- Medical School - UT Southwestern Medical School (1994-1998)
- Fellowship - UT Southwestern Medical Center (2001-2004), Gastroenterology
- Residency - University of Alabama Medical Center at Birmingham (1999-2001), Internal Medicine
- Internship - University of Alabama Medical Center at Birmingham (1998-1999), Internal Medicine
Jeffrey Browning, M.D.
- Margo A. Denke, M.D. Professorship in Clinical Nutrition Research
- Internal Medicine - Digestive and Liver Diseases
The focus of my research is the comprehensive study of non-alcoholic fatty liver disease (NAFLD) in humans. The overarching goal is to understand the metabolic derangements that lead to this disease through the application of advanced imaging and metabolic techniques. Translating these basic science techniques to the clinical realm allows for a more complete understanding of the pathophysiology of NAFLD and extension of this understanding through complimentary studies utilizing traditional clinical research tools (epidemiology, retrospective and prospective studies, and clinical trials). In addition to the knowledge gained, this approach allows for the development of novel therapeutic and diagnostic modalities in a logical, disease- and patient-oriented manner.
My initial interest in metabolism began during medical school when I participated in nuclear magnetic resonance (NMR) studies using a variety of stable isotope tracers to investigate glycolysis in rats. As a result of my initial work, I have returned to the group at the Advanced Imaging Research Center (AIRC), becoming proficient in the application of high-field NMR spectroscopy and stable isotopes to track metabolic pathways in humans. The primary goal of my research is to create an integrated approach to the study of hepatic glucose and lipid metabolism that allows for multiple simultaneous metabolic flux measurements to be made. We have already applied these techniques in rodents as well as humans (with and without NAFLD) under a variety of conditions.
It is my view that disease-oriented research should be comprehensive in nature, exploiting available basic science modalities to enhance our understanding of the pathophysiology of a disease while simultaneously translating this new-found knowledge into the clinical realm. This allows for a focused and logical approach to the study of a disease, an approach that has a high likelihood of impacting clinical practice and improving patient care.
- Medical Director (2010), Simmons Ambulatory Surgical Center Endoscopy Lab
- Holder, Lancaster Family Fund in Gastroenterology 2010, University of Texas Southwestern Medical School, Dallas, TX
- Disease Oriented Clinical Scholar (DOCS) 2006, University of Texas Southwestern Medical School, Dallas, TX
- Diplomate 2001, American Board of Internal Medicine
- Research Excellence in GI and Liver (REGAL) Award 2005, University of Kansas Medical Center / Janssen Pharmaceutica / Centocor / Ortho-Biotech Products
- NIH Training Fellowship 2003, NIH
- Ben Friedman Award for excellence in teaching 1998, University of Alabama, Birmingham, Birmingham, AL
- Postdoctoral Fellowship 2003, American Liver Foundation
Gallstone Disease in Sleisinger & Fordtran's Gastrointestinal and Liver Disease, 8th edition
Browning JD, Sreenarasimhaiah J (2006), Philadelphia, Saunders
- Gallstone Disease in Sleisinger & Fordtran's Gastrointestinal and Liver Disease, 8th edition
Metabolomics, Stable Isotopes, and A-ß+ Ketosis-Prone Diabetes.
Ramos-Roman MA, Burgess SC, Browning JD Diabetes 2013 Mar 62 3 682-4
Sertraline: evidence for a role in the treatment of cholestatic pruritus. .
Browning J, Combes B, Mayo M. Am J Gastroenterol 2003 98 2736-2741
Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population.
Szczepaniak LS, Nurenberg P, Leonard D, Browning JD, Reingold JS, Grundy S, Hobbs HH, Dobbins RL American journal of physiology. Endocrinology and metabolism 2005 Feb 288 2 E462-8
Excessive hepatic mitochondrial TCA cycle and gluconeogenesis in humans with nonalcoholic fatty liver disease.
Sunny NE, Parks EJ, Browning JD, Burgess SC Cell metabolism 2011 Dec 14 6 804-10
Short-term weight loss and hepatic triglyceride reduction: evidence of a metabolic advantage with dietary carbohydrate restriction.
Browning JD, Baker JA, Rogers T, Davis J, Satapati S, Burgess SC The American journal of clinical nutrition 2011 May 93 5 1048-52
T(2) measurement of J-coupled metabolites in the human brain at 3T.
Ganji SK, Banerjee A, Patel AM, Zhao YD, Dimitrov IE, Browning JD, Sherwood Brown E, Maher EA, Choi C NMR in biomedicine 2011 Aug
Molecular mediators of hepatic steatosis and liver injury.
Browning JD, Horton JD The Journal of clinical investigation 2004 Jul 114 2 147-52
Ethnic differences in the prevalence of cryptogenic cirrhosis.
Browning JD, Kumar KS, Saboorian MH, Thiele DL The American journal of gastroenterology 2004 Feb 99 2 292-8
Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity.
Browning JD, Szczepaniak LS, Dobbins R, Nuremberg P, Horton JD, Cohen JC, Grundy SM, Hobbs HH Hepatology (Baltimore, Md.) 2004 Dec 40 6 1387-95
Gallstone disease and its complications.
Browning JD, Horton JD Seminars in gastrointestinal disease 2003 Oct 14 4 165-77
Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver.
Satapati S, Kucejova B, Duarte JA, Fletcher JA, Reynolds L, Sunny NE, He T, Nair LA, Livingston KA, Fu X, Merritt ME, Sherry AD, Malloy CR, Shelton JM, Lambert J, Parks EJ, Corbin I, Magnuson MA, Browning JD, Burgess SC The Journal of clinical investigation 2016 Apr 126 4 1605
Complicating factors in the application of the "average method" for determining the contribution of gluconeogenesis.
Burgess SC, Chandramouli V, Browning JD, Schumann WC, Previs SF Journal of applied physiology (Bethesda, Md. : 1985) 2008 Jun 104 6 1852-3; author reply 1854-5
Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver.
Satapati S, Kucejova B, Duarte JA, Fletcher JA, Reynolds L, Sunny NE, He T, Nair LA, Livingston K, Fu X, Merritt ME, Sherry AD, Malloy CR, Shelton JM, Lambert J, Parks EJ, Corbin I, Magnuson MA, Browning JD, Burgess SC The Journal of clinical investigation 2015 Dec 125 12 4447-4462
A HFD suppresses de novo lipogenesis and desaturation, but not elongation and triglyceride synthesis in mice.
Duarte JA, Carvalho F, Pearson M, Horton JD, Browning JD, Jones JG, Burgess SC Journal of lipid research 2014 Sep
Increased de novo lipogenesis is a distinct characteristic of individuals with nonalcoholic Fatty liver disease.
Lambert JE, Ramos-Roman MA, Browning JD, Parks EJ Gastroenterology 2014 Mar 146 3 726-35
Fat and iron quantification in the liver: past, present, and future.
Yokoo T, Browning JD Topics in magnetic resonance imaging : TMRI 2014 Apr 23 2 129-50
Adiponectin as an independent predictor of the presence and degree of hepatic steatosis in the dallas heart study.
Turer AT, Browning JD, Ayers CR, Das SR, Khera A, Vega GL, Grundy SM, Scherer PE The Journal of clinical endocrinology and metabolism 2012 Jun 97 6 E982-6
Use of (2)H(2)O for estimating rates of gluconeogenesis: determination and correction of error due to transaldolase exchange.
Browning JD, Burgess SC American journal of physiology. Endocrinology and metabolism 2012 Dec 303 11 E1304-12
The effect of short-term fasting on liver and skeletal muscle lipid, glucose, and energy metabolism in healthy women and men.
Browning JD, Baxter J, Satapati S, Burgess SC Journal of lipid research 2011 Dec
Patatin-like phospholipase domain-containing 3 and the pathogenesis and progression of pediatric nonalcoholic fatty liver disease.
Browning JD, Cohen JC, Hobbs HH Hepatology (Baltimore, Md.) 2010 Oct 52 4 1189-92
Colonoscopy: an unusual complication.
Alder AC, Scott DL, Browning JD Gastroenterology 2010 Feb 138 2 434, 794
New imaging techniques for non-alcoholic steatohepatitis.
Browning JD Clinics in liver disease 2009 Nov 13 4 607-19
Ethnic differences in hepatic steatosis: an insulin resistance paradox?
Guerrero R, Vega GL, Grundy SM, Browning JD Hepatology (Baltimore, Md.) 2009 Mar 49 3 791-801
A case of diarrhea, ataxia, and capsule endoscope retention.
Guerrero R, Lara LF, Browning JD Digestive diseases and sciences 2007 Nov 52 11 3174-7
Cytosolic phosphoenolpyruvate carboxykinase does not solely control the rate of hepatic gluconeogenesis in the intact mouse liver.
Burgess SC, He T, Yan Z, Lindner J, Sherry AD, Malloy CR, Browning JD, Magnuson MA Cell metabolism 2007 Apr 5 4 313-20
A low-carbohydrate diet rapidly and dramatically reduces intrahepatic triglyceride content.
Browning JD, Davis J, Saboorian MH, Burgess SC Hepatology (Baltimore, Md.) 2006 Aug 44 2 487-8
Statins and hepatic steatosis: perspectives from the Dallas Heart Study.
Browning JD Hepatology (Baltimore, Md.) 2006 Aug 44 2 466-71
Alterations in hepatic glucose and energy metabolism as a result of calorie and carbohydrate restriction.
Browning JD, Weis B, Davis J, Satapati S, Merritt M, Malloy CR, Burgess SC Hepatology (Baltimore, Md.) 2008 Nov 48 5 1487-96
Influence of Liver Triglycerides on Suppression of Glucose Production by Insulin in Men.
Jin ES, Szuszkiewicz-Garcia M, Browning JD, Baxter JD, Abate N, Malloy CR The Journal of clinical endocrinology and metabolism 2014 Sep jc20142404
Elevated TCA cycle function in the pathology of diet-induced hepatic insulin resistance and fatty liver.
Satapati S, Sunny NE, Kucejova B, Fu X, He TT, Méndez-Lucas A, Shelton JM, Perales JC, Browning JD, Burgess SC Journal of lipid research 2012 Jun 53 6 1080-92
Hepatic triglyceride content in individuals with reduced intestinal cholesterol absorption due to variants in Nieman Pick C1-like 1.
Ramirez R, Cohen JC, Hobbs HH, Browning JD Hepatology (Baltimore, Md.) 2011 Aug 54 2 736-7
Fasting reduces plasma proprotein convertase, subtilisin/kexin type 9 and cholesterol biosynthesis in humans.
Browning JD, Horton JD Journal of lipid research 2010 Nov 51 11 3359-63
Progressive adaptation of hepatic ketogenesis in mice fed a high-fat diet.
Sunny NE, Satapati S, Fu X, He T, Mehdibeigi R, Spring-Robinson C, Duarte J, Potthoff MJ, Browning JD, Burgess SC American journal of physiology. Endocrinology and metabolism 2010 Jun 298 6 E1226-35
Partial resistance to peroxisome proliferator-activated receptor-alpha agonists in ZDF rats is associated with defective hepatic mitochondrial metabolism.
Satapati S, He T, Inagaki T, Potthoff M, Merritt ME, Esser V, Mangelsdorf DJ, Kliewer SA, Browning JD, Burgess SC Diabetes 2008 Aug 57 8 2012-21
Combination therapy for the treatment of hepatitis C in the veteran population: higher than expected rates of therapy discontinuation.
Getachew Y, Browning JD, Prebis M, Rogers T, Brown GR Alimentary pharmacology & therapeutics 2004 Sep 20 6 629-36
Limitations of detection of anaplerosis and pyruvate cycling from metabolism of [1-(13)C] acetate.
Burgess SC, Merritt ME, Jones JG, Browning JD, Sherry AD, Malloy CR Nature medicine 2015 Feb 21 2 108-9
Dallas Steatosis Index Identifies Patients With Nonalcoholic Fatty Liver Disease.
McHenry S, Park Y, Browning JD, Sayuk G, Davidson NO, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2020 Jan
Pyruvate-Carboxylase-Mediated Anaplerosis Promotes Antioxidant Capacity by Sustaining TCA Cycle and Redox Metabolism in Liver.
Cappel DA, Deja S, Duarte JAG, Kucejova B, Iñigo M, Fletcher JA, Fu X, Berglund ED, Liu T, Elmquist JK, Hammer S, Mishra P, Browning JD, Burgess SC, Cell metabolism 2019 Apr
Fatty Liver Disrupts Glycerol Metabolism in Gluconeogenic and Lipogenic Pathways in Humans.
Jin ES, Browning JD, Murphy RE, Malloy CR Journal of lipid research 2018 Jul
Impaired ketogenesis and increased acetyl-CoA oxidation promote hyperglycemia in human fatty liver.
Fletcher JA, Deja S, Satapati S, Fu X, Burgess SC, Browning JD, JCI insight 2019 Apr 5
Simultaneous tracers and a unified model of positional and mass isotopomers for quantification of metabolic flux in liver.
Deja S, Fu X, Fletcher JA, Kucejova B, Browning JD, Young JD, Burgess SC, Metabolic engineering 2019 Dec
Cytosolic Phosphoenolpyruvate Carboxykinase as a Cataplerotic Pathway in the Small Intestine.
Potts A, Uchida A, Deja S, Berglund ED, Kucejova B, Duarte JAG, Fu X, Browning JD, Magnuson MA, Burgess SC American journal of physiology. Gastrointestinal and liver physiology 2018 Apr
Crohn's Disease Is Associated With an Increased Prevalence of Nonalcoholic Fatty Liver Disease: A Cross-Sectional Study Using Magnetic Resonance Proton Density Fat Fraction Mapping.
Mchenry S, Sharma Y, Tirath A, Tsai R, Mintz A, Fraum TJ, Salter A, Browning JD, Flores AG, Davidson NO, Fowler KJ, Ciorba MA, Deepa P, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2019 Mar
Racial and Ethnic Disparities in Non-alcoholic Fatty Liver Disease Prevalence, Severity, and Outcomes in the United States: A Systematic Review and Meta-analysis.
Rich NE, Oji S, Mufti AR, Browning JD, Parikh ND, Odewole M, Mayo H, Singal AG Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2017 Sep
- Metabolomics, Stable Isotopes, and A-ß+ Ketosis-Prone Diabetes.