Kathryn Dickerson, M.D.

Pediatrics - Hematology-Oncology

Biography

Kathryn E. Dickerson, M.D., is an Assistant Professor in the Department of Pediatrics, Division of Hematology and Oncology, and 2015 Translational Research Scholar in the UTSW Center for Translational Medicine. She earned her undergraduate degree in Biochemistry with a minor in Spanish from Indiana University. Before attending medical school, she completed a post-baccalaureate research training program at the NIH working, in the laboratory of Dr. Lee Weinstein. She returned to Indiana University to earn her medical degree, working in the laboratory of Dr. Nadia Carlesso. She completed her pediatric residency training in an integrated research pathway at The Ohio State University/Nationwide Children's Hospital, working in the laboratory of Dr. Michael Caligiuri. Her clinical interest is pediatric hematology with an emphasis on bone marrow failure disorders and cancer predisposition. Her research interest is in the epigenetic regulation of myeloid development in models of acute myelogenous leukemia (AML), myeloproliferative disorders (MPD), and myelodysplastic syndromes (MDS). Dr. Dickerson conducts her research under the mentorship of Dr. Jian Xu of the Children's Research Institute.

Education & Training

Graduate School - UT Southwestern Graduate School of Biomedical Sciences (2017-2018)
Residency - Ohio State University/Nationwide Children's Hospital (2011-2014), Pediatrics
Medical School - Indiana University School of Medicine (2007-2011)
Fellowship - UT Southwestern/Children's Medical Center (2014-2017), Pediatric Hematology/oncology
Other Post Graduate Training - UT Southwestern Graduate School of Biomedical Sciences (2017-2018)

Professional Associations & Affiliations

The American Society of Hematology (2014)
American Society of Clinical Oncology/American Society of Pediatric Hematology Oncology (2014)
American Association for Cancer Research (2012)
American Academy of Pediatrics (2011)

Honors & Awards

Texas Monthly Super Doctors, Rising Star 2020
Hyundai Hope on Wheels Young Investigator Award 2017
Children's Cancer Fund "Call for Cure" Award Recipient 2017
Certificate in Academic Medicine 2014, Nationwide Children's Hospital
Certificate in Global Health 2014, Nationwide Children's Hospital
Community Service Award 2011, Indiana University School of Medicine
E. Jane Brownley Award 2011, Department of Pediatrics, Indiana University School of Medicine
Member, Gold Humanism Honorary Society 2010
Red Shoes Award 2010, Riley Hospital for Children
Post-Baccalaureate Intramural Research Training Award 2006, National Institutes of Health/National Institute of Diabetes, Digestive, and Kidney disorders, Dr. Lee Weinstein Laboratory
Member, Phi Beta Kappa 2005

Books & Publications

Publications
- Structural Variation Cooperates with Permissive Chromatin to Control Enhancer Hijacking-Mediated Oncogenic Transcription.
  Botten G, Zhang Y, Dudnyk K, Kim YJ, Liu X, Sanders JT, Imanci A, Droin NM, Cao H, Kaphle P, Dickerson KE, Kumar KR, Chen M, Chen W, Solary E, Ly P, Zhou J, Xu J, Blood 2023 Mar
- Disabling Uncompetitive Inhibition of Oncogenic IDH Mutations Drives Acquired Resistance.
  Lyu J, Liu Y, Gong L, Chen M, Madanat YF, Zhang Y, Cai F, Gu Z, Cao H, Kaphle P, Kim YJ, Kalkan FN, Stephens H, Dickerson KE, Ni M, Chen W, Patel P, Mims AS, Borate U, Burd A, Cai SF, Yin CC, You MJ, Chung SS, Collins RH, DeBerardinis RJ, Liu X, Xu J, Cancer discovery 2022 Oct
- Immature platelet fraction as a biomarker for disease severity in pediatric respiratory Coronavirus Disease 2019.
  Lee NC, Demir YK, Ashraf B, Ibrahim I, Bat T, Dickerson KE, The Journal of pediatrics 2022 Aug
- Convergence of oncogenic cooperation at single-cell and single-gene levels drives leukemic transformation.
  Liu Y, Gu Z, Cao H, Kaphle P, Lyu J, Zhang Y, Hu W, Chung SS, Dickerson KE, Xu J, Nature communications 2021 11 12 1 6323
- SLC25A38 Congenital Sideroblastic Anemia: Phenotypes and genotypes of 31 individuals from 24 families, including 11 novel mutations, and a review of the literature.
  Heeney MM, Berhe S, Campagna DR, Oved JH, Kurre P, Shaw PJ, Teo J, Shanap MA, Hassab HM, Glader BE, Shah S, Yoshimi A, Ameri A, Antin JH, Boudreaux J, Briones M, Dickerson KE, Fernandez CV, Farah R, Hasle H, Keel SB, Olson TS, Powers JM, Rose MJ, Shimamura A, Bottomley SS, Fleming MD, Human mutation 2021 Jul
- Silencing of LINE-1 retrotransposons is a selective dependency of myeloid leukemia.
  Gu Z, Liu Y, Zhang Y, Cao H, Lyu J, Wang X, Wylie A, Newkirk SJ, Jones AE, Lee M, Botten GA, Deng M, Dickerson KE, Zhang CC, An W, Abrams JM, Xu J, Nature genetics 2021 05 53 5 672-682
- Diagnosis and treatment of pediatric myelodysplastic syndromes: A survey of the North American Pediatric Aplastic Anemia Consortium.
  Nakano TA, Lau BW, Dickerson KE, Wlodarski M, Pollard J, Shimamura A, Hofmann I, Sasa G, Elghetany T, Cada M, Dror Y, Ding H, Allen SW, Hanna R, Campbell K, Olson TS, Pediatric blood & cancer 2020 10 67 10 e28652
- Therapy Response and Outcome Explained by Leukemia Cell of Origin.
  Gu Z, Dickerson KE, Xu J, Cancer discovery 2020 10 10 10 1445-1447
- A study assessing the feasibility of randomization of pediatric and young adult patients between matched unrelated donor bone marrow transplantation and immune-suppressive therapy for newly diagnosed severe aplastic anemia: A joint pilot trial of the North American Pediatric Aplastic Anemia Consortium and the Pediatric Transplantation and Cellular Therapy Consortium.
  Pulsipher MA, Lehmann LE, Bertuch AA, Sasa G, Olson T, Nakano T, Gilio A, Burroughs LM, Lipton JM, Huang JN, Dickerson K, Bertaina A, Zhuang C, Malsch M, Fleming M, Weller E, Shimamura A, Williams DA, Pediatric blood & cancer 2020 Aug e28444
- Connecting the Dots From Fever of Unknown Origin to Myelodysplastic Syndrome: GATA2 Haploinsufficiency.
  Montiel-Esparza R, Reys B, Rogers ZR, Evans AS, Wysocki CA, Timmons C, Dickerson KE, Journal of pediatric hematology/oncology 2020 07 42 5 e365-e368
- Noncoding Variants Connect Enhancer Dysregulation with Nuclear Receptor Signaling in Hematopoietic Malignancies.
  Li K, Zhang Y, Liu X, Liu Y, Gu Z, Cao H, Dickerson KE, Chen M, Chen W, Shao Z, Ni M, Xu J, Cancer discovery 2020 05 10 5 724-745
- Interrogation of enhancer function by enhancer-targeting CRISPR epigenetic editing.
  Li K, Liu Y, Cao H, Zhang Y, Gu Z, Liu X, Yu A, Kaphle P, Dickerson KE, Ni M, Xu J, Nature communications 2020 01 11 1 485
- Loss of EZH2 Reprograms BCAA Metabolism to Drive Leukemic Transformation.
  Gu Z, Liu Y, Cai F, Patrick M, Zmajkovic J, Cao H, Zhang Y, Tasdogan A, Chen M, Qi L, Liu X, Li K, Lyu J, Dickerson KE, Chen W, Ni M, Merritt ME, Morrison SJ, Skoda RC, DeBerardinis RJ, Xu J, Cancer discovery 2019 09 9 9 1228-1247
- Abnormal Uterine Bleeding in Young Women with Blood Disorders.
  Dickerson KE, Menon NM, Zia A Pediatric clinics of North America 2018 Jun 65 3 543-560
- In Situ Capture of Chromatin Interactions by Biotinylated dCas9.
  Liu X, Zhang Y, Chen Y, Li M, Zhou F, Li K, Cao H, Ni M, Liu Y, Gu Z, Dickerson KE, Xie S, Hon GC, Xuan Z, Zhang MQ, Shao Z, Xu J Cell 2017 Aug 170 5 1028-1043.e19
- Regulation of mitochondrial biogenesis in erythropoiesis by mTORC1-mediated protein translation.
  Liu X, Zhang Y, Ni M, Cao H, Signer RAJ, Li D, Li M, Gu Z, Hu Z, Dickerson KE, Weinberg SE, Chandel NS, DeBerardinis RJ, Zhou F, Shao Z, Xu J Nature cell biology 2017 Jun 19 6 626-638
- Eradicating acute myeloid leukemia in a Mll(PTD/wt):Flt3(ITD/wt) murine model: a path to novel therapeutic approaches for human disease.
  Bernot KM, Nemer JS, Santhanam R, Liu S, Zorko NA, Whitman SP, Dickerson KE, Zhang M, Yang X, McConnell KK, Ahmed EH, Muñoz MR, Siebenaler RF, Marcucci GG, Mundy-Bosse BL, Brook DL, Garman S, Dorrance AM, Zhang X, Zhang J, Lee RJ, Blum W, Caligiuri MA, Marcucci G Blood 2013 Nov 122 23 3778-83
- Towards personalized therapy in AML: In vivo benefit of targeting aberrant epigenetics in MLL-PTD-associated AML.
  Bernot KM, Siebenaler RF, Whitman SP, Zorko NA, Marcucci GG, Santhanam R, Ahmed EH, Ngangana M, McConnell KK, Nemer JS, Brook DL, Kulp SK, Chen CS, Frankhouser D, Yan P, Bundschuh R, Zhang X, Dorrance AM, Dickerson K, Jarjoura D, Blum W, Marcucci G, Caligiuri MA Leukemia 2013 May
- Central nervous system imprinting of the G protein G(s)alpha and its role in metabolic regulation.
  Chen M, Wang J, Dickerson KE, Kelleher J, Xie T, Gupta D, Lai EW, Pacak K, Gavrilova O, Weinstein LS Cell metabolism 2009 Jun 9 6 548-55
- G(s)alpha deficiency in skeletal muscle leads to reduced muscle mass, fiber-type switching, and glucose intolerance without insulin resistance or deficiency.
  Chen M, Feng HZ, Gupta D, Kelleher J, Dickerson KE, Wang J, Hunt D, Jou W, Gavrilova O, Jin JP, Weinstein LS American journal of physiology. Cell physiology 2009 Apr 296 4 C930-40

Research

Myeloproliferative disorders
Myelodysplastic syndrome
Malignant transformation in inherited bone marrow failure (BMF) syndromes
Acute myelogenous leukemia
Epigenetics