Lan Peng, M.D.

Harold C. Simmons Comprehensive Cancer Center

Pathology
Gastrointestinal/Liver Pathology

Biography

Lan Peng, M.D., is a board-certified Professor of Pathology and the Director of the Gastrointestinal and Liver Pathology Program at UT Southwestern Medical Center. Her clinical interests and expertise include neoplastic and non-neoplastic liver and gastrointestinal pathology and liver transplant pathology.

Dr. Lan Peng completed her medical residency in pathology at New York University. She completed a surgical oncology pathology fellowship at MD Anderson Cancer Center in Houston, and a liver and gastrointestinal pathology fellowship at Mount Sinai Medical Center in New York.

Before joining the UT Southwestern faculty in 2011, Dr. Peng spent two years as an Assistant Professor at the University of Massachusetts Medical School.

She is on the editorial board of several journals in the field of gastrointestinal and liver disorders.

Education & Training

Medical School - Hunan Medical College (1987-1992)
Residency - New York University Hospital (2003-2007), Pathology
Fellowship - UT MD Anderson Cancer Center (2007-2008), Surgical Pathology
Fellowship - Mount Sinai Medical Center (2008-2009), Liver & Gi Pathology

Books & Publications

Books
- Targeted gene repair in mammalian cells using chimerical Oligonucleotides. in Genetic Engineering: Principles and Methods
  Kmiec EB, Ye S and Peng L (2001), New York, USA, Springer
Publications
- Nuclear localization of Argonaute 2 is affected by cell density and may relieve repression by microRNAs.
  Johnson KC, Kilikevicius A, Hofman C, Hu J, Liu Y, Aguilar S, Graswich J, Han Y, Wang T, Westcott JM, Brekken RA, Peng L, Karagkounis G, Corey DR, Nucleic acids research 2023 Dec
- A Rare Case of a Pancreatic Intraductal Oncocytic Papillary Neoplasm Associated With Invasive Adenocarcinoma Presenting as a Gastric Mass.
  Younes AI, Hu X, Peng L, Chi Z, Cureus 2023 Oct 15 10 e47886
- Chronic Use of Proton Pump Inhibitors Is Associated With an Increased Risk of Immune Checkpoint Inhibitor Colitis in Renal Cell Carcinoma.
  Yin J, Elias R, Peng L, Levonyak N, Asokan A, Christie A, Kubiliun N, Brugarolas J, Hammers HJ, Clinical genitourinary cancer 2022 Feb
- Characterization of Desmoglein 3 (DSG3) as a Sensitive and Specific Marker for Esophageal Squamous Cell Carcinoma.
  Chi Z, Balani J, Gopal P, Hammer S, Lewis CM, Peng L, Gastroenterology research and practice 2022 2022 2220940
- GATA3 positivity is associated with poor prognosis in patients with oesophageal squamous cell carcinoma.
  Chi Z, Balani J, Gopal P, Hammer S, Xu J, Peng L, Journal of clinical pathology 2022 Jan
- Variations of P40 and P63 Immunostains in Different Grades of Esophageal Squamous Cell Carcinoma: A Potential Diagnostic Pitfall.
  Chi Z, Balani J, Gopal P, Peng L, Hammer S, Applied immunohistochemistry & molecular morphology : AIMM 2021 May
- Deep learning model for the prediction of microsatellite instability in colorectal cancer: a diagnostic study.
  Yamashita R, Long J, Longacre T, Peng L, Berry G, Martin B, Higgins J, Rubin DL, Shen J, The Lancet. Oncology 2021 01 22 1 132-141
- Dietary simple sugars alter microbial ecology in the gut and promote colitis in mice.
  Khan S, Waliullah S, Godfrey V, Khan MAW, Ramachandran RA, Cantarel BL, Behrendt C, Peng L, Hooper LV, Zaki H, Science translational medicine 2020 Oct 12 567
- NLRP12 suppresses hepatocellular carcinoma via downregulation of cJun N-terminal kinase activation in the hepatocyte.
  Udden SN, Kwak YT, Godfrey V, Khan MAW, Khan S, Loof N, Peng L, Zhu H, Zaki H, eLife 2019 Apr 8
- restrains pancreatic neoplasia formation.
  Wang SC, Nassour I, Xiao S, Zhang S, Luo X, Lee J, Li L, Sun X, Nguyen LH, Chuang JC, Peng L, Daigle S, Shen J, Zhu H Gut 2018 Oct
- Herpes Simplex Virus-Associated Acute Liver Failure Often Goes Unrecognized.
  Little L, Rule J, Peng L, Gottfried M, Lee WM Hepatology (Baltimore, Md.) 2018 Aug
- Multiple Admissions for Acetaminophen (APAP) Overdose: APAP Frequent Fliers, a New Entity?
  Yang E, Peng L, Lee WM Hepatology (Baltimore, Md.) 2018 Apr
- Pasireotide for the Treatment of Refractory Hypoglycemia from Malignant Insulinoma.
  Hendren NS, Panach K, Brown TJ, Peng L, Beg MS, Weissler J, Mirfakhraee S Clinical endocrinology 2017 Oct
- Hepatoid Adenocarcinoma of Unknown Primary Masquerading as a Pancreatic Tumor.
  Dogeas E, Peng L, Choti MA Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2017 Jul
- NOD2 Suppresses Colorectal Tumorigenesis via Downregulation of the TLR Pathways.
  Udden SMN, Peng L, Gan JL, Shelton JM, Malter JS, Hooper LV, Zaki MH Cell reports 2017 Jun 19 13 2756-2770
- Syphilitic proctitis.
  Yang JF, Peng L, Siddiqui AA, Mayorga CA Proceedings (Baylor University. Medical Center) 2016 Jul 29 3 327-8
- Abdominal Pain and Bloody Diarrhea.
  Gupta A, Peng L, Li HC JAMA oncology 2016 Jul
- Synthesis, Characterization, and In Vitro and In Vivo Evaluations of 4-(N)-Docosahexaenoyl 2', 2'-Difluorodeoxycytidine with Potent and Broad-Spectrum Antitumor Activity.
  Naguib YW, Lansakara-P D, Lashinger LM, Rodriguez BL, Valdes S, Niu M, Aldayel AM, Peng L, Hursting SD, Cui Z Neoplasia (New York, N.Y.) 2016 Jan 18 1 33-48
- The DNA Sensor AIM2 Maintains Intestinal Homeostasis via Regulation of Epithelial Antimicrobial Host Defense.
  Hu S, Peng L, Kwak YT, Tekippe EM, Pasare C, Malter JS, Hooper LV, Zaki MH Cell reports 2015 Dec 13 9 1922-36
- Surveillance for hepatocellular carcinoma secondary to cardiogenic cirrhosis in patients with congenital heart disease.
  Augustyn A, Peng L, Singal AG, Yopp AC Clinical research in cardiology : official journal of the German Cardiac Society 2015 May 104 5 446-9
- Mature cystic teratoma of the pancreas: Role of endoscopic ultrasound.
  Ahmed A, Peng L, Agrawal D Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2015 May
- A solitary hyperfunctioning thyroid nodule harboring thyroid carcinoma: review of the literature.
  Mirfakhraee S, Mathews D, Peng L, Woodruff S, Zigman JM Thyroid research 2013 6 1 7
- Pancreatic Neuroendocrine Tumors: Signal Pathways and Targeted Therapies.
  Peng L, Schwarz RE Current molecular medicine 2013 Jan
- Collision tumor in form of primary adenocarcinoma and neuroendocrine carcinoma of the duodenum.
  Peng L, Schwarz RE Rare tumors 2012 Apr 4 2 e20
- Histologic tumor involvement of superior mesenteric vein/portal vein predicts poor prognosis in patients with stage II pancreatic adenocarcinoma treated with neoadjuvant chemoradiation.
  Wang J, Estrella JS, Peng L, Rashid A, Varadhachary GR, Wang H, Lee JE, Pisters PW, Vauthey JN, Katz MH, Gomez HF, Evans DB, Abbruzzese JL, Fleming JB, Wang H Cancer 2011 Dec
- High levels of nucleolar expression of nucleolin are associated with better prognosis in patients with stage II pancreatic ductal adenocarcinoma.
  Peng L, Liang J, Wang H, Song X, Rashid A, Gomez HF, Corley LJ, Abbruzzese JL, Fleming JB, Evans DB, Wang H Clinical cancer research : an official journal of the American Association for Cancer Research 2010 Jul 16 14 3734-42
- Novel PRKAR1A gene mutations in Carney Complex.
  Pan L, Peng L, Jean-Gilles J, Zhang X, Wieczorek R, Jain S, Levine V, Osman I, Prieto VG, Lee P International journal of clinical and experimental pathology 2010 3 5 545-8
- Vaccination as a triggering event for autoimmune hepatitis.
  Perumalswami P, Peng L, Odin JA Seminars in liver disease 2009 Aug 29 3 331-4
- Expression of insulin-like growth factors (IGFs) and IGF signaling: molecular complexity in uterine leiomyomas.
  Peng L, Wen Y, Han Y, Wei A, Shi G, Mizuguchi M, Lee P, Hernando E, Mittal K, Wei JJ Fertility and sterility 2009 Jun 91 6 2664-75
- Patient with hepatitis B and alcoholic liver disease before and after liver transplantation.
  Ward SC, Chang CY, Peng L, Liu LU Seminars in liver disease 2009 May 29 2 233-7
- Nuclear factor of activated T-cells (NFAT) rescues osteoclastogenesis in precursors lacking c-Fos.
  Matsuo K, Galson DL, Zhao C, Peng L, Laplace C, Wang KZ, Bachler MA, Amano H, Aburatani H, Ishikawa H, Wagner EF The Journal of biological chemistry 2004 Jun 279 25 26475-80
- Tissue-specific and ubiquitous promoters direct the expression of alternatively spliced transcripts from the calcitonin receptor gene.
  Anusaksathien O, Laplace C, Li X, Ren Y, Peng L, Goldring SR, Galson DL The Journal of biological chemistry 2001 Jun 276 25 22663-74
- Targeted gene repair in mammalian cells using chimeric oligonucleotides.
  Kmiec EB, Ye S, Peng L Genetic engineering 2000 22 23-31
- Analysis of the human RAD51L1 promoter region and its activation by UV light.
  Peng L, Rice MC, Kmiec EB Genomics 1998 Dec 54 3 529-41
- Adeno-associated virus type 2-mediated transfer of ecotropic retrovirus receptor cDNA allows ecotropic retroviral transduction of established and primary human cells.
  Qing K, Bachelot T, Mukherjee P, Wang XS, Peng L, Yoder MC, Leboulch P, Srivastava A Journal of virology 1997 Jul 71 7 5663-7
- Construction of recombinant adeno-associated virus vector containing the rat preproinsulin II gene.
  Peng L, Sidner RA, Bochan MR, Burton MM, Cooper ST, Jindal RM The Journal of surgical research 1997 Apr 69 1 193-8

Research

Transplant Liver Pathology
Pancreatic Neoplasm
Medical Liver Disease

Clinical Focus

Gastrointestinal/Liver Pathology