- Medical School - University of Colorado School of Medicine (2009-2013)
- Residency - University of Connecticut School of Medicine/CT Children's Medical Center (2013-2017), Pediatrics
- Fellowship - Johns Hopkins University/ John Hopkins Hospital (2017-2021), Pediatric Cardiology
- Fellowship - Columbia University Irving Medical Center (2021-2022), Pediatrics
Megan Griffiths, M.D.
- Pediatrics - Cardiology
- Pediatric Cardiology
- Pulmonary Hypertension
Biography
Megan Griffiths, M.D., is an Assistant Professor in the Department of Pediatrics at UT Southwestern Medical Center. She specializes in pulmonary hypertension and right heart failure and serves as the Director of Pediatric Pulmonary Hypertension for the Division of Pediatric Cardiology.
Dr. Griffiths earned her medical degree at the University of Colorado School of Medicine. She completed a residency in pediatrics at the University of Connecticut and Connecticut Children’s Medical Center, where she served as Chief Resident. She completed a fellowship in pediatric cardiology at Johns Hopkins University and Bloomberg Children’s Center, during which time she was selected as a Fellow in the Pediatric Scientist Development Program. She also completed an advanced fellowship in pulmonary hypertension at Columbia University and Morgan Stanley Children’s Hospital.
Certified by the American Board of Pediatrics in pediatric cardiology, she joined the UT Southwestern faculty in 2022.
Dr. Griffiths is a member of several professional societies, including the American Thoracic Society, the American Heart Association, and the Pulmonary Vascular Research Institute.
Her research focuses on developing new ways to identify, understand, and treat pulmonary vascular disease and right heart failure, especially through the fields of proteomics and metabolomics. She has delivered many presentations and lectures and published numerous academic articles related to her areas of expertise. She also serves as a peer reviewer for several scholarly journals.
Personal Note
Dr. Griffiths says, “New research in pulmonary hypertension and right heart failure is yielding treatment options for babies and children who previously had none. I’m passionate about partnering with my patients and their families to give them top-quality treatment and the best possible quality of life.”
Education & Training
Professional Associations & Affiliations
- American Academy of Pediatrics
- American College of Cardiology
- American Heart Association
- American Thoracic Society
- International Society for Heart and Lung Transplantation
- Pulmonary Hypertension Association
- Pulmonary Vascular Research Institute
- Society for Pediatric Research
Honors & Awards
- Best Abstract 2022, Leonard Steinfeld Research Symposium, Pediatric Cardiology Society of Greater New York
- Finalist for Cournand and Comroe Early Career Investigator Award 2021, American Heart Association
- Francis D. Schwentker Award for excellence in research 2021, Johns Hopkins University
- Pediatric Scientist Development Program Fellowship 2019-2021, Association of Medical School Pediatric Department Chairs and the National Institutes of Childhood Health and Human Development
- Featured Early Career Investigator 2020, Pediatric Research, Nature Publications Group
- Travel Award 2019, American Heart Association
- Fellow’s Clinical Research Award 2018, Society for Pediatric Research
- Chief Resident 2016-2017, University of Connecticut
- Outstanding Resident in Pediatrics 2016, University of Connecticut
- Residency Commendation 2014-2015, Connecticut Children’s Medical Center
- Outstanding Student in Psychiatry Clerkship 2011, University of Colorado School of Medicine
Books & Publications
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Publications
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Perinatal Inflammatory Biomarkers and Respiratory Disease in Preterm Infants.
Collaco JM, McGrath-Morrow SA, Griffiths M, Chavez-Valdez R, Parkinson C, Zhu J, Northington FJ, Graham EM, Everett AD, The Journal of pediatrics 2022 07 246 34-39.e3 -
Cardiac Dysfunction Biomarkers are Associated with Potential for Successful Separation from Extracorporeal Membrane Oxygenation in Children.
Coletti K, Griffiths M, Nies M, Brandal S, Everett AD, Bembea MM, ASAIO journal (American Society for Artificial Internal Organs : 1992) 2022 May -
Proteomics discovery of pulmonary hypertension biomarkers: Insulin-like growth factor binding proteins are associated with disease severity.
Nies MK, Yang J, Griffiths M, Damico R, Zhu J, Vaydia D, Fu Z, Brandal S, Austin ED, Ivy DD, Hassoun PM, Van Eyk JE, Everett AD, Pulmonary circulation 2022 Apr 12 2 e12039 -
COL18A1 genotypic associations with endostatin levels and clinical features in pulmonary arterial hypertension: a quantitative trait association study.
Simpson CE, Griffiths M, Yang J, Nies MK, Vaidya D, Brandal S, Martin LJ, Pauciulo MW, Lutz KA, Coleman AW, Austin ED, Ivy DD, Nichols WC, Everett AD, Hassoun PM, Damico RL, ERJ open research 2022 Apr 8 2 -
Biomarkers of Pulmonary Hypertension Are Altered in Children with Down Syndrome and Pulmonary Hypertension.
Griffiths M, Yang J, Vaidya D, Nies M, Brandal S, Ivy DD, Hickey F, Wolter-Warmerdam K, Austin ED, Mullen M, Pauciulo MW, Lutz KA, Rosenzweig EB, Hirsch R, Yung D, Nichols WC, Everett AD, The Journal of pediatrics 2022 02 241 68-76.e3 -
Hepatoma-derived growth factor is associated with pulmonary vascular remodeling and PAH disease severity and survival.
Yang J, Ambade AS, Nies M, Griffiths M, Damico R, Vaidya D, Brandal S, Pauciulo MW, Lutz KA, Coleman AW, Nichols WC, Austin ED, Ivy D, Hassoun PM, Everett AD, Pulmonary circulation 2022 Jan 12 1 e12007 -
The angiostatic peptide endostatin enhances mortality risk prediction in pulmonary arterial hypertension.
Simpson CE, Griffiths M, Yang J, Nies MK, Vaidya RD, Brandal S, Martin LJ, Pauciulo MW, Lutz KA, Coleman AW, Austin ED, Ivy DD, Nichols WC, Everett AD, Hassoun PM, Damico RL, ERJ open research 2021 Oct 7 4 -
Angiostatic Peptide, Endostatin, Predicts Severity in Pediatric Congenital Heart Disease-Associated Pulmonary Hypertension.
Daly CM, Griffiths M, Simpson CE, Yang J, Damico RL, Vaidya RD, Williams M, Brandal S, Jone PN, Polsen C, Ivy DD, Austin ED, Nichols WC, Pauciulo MW, Lutz K, Nies MK, Rosenzweig EB, Hirsch R, Yung D, Everett AD, Journal of the American Heart Association 2021 10 10 20 e021409 -
ST2 Is a Biomarker of Pediatric Pulmonary Arterial Hypertension Severity and Clinical Worsening.
Griffiths M, Yang J, Simpson CE, Vaidya D, Nies M, Brandal S, Damico R, Ivy DD, Austin ED, Pauciulo MW, Lutz KA, Rosenzweig EB, Hirsch R, Yung D, Nichols WC, Everett AD, Chest 2021 07 160 1 297-306 -
Megan Griffiths biocommentary.
Griffiths M, Pediatric research 2020 12 88 6 826 -
Pediatric pulmonary hypertension: insulin-like growth factor-binding protein 2 is a novel marker associated with disease severity and survival.
Griffiths M, Yang J, Nies M, Vaidya D, Brandal S, Williams M, Matsui EC, Grant T, Damico R, Ivy D, Austin ED, Nichols WC, Pauciulo MW, Lutz K, Rosenzweig EB, Hirsch R, Yung D, Everett AD, Pediatric research 2020 12 88 6 850-856 -
Endostatin and ST2 are predictors of pulmonary hypertension disease course in infants.
Griffiths M, Yang J, Everett AD, Jennings JM, Freire G, Williams M, Nies M, McGrath-Morrow SA, Collaco JM, Journal of perinatology : official journal of the California Perinatal Association 2020 11 40 11 1625-1633 -
Insulin-like growth factor binding protein-2: a new circulating indicator of pulmonary arterial hypertension severity and survival.
Yang J, Griffiths M, Nies MK, Brandal S, Damico R, Vaidya D, Tao X, Simpson CE, Kolb TM, Mathai SC, Pauciulo MW, Nichols WC, Ivy DD, Austin ED, Hassoun PM, Everett AD, BMC medicine 2020 10 18 1 268 -
Elevated Interleukin-6 Levels Predict Clinical Worsening in Pediatric Pulmonary Arterial Hypertension.
Chen JY, Griffiths M, Yang J, Nies MK, Damico RL, Simpson CE, Vaidya RD, Brandal S, Ivy DD, Austin ED, Nichols WC, Pauciulo MW, Lutz K, Rosenzweig EB, Hirsch R, Yung D, Everett AD, The Journal of pediatrics 2020 08 223 164-169.e1 -
Association of Neurodevelopmental Outcomes With Environmental Exposure to Cyclohexanone During Neonatal Congenital Cardiac Operations: A Secondary Analysis of a Randomized Clinical Trial.
Everett AD, Buckley JP, Ellis G, Yang J, Graham D, Griffiths M, Bembea M, Graham EM, JAMA network open 2020 05 3 5 e204070 -
Cellular sources of interleukin-6 and associations with clinical phenotypes and outcomes in pulmonary arterial hypertension.
Simpson CE, Chen JY, Damico RL, Hassoun PM, Martin LJ, Yang J, Nies M, Griffiths M, Vaidya RD, Brandal S, Pauciulo MW, Lutz KA, Coleman AW, Austin ED, Ivy DD, Nichols WC, Everett AD, The European respiratory journal 2020 04 55 4 -
T-Cell Receptor Excision Circles in Newborns with Congenital Heart Disease.
Davey BT, Elder RW, Cloutier MM, Bennett N, Lee JH, Wang Z, Manning A, Doan T, Griffiths M, Perez M, Ahluwalia N, Toro-Salazar OH, The Journal of pediatrics 2019 10 213 96-102.e2 -
Attending rounds in the current era: what is and is not happening.
Stickrath C, Noble M, Prochazka A, Anderson M, Griffiths M, Manheim J, Sillau S, Aagaard E, JAMA internal medicine 2013 Jun 173 12 1084-9
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Perinatal Inflammatory Biomarkers and Respiratory Disease in Preterm Infants.
Research
- Proteomics and metabolomics of pulmonary vascular disease and right heart failure
Clinical Focus
- Pediatric Cardiology
- Pulmonary Hypertension
- Right Heart Failure