- American Academy of Pediatrics
- American College of Cardiology
- American Heart Association
- American Thoracic Society
- International Society for Heart and Lung Transplantation
- Pulmonary Hypertension Association
- Pulmonary Vascular Research Institute
- Society for Pediatric Research
Megan Griffiths, M.D.
- Pediatrics - Cardiology
- Pediatric Cardiology
- Pulmonary Hypertension
Biography
Megan Griffiths, M.D., is an Assistant Professor in the Department of Pediatrics at UT Southwestern Medical Center. She specializes in pulmonary hypertension and right heart failure and serves as the Director of Pediatric Pulmonary Hypertension for the Division of Pediatric Cardiology.
Dr. Griffiths earned her medical degree at the University of Colorado School of Medicine. She completed a residency in pediatrics at the University of Connecticut and Connecticut Children’s Medical Center, where she served as Chief Resident. She completed a fellowship in pediatric cardiology at Johns Hopkins University and Bloomberg Children’s Center, during which time she was selected as a Fellow in the Pediatric Scientist Development Program. She also completed an advanced fellowship in pulmonary hypertension at Columbia University and Morgan Stanley Children’s Hospital.
Certified by the American Board of Pediatrics in pediatric cardiology, she joined the UT Southwestern faculty in 2022.
Dr. Griffiths is a member of several professional societies, including the American Thoracic Society, the American Heart Association, and the Pulmonary Vascular Research Institute.
Her research focuses on developing new ways to identify, understand, and treat pulmonary vascular disease and right heart failure, especially through the fields of proteomics and metabolomics. She has delivered many presentations and lectures and published numerous academic articles related to her areas of expertise. She also serves as a peer reviewer for several scholarly journals.
Personal Note
Dr. Griffiths says, “New research in pulmonary hypertension and right heart failure is yielding treatment options for babies and children who previously had none. I’m passionate about partnering with my patients and their families to give them top-quality treatment and the best possible quality of life.”
Education & Training
- Medical School - University of Colorado School of Medicine (2009-2013)
- Residency - University of Connecticut School of Medicine/CT Children's Medical Center (2013-2017), Pediatrics
- Fellowship - Johns Hopkins University/ John Hopkins Hospital (2017-2021), Pediatric Cardiology
- Fellowship - Columbia University Irving Medical Center (2021-2022), Pediatrics
Professional Associations & Affiliations
Honors & Awards
- Best Abstract 2022, Leonard Steinfeld Research Symposium, Pediatric Cardiology Society of Greater New York
- Finalist for Cournand and Comroe Early Career Investigator Award 2021, American Heart Association
- Francis D. Schwentker Award for excellence in research 2021, Johns Hopkins University
- Pediatric Scientist Development Program Fellowship 2019-2021, Association of Medical School Pediatric Department Chairs and the National Institutes of Childhood Health and Human Development
- Featured Early Career Investigator 2020, Pediatric Research, Nature Publications Group
- Travel Award 2019, American Heart Association
- Fellow’s Clinical Research Award 2018, Society for Pediatric Research
- Chief Resident 2016-2017, University of Connecticut
- Outstanding Resident in Pediatrics 2016, University of Connecticut
- Residency Commendation 2014-2015, Connecticut Children’s Medical Center
- Outstanding Student in Psychiatry Clerkship 2011, University of Colorado School of Medicine
Books & Publications
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Publications
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Clinically relevant outcomes for research in pediatric pulmonary embolism: communication from the ISTH SSC Subcommittee on Pediatric/Neonatal Thrombosis and Hemostasis
Zia A, Whitworth H, Avila L, Klok FA, Alqahtani M, Gopalan D, Griffiths M, Rosovsky RP, Williams S, Babb TG, Rajpurkar M Journal of Thrombosis and Haemostasis 2026 Feb 24 766-780 -
Authors’ Perspective on the International Society for Heart and Lung Transplantation Consensus Statement on Risk Stratification in Pulmonary Arterial Hypertension
Sahay S, Visovatti S, Tonelli AR, Villasmil Hernandez N, Austin ED, Badagliacca R, Berger RM, Boucly A, Chen Y, Church C, Delcroix M, Everett AD, Farber HW, Fauvel C, Gomberg-Maitland M, Griffiths M, Haddad F, Han Y, Hemnes A, Hoeper MM, Kanwar MK, Lachant D, Murthy S, Olsson KM, Preston I, Rådegran G, Sitbon O, Trivieri MG, Vachiery JL, Vanderpool R, Weatherald J, White RJ, Whitford H, Wilson M, L. Benza R Journal of Heart and Lung Transplantation 2025 Nov 44 1683-1687 -
International Society for Heart and Lung Transplantation (ISHLT) Consensus Statement on Risk Stratification in Pulmonary Arterial Hypertension
Sahay S, Visovatti S, Tonelli AR, Villasmil Hernandez N, Austin ED, Badagliacca R, Berger RM, Boucly A, Chen Y, Church C, Delcroix M, Everett AD, Farber HW, Fauvel C, Gomberg-Maitland M, Griffiths M, Haddad F, Han Y, Hemnes A, Hoeper MM, Kanwar MK, Lachant D, Murthy S, Olsson KM, Preston I, Rådegran G, Sitbon O, Trivieri MG, Vachiery JL, Vanderpool R, Weatherald J, White RJ, Whitford H, Wilson M, L. Benza R Journal of Heart and Lung Transplantation 2025 Nov 44 e73-e131 -
Beyond Resistance: Pulmonary Vascular Compromise as a Mechanistic Window Into Pediatric Pulmonary Hypertension
Griffiths M Pulmonary Circulation 2025 Oct 15 -
Enhancing Drug Development for Paediatric Pulmonary Hypertension—An Integrative Perspective
Abman SH, Nikkho SM, Berger RM, del Cerro MJ, Austin ED, Beghetti M, Ivy D, Griffiths M, Hilgendorff A, Kawut SH, Krishnan US, Mullen MP, Moledina S, Thébaud B, Stockbridge N Pulmonary Circulation 2025 Jul 15 -
Cellular Communication Network Protein 2 in the Right Ventricle of Pulmonary Arterial Hypertension
Byrd CE, Schramm JE, Yang J, Barnes AE, Griffiths M, Ambade AS, Rosen DT, Cubero Salazar IM, Simpson CE, Tedford RJ, Hsu S, Vaidya D, Kolb TM, Pauciulo MW, Nichols WC, Ivy DD, Austin ED, Hassoun PM, Damico RL, Everett AD Pulmonary Circulation 2025 Apr 15 -
The Role of Imaging in Pulmonary Vascular Disease: The Clinician's Perspective
Jakubowski BR, Griffiths M, Goss KN Radiologic Clinics of North America 2025 Mar 63 305-313 -
Complications of Pulmonary Embolism in a Pediatric Patient
Patil S, Zia A, Fuller J, Billa R, Goss K, Andersen ND, Griffiths M JACC: Case Reports 2025 Feb 30 -
Equivalency of Multiple Biomarkers to Clinical Pulmonary Arterial Hypertension Survival Risk Models
Griffiths M, Simpson CE, Yang J, Vaidya D, Nies MK, Brandal S, Damico R, Hassoun P, Ivy DD, Austin ED, Pauciulo MW, Lutz KA, Martin LJ, Rosenzweig EB, Benza RL, Nichols WC, Manlhiot C, Everett AD CHEST 2024 Dec 166 1511-1531 -
Resistin predicts disease severity and survival in patients with pulmonary arterial hypertension
Gao L, Skinner J, Nath T, Lin Q, Griffiths M, Damico RL, Pauciulo MW, Nichols WC, Hassoun PM, Everett AD, Johns RA Respiratory Research 2024 Dec 25 -
Metabolomic Differences in Connective Tissue Disease–Associated Versus Idiopathic Pulmonary Arterial Hypertension in the PVDOMICS Cohort
Simpson CE, Hemnes AR, Griffiths M, Grunig G, Tang WH, Garcia JG, Barnard J, Comhair SA, Damico RL, Mathai SC, Hassoun PM Arthritis and Rheumatology 2023 Dec 75 2240-2251 -
Kynurenine pathway metabolism evolves with development of preclinical and scleroderma-associated pulmonary arterial hypertension
Simpson CE, Ambade AS, Harlan R, Roux A, Aja S, Graham D, Shah AA, Hummers LK, Hemnes AR, Leopold JA, Horn EM, Berman-Rosenzweig ES, Grunig G, Aldred MA, Barnard J, Comhair SA, Tang WH, Griffiths M, Rischard F, Frantz RP, Erzurum SC, Beck GJ, Hill NS, Mathai SC, Hassoun PM, Damico RL American Journal of Physiology - Lung Cellular and Molecular Physiology 2023 Nov 325 L617-L627 -
Intravenous prostacyclins for right ventricular failure following left ventricular assist device in paediatric heart failure
Radel LJ, Iqbal M, Griffiths M Cardiology in the Young 2023 Nov 33 2422-2424 -
Low-affinity insulin-like growth factor binding protein 7 and its association with pulmonary arterial hypertension severity and survival
Torres G, Lancaster AC, Yang J, Griffiths M, Brandal S, Damico R, Vaidya D, Simpson CE, Martin LJ, Pauciulo MW, Nichols WC, Ivy DD, Austin ED, Hassoun PM, Everett AD Pulmonary Circulation 2023 Jul 13 -
Insulin-like growth factor binding Protein-4: A novel indicator of pulmonary arterial hypertension severity and survival
Torres G, Yang J, Griffiths M, Brandal S, Damico R, Vaidya D, Simpson CE, Pauciulo MW, Nichols WC, Ivy DD, Austin ED, Hassoun PM, Everett AD Pulmonary Circulation 2023 Apr 13 -
Cardiac Dysfunction Biomarkers Are Associated with Potential for Successful Separation from Extracorporeal Membrane Oxygenation in Children
Coletti K, Griffiths M, Nies M, Brandal S, Everett AD, Bembea MM ASAIO Journal 2023 Feb 69 198-204 -
Perinatal Inflammatory Biomarkers and Respiratory Disease in Preterm Infants
Collaco JM, McGrath-Morrow SA, Griffiths M, Chavez-Valdez R, Parkinson C, Zhu J, Northington FJ, Graham EM, Everett AD Journal of Pediatrics 2022 Jul 246 34-39.e3 -
Proteomics discovery of pulmonary hypertension biomarkers: Insulin-like growth factor binding proteins are associated with disease severity
Nies MK, Yang J, Griffiths M, Damico R, Zhu J, Vaydia D, Fu Z, Brandal S, Austin ED, Ivy DD, Hassoun PM, Van Eyk JE, Everett AD Pulmonary Circulation 2022 Apr 12 -
Cellular sources of interleukin-6 and associations with clinical phenotypes and outcomes in pulmonary arterial hypertension
Simpson CE, Chen JY, Damico RL, Hassoun PM, Martin LJ, Yang J, Nies M, Griffiths M, Vaidya D, Brandal S, Pauciulo MW, Lutz KA, Coleman AW, Austin ED, Ivy DD, Nichols WC, Everett AD European Respiratory Journal 2022 Apr 59 -
COL18A1 genotypic associations with endostatin levels and clinical features in pulmonary arterial hypertension: a quantitative trait association study
Simpson CE, Griffiths M, Yang J, Nies MK, Vaidya D, Brandal S, Martin LJ, Pauciulo MW, Lutz KA, Coleman AW, Austin ED, Ivy DD, Nichols WC, Everett AD, Hassoun PM, Damico RL ERJ Open Research 2022 Apr 8 -
Biomarkers of Pulmonary Hypertension Are Altered in Children with Down Syndrome and Pulmonary Hypertension
Griffiths M, Yang J, Vaidya D, Nies M, Brandal S, Ivy DD, Hickey F, Wolter-Warmerdam K, Austin ED, Mullen M, Pauciulo MW, Lutz KA, Rosenzweig EB, Hirsch R, Yung D, Nichols WC, Everett AD Journal of Pediatrics 2022 Feb 241 68-76.e3 -
Hepatoma-derived growth factor is associated with pulmonary vascular remodeling and PAH disease severity and survival
Yang J, Ambade AS, Nies M, Griffiths M, Damico R, Vaidya D, Brandal S, Pauciulo MW, Lutz KA, Coleman AW, Nichols WC, Austin ED, Ivy D, Hassoun PM, Everett AD Pulmonary Circulation 2022 Jan 12 -
The angiostatic peptide endostatin enhances mortality risk prediction in pulmonary arterial hypertension
Simpson CE, Griffiths M, Yang J, Nies MK, Vaidya RD, Brandal S, Martin LJ, Pauciulo MW, Lutz KA, Coleman AW, Austin ED, Ivy DD, Nichols WC, Everett AD, Hassoun PM, Damico RL ERJ Open Research 2021 Oct 7 -
Angiostatic peptide, endostatin, predicts severity in pediatric congenital heart disease–associated pulmonary hypertension
Daly CM, Griffiths M, Simpson CE, Yang J, Damico RL, Vaidya RD, Williams M, Brandal S, Jone PN, Polsen C, Ivy DD, Austin ED, Nichols WC, Pauciulo MW, Lutz K, Nies MK, Rosenzweig EB, Hirsch R, Yung D, Everett AD Journal of the American Heart Association 2021 Oct 10 -
ST2 Is a Biomarker of Pediatric Pulmonary Arterial Hypertension Severity and Clinical Worsening
Griffiths M, Yang J, Simpson CE, Vaidya D, Nies M, Brandal S, Damico R, Ivy DD, Austin ED, Pauciulo MW, Lutz KA, Rosenzweig EB, Hirsch R, Yung D, Nichols WC, Everett AD CHEST 2021 Jul 160 297-306 -
Megan Griffiths biocommentary
Griffiths M Pediatric Research 2020 Dec 88 826 -
Pediatric pulmonary hypertension: insulin-like growth factor-binding protein 2 is a novel marker associated with disease severity and survival
Griffiths M, Yang J, Nies M, Vaidya D, Brandal S, Williams M, Matsui EC, Grant T, Damico R, Ivy D, Austin ED, Nichols WC, Pauciulo MW, Lutz K, Rosenzweig EB, Hirsch R, Yung D, Everett AD Pediatric Research 2020 Dec 88 850-856 -
Endostatin and ST2 are predictors of pulmonary hypertension disease course in infants
Griffiths M, Yang J, Everett AD, Jennings JM, Freire G, Williams M, Nies M, McGrath-Morrow SA, Collaco JM Journal of Perinatology 2020 Nov 40 1625-1633 -
Correction: Endostatin and ST2 are predictors of pulmonary hypertension disease course in infants (Journal of Perinatology, (2020), 40, 11, (1625-1633), 10.1038/s41372-020-0671-8)
Griffiths M, Yang J, Everett AD, Jennings JM, Freire G, Williams M, Nies M, McGrath-Morrow SA, Collaco JM Journal of Perinatology 2020 Nov 40 1729 -
Insulin-like growth factor binding protein-2: A new circulating indicator of pulmonary arterial hypertension severity and survival
Yang J, Griffiths M, Nies MK, Brandal S, Damico R, Vaidya D, Tao X, Simpson CE, Kolb TM, Mathai SC, Pauciulo MW, Nichols WC, Ivy DD, Austin ED, Hassoun PM, Everett AD BMC medicine 2020 Oct 18 -
Elevated Interleukin-6 Levels Predict Clinical Worsening in Pediatric Pulmonary Arterial Hypertension
Chen JY, Griffiths M, Yang J, Nies MK, Damico RL, Simpson CE, Vaidya RD, Brandal S, Ivy DD, Austin ED, Nichols WC, Pauciulo MW, Lutz K, Rosenzweig EB, Hirsch R, Yung D, Everett AD Journal of Pediatrics 2020 Aug 223 164-169.e1 -
Association of Neurodevelopmental Outcomes with Environmental Exposure to Cyclohexanone during Neonatal Congenital Cardiac Operations: A Secondary Analysis of a Randomized Clinical Trial
Everett AD, Buckley JP, Ellis G, Yang J, Graham D, Griffiths M, Bembea M, Graham EM JAMA Network Open 2020 May 3 -
Cellular sources of IL-6 and associations with clinical phenotypes and outcomes in PAH
Simpson CE, Chen JY, Damico RL, Hassoun PM, Martin LJ, Yang J, Nies M, Griffiths M, Dhananjay Vaidya R, Brandal S, Pauciulo MW, Lutz KA, Coleman AW, Austin ED, Ivy DD, Nichols WC, Everett AD European Respiratory Journal 2020 Apr 55 -
T-Cell Receptor Excision Circles in Newborns with Congenital Heart Disease
Davey BT, Elder RW, Cloutier MM, Bennett N, Lee JH, Wang Z, Manning A, Doan T, Griffiths M, Perez M, Ahluwalia N, Toro-Salazar OH Journal of Pediatrics 2019 Oct 213 96-102.e2 -
Attending rounds in the current era: What is and is not happening
Stickrath C, Noble M, Prochazka A, Anderson M, Griffiths M, Manheim J, Sillau S, Aagaard E JAMA Internal Medicine 2013 Jun 173 1084-1089
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Clinically relevant outcomes for research in pediatric pulmonary embolism: communication from the ISTH SSC Subcommittee on Pediatric/Neonatal Thrombosis and Hemostasis
Research
- Proteomics and metabolomics of pulmonary vascular disease and right heart failure
Clinical Focus
- Pediatric Cardiology
- Pulmonary Hypertension
- Right Heart Failure