Purva Gopal, M.D.

Harold C. Simmons Comprehensive Cancer Center

Pathology
Gastrointestinal/Liver Pathology

Education & Training

Other Post Graduate Training - University of Louisville School of Medicine (1999-2001)
Residency - University of Louisville Hospital (2005-2009), Pathology
Fellowship - Vanderbilt University Medical Center (2010-2011), Gastrointestinal Pathology
Graduate School - University of Louisville School of Medicine (1999-2001)
Medical School - University of Louisville School of Medicine (2001-2005)
Fellowship - University of Michigan Medical Center (2009-2010), Surgical Pathology

Books & Publications

Publications
- Diagnostic and therapeutic implications of a novel immunohistochemical panel detecting duodenal mucosal invasion by pancreatic ductal adenocarcinoma.
  Sopha SC, Gopal P, Merchant NB, Revetta FL, Gold DV, Washington K, Shi C International journal of clinical and experimental pathology 2013 6 11 2476-86
- Meta-analysis: underutilisation and disparities of treatment among patients with hepatocellular carcinoma in the United States.
  Tan D, Yopp A, Beg MS, Gopal P, Singal AG Alimentary pharmacology & therapeutics 2013 Aug
- The clinical significance of focally enhanced gastritis in children.
  McHugh JB, Gopal P, Greenson JK The American journal of surgical pathology 2013 Feb 37 2 295-9
- Factors that Affect Accuracy of a-Fetoprotein Test in Detection of Hepatocellular Carcinoma in Patients with Cirrhosis.
  Gopal P, Yopp AC, Waljee AK, Chiang J, Nehra M, Kandunoori P, Singal AG Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2013 Oct
- The Effect of PNPLA3 on Fibrosis Progression and Development of Hepatocellular Carcinoma: A Meta-analysis.
  Singal AG, Manjunath H, Yopp AC, Beg MS, Marrero JA, Gopal P, Waljee AK The American journal of gastroenterology 2014 Jan
- Accuracy of Ultrasound and Noninvasive Markers of Fibrosis to Identify Patients with Cirrhosis.
  Martin J, Khatri G, Gopal P, Singal AG Digestive diseases and sciences 2015 Jan
- The Synthetic Triterpenoid RTA 405 (CDDO-EA) Halts Progression of Liver Fibrosis and Reduces Hepatocellular Carcinoma Size Resulting in Increased Survival in an Experimental Model of Chronic Liver Injury.
  Getachew Y, Cusimano FA, Gopal P, Reisman SA, Shay JW Toxicological sciences : an official journal of the Society of Toxicology 2015 Oct
- Global cerebral ischemia due to circulatory arrest: insights into cellular pathophysiology and diagnostic modalities.
  Sanganalmath SK, Gopal P, Parker JR, Downs RK, Parker JC, Dawn B Molecular and cellular biochemistry 2016 Nov
- The Clinical Significance of Crohn Disease Activity at Resection Margins.
  Setoodeh S, Liu L, Boukhar SA, Singal AG, Westerhoff M, Waljee AK, Ahmed T, Gopal P Archives of pathology & laboratory medicine 2018 Nov
- Direct-Acting Antiviral Therapy for HCV Infection is Associated with Increased Survival in Patients With a History of Hepatocellular Carcinoma.
  Singal AG, Rich NE, Mehta N, Branch A, Pillai A, Hoteit M, Volk M, Odewole M, Scaglione S, Guy J, Said A, Feld JJ, John BV, Frenette C, Mantry P, Rangnekar AS, Oloruntoba O, Leise M, Jou JH, Bhamidimarri KR, Kulik L, Ioannou GN, Huang A, Tran T, Samant H, Dhanasekaran R, Duarte-Rojo A, Salgia R, Eswaran S, Jalal P, Flores A, Satapathy SK, Kagan S, Gopal P, Wong R, Parikh ND, Murphy CC, Gastroenterology 2019 Jul
- Editing of the gut microbiota reduces carcinogenesis in mouse models of colitis-associated colorectal cancer.
  Zhu W, Miyata N, Winter MG, Arenales A, Hughes ER, Spiga L, Kim J, Sifuentes-Dominguez L, Starokadomskyy P, Gopal P, Byndloss MX, Santos RL, Burstein E, Winter SE, The Journal of experimental medicine 2019 Jul
- Reproducibility of AJCC Criteria for Classifying Deeply Invasive Colon Cancers Is Suboptimal for Consistent Cancer Staging.
  Panarelli NC, Hammer STG, Lin J, Gopal P, Nalbantoglu I, Zhao L, Cheng J, Gersten AJ, McHugh JB, Parkash V, Lucas E, Westerhoff M, The American journal of surgical pathology 2020 10 44 10 1381-1388
- Randomized Clinical Trial of Inreach With or Without Mailed Outreach to Promote Hepatitis C Screening in a Difficult-to-Reach Patient Population.
  Desai N, Rich NE, Jain MK, Blackwell JM, Murphy CC, Perryman P, McBryde J, Quirk L, Clark C, Villarreal D, Waljee AK, Gopal P, Singal AG, The American journal of gastroenterology 2020 Dec Publish Ahead of Print
- Uncovering biological factors that regulate hepatocellular carcinoma growth using patient derived xenograft assays.
  Zhu M, Li L, Lu T, Yoo H, Zhu J, Gopal P, Wang SC, Porempka MR, Rich NE, Kagan S, Odewole M, Renteria V, Waljee AK, Wang T, Singal AG, Yopp AC, Zhu H, Hepatology (Baltimore, Md.) 2020 Jan
- Increased Frequency of Heterozygous Alpha-1-Antitrypsin Deficiency in Liver Explants From Nonalcoholic Steatohepatitis Patients.
  Cheeney G, Pac LJ, Gopal P, Landis CS, Konnick EQ, Swanson PE, Greene DN, Lockwood CM, Westerhoff M, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2020 Jan 26 1 17-24
- Clinical and Histopathologic Features Can Help Target Immunohistochemical Stain Use in the Diagnosis of Viral Esophagitis.
  Desai N, Albahra S, Lucas E, Singal AG, Hammer STG, Gopal P, Applied immunohistochemistry & molecular morphology : AIMM 2021 Aug
- Hepatocellular carcinoma tumour volume doubling time: a systematic review and meta-analysis.
  Nathani P, Gopal P, Rich N, Yopp A, Yokoo T, John B, Marrero J, Parikh N, Singal AG, Gut 2021 Feb 70 2 401-407
- Histopathological diagnosis of tumour deposits in colorectal cancer: a Delphi consensus study.
  Lord A, Brown G, Abulafi M, Bateman A, Frankel W, Goldin R, Gopal P, Kirsch R, Loughrey MB, Märkl B, Moran B, Puppa G, Rasheed S, Shimada Y, Snaebjornsson P, Svrcek M, Washington K, West N, Wong N, Nagtegaal I, Histopathology 2021 Jan
- Paneth cell-derived growth factors support tumorigenesis in the small intestine.
  Chen Q, Suzuki K, Sifuentes-Dominguez L, Miyata N, Song J, Lopez A, Starokadomskyy P, Gopal P, Dozmorov I, Tan S, Ge B, Burstein E, Life science alliance 2021 Mar 4 3
- Cribriform colon cancer: a morphological growth pattern associated with extramural venous invasion, nodal metastases and microsatellite stability.
  Taylor AS, Liu N, Fang JM, Panarelli N, Zhao L, Cheng J, Gopal P, Hammer S, Sun J, Appelman H, Westerhoff M, Journal of clinical pathology 2021 Mar
- High Neutrophil-Lymphocyte Ratio and Delta Neutrophil-Lymphocyte Ratio Are Associated with Increased Mortality in Patients with Hepatocellular Cancer.
  Rich NE, Parvathaneni A, Sen A, Odewole M, Arroyo A, Mufti AR, Kerr TA, Grant L, Tujios SR, Mayo MJ, Lee WM, Yang JD, Yokoo T, Gopal P, Hoshida Y, Zhu H, Yopp AC, Marrero JA, Singal AG, Digestive diseases and sciences 2021 May
- Variations of P40 and P63 Immunostains in Different Grades of Esophageal Squamous Cell Carcinoma: A Potential Diagnostic Pitfall.
  Chi Z, Balani J, Gopal P, Peng L, Hammer S, Applied immunohistochemistry & molecular morphology : AIMM 2021 May
- Clinical Outcomes of Patients with LI-RADS 3 or LI-RADS 4 Observations in Patients with Cirrhosis: A Systematic Review.
  Kanneganti M, Marrero JA, Parikh ND, Kanwal F, Yokoo T, Mendiratta-Lala M, Rich NE, Gopal P, Singal AG, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2022 Aug
- In vivo CRISPR screening identifies BAZ2 chromatin remodelers as druggable regulators of mammalian liver regeneration.
  Jia Y, Li L, Lin YH, Gopal P, Shen S, Zhou K, Yu X, Sharma T, Zhang Y, Siegwart DJ, Ready JM, Zhu H, Cell stem cell 2022 Jan
- Multicenter Validation of Abbreviated MRI for Detecting Early-Stage Hepatocellular Carcinoma.
  Yokoo T, Masaki N, Parikh ND, Lane BF, Feng Z, Mendiratta-Lala M, Lee CH, Khatri G, Marsh TL, Shetty K, Dunn CT, Al-Jarrah T, Aslam A, Davenport MS, Gopal P, Rich NE, Lok AS, Singal AG, Radiology 2023 Jan 220917
- Arid1a loss drives non-alcoholic steatohepatitis in mice via epigenetic dysregulation of hepatic lipogenesis and fatty acid oxidation.
  Moore A, Wu L, Chuang JC, Sun X, Luo X, Gopal P, Li L, Celen C, Zimmer M, Zhu H Hepatology (Baltimore, Md.) 2018 Dec
- Cystic hypersecretory carcinoma of the breast with paget disease of the nipple: a diagnostic challenge.
  Sahoo S, Gopal P, Roland L, Pile N International journal of surgical pathology 2008 Apr 16 2 208-12
- Autoimmune Gastritis Treated With Mycophenolate Mofetil.
  Harb AH, Vemulapalli R, Gopal P, Park JY, ACG case reports journal 2020 Dec 7 12 e00496
- Ablating putative Ku70 phosphorylation sites results in defective DNA damage repair and spontaneous induction of hepatocellular carcinoma.
  Saha J, Bae J, Wang SY, Lu H, Chappell LJ, Gopal P, Davis AJ, Nucleic acids research 2021 Aug
- Unique causes of esophageal inflammation: a histopathologic perspective.
  Gopal P, Gibson JA, Lisvosky M, Nalbantoglu I Annals of the New York Academy of Sciences 2018 May
- Assessing the Safety of Transarterial Locoregional Delivery of Low-Density Lipoprotein Docosahexaenoic Acid Nanoparticles to the Rat Liver.
  Li J, Canseco D, Wang Y, Vale G, Chaudhary J, Anwar A, Baniasadi H, Williams NS, Gopal P, Sutphin PD, McDonald JG, Putnam WC, Corbin IR, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 2020 Nov
- Matrigel influences morphology and cathepsin B distribution of prostate cancer PC3 cells.
  Gopal P, Rehman RU, Chadha KS, Qiu M, Colella R Oncology reports 2006 Aug 16 2 313-20
- A Variant in PNPLA3 Associated with Fibrosis Progression but not Hepatocellular Carcinoma in Patients With HCV Infection.
  Ali M, Yopp A, Gopal P, Beg MS, Zhu H, Lee W, Singal AG Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2015 Aug
- Knockdown of Anillin Actin Binding Protein Blocks Cytokinesis in Hepatocytes and Reduces Liver Tumor Development in Mice without Affecting Regeneration.
  Zhang S, Nguyen LH, Zhou K, Tu HC, Sehgal A, Nassour I, Li L, Gopal P, Goodman J, Singal AG, Yopp A, Zhang Y, Siegwart DJ, Zhu H Gastroenterology 2017 Dec
- Colorectal neoplasia among patients with and without human immunodeficiency virus.
  Faqih A, Singal AG, Fullington HM, Hewitt B, Burstein E, Gopal P, Wylie A, Abrams J, Murphy CC, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2020 May
- GATA3 positivity is associated with poor prognosis in patients with oesophageal squamous cell carcinoma.
  Chi Z, Balani J, Gopal P, Hammer S, Xu J, Peng L, Journal of clinical pathology 2022 Jan
- Human papillomavirus in metastatic squamous carcinoma from unknown primaries in the head and neck: a retrospective 7 year study.
  Desai PC, Jaglal MV, Gopal P, Ghim SJ, Miller DM, Farghaly H, Jenson AB Experimental and molecular pathology 2009 Oct 87 2 94-8
- Characterization of Desmoglein 3 (DSG3) as a Sensitive and Specific Marker for Esophageal Squamous Cell Carcinoma.
  Chi Z, Balani J, Gopal P, Hammer S, Lewis CM, Peng L, Gastroenterology research and practice 2022 2022 2220940
- VEGFR2 activity on myeloid cells mediates immune suppression in the tumor microenvironment.
  Zhang Y, Huang H, Coleman M, Ziemys A, Gopal P, Kazmi SM, Brekken RA, JCI insight 2021 Oct
- Association between ultrasound quality and test performance for HCC surveillance in patients with cirrhosis: a retrospective cohort study.
  Chong N, Schoenberger H, Yekkaluri S, Fetzer DT, Rich NE, Yokoo T, Gopal P, Manwaring C, Quirk L, Singal AG, Alimentary pharmacology & therapeutics 2022 Feb
- Improved Performance of Serum Alpha-Fetoprotein for Hepatocellular Carcinoma Diagnosis in HCV cirrhosis with Normal Alanine Transaminase.
  Yang JD, Dai J, Singal AG, Gopal P, Addissie B, Nguyen MH, Befeler AS, Reddy KR, Schwartz M, Harnois DM, Yamada H, Gores GJ, Feng Z, Marrero JA, Roberts LR Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2017 Mar
- SARS-CoV-2-related Hypercoagulable State Leading to Ischemic Enteritis Secondary to Superior Mesenteric Artery Thrombosis.
  Mitchell JM, Rakheja D, Gopal P, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2020 Jun
- SCGN deficiency results in colitis susceptibility.
  Sifuentes-Dominguez LF, Li H, Llano E, Liu Z, Singla A, Patel AS, Kathania M, Khoury A, Norris N, Rios JJ, Starokadomskyy P, Park JY, Gopal P, Liu Q, Tan S, Chan L, Ross T, Harrison S, Venuprasad K, Baker LA, Jia D, Burstein E, eLife 2019 Oct 8
- Hemorrhagic Gastrointestinal Stromal Tumor.
  Perez Del Nogal G, Gopal P, Okwara C, ACG case reports journal 2022 Nov 9 11 e00923
- Arid1a Has Context-Dependent Oncogenic and Tumor Suppressor Functions in Liver Cancer.
  Sun X, Wang SC, Wei Y, Luo X, Jia Y, Li L, Gopal P, Zhu M, Nassour I, Chuang JC, Maples T, Celen C, Nguyen LH, Wu L, Fu S, Li W, Hui L, Tian F, Ji Y, Zhang S, Sorouri M, Hwang TH, Letzig L, James L, Wang Z, Yopp AC, Singal AG, Zhu H Cancer cell 2017 Nov 32 5 574-589.e6
- Tumor deposits in rectal adenocarcinoma after neoadjuvant chemoradiation are associated with poor prognosis.
  Gopal P, Lu P, Ayers GD, Herline AJ, Washington MK Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2014 Jan
- The Polyploid State Plays a Tumor-Suppressive Role in the Liver.
  Zhang S, Zhou K, Luo X, Li L, Tu HC, Sehgal A, Nguyen LH, Zhang Y, Gopal P, Tarlow BD, Siegwart DJ, Zhu H Developmental cell 2018 Feb 44 4 447-459.e5
- Lymphadenopathy and Jaundice.
  Law JY, Gopal P, Li HC JAMA oncology 2015 Aug
- Follicular Dendritic Cell Sarcoma.
  Chen T, Gopal P Archives of pathology & laboratory medicine 2017 Apr 141 4 596-599
- Blocking monocytic myeloid-derived suppressor cell function via anti-DC-HIL/GPNMB antibody restores the in vitro integrity of T-cells from cancer patients.
  Kobayashi M, Chung JS, Beg M, Arriaga Y, Verma UN, Courtney K, Mansour JC, Haley B, Khan SA, Horiuchi Y, Ramani V, Harker D, Gopal P, Araghizadeh F, Cruz PD, Ariizumi K Clinical cancer research : an official journal of the American Association for Cancer Research 2018 Jul
- Increased cell density decreases cysteine proteinase inhibitor activity and increases invasive ability of two prostate tumor cell lines.
  Colella R, Goodwyn E, Gopal P Cancer letters 2002 Nov 185 2 163-72
- The collagenous gastroenteritides: similarities and differences.
  Gopal P, McKenna BJ Archives of pathology & laboratory medicine 2010 Oct 134 10 1485-9
- Predictors of guideline concordance for surveillance colonoscopy recommendations in patients at a safety-net health system.
  Kahn B, Freeland Z, Gopal P, Agrawal D, Mayorga CA, Mithani R, Skinner CS, Halm EA, Singal AG Cancer causes & control : CCC 2015 Sep
- Choroid plexus carcinoma.
  Gopal P, Parker JR, Debski R, Parker JC Archives of pathology & laboratory medicine 2008 Aug 132 8 1350-4
- Single-Agent Brentuximab as Bridging Therapy for Hodgkin Lymphoma Patients With Hepatic Impairment.
  Gupta A, Petrasek J, Sen S, Gopal P, Naina HV Clinical lymphoma, myeloma & leukemia 2016 Feb 16 2 e11-4
- Arid1a Has Context-Dependent Oncogenic and Tumor Suppressor Functions in Liver Cancer.
  Sun X, Wang SC, Wei Y, Luo X, Jia Y, Li L, Gopal P, Zhu M, Nassour I, Chuang JC, Maples T, Celen C, Nguyen LH, Wu L, Fu S, Li W, Hui L, Tian F, Ji Y, Zhang S, Sorouri M, Hwang TH, Letzig L, James L, Wang Z, Yopp AC, Singal AG, Zhu H Cancer cell 2018 Jan 33 1 151-152
- Intracranial anaplastic hemangiopericytoma presenting with simultaneous extra-cranial metastases: A case report and review of the literature.
  Reddy S, Plitt A, Raisanen J, Patel AR, Gopal P, Timmerman R, Patel TR, Surgical neurology international 2019 10 148
- Clinical Outcomes of Patients with Suspicious (LI-RADS 4) Liver Observations.
  Onyirioha K, Joshi S, Burkholder D, Yekkaluri S, Parikh ND, Singal AG, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2022 Apr
- Nestin as a diagnostic and prognostic marker for combined hepatocellular-cholangiocarcinoma.
  Calderaro J, Di Tommaso L, Maillé P, Beaufrère A, Nguyen CT, Heij L, Gnemmi V, Graham RP, Charlotte F, Chartier S, Wendum D, Vij M, Allende D, Diaz A, Fuster C, Rivière B, Herrero A, Augustin J, Evert K, Calvisi DF, Leow WQ, Wai Leung HH, Bednarsch J, Boleslawski E, Rela M, Wing-Hung Chan A, Forner A, Reig M, Pujals A, Favre L, Allaire M, Scatton O, Uguen A, Trépo E, Sanchez LO, Chatelain D, Remmelink M, Boulagnon-Rombi C, Bazille C, Sturm N, Menahem B, Frouin E, Tougeron D, Tournigand C, Kempf E, Kim H, Ningarhari M, Michalak-Provost S, Kather JN, Gouw ASH, Gopal P, Brustia R, Vibert E, Schulze K, Rüther DF, Weidemann SA, Rhaiem R, Nault JC, Laurent A, Amaddeo G, Regnault H, de Martin E, Sempoux C, Navale P, Shinde J, Bacchuwar K, Westerhoff M, Cheuk-Lam Lo R, Sebbagh M, Guettier C, Lequoy M, Komuta M, Ziol M, Paradis V, Shen J, Caruso S, Journal of hepatology 2022 Aug
- Detection of lupus pleuritis: a tale of lights and shadows.
  Gopal P, Math SK, Hollensead SC MLO: medical laboratory observer 2008 Nov 40 11 10, 12, 14 passim
- Metachronous Uterine Endometrioid Adenocarcinoma and Peritoneal Mesothelioma in Lynch Syndrome: A Case Report.
  Lu Y, Milchgrub S, Khatri G, Gopal P International journal of surgical pathology 2016 Nov
- Somatic Mutations Increase Hepatic Clonal Fitness and Regeneration in Chronic Liver Disease.
  Zhu M, Lu T, Jia Y, Luo X, Gopal P, Li L, Odewole M, Renteria V, Singal AG, Jang Y, Ge K, Wang SC, Sorouri M, Parekh JR, MacConmara MP, Yopp AC, Wang T, Zhu H, Cell 2019 Apr 177 3 608-621.e12
- Evaluation and Management of Hepatocellular Adenomas.
  Mittal S, Gopal P, Khatri G, Singal AG, Clinical liver disease 2021 Feb 17 2 57-60
- Primary Anal Canal Syphilis in Men: The Clinicopathologic Spectrum of an Easily Overlooked Diagnosis.
  Gopal P, Shah RB Archives of pathology & laboratory medicine 2015 Sep 139 9 1156-60
- Sarcina ventriculi in a patient with slipped gastric band and gastric distention.
  Liu L, Gopal P Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2017 Jun
- Spirochete Flashback: An Almost Forgotten Cause of Hepatitis.
  Khambaty M, Singal AG, Gopal P Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2014 Oct
- Impact of a Clinical Decision Support System on Guideline Adherence of Surveillance Recommendations for Colonoscopy After Polypectomy.
  Magrath M, Yang E, Ahn C, Mayorga CA, Gopal P, Murphy CC, Gupta S, Agrawal D, Halm EA, Borton EK, Skinner CS, Singal AG Journal of the National Comprehensive Cancer Network : JNCCN 2018 Nov 16 11 1321-1328
- Correlation of LI-RADS 3 or 4 Observations with Histopathologic Diagnosis in Patients with Cirrhosis.
  Dunn C, Lin B, Rich NE, Patel MS, Gopal P, Singal AG, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2022 Mar

Clinical Focus

Gastrointestinal/Liver Pathology