Erin Butler, M.D.

Harold C. Simmons Comprehensive Cancer Center

Pediatrics - Hematology-Oncology
Histiocytic Disorders
Solid Tumor Malignancy

Biography

Erin Butler, M.D., is an Assistant Professor in the Department of Pediatrics at UT Southwestern Medical Center. She specializes in histiocytic disorders, solid tumor malignancy, and benign hematology.

Dr. Butler earned her medical degree at UT Southwestern Medical School. She completed a residency in pediatrics at Children’s Medical Center Dallas. She gained advanced training through a pediatric hematology and oncology fellowship at UT Southwestern Medical Center, where she served as Chief Fellow.

Certified by the American Board of Pediatrics in hematology and oncology, she joined the UT Southwestern faculty in 2018.

Dr. Butler is the Program Leader of Histiocytic Disorders at UT Southwestern and leads the HLH Task Force. She also serves on the Histiocytic Neoplasms Panel of the National Comprehensive Cancer Network.

Dr. Butler has published peer-reviewed academic articles related to her areas of expertise and has lectured on oncologic emergencies, bone sarcomas, histiocytic disorders, and other topics.

Education & Training

Medical School - UT Southwestern Medical School (2008-2012)
Residency - UT Southwestern/Children's Medical Center (2012-2015), Pediatrics
Fellowship - UT Southwestern/Children's Medical Center (2015-2018), Pediatric Hematology/oncology

Professional Associations & Affiliations

American Society of Pediatric Hematology/Oncology
Children's Oncology Group
Histiocyte Society
North American Consortium for Histiocytosis

Honors & Awards

D Magazine Best Doctor 2025
Wipe Out Kids’ Cancer Award 2021-2022, Wipe Out Kids’ Cancer
Call for Cure Award 2020-2021, Children's Cancer Fund
TeamConnor Childhood Cancer Fund Award 2020-2021, TeamConnor Childhood Cancer Foundation
Young Investigator Award 2019-2021, Hyundai Hope on Wheels Foundation
K12 Clinical Scientist Institutional Career Development Program Award 2019-2020, UT Southwestern

Books & Publications

Publications
- Genomic profiling of subcutaneous patient-derived xenografts reveals immune constraints on tumor evolution in childhood solid cancer
  He F, Bandyopadhyay AM, Klesse LJ, Rogojina A, Chun SH, Butler E, Hartshorne T, Holland T, Garcia D, Weldon K, Prado LN, Langevin AM, Grimes AC, Sugalski A, Shah S, Assanasen C, Lai Z, Zou Y, Kurmashev D, Xu L, Xie Y, Chen Y, Wang X, Tomlinson GE, Skapek SX, Houghton PJ, Kurmasheva RT, Zheng S Nature communications 2023 Dec 14
- Comprehensive characterization of patient-derived xenograft models of pediatric leukemia
  Rogojina A, Klesse LJ, Butler E, Kim J, Zhang H, Xiao X, Guo L, Zhou Q, Hartshorne T, Garcia D, Weldon K, Holland T, Bandyopadhyay A, Prado LP, Wang S, Yang DM, Langevan AM, Zou Y, Grimes AC, Assanasen C, Gidvani-Diaz V, Zheng S, Lai Z, Chen Y, Xie Y, Tomlinson GE, Skapek SX, Kurmasheva RT, Houghton PJ, Xu L iScience 2023 Nov 26
- Exon skipping in genes encoding lineage-defining myogenic transcription factors in rhabdomyosarcoma
  Butler E, Xu L, Rakheja D, Schwettmann B, Toubbeh S, Guo L, Kim J, Skapek SX, Zheng Y Cold Spring Harbor Molecular Case Studies 2022 Aug 8
- Extrarenal Anaplastic Wilms Tumor: A Case Report with Genomic Analysis and Tumor Models
  Willis KR, Sathe AA, Xing C, Koduru P, Artunduaga M, Butler EB, Park JY, Kurmasheva RT, Houghton PJ, Chen KS, Rakheja D Journal of Pediatric Hematology/Oncology 2022 May 44 147-154
- Histiocytic neoplasms, version 2.2021
  Go RS, Jacobsen E, Baiocchi R, Buhtoiarov I, Butler EB, Campbell PK, Coulter DW, Diamond E, Flagg A, Goodman AM, Goyal G, Gratzinger D, Hendrie PC, Higman M, Hogarty MD, Janku F, Karmali R, Morgan D, Raldow AC, Stefanovic A, Tantravahi SK, Walkovich K, Zhang L, Bergman MA, Darlow SD JNCCN Journal of the National Comprehensive Cancer Network 2021 Nov 19 1277-1303
- Recent progress in the treatment of cancer in children
  Butler E, Ludwig K, Pacenta HL, Klesse LJ, Watt TC, Laetsch TW CA Cancer Journal for Clinicians 2021 Jul 71 315-332
- Functional imaging of RAS pathway targeting in malignant peripheral nerve sheath tumor cells and xenografts
  Butler E, Schwettmann B, Geboers S, Hao G, Kim J, Nham K, Sun X, Laetsch TW, Xu L, Williams NS, Skapek SX Pediatric Blood and Cancer 2020 Dec 67
- Rhabdomyosarcoma
  Skapek SX, Ferrari A, Gupta AA, Lupo PJ, Butler E, Shipley J, Barr FG, Hawkins DS Nature Reviews Disease Primers 2019 Dec 5
- Novel PDGFRB rearrangement in multifocal infantile myofibromatosis is tumorigenic and sensitive to imatinib
  Hassan M, Butler E, Wilson R, Roy A, Zheng Y, Liem P, Rakheja D, Pavlick D, Young LL, Rosenzweig M, Erlich R, Ali SM, Leavey PJ, Williams Parsons D, Skapek SX, Laetsch TW Cold Spring Harbor Molecular Case Studies 2019 5

Research

Ewing sarcoma
Histiocytic disorders
Rhabdomyosarcoma
Soft tissue sarcoma

Clinical Focus

Histiocytic Disorders
Solid Tumor Malignancy
Benign Hematology

New Patient Appointment