Makoto Ishii, M.D., Ph.D.

Neurology

New Patient Appointment Accepting Virtual Visits or 214-645-8800

New Patient Appointment or 214-645-8800

Education & Training

Residency - New York Presbyterian Hospital - Weill Cornell Medical Center (2008-2012), Neurology
Medical School - Weill Cornell Medical College (2002-2008)

Books & Publications

Publications
- Comparing the effects of four common drug classes on the progression of mild cognitive impairment to dementia using electronic health records.
  Xu J, Wang F, Zang C, Zhang H, Niotis K, Liberman AL, Stonnington CM, Ishii M, Adekkanattu P, Luo Y, Mao C, Rasmussen LV, Xu Z, Brandt P, Pacheco JA, Peng Y, Jiang G, Isaacson R, Pathak J, Scientific reports 2023 May 13 1 8102
- Sexually Dimorphic Association of Circulating Plasminogen Activator Inhibitor-1 Levels and Body Mass Index with Cerebrospinal Fluid Biomarkers of Alzheimer's Pathology in Preclinical Alzheimer's Disease.
  Eruysal E, Ravdin L, Zhang C, Kamel H, Iadecola C, Ishii M, Journal of Alzheimer's disease : JAD 2023 91 3 1073-1083
- Midlife dyslipidaemia as a modifiable risk factor for later-life dementia.
  Ishii M, The lancet. Healthy longevity 2021 Aug 2 8 e453-e454
- A Novel Neurovascular Liaison Governing the Blood-Brain Barrier.
  Ishii M, Iadecola C, Neuron 2020 Jul 107 2 205-207
- Risk factor for Alzheimer's disease breaks the blood-brain barrier.
  Ishii M, Iadecola C, Nature 2020 May 581 7806 31-32
- Plasma lipocalin-2 levels in the preclinical stage of Alzheimer's disease.
  Eruysal E, Ravdin L, Kamel H, Iadecola C, Ishii M, Alzheimer's & dementia (Amsterdam, Netherlands) 2019 Dec 11 646-653
- Amyloid-Beta Modulates Low-Threshold Activated Voltage-Gated L-Type Calcium Channels of Arcuate Neuropeptide Y Neurons Leading to Calcium Dysregulation and Hypothalamic Dysfunction.
  Ishii M, Hiller AJ, Pham L, McGuire MJ, Iadecola C, Wang G, The Journal of neuroscience : the official journal of the Society for Neuroscience 2019 Oct 39 44 8816-8825
- Apolipoprotein B as a New Link Between Cholesterol and Alzheimer Disease.
  Ishii M, JAMA neurology 2019 Jul 76 7 751-753
- McLeod syndrome: Five new pedigrees with novel mutations.
  Weaver J, Sarva H, Barone D, Bobker S, Bushara K, Hiller A, Ishii M, Jankovic J, Lakhani S, Niotis K, Scharre DW, Tuite P, Stutz A, Westhoff CM, Walker RH, Parkinsonism & related disorders 2019 Jul 64 293-299
- Retinol Binding Protein 4 Levels Are Not Altered in Preclinical Alzheimer's Disease and Not Associated with Cognitive Decline or Incident Dementia.
  Ishii M, Kamel H, Iadecola C, Journal of Alzheimer's disease : JAD 2019 67 1 257-263
- Disorders of Body Weight, Sleep and Circadian Rhythm as Manifestations of Hypothalamic Dysfunction in Alzheimer's Disease.
  Hiller AJ, Ishii M, Frontiers in cellular neuroscience 2018 12 471
- Endocrine Emergencies With Neurologic Manifestations.
  Ishii M, Continuum (Minneapolis, Minn.) 2017 Jun 23 3, Neurology of Systemic Disease 778-801
- Adipocyte-derived factors in age-related dementia and their contribution to vascular and Alzheimer pathology.
  Ishii M, Iadecola C, Biochimica et biophysica acta 2016 May 1862 5 966-74
- Leptin Dysfunction and Alzheimer's Disease: Evidence from Cellular, Animal, and Human Studies.
  McGuire MJ, Ishii M, Cellular and molecular neurobiology 2016 Mar 36 2 203-17
- Metabolic and Non-Cognitive Manifestations of Alzheimer's Disease: The Hypothalamus as Both Culprit and Target of Pathology.
  Ishii M, Iadecola C, Cell metabolism 2015 Nov 22 5 761-76
- Transgenic mice overexpressing amyloid precursor protein exhibit early metabolic deficits and a pathologically low leptin state associated with hypothalamic dysfunction in arcuate neuropeptide y neurons.
  Ishii M, Wang G, Racchumi G, Dyke JP, Iadecola C The Journal of neuroscience : the official journal of the Society for Neuroscience 2014 Jul 34 27 9096-106
- Amyloid ?-Related Central Nervous System Angiitis Presenting With an Isolated Seizure.
  Ishii M, Lavi E, Kamel H, Gupta A, Iadecola C, Navi BB The Neurohospitalist 2014 Apr 4 2 86-9
- Critical role of neuropeptides b/w receptor 1 signaling in social behavior and fear memory.
  Nagata-Kuroiwa R, Furutani N, Hara J, Hondo M, Ishii M, Abe T, Mieda M, Tsujino N, Motoike T, Yanagawa Y, Kuwaki T, Yamamoto M, Yanagisawa M, Sakurai T PloS one 2011 6 2 e16972
- Fasting-induced hypothermia and reduced energy production in mice lacking acetyl-CoA synthetase 2.
  Sakakibara I, Fujino T, Ishii M, Tanaka T, Shimosawa T, Miura S, Zhang W, Tokutake Y, Yamamoto J, Awano M, Iwasaki S, Motoike T, Okamura M, Inagaki T, Kita K, Ezaki O, Naito M, Kuwaki T, Chohnan S, Yamamoto TT, Hammer RE, Kodama T, Yanagisawa M, Sakai J Cell metabolism 2009 Feb 9 2 191-202
- Effect of neuropeptide B on feeding behavior is influenced by endogenous corticotropin-releasing factor activities.
  Aikawa S, Ishii M, Yanagisawa M, Sakakibara Y, Sakurai T Regulatory peptides 2008 Nov 151 1-3 147-52
- The NPB/NPW neuropeptide system and its role in regulating energy homeostasis, pain, and emotion.
  Hondo M, Ishii M, Sakurai T, Results and problems in cell differentiation 2008 46 239-56
- Distribution of neuropeptide W immunoreactivity and mRNA in adult rat brain.
  Kitamura Y, Tanaka H, Motoike T, Ishii M, Williams SC, Yanagisawa M, Sakurai T Brain research 2006 Jun 1093 1 123-34
- Targeted disruption of GPR7, the endogenous receptor for neuropeptides B and W, leads to metabolic defects and adult-onset obesity.
  Ishii M, Fei H, Friedman JM, Proceedings of the National Academy of Sciences of the United States of America 2003 Sep 100 18 10540-5
- Mechanism-based inhibition of the melatonin rhythm enzyme: pharmacologic exploitation of active site functional plasticity.
  Khalil EM, De Angelis J, Ishii M, Cole PA, Proceedings of the National Academy of Sciences of the United States of America 1999 Oct 96 22 12418-23
- Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior.
  Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, Williams SC, Richardson JA, Kozlowski GP, Wilson S, Arch JR, Buckingham RE, Haynes AC, Carr SA, Annan RS, McNulty DE, Liu WS, Terrett JA, Elshourbagy NA, Bergsma DJ, Yanagisawa M Cell 1998 Feb 92 4 573-85

New Patient Appointment Accepting Virtual Visits or 214-645-8800