Lauren Truby, M.D.

Internal Medicine - Cardiology
Advanced Heart Failure
General Cardiology

Biography

Lauren Truby, M.D., M.S., is an Assistant Professor in the Department of Internal Medicine at UT Southwestern Medical Center. She specializes in advanced heart failure and heart transplantation.

Dr. Truby earned her medical degree at the Columbia University College of Physicians and Surgeon and completed a residency in internal medicine at NewYork-Presbyterian/Columbia University Irving Medical Center. She completed fellowships in cardiovascular disease at Duke University Medical Center and in advanced heart failure and transplant cardiology at UT Southwestern.

She also earned a master’s degree in biostatistics at Duke University in North Carolina.

Certified by the American Board of Internal Medicine in internal medicine and cardiovascular disease, she joined the UT Southwestern faculty in 2023.

Dr. Truby has published numerous articles in peer-reviewed journals and has presented her research at conferences across the globe. She is a member of the American College of Cardiology, the American Heart Association, the American Society of Transplantation, and the International Society for Heart and Lung Transplantation.

In 2021, Dr. Truby was named a Joseph C. Greenfield Scholar in Cardiology by Duke University. She is a current recipient of an American Heart Association Career Development Award and the Distinguished Researcher Award from the UT Southwestern President’s Research Council. She is also a UT Southwestern Dean’s Scholar in Clinical Research.

Personal Note

When she’s not at work, Dr. Truby enjoys hiking, cycling, gardening, and spending time with her husband, Kyle, and their dog, Maggie.

Education & Training

Medical School - Columbia University College of Physicians & Surgeons (2011-2015)
Residency - New York Presbyterian Hospital (Columbia Campus)) (2015-2018), Internal Medicine
Graduate School - Duke University School of Medicine (2020-2022), Biostatistics
Fellowship - Duke University Medical Center (2018-2022), Cardiology
Fellowship - UT Southwestern Medical Center (2022-2023), Advanced Heart Failure & Transplant Cardiology

Professional Associations & Affiliations

American College of Cardiology
American Heart Association
American Society of Transplantation
International Society for Heart and Lung Transplantation

Honors & Awards

Distinguished Researcher Award 2023, President’s Research Council, UT Southwestern
Dean’s Scholar in Clinical Research 2023, UT Southwestern
Joseph C. Greenfield Scholar in Cardiology 2021, Duke University Hospital
Finalist, Northwestern Cardiovascular Young Investigators Forum 2018-2019, Duke University Medical Center
Resident Housestaff Physician of the Year 2017, New York-Presbyterian Hospital
Robert E. Loeb Award for Excellence in Clinical Medicine, Columbia University College of Physicians and Surgeons
Allen O. Whipple Memorial Prize for Excellence in Surgery, Columbia University College of Physicians and Surgeons
Albert B. Knapp Scholarship, Awarded for Highest Scholarship, Columbia University College of Physicians and Surgeons
Glasgow-Rubin Achievement Award, Columbia University College of Physicians and Surgeons
Alpha Omega Alpha Honor Society, Columbia University College of Physicians and Surgeons

Books & Publications

Publications
- Beyond Stage C: Considerations in the Management of Patients With Heart Failure Progression and Gaps in Evidence.
  Carroll AM, Farr M, Russell SD, Schlendorf KH, Truby LK, Gilotra NA, Vader JM, Patel CB, Devore AD, Journal of cardiac failure 2023 May 29 5 818-831
- Sex differences in heart failure: the evolving use of biomarkers.
  Blumer V, Truby LK, Zieroth S, European journal of heart failure 2023 Apr 25 4 448-449
- Donation after circulatory determination of death in heart transplant: impact on current and future allocation policy.
  Hendren NS, Truby LK, Farr M, Current opinion in cardiology 2023 Mar 38 2 124-129
- Improved Outcomes in Severe Primary Graft Dysfunction After Heart Transplantation Following Donation After Circulatory Death Compared With Donation After Brain Death.
  Ayer A, Truby LK, Schroder JN, Casalinova S, Green CL, Bishawi MA, Bryner BS, Milano CA, Patel CB, Devore AD, Journal of cardiac failure 2023 Jan 29 1 67-75
- Residual mitral regurgitation in patients with left ventricular assist device support - An INTERMACS analysis.
  Jain R, Truby LK, Topkara VK, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2022 Nov 41 11 1638-1645
- Protein biomarkers of cardiac remodeling and inflammation associated with HFpEF and incident events.
  Regan JA, Truby LK, Tahir UA, Katz DH, Nguyen M, Kwee LC, Deng S, Wilson JG, Mentz RJ, Kraus WE, Hernandez AF, Gerszten RE, Peterson ED, Holman RR, Shah SH, Scientific reports 2022 Nov 12 1 20072
- Donation After Circulatory Death in Heart Transplantation: History, Outcomes, Clinical Challenges, and Opportunities to Expand the Donor Pool.
  Truby LK, Casalinova S, Patel CB, Agarwal R, Holley CL, Mentz RJ, Milano C, Bryner B, Schroder JN, Devore AD, Journal of cardiac failure 2022 Sep 28 9 1456-1463
- Increased Opportunities for Transplantation for Women in the New Heart Allocation System.
  Defilippis EM, Truby LK, Clerkin KJ, Donald E, Sinnenberg L, Varshney AS, Cogswell R, Kittleson MM, Haythe JH, Givertz MM, Hsich EM, Agarwal R, Topkara VK, Farr M, Journal of cardiac failure 2022 Jul 28 7 1149-1157
- Cardiovascular risk stratification in the noncardiac solid organ transplant candidate.
  Truby LK, Mentz RJ, Agarwal R, Current opinion in organ transplantation 2022 Feb 27 1 22-28
- Critically appraising the 2018 United Network for Organ Sharing donor allocation policy: adding life boats or rearranging the deck chairs?
  Truby LK, Farr M, Topkara VK, Current opinion in anaesthesiology 2022 Feb 35 1 42-47
- Proteomic profiling identifies CLEC4C expression as a novel biomarker of primary graft dysfunction after heart transplantation.
  Truby LK, Kwee LC, Agarwal R, Grass E, DeVore AD, Patel CB, Chen D, Schroder JN, Bowles D, Milano CA, Shah SH, Holley CL, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2021 Dec 40 12 1589-1598
- Impact of heart failure drug therapy on rates of gastrointestinal bleeding in LVAD recipients: An INTERMACS analysis.
  Jennings DL, Truby LK, Littlefield AJ, Ciolek AM, Marshall D, Jain R, Topkara VK, The International journal of artificial organs 2021 Dec 44 12 965-971
- Advanced heart failure patients supported with ambulatory inotropic therapy: What defines success of therapy?
  Grubb CS, Truby LK, Topkara VK, Bohnen MS, Yuzefpolskaya M, DeFilippis EM, Kleet A, Nakagawa S, Haythe JH, Axsom K, Colombo P, Takeda K, Uriel N, Sayer G, Garan H, Naka Y, Farr M, American heart journal 2021 Sep 239 11-18
- C-Reactive Protein Levels Predict Outcomes in Continuous-Flow Left Ventricular Assist Device Patients: An INTERMACS Analysis.
  Batra J, Truby LK, Defilippis EM, Takeda K, Takayama H, Naka Y, Yuzefpolskaya M, Colombo PC, Sayer G, Farr MA, Garan AR, Uriel N, Topkara VK, ASAIO journal (American Society for Artificial Internal Organs : 1992) 2021 Aug 67 8 884-890
- Circulating long chain acylcarnitines and outcomes in diabetic heart failure: an HF-ACTION clinical trial substudy.
  Truby LK, Regan JA, Giamberardino SN, Ilkayeva O, Bain J, Newgard CB, O'Connor CM, Felker GM, Kraus WE, McGarrah RW, Shah SH, Cardiovascular diabetology 2021 Aug 20 1 161
- Plasma kallikrein predicts primary graft dysfunction after heart transplant.
  Giangreco NP, Lebreton G, Restaino S, Jane Farr M, Zorn E, Colombo PC, Patel J, Levine R, Truby L, Soni RK, Leprince P, Kobashigawa J, Tatonetti NP, Fine BM, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2021 Jul
- Incidence and impact of primary graft dysfunction in adult heart transplant recipients: A systematic review and meta-analysis.
  Buchan TA, Moayedi Y, Truby LK, Guyatt G, Posada JD, Ross HJ, Khush KK, Alba AC, Foroutan F, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2021 Jul 40 7 642-651
- ECMO as a Bridge to Left Ventricular Assist Device or Heart Transplantation.
  DeFilippis EM, Clerkin K, Truby LK, Francke M, Fried J, Masoumi A, Garan AR, Farr MA, Takayama H, Takeda K, Uriel N, Topkara VK, JACC. Heart failure 2021 Apr 9 4 281-289
- Psychosocial Risk and Its Association With Outcomes in Continuous-Flow Left Ventricular Assist Device Patients.
  DeFilippis EM, Breathett K, Donald EM, Nakagawa S, Takeda K, Takayama H, Truby LK, Sayer G, Colombo PC, Yuzefpolskaya M, Uriel N, Farr MA, Topkara VK, Circulation. Heart failure 2020 Sep 13 9 e006910
- Identification of Undetected Monogenic Cardiovascular Disorders.
  Abdulrahim JW, Kwee LC, Alenezi F, Sun AY, Baras A, Ajayi TA, Henao R, Holley CL, McGarrah RW, Daubert JP, Truby LK, Vemulapalli S, Wang A, Khouri MG, Shah SH, Journal of the American College of Cardiology 2020 Aug 76 7 797-808
- Advanced Heart Failure: Epidemiology, Diagnosis, and Therapeutic Approaches.
  Truby LK, Rogers JG, JACC. Heart failure 2020 Jul 8 7 523-536
- Impact of Obesity on Ventricular Assist Device Outcomes.
  Jaiswal A, Truby LK, Chichra A, Jain R, Myers L, Patel N, Topkara VK, Journal of cardiac failure 2020 Apr 26 4 287-297
- Effect of Socioeconomic Status on Patients Supported with Contemporary Left Ventricular Assist Devices.
  Clemons AM, Flores RJ, Blum R, Wayda B, Brunjes DL, Habal M, Givens RC, Truby LK, Garan AR, Yuzefpolskaya M, Takeda K, Takayama H, Farr MA, Naka Y, Colombo PC, Topkara VK, ASAIO journal (American Society for Artificial Internal Organs : 1992) 2020 Apr 66 4 373-380
- Potential for donation after circulatory death heart transplantation in the United States: Retrospective analysis of a limited UNOS dataset.
  Farr M, Truby LK, Lindower J, Jorde U, Taylor S, Chen L, Gass A, Stevens G, Reyentovich A, Mancini D, Arcasoy S, Delair S, Pinney S, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2020 Feb 20 2 525-529
- Response by Truby and Topkara to Letter Regarding Article, "Impact of Bridge to Transplantation With Continuous-Flow Left Ventricular Assist Devices on Posttransplantation Mortality: A Propensity-Matched Analysis of the United Network of Organ Sharing Database".
  Truby LK, Topkara VK, Circulation 2019 Dec 140 25 e942-e943
- Impact of Bridge to Transplantation With Continuous-Flow Left Ventricular Assist Devices on Posttransplantation Mortality.
  Truby LK, Farr MA, Garan AR, Givens R, Restaino SW, Latif F, Takayama H, Naka Y, Takeda K, Topkara VK, Circulation 2019 Aug 140 6 459-469
- Management of primary graft failure after heart transplantation: Preoperative risks, perioperative events, and postoperative decisions.
  Truby LK, DeRoo S, Spellman J, Jennings DL, Takeda K, Fine B, Restaino S, Farr M, Clinical transplantation 2019 Jun 33 6 e13557
- Sex-Related Differences in Use and Outcomes of Left Ventricular Assist Devices as Bridge to Transplantation.
  DeFilippis EM, Truby LK, Garan AR, Givens RC, Takeda K, Takayama H, Naka Y, Haythe JH, Farr MA, Topkara VK, JACC. Heart failure 2019 Mar 7 3 250-257
- Red Cell Distribution Width Predicts 90 Day Mortality in Continuous-Flow Left Ventricular Assist Device Patients.
  Truby LK, Sridharan L, Flores RJ, Garan AR, Jennings D, Yuzefpolskaya M, Takeda K, Takayama H, Naka Y, Colombo PC, Topkara VK, ASAIO journal (American Society for Artificial Internal Organs : 1992) 2019 65 3 233-240
- EC-VAD: Combined Use of Extracorporeal Membrane Oxygenation and Percutaneous Microaxial Pump Left Ventricular Assist Device.
  Akanni OJ, Takeda K, Truby LK, Kurlansky PA, Chiuzan C, Han J, Topkara VK, Yuzefpolskaya M, Colombo PC, Karmpaliotis D, Moses JW, Naka Y, Garan AR, Kirtane AJ, Takayama H, ASAIO journal (American Society for Artificial Internal Organs : 1992) 2019 65 3 219-226
- Risk of severe primary graft dysfunction in patients bridged to heart transplantation with continuous-flow left ventricular assist devices.
  Truby LK, Takeda K, Topkara VK, Takayama H, Garan AR, Yuzefpolskaya M, Colombo P, Naka Y, Farr M, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2018 Dec 37 12 1433-1442
- Aortic Insufficiency During Contemporary Left Ventricular Assist Device Support: Analysis of the INTERMACS Registry.
  Truby LK, Garan AR, Givens RC, Wayda B, Takeda K, Yuzefpolskaya M, Colombo PC, Naka Y, Takayama H, Topkara VK, JACC. Heart failure 2018 Nov 6 11 951-960
- VA-ECMO for cardiogenic shock in the contemporary era of heart transplantation: Which patients should be urgently transplanted?
  Habal MV, Truby L, Ando M, Ikegami H, Garan AR, Topkara VK, Colombo P, Takeda K, Takayama H, Naka Y, Farr MA, Clinical transplantation 2018 09 32 9 e13356
- Prognostic Impact of Pulmonary Artery Pulsatility Index (PAPi) in Patients With Advanced Heart Failure: Insights From the ESCAPE Trial.
  Kochav SM, Flores RJ, Truby LK, Topkara VK, Journal of cardiac failure 2018 Jul 24 7 453-459
- Ventricular Assist Device Utilization in Heart Transplant Candidates: Nationwide Variability and Impact on Waitlist Outcomes.
  Truby LK, Garan AR, Givens RC, Takeda K, Takayama H, Trinh PN, Yuzefpolskaya M, Farr MA, Naka Y, Colombo PC, Topkara VK, Circulation. Heart failure 2018 Apr 11 4 e004586
- Mechanical Circulatory Support Device Utilization and Heart Transplant Waitlist Outcomes in Patients With Restrictive and Hypertrophic Cardiomyopathy.
  Sridharan L, Wayda B, Truby LK, Latif F, Restaino S, Takeda K, Takayama H, Naka Y, Colombo PC, Maurer M, Farr MA, Topkara VK, Circulation. Heart failure 2018 Mar 11 3 e004665
- Incidence and Impact of On-Cardiopulmonary Bypass Vasoplegia During Heart Transplantation.
  Truby LK, Takeda K, Farr M, Beck J, Yuzefpolskaya M, Colombo PC, Topkara VK, Mancini D, Naka Y, Takayama H, ASAIO journal (American Society for Artificial Internal Organs : 1992) 2018 64 1 43-51
- Dose-dependent association between amiodarone and severe primary graft dysfunction in orthotopic heart transplantation.
  Wright M, Takeda K, Mauro C, Jennings D, Kurlansky P, Han J, Truby L, Stein S, Topkara V, Garan AR, Yuzefpolskaya M, Colombo P, Naka Y, Farr M, Takayama H, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2017 Nov 36 11 1226-1233
- Importance of stratifying acute kidney injury in cardiogenic shock resuscitated with mechanical circulatory support therapy.
  Abadeer AI, Kurlansky P, Chiuzan C, Truby L, Radhakrishnan J, Garan R, Topkara V, Yuzefpolskaya M, Colombo P, Takeda K, Naka Y, Takayama H, The Journal of thoracic and cardiovascular surgery 2017 Sep 154 3 856-864.e4
- Incidence and Implications of Left Ventricular Distention During Venoarterial Extracorporeal Membrane Oxygenation Support.
  Truby LK, Takeda K, Mauro C, Yuzefpolskaya M, Garan AR, Kirtane AJ, Topkara VK, Abrams D, Brodie D, Colombo PC, Naka Y, Takayama H, ASAIO journal (American Society for Artificial Internal Organs : 1992) 2017 63 3 257-265
- Combined Therapy of Ventricular Assist Device and Membrane Oxygenator for Profound Acute Cardiopulmonary Failure.
  Fujita K, Takeda K, Li B, Mauro C, Kurlansky P, Sreekanth S, Han J, Truby LK, Garan AR, Topkara V, Yuzefpolskaya M, Colombo P, Naka Y, Takayama H, ASAIO journal (American Society for Artificial Internal Organs : 1992) 2017 63 6 713-719
- Angiopoietin-2: marker or mediator of angiogenesis in continuous-flow left ventricular assist device patients?
  Truby LK, Topkara VK, Journal of thoracic disease 2016 Nov 8 11 3042-3045
- Reply to Spiliopoulos et al.
  Truby L, Takayama H, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 2016 Apr 49 4 1299
- Durability and clinical impact of tricuspid valve procedures in patients receiving a continuous-flow left ventricular assist device.
  Han J, Takeda K, Takayama H, Kurlansky PA, Mauro CM, Colombo PC, Yuzefpolskaya M, Fukuhara S, Truby LK, Topkara VK, Garan AR, Mancini DM, Naka Y, The Journal of thoracic and cardiovascular surgery 2016 Feb 151 2 520-7.e1
- Important role of mechanical circulatory support in acute myocardial infarction complicated by cardiogenic shock.
  Truby L, Naka Y, Kalesan B, Ota T, Kirtane AJ, Kodali S, Nikic N, Mundy L, Colombo P, Jorde UP, Takayama H, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 2015 Aug 48 2 322-8
- Feasibility of smaller arterial cannulas in venoarterial extracorporeal membrane oxygenation.
  Takayama H, Landes E, Truby L, Fujita K, Kirtane AJ, Mongero L, Yuzefpolskaya M, Colombo PC, Jorde UP, Kurlansky PA, Takeda K, Naka Y, The Journal of thoracic and cardiovascular surgery 2015 May 149 5 1428-33
- Contemporary Outcomes of Venoarterial Extracorporeal Membrane Oxygenation for Refractory Cardiogenic Shock at a Large Tertiary Care Center.
  Truby L, Mundy L, Kalesan B, Kirtane A, Colombo PC, Takeda K, Fukuhara S, Naka Y, Takayama H, ASAIO journal (American Society for Artificial Internal Organs : 1992) 2015 61 4 403-9
- Bridge-to-decision therapy with a continuous-flow external ventricular assist device in refractory cardiogenic shock of various causes.
  Takayama H, Soni L, Kalesan B, Truby LK, Ota T, Cedola S, Khalpey Z, Uriel N, Colombo P, Mancini DM, Jorde UP, Naka Y, Circulation. Heart failure 2014 Sep 7 5 799-806
- Clinical outcome of mechanical circulatory support for refractory cardiogenic shock in the current era.
  Takayama H, Truby L, Koekort M, Uriel N, Colombo P, Mancini DM, Jorde UP, Naka Y, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2013 Jan 32 1 106-11

Research

Advanced heart failure and transplantation
Metabolomics
Proteomics

Clinical Focus

Advanced Heart Failure
General Cardiology
Heart Transplantation

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