Ralph DeBerardinis, M.D., Ph.D.

Chief, Division of Pediatric Genetics and Metabolism

Harold C. Simmons Comprehensive Cancer Center

Joel B. Steinberg, M.D. Distinguished Chair in Pediatrics
Sowell Family Scholar in Medical Research

Pediatrics - Genetics and Metabolism

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Biography

Ralph DeBerardinis earned a B.S. in biology from St. Joseph’s University and M.D. and Ph.D. degrees from the University of Pennsylvania. Dr. DeBerardinis was the first trainee in the combined residency program in pediatrics and medical genetics at The Children’s Hospital of Philadelphia (CHOP) and received several awards for teaching and clinical care. He ultimately achieved board certification in pediatrics, medical genetics and clinical biochemical genetics.

Dr. DeBerardinis performed postdoctoral research in Craig Thompson’s laboratory in the Penn Cancer Center from 2004 to 2007. He joined the faculty of the University of Texas Southwestern Medical Center in 2008 and joined the Children’s Medical Center Research Institute at UT Southwestern (CRI) shortly after its founding in 2012. Dr. DeBerardinis serves as chief of Pediatric Genetics and Metabolism at UT Southwestern and director of the Genetic and Metabolic Disease Program in the CRI.

He was included in D Magazine's Best Doctors list nearly every year since 2016.

About His Laboratory

The DeBerardinis laboratory is interested in the role of altered metabolic states in human diseases, particularly pediatric inborn errors of metabolism and cancer. This research is tightly integrated with clinical activities in medical genetics, oncology and radiology, providing seamless opportunities to examine the relevance of findings in patients.

DeBerardinis Laboratory

Education & Training

Residency - Children's Hospital of Philadelphia (2000-2005), Pediatrics & Medical Genetics
Medical School - University of Pennsylvania School of Medicine (1992-2000)

Professional Associations & Affiliations

Investigator, Howard Hughes Medical Institute (2018)
Society for Pediatrics Research
Society for Inherited Metabolic Disorders
American Society of Human Genetics
American Association for Cancer Research
American Academy of Pediatrics
American Society for Clinical Investigation

Honors & Awards

D Magazine Best Doctor, 2016, 2018-2022
D Magazine Best Pediatric Specialist 2020-2021
Edith and Peter O’Donnell Award in Medicine, The Academy of Medicine, Engineering, and Science of Texas 2018
Robert L. Moody, Sr. Faculty Scholar 2017
Howard Hughes Medical Institute Faculty Scholar 2017
NCI Outstanding Investigator 2017
American Society for Clinical Investigation
Damon Runyon Cancer Research Foundation Clinical Investigator Award 2011
William K. Bowes, Jr. Award in Medical Genetics 2008
Sowell Family Scholar in Medical Research 2008
Soc. for Inherited Metabolic Disorders Neil Buist Award 2008
President’s Research Council Distinguished Young Researcher Award 2008
CHOP Pediatric Scholars Program & Faculty Honor Roll 2007

Books & Publications

Publications
- Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis.
  DeBerardinis RJ, Mancuso A, Daikhin E, Nissim I, Yudkoff M, Wehrli S, Thompson CB Proceedings of the National Academy of Sciences of the United States of America 2007 Dec 104 49 19345-50
- Analysis of tumor metabolism reveals mitochondrial glucose oxidation in genetically diverse human glioblastomas in the mouse brain in vivo.
  Marin-Valencia I, Yang C, Mashimo T, Cho S, Baek H, Yang XL, Rajagopalan KN, Maddie M, Vemireddy V, Zhao Z, Cai L, Good L, Tu BP, Hatanpaa KJ, Mickey BE, Matés JM, Pascual JM, Maher EA, Malloy CR, Deberardinis RJ, Bachoo RM Cell metabolism 2012 Jun 15 6 827-37
- Systematic identification of molecular subtype-selective vulnerabilities in non-small-cell lung cancer.
  Kim HS, Mendiratta S, Kim J, Pecot CV, Larsen JE, Zubovych I, Seo BY, Kim J, Eskiocak B, Chung H, McMillan E, Wu S, De Brabander J, Komurov K, Toombs JE, Wei S, Peyton M, Williams N, Gazdar AF, Posner BA, Brekken RA, Sood AK, Deberardinis RJ, Roth MG, Minna JD, White MA Cell 2013 Oct 155 3 552-66
- Metabolic plasticity maintains proliferation in pyruvate dehydrogenase deficient cells.
  Rajagopalan KN, Egnatchik RA, Calvaruso MA, Wasti AT, Padanad MS, Boroughs LK, Ko B, Hensley CT, Acar M, Hu Z, Jiang L, Pascual JM, Scaglioni PP, DeBerardinis RJ Cancer & metabolism 2015 3 7
- Reductive carboxylation supports redox homeostasis during anchorage-independent growth.
  Jiang L, Shestov AA, Swain P, Yang C, Parker SJ, Wang QA, Terada LS, Adams ND, McCabe MT, Pietrak B, Schmidt S, Metallo CM, Dranka BP, Schwartz B, DeBerardinis RJ Nature 2016 Apr 532 7598 255-8
- Mechanisms and Implications of Metabolic Heterogeneity in Cancer.
  Kim J, DeBerardinis RJ, Cell metabolism 2019 Sep 30 3 434-446
- Metabolic heterogeneity confers differences in melanoma metastatic potential.
  Tasdogan A, Faubert B, Ramesh V, Ubellacker JM, Shen B, Solmonson A, Murphy MM, Gu Z, Gu W, Martin M, Kasitinon SY, Vandergriff T, Mathews TP, Zhao Z, Schadendorf D, DeBerardinis RJ, Morrison SJ, Nature 2020 01 577 7788 115-120
- Pyruvate carboxylase is required for glutamine-independent growth of tumor cells.
  Cheng T, Sudderth J, Yang C, Mullen AR, Jin ES, Matés JM, DeBerardinis RJ Proceedings of the National Academy of Sciences of the United States of America 2011 May 108 21 8674-9
- Lactate Metabolism in Human Lung Tumors.
  Faubert B, Li KY, Cai L, Hensley CT, Kim J, Zacharias LG, Yang C, Do QN, Doucette S, Burguete D, Li H, Huet G, Yuan Q, Wigal T, Butt Y, Ni M, Torrealba J, Oliver D, Lenkinski RE, Malloy CR, Wachsmann JW, Young JD, Kernstine K, DeBerardinis RJ Cell 2017 Oct 171 2 358-371.e9
- Reductive carboxylation supports growth in tumour cells with defective mitochondria.
  Mullen AR, Wheaton WW, Jin ES, Chen PH, Sullivan LB, Cheng T, Yang Y, Linehan WM, Chandel NS, Deberardinis RJ Nature 2011 Nov
- CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells.
  Kim J, Hu Z, Cai L, Li K, Choi E, Faubert B, Bezwada D, Rodriguez-Canales J, Villalobos P, Lin YF, Ni M, Huffman KE, Girard L, Byers LA, Unsal-Kacmaz K, Peña CG, Heymach JV, Wauters E, Vansteenkiste J, Castrillon DH, Chen BPC, Wistuba I, Lambrechts D, Xu J, Minna JD, DeBerardinis RJ Nature 2017 Jun 546 7656 168-172
- Metabolic Diversity in Human Non-Small Cell Lung Cancer Cells.
  Chen PH, Cai L, Huffman K, Yang C, Kim J, Faubert B, Boroughs L, Ko B, Sudderth J, McMillan EA, Girard L, Chen D, Peyton M, Shields MD, Yao B, Shames DS, Kim HS, Timmons B, Sekine I, Britt R, Weber S, Byers LA, Heymach JV, Chen J, White MA, Minna JD, Xiao G, DeBerardinis RJ, Molecular cell 2019 Sep
- Quantitative metabolic flux analysis reveals an unconventional pathway of fatty acid synthesis in cancer cells deficient for the mitochondrial citrate transport protein.
  Jiang L, Boufersaoui A, Yang C, Ko B, Rakheja D, Guevara G, Hu Z, DeBerardinis RJ Metabolic engineering 2016 Nov
- The abundance of metabolites related to protein methylation correlates with the metastatic capacity of human melanoma xenografts.
  Shi X, Tasdogan A, Huang F, Hu Z, Morrison SJ, DeBerardinis RJ Science advances 2017 Nov 3 11 eaao5268
- Mitochondrial reactive oxygen species promote epidermal differentiation and hair follicle development.
  Hamanaka RB, Glasauer A, Hoover P, Yang S, Blatt H, Mullen AR, Getsios S, Gottardi CJ, Deberardinis RJ, Lavker RM, Chandel NS Science signaling 2013 6 261 ra8
- Oxidation of Alpha-Ketoglutarate Is Required for Reductive Carboxylation in Cancer Cells with Mitochondrial Defects.
  Mullen AR, Hu Z, Shi X, Jiang L, Boroughs LK, Kovacs Z, Boriack R, Rakheja D, Sullivan LB, Linehan WM, Chandel NS, DeBerardinis RJ Cell reports 2014 May
- Fundamentals of cancer metabolism.
  DeBerardinis RJ, Chandel NS Science advances 2016 May 2 5 e1600200
- Glutamine oxidation maintains the TCA cycle and cell survival during impaired mitochondrial pyruvate transport.
  Yang C, Ko B, Hensley CT, Jiang L, Wasti AT, Kim J, Sudderth J, Calvaruso MA, Lumata L, Mitsche M, Rutter J, Merritt ME, DeBerardinis RJ Molecular cell 2014 Nov 56 3 414-24
- Isotope Tracing of Human Clear Cell Renal Cell Carcinomas Demonstrates Suppressed Glucose Oxidation In Vivo.
  Courtney KD, Bezwada D, Mashimo T, Pichumani K, Vemireddy V, Funk AM, Wimberly J, McNeil SS, Kapur P, Lotan Y, Margulis V, Cadeddu JA, Pedrosa I, DeBerardinis RJ, Malloy CR, Bachoo RM, Maher EA Cell metabolism 2018 Aug
- Metabolic Heterogeneity in Human Lung Tumors.
  Hensley CT, Faubert B, Yuan Q, Lev-Cohain N, Jin E, Kim J, Jiang L, Ko B, Skelton R, Loudat L, Wodzak M, Klimko C, McMillan E, Butt Y, Ni M, Oliver D, Torrealba J, Malloy CR, Kernstine K, Lenkinski RE, DeBerardinis RJ Cell 2016 Feb 164 4 681-94
- Functional Assessment of Lipoyltransferase-1 Deficiency in Cells, Mice, and Humans.
  Ni M, Solmonson A, Pan C, Yang C, Li D, Notzon A, Cai L, Guevara G, Zacharias LG, Faubert B, Vu HS, Jiang L, Ko B, Morales NM, Pei J, Vale G, Rakheja D, Grishin NV, McDonald JG, Gotway GK, McNutt MC, Pascual JM, DeBerardinis RJ, Cell reports 2019 Apr 27 5 1376-1386.e6
- 2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas.
  Choi C, Ganji SK, DeBerardinis RJ, Hatanpaa KJ, Rakheja D, Kovacs Z, Yang XL, Mashimo T, Raisanen JM, Marin-Valencia I, Pascual JM, Madden CJ, Mickey BE, Malloy CR, Bachoo RM, Maher EA Nature medicine 2012 Apr 18 4 624-9
- Cellular metabolism and disease: what do metabolic outliers teach us?
  DeBerardinis RJ, Thompson CB Cell 2012 Mar 148 6 1132-44
- Metabolic pathways promoting cancer cell survival and growth.
  Boroughs LK, DeBerardinis RJ Nature cell biology 2015 Apr 17 4 351-359
- The biology of cancer: metabolic reprogramming fuels cell growth and proliferation.
  DeBerardinis RJ, Lum JJ, Hatzivassiliou G, Thompson CB Cell metabolism 2008 Jan 7 1 11-20
- Genomic regression analysis of coordinated expression.
  Cai L, Li Q, Du Y, Yun J, Xie Y, DeBerardinis RJ, Xiao G Nature communications 2017 Dec 8 1 2187
- Inosine Monophosphate Dehydrogenase Dependence in a Subset of Small Cell Lung Cancers.
  Huang F, Ni M, Chalishazar MD, Huffman KE, Kim J, Cai L, Shi X, Cai F, Zacharias LG, Ireland AS, Li K, Gu W, Kaushik AK, Liu X, Gazdar AF, Oliver TG, Minna JD, Hu Z, DeBerardinis RJ Cell metabolism 2018 Jun
- Understanding the Intersections between Metabolism and Cancer Biology.
  Vander Heiden MG, DeBerardinis RJ Cell 2017 Feb 168 4 657-669
- Tumor Microenvironment, Metabolism, and Immunotherapy.
  DeBerardinis RJ, The New England journal of medicine 2020 02 382 9 869-871

Research

Metabolism
Inborn errors of metabolism
Genetic disorders in children
Cancer

Links

New Patient Appointment or 214-645-8300 or 817-882-2400