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Mathew Augustine, M.D., Ph.D.
Mathew Augustine, M.D., Ph.D.

Mathew Augustine, M.D., Ph.D.

  • Surgery - Surgical Oncology
  • Surgery for Pancreatic Cancer
  • Liver Cancer


Mathew Augustine, M.D., Ph.D., is an Assistant Professor in the Department of Surgery at UT Southwestern Medical Center. 

Dr. Augustine is a surgical oncologist who specializes in treating gastrointestinal cancer. He is American Board of Surgery-certified in both general surgery and complex general surgical oncology.

He joined the UT Southwestern faculty in 2014.

Dr. Augustine completed his bachelor’s degree at Johns Hopkins University where he graduated Phi Beta Kappa. He earned his medical degree with honors (Alpha Omega Alpha and cum laude) at the Yale University School of Medicine. He then completed a general surgery internship and residency at the Johns Hopkins Hospital, as well as a fellowship in complex general surgical oncology at Memorial Sloan-Kettering Cancer Center.

He holds a Ph.D. in molecular biology and immunology from the Johns Hopkins School of Medicine. He also completed a Howard Hughes Medical Student Research Fellowship while at Yale.

Dr. Augustine has published more than a dozen journal articles and book chapters. His honors include the Yale University School of Medicine’s 2003 Dr. Louis H. Nahum Prize and a number of teaching awards from Johns Hopkins nurses, medical students, and residents.

He is a member of the American College of Surgery, the Society of Surgical Oncology, and the Association of Academic Surgeons.

Personal Note

Dr. Augustine and his wife, a psychiatrist, have three children.

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Meet Dr. Augustine

Gastrointestinal Cancer Surgeon in Dallas

Surgical oncologist M. Mathew Augustine, M.D., Ph.D., fights gastrointestinal cancer in both the operating room and the laboratory at UT Southwestern Medical Center.

Dr. Augustine uses his surgical expertise to treat patients with pancreatic, liver, bile duct (biliary), and gallbladder cancer. In addition, he also treats other gastrointestinal conditions, both cancerous and benign. These include cysts of the pancreas, pancreatic neuroendocrine tumors (PNETs), gastrointestinal stromal tumors (GISTs), gastric cancer, colon cancer, carcinoid tumors, and retroperitoneal sarcomas. 

Although many patients require traditional open surgery, Dr. Augustine offers treatments such as laparoscopic and robotic surgery in highly selected cases. 

In addition to his surgical expertise, Dr. Augustine is also active in the laboratory as a basic science researcher and is broadening UT Southwestern’s study of gastrointestinal malignancies – critical to developing new and more effective therapies. 

“I hope to understand why patients develop treatment resistance to pancreatic cancer, colon cancer, and gastrointestinal stromal tumor,” he says. “We hope that discoveries related to this work impact all patients undergoing therapy for cancer today.“ 

As a member of the GI Cancer Surgical Team at UT Southwestern, Dr. Augustine offers patients a comprehensive, multidisciplinary approach to cancer care.

“Receiving a diagnosis of cancer charts patients on a long journey during which they are confronted with a myriad of complicated, life-altering choices and decisions,” Dr. Augustine says. 

He has witnessed firsthand the critical role that surgical oncologists play in guiding patients through the decision-making process. 

“We have a dedicated multidisciplinary oncology team, comprising gastroenterologists, medical and radiation oncologists, radiologists, geneticists, pathologists, and surgeons motivated by the same common purpose: to provide patients with a highly personalized, cutting-edge approach to their cancer care,” he says. 

“Patients and their loved ones come to us seeking not only knowledge and direction, but most importantly understanding and hope. I am very fortunate to be among a group of extraordinary individuals dedicated to their care,” Dr. Augustine says.

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Education & Training
  • Medical School - Yale University School of Medicine (1999-2003)
  • Residency - Johns Hopkins University School of Medicine (2003-2012), General Surgery
  • Graduate School - Johns Hopkins University School of Medicine, Molecular Biology
  • Fellowship - Memorial Sloan-Kettering Cancer Center (2012-2014), Surgical Oncology

Clinical Focus

  • Surgery for Pancreatic Cancer
  • Liver Cancer
  • Gallbladder/Bile Duct (Cholangiocarcinoma) Cancer
  • Surgery for Gastrointestinal Cancer

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Q&A by Mathew Augustine, M.D., Ph.D.

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