Payal Kapur, M.D.

Harold C. Simmons Comprehensive Cancer Center

Jan and Bob Pickens Distinguished Professorship in Medical Science, in Memory of Jerry Knight Rymer and Annette Brannon Rymer and Mr. and Mrs. W.L. Pickens

Pathology
Pathology/Diagnosis of Genitourinary Cancers

Biography

Dr. Kapur completed her medical education in 1997 at the University College of Medical Sciences (UCMS), New Delhi, India. After completing a pathology residency in 2000 at Maulana Azad Medical College, New Delhi, she was awarded the Dr. RP Mathur Memorial Award for the best outgoing III year pathology resident. Subsequently, she came to Dallas and did a Residency in Anatomic and Clinical Pathology at UT Southwestern Medical Center (2002-2006). She is certified in Anatomic Pathology and Clinical Pathology by the American Board of Pathology.

Currently she is on faculty in the Department of Pathology and Urology at UT Southwestern and the Group Leader of Genitourinary Pathology and the Co-Leader of the Kidney Cancer Program at Simmons Cancer Center. She is the Pathology representative at the UT Southwestern weekly Urology Spence Conference, and monthly Multidisciplinary Renal Cell Carcinoma Tumor Board.

She is actively involved in Anatomic Pathology residency education and received the Vernie A. Stembridge, M.D. Resident Teaching Award in 2010 and 2011. Dr. Payal Kapur was the former Assistant Director (Anatomic Pathology) of UT Southwestern Pathology Residency Training (2010-2013), the Co-Director of UT Southwestern Tumor Registry Core Facility at Simmons Cancer Institution (2008-2013), the Director of the Philip O’Brien Montgomery Visiting Lectureship (2007-2013), and the Director of the Anatomical Pathology Resident Education Seminar Series (2007-2013). She was also the former Medical Director of Surgical Pathology at Parkland Hospital (2013-2015)

Dr. Kapur’s research is focused on characterizing adult genitourinary tumors and developing prognostic, therapeutic, and diagnostic biomarkers. She has extensive experience in developing immunohistochemistry (IHC) tests, and of greatest relevance to the field of kidney cancer.

Education & Training

Internship - Parkland Health and Hospital System (2002-2003), Pathology
Medical School - University College of Medical Sciences (1991-1997)
Residency - Parkland Health and Hospital System (2003-2006), Pathology
Residency - Maulana Azas Medical College (1997-2000), Pathology

Professional Associations & Affiliations

Associate Professor, Pathology (2012), UT Southwestern Medical Center, Dallas TX
Associate Professor, Urology (2012), UT Southwestern Medical Center, Dallas TX
Co-Director of UT Southwestern Tissue Resource (UTSTR) (2008-2013), Simmons Cancer Center, Dallas, TX
Medical Director of Surgical Pathology (2013-2015), Parkland Memorial Hospital, Dallas, TX
Assistant Director of Anatomic Pathology Resident Education (2010-2013), UT Southwestern Medical Center, Dallas, TX

Honors & Awards

Teaching Award 2006, Pathology Sophomore Curriculum, UT Southwestern
Dr. RP Mathur Memorial Award 2002, Maulana Azad Medical College, Delhi University, India
Vernie A. Stembridge, M.D. 2010, Resident Teaching Award, UT Southwestern
Gordon L. Vawter Award 2002, Pathologist-in-training Award for platform presentation entitled "MIB-1 Labeling Index predicts progression free survival in a large group of pediatric pilocytic astrocytomas". Society for Pediatric Pathology.
Resident’s Case Presentation Award 2004, For the essay entitled "Mosaic variegated aneuploidy: a case report". Society for Pediatric Pathology.

Books & Publications

Publications
- Loss of PBRM1 and BAP1 expression is less common in non-clear cell renal cell carcinoma than in clear cell renal cell carcinoma.
  Ho TH, Kapur P, Joseph RW, Serie DJ, Eckel-Passow JE, Parasramka M, Cheville JC, Wu KJ, Frenkel E, Rakheja D, Stefanius K, Brugarolas J, Parker AS Urologic oncology 2015 Jan 33 1 23.e9-23.e14
- Spectrum of diverse genomic alterations define non-clear cell renal carcinoma subtypes.
  Durinck S, Stawiski EW, Pavía-Jiménez A, Modrusan Z, Kapur P, Jaiswal BS, Zhang N, Toffessi-Tcheuyap V, Nguyen TT, Pahuja KB, Chen YJ, Saleem S, Chaudhuri S, Heldens S, Jackson M, Peña-Llopis S, Guillory J, Toy K, Ha C, Harris CJ, Holloman E, Hill HM, Stinson J, Rivers CS, Janakiraman V, Wang W, Kinch LN, Grishin NV, Haverty PM, Chow B, Gehring JS, Reeder J, Pau G, Wu TD, Margulis V, Lotan Y, Sagalowsky A, Pedrosa I, de Sauvage FJ, Brugarolas J, Seshagiri S Nature genetics 2014 Nov
- Bap1 is essential for kidney function and cooperates with Vhl in renal tumorigenesis.
  Wang SS, Gu YF, Wolff N, Stefanius K, Christie A, Dey A, Hammer RE, Xie XJ, Rakheja D, Pedrosa I, Carroll T, McKay RM, Kapur P, Brugarolas J Proceedings of the National Academy of Sciences of the United States of America 2014 Nov 111 46 16538-43
- Ablation of the oncogenic transcription factor ERG by deubiquitinase inhibition in prostate cancer.
  Wang S, Kollipara RK, Srivastava N, Li R, Ravindranathan P, Hernandez E, Freeman E, Humphries CG, Kapur P, Lotan Y, Fazli L, Gleave ME, Plymate SR, Raj GV, Hsieh JT, Kittler R Proceedings of the National Academy of Sciences of the United States of America 2014 Mar 111 11 4251-6
- Loss of BAP1 protein expression is an independent marker of poor prognosis in patients with low-risk clear cell renal cell carcinoma.
  Joseph RW, Kapur P, Serie DJ, Eckel-Passow JE, Parasramka M, Ho T, Cheville JC, Frenkel E, Rakheja D, Brugarolas J, Parker A Cancer 2013 Dec
- BAP1 immunohistochemistry in a multi-institutional cohort predicts outcomes in patients with clear cell renal cell carcinoma.
  Kapur P, Christie A, Raman JD, Then MT, Nuhn P, Buchner A, Bastian P, Seitz C, Shariat SF, Bensalah K, Rioux-Leclercq N, Xie XJ, Lotan Y, Margulis V, Brugarolas J The Journal of urology 2013 Sep
- A gain-of-function mutation in DHT synthesis in castration-resistant prostate cancer.
  Chang KH, Li R, Kuri B, Lotan Y, Roehrborn CG, Liu J, Vessella R, Nelson PS, Kapur P, Guo X, Mirzaei H, Auchus RJ, Sharifi N Cell 2013 Aug 154 5 1074-84
- Effects on survival of BAP1 and PBRM1 mutations in sporadic clear-cell renal-cell carcinoma: a retrospective analysis with independent validation.
  Kapur P, Peña-Llopis S, Christie A, Zhrebker L, Pavía-Jiménez A, Rathmell WK, Xie XJ, Brugarolas J The lancet oncology 2013 Feb 14 2 159-67
- Cumulative Number of Altered Biomarkers in Mammalian Target of Rapamycin Pathway Is an Independent Predictor of Outcome in Patients With Clear Cell Renal Cell Carcinoma.
  Darwish OM, Kapur P, Youssef RF, Bagrodia A, Belsante M, Alhalabi F, Sagalowsky AI, Lotan Y, Margulis V Urology 2013 Jan
- DAB2IP regulates autophagy in prostate cancer in response to combined treatment of radiation and a DNA-PKcs inhibitor.
  Yu L, Tumati V, Tseng SF, Hsu FM, Kim DN, Hong D, Hsieh JT, Jacobs C, Kapur P, Saha D Neoplasia (New York, N.Y.) 2012 Dec 14 12 1203-12
- BAP1 loss defines a new class of renal cell carcinoma.
  Peña-Llopis S, Vega-Rubín-de-Celis S, Liao A, Leng N, Pavía-Jiménez A, Wang S, Yamasaki T, Zhrebker L, Sivanand S, Spence P, Kinch L, Hambuch T, Jain S, Lotan Y, Margulis V, Sagalowsky AI, Summerour PB, Kabbani W, Wong SW, Grishin N, Laurent M, Xie XJ, Haudenschild CD, Ross MT, Bentley DR, Kapur P, Brugarolas J Nature genetics 2012 Jul 44 7 751-9
- A validated tumorgraft model reveals activity of dovitinib against renal cell carcinoma.
  Sivanand S, Peña-Llopis S, Zhao H, Kucejova B, Spence P, Pavia-Jimenez A, Yamasaki T, McBride DJ, Gillen J, Wolff NC, Morlock L, Lotan Y, Raj GV, Sagalowsky A, Margulis V, Cadeddu JA, Ross MT, Bentley DR, Kabbani W, Xie XJ, Kapur P, Williams NS, Brugarolas J Science translational medicine 2012 Jun 4 137 137ra75
- Interplay between pVHL and mTORC1 pathways in clear-cell renal cell carcinoma.
  Kucejova B, Peña-Llopis S, Yamasaki T, Sivanand S, Tran TA, Alexander S, Wolff NC, Lotan Y, Xie XJ, Kabbani W, Kapur P, Brugarolas J Molecular cancer research : MCR 2011 Jul 1255-65
- Bilharzial vs non-bilharzial related bladder cancer: pathological characteristics and value of cyclooxygenase-2 expression.
  Youssef R, Kapur P, Kabbani W, Shariat SF, Mosbah A, Abol-Enein H, Ghoniem M, Lotan Y BJU international 2011 Jul 108 1 31-7
- Primary adenocarcinoma of the urinary bladder: value of cell cycle biomarkers.
  Kapur P, Lotan Y, King E, Kabbani W, Mitra AP, Mosbah A, Abol-Enein H, Ghoneim M, Youssef RF American journal of clinical pathology 2011 Jun 135 6 822-30
- Tailoring treatment of rectal adenocarcinoma: immunohistochemistry for predictive biomarkers.
  Kapur P Anti-cancer drugs 2011 Apr 22 4 362-70
- Expression of cell cycle-related molecular markers in patients treated with radical cystectomy for squamous cell carcinoma of the bladder.
  Youssef RF, Shariat SF, Kapur P, Kabbani W, Ghoneim T, King E, Cockburn A, Mosbah A, Abol-Enein H, Ghoneim M, Lotan Y Human pathology 2011 Mar 42 3 347-55
- Prognostic value of cyclooxygenase-2 expression in squamous cell carcinoma of the bladder.
  Youssef RF, Shariat SF, Kapur P, Kabbani W, Mosbah A, Abol-Enein H, Ghoniem M, Lotan Y The Journal of urology 2011 Mar 185 3 1112-7
- Immunohistochemical expression of neural cell adhesion molecule in Wilms tumors, nephrogenic rests, and fetal and postnatal renal cortices.
  Kapur P, Rakheja D Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society 2011 Jan-Feb 14 1 16-9
- Microsatellite instability among individuals of Hispanic origin with colorectal cancer.
  Gupta S, Ashfaq R, Kapur P, Afonso BB, Nguyen TP, Ansari F, Boland CR, Goel A, Rockey DC Cancer 2010 Nov 116 21 4965-72
- Tissue microarray constructs to predict a response to chemoradiation in rectal cancer.
  Huerta S, Hrom J, Gao X, Saha D, Anthony T, Reinhart H, Kapur P Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2010 Oct 42 10 679-84
- Phosphorylated histone H3, Ki-67, p21, fatty acid synthase, and cleaved caspase-3 expression in benign and atypical granular cell tumors
  Kapur P, Rakheja D, Balani JP, Roy LC, Amirkhan RH, Hoang MP. Arch Pathol Lab Med 2007 131(1): 57-64.
- Congenital self-healing reticulohistiocytosis (Hashimoto-Pritzker disease): 10-year experience at Dallas Children?s Medical Center.
  Kapur P, Erickson C, Rakheja D, Carder KR, Hoang MP. J Am Acad Dermatol 2007 2007; 56(2): 290-294.
- Primary mucinous adenocarcinoma of the thymus: a case report and review of the literature
  Kapur P, Rakheja D, Bastasch M, Molberg KH, Sarode VR Arch Pathol Lab Med. 2006 130(2): 201-204.
- Sclerosing lobular hyperplasia of breast: cytomorphologic and histomorphologic features: a case report.
  Kapur P, Rakheja D, Cavuoti DC, Johnson-Welch SF. Cytojournal 2006 3(3): 3
- Fatty acid synthase expression in cutaneous melanocytic lesions
  Kapur P, Rakheja D, Roy LC, Hoang MP. Mod Pathol. 2005 18(8): 1107-1112
- Characterization of inflammation in syphilitic villitis and in villitis of unknown etiology.
  Kapur P, Rakheja D, Gomez AM, Sheffield J, Sanchez P, Rogers BB. Pediatric and Development Pathology September 2004 7(5) 453-8
- Spitz nevi and atypical Spitz nevi/tumors: a histologic and immunohistochemical analysis.
  Kapur P, Selim MA, Roy LC, Yegappan M, Weinberg AG, Hoang MP. Modern Pathology 2004 18(2): 197-204
- Study of the MIB-1 labeling index as a predictor of tumor progression in pilocytic astrocytomas in children and adolescents.
  Bowers DC, Gargan L, Kapur P, Reisch JS, Mulne AF, Shapiro KN, Elterman RD, Winick NJ, Margraf LR. Journal of Clinical Oncology August 2003 1; 21(15) 2968-73
- Bridging a gap in oesophageal atresia using Rehbein's technique: dilatation of a thread canal.
  Sigge W, Würtenberger H, Franz A, Albrecht M Zeitschrift für Kinderchirurgie : organ der Deutschen, der Schweizerischen und der Osterreichischen Gesellschaft für Kinderchirurgie = Surgery in infancy and childhood 1986 Feb 41 1 5-9

Research

Understanding pathogenesis and biology of genitourinary tumors especially renal and prostate tumors
Genitourinary Pathology
Developing prognostic and predictive subtype of renal tumors
Characterizing Renal tumors

Clinical Focus

Pathology/Diagnosis of Genitourinary Cancers