical Focus

Inflammatory Bowel Disease
Ulcerative Colitis
Crohn's Disease