Ralph DeBerardinis, M.D., Ph.D.

Director of the Eugene McDermott Center for Human Growth and Development; Director, Genetic and Metabolic Disease Program (CRI)

Harold C. Simmons Comprehensive Cancer Center

Eugene McDermott Distinguished Chair for the Study of Human Growth and Development
Philip O'Bryan Montgomery Jr., M.D., Distinguished Chair in Developmental Biology
Sowell Family Scholar in Medical Research

Pediatrics - Genetics and Metabolism

Biography

Ralph DeBerardinis earned a B.S. in biology from St. Joseph's University and M.D. and Ph.D. degrees from the University of Pennsylvania. He performed his Ph.D. research on mammalian retrotransposons with Haig H. Kazazian Jr. Dr. DeBerardinis was the first trainee in the combined residency program in pediatrics and medical genetics at The Children's Hospital of Philadelphia (CHOP) and received several awards for teaching and clinical care. He ultimately achieved board certification in pediatrics, medical genetics, and clinical biochemical genetics.

Dr. DeBerardinis performed postdoctoral research in Craig Thompson's laboratory at the Penn Cancer Center from 2004 to 2007. He joined the faculty of UT Southwestern Medical Center in 2008 and joined Children’s Medical Center Research Institute at UT Southwestern (CRI) in 2011. Dr. DeBerardinis serves as Chief of Pediatric Genetics and Metabolism at UT Southwestern and Director of CRI's Genetic and Metabolic Disease Program.

Dr. DeBerardinis received Outstanding Investigator Awards from the National Cancer Institute in 2017 and 2023, and he was named an Investigator of the Howard Hughes Medical Institute in 2018. He received the Edith and Peter O'Donnell Award in Medicine from The Academy of Medicine, Engineering and Science of Texas in 2019 and the Paul Marks Prize for Cancer Research in 2021. Dr. DeBerardinis holds the Joel B. Steinberg, M.D. Distinguished Chair in Pediatrics, and he is a Sowell Family Scholar in Medical Research and a Robert L. Moody Faculty Scholar. In 2020, he was elected to the National Academy of Medicine, and in 2026, he was elected to the National Academy of Sciences.

He has been included in D Magazine's Best Doctors list nearly every year since 2016.

About His Laboratory

The DeBerardinis laboratory is interested in the role of altered metabolic states in human diseases, particularly pediatric inborn errors of metabolism and cancer. This research is tightly integrated with clinical activities in medical genetics, oncology, and radiology, providing seamless opportunities to examine the relevance of findings in patients.

DeBerardinis Laboratory

Education & Training

Residency - Children's Hospital of Philadelphia (2000-2005), Pediatrics & Medical Genetics
Medical School - University of Pennsylvania School of Medicine (1992-2000)

Professional Associations & Affiliations

Investigator, Howard Hughes Medical Institute (2018)
Society for Pediatrics Research
Society for Inherited Metabolic Disorders
American Society of Human Genetics
American Association for Cancer Research
American Academy of Pediatrics
American Society for Clinical Investigation
National Academy of Medicine
Association of American Physicians
Texas Academy of Medicine, Engineering, Science & Technology

Honors & Awards

Elected Member 2026, National Academy of Sciences
National Academy of Medicine 2020
Paul Marks Prize for Cancer Research 2021
D Magazine Best Doctor, 2016, 2018-2022
D Magazine Best Pediatric Specialist 2020-2021
Edith and Peter O’Donnell Award in Medicine, The Academy of Medicine, Engineering, and Science of Texas 2018
Robert L. Moody Sr. Faculty Scholar 2017
Howard Hughes Medical Institute Faculty Scholar 2017
NCI Outstanding Investigator 2017
American Society for Clinical Investigation
Damon Runyon Cancer Research Foundation Clinical Investigator Award 2011
William K. Bowes, Jr. Award in Medical Genetics 2008
Sowell Family Scholar in Medical Research 2008
Soc. for Inherited Metabolic Disorders Neil Buist Award 2008
President’s Research Council Distinguished Young Researcher Award 2008
CHOP Pediatric Scholars Program & Faculty Honor Roll 2007

Books & Publications

Publications
- ZNF395 Is a Hypoxia-Responsive Regulator of Mitochondrial Glutaminolysis in Clear Cell Renal Cell Carcinoma
  Koh J, Liao C, Ng MS, Hong JH, Heng HL, Gui DY, Wang Z, Chua BY, Li Z, Sobota RM, Lee LS, Iqbal J, Lim KJ, Bezwada D, DeBerardinis RJ, Steger G, Ching J, Tan P, Teh BT, Zhang Q, Yao X Cancer research 2026 Apr 86 1676-1689
- LINE-1 Locus Transcription Nucleates Oncogenic Chromatin Architecture
  Lee M, Zhang Y, Lim JY, Dai T, Ye J, Cervantes MB, Sondhi V, Zheng S, Kim YJ, Chen B, Deberardinis RJ, Xu J Cancer discovery 2026 Apr 16 800-821
- Stable isotope tracing in human plasma-like medium reveals metabolic and immune modulation of the glioblastoma microenvironment
  Savani MR, El Shami M, Miki K, Gattie LC, Smith BC, Hicks WH, Weiss JO, Oken SS, Katta LN, Shipman T, Ghoche MT, Zacharias LG, Martin-Sandoval MS, Montgomery EY, Xiao Y, Shi DD, Rich JN, Richardson TE, Zinn PO, Lega BC, Mathews TP, DeBerardinis RJ, Abdullah KG, McBrayer SK Neuro-oncology 2026 Feb 28 415-429
- A recurrent ACAA2 variant causes a dominant syndrome of lipodystrophy, lipomatosis, infantile steatohepatitis, and hypoglycemia
  Simha V, LoPiccolo MK, Platt A, Brown RJ, Johnson X, Carere DA, Donnelly C, Snyder MT, Xing C, Mathews TP, Gopal P, Ward SC, Tomchick DR, Agarwal AK, DeBerardinis RJ, Garg A The Journal of clinical investigation 2026 Jan 136
- BBOX1 restrains TBK1-mTORC1 oncogenic signaling in clear cell renal cell carcinoma
  Liao C, Hu L, Jia L, Zhou J, Wang T, Kim K, Zhong H, Yao H, Dong L, Guo L, Liang Q, Zhang C, Zhao F, Fang J, Liu H, Li S, Xu L, Simon JM, Malladi S, Kapur P, Brugarolas J, DeBerardinis RJ, Zhang Q Nature communications 2025 Dec 16
- Cancer Metabolism: Historical Landmarks, New Concepts, and Opportunities
  Chandel NS, Vousden KH, Deberardinis RJ Cold Spring Harbor Perspectives in Medicine 2025 Dec 15
- TMPRSS11B promotes an acidified microenvironment and immune suppression in squamous lung cancer
  Sunil HS, Clemenceau JR, Grichuk A, Barnfather I, Nakkireddy SR, Izzo L, Feng Q, Hartnett W, Evers BM, Thomas L, Subramaniyan I, Li L, Putnam WC, Hepensteil S, Zhu J, Updegraff B, Minna JD, DeBerardinis RJ, Hwang TH, Gao J, Oliver TG, O’Donnell KA EMBO Reports 2025 Dec 26 6346-6379
- NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT
  Wu Z, Nguyen PT, Sondhi V, Yao RW, Lu Z, Dai T, Chiang JC, Cai F, Williams IM, Blatt EB, Shang Z, Cai L, Zhang J, Moore MD, Alshamleh I, Li X, Ogu T, Zacharias LG, Winston R, Patricio JS, Johnson X, Chen WM, Cong Q, Mathews TP, Zhang Y, Zhang L, DeBerardinis RJ Science 2025 Dec 390 1134-1142
- Cancer Metabolism: Aspirations for the Coming Decade
  DeBerardinis RJ, Vousden KH, Chandel NS Cold Spring Harbor Perspectives in Medicine 2025 Oct 15
- Glycosaminoglycan-driven lipoprotein uptake protects tumours from ferroptosis
  Calhoon D, Sang L, Ji F, Bezwada D, Hsu SC, Cai F, Kim N, Basu A, Wu R, Pimentel A, Brooks B, La K, Paulina Serrano A, Cassidy DL, Cai L, Toffessi-Tcheuyap V, Moussa ME, Uritboonthai W, Hoang LT, Kolli M, Jackson B, Margulis V, Siuzdak G, Brugarolas J, Corbin I, Pratt DA, Weiss RJ, DeBerardinis RJ, Birsoy K, Garcia-Bermudez J Nature 2025 Aug 644 799-808
- PEX39 facilitates the peroxisomal import of PTS2-containing proteins
  Chen WW, Rodrigues TA, Wendscheck D, Pedrosa AG, Yang C, Francisco T, Möcklinghoff T, Zografakis A, Nunes-Silva B, Avraham RE, Silva AR, Ferreira MJ, Das H, Koster J, Neuwirth S, Bender J, Oeljeklaus S, Sondhi V, Gatsogiannis C, Schuldiner M, Zalckvar E, Hofmann K, Waterham HR, DeBerardinis RJ, Azevedo JE, Warscheid B Nature cell biology 2025 Aug 27 1256-1271
- An unexpected career in cancer metabolism
  DeBerardinis RJ Nature Cancer 2025 Aug 6 1297-1298
- Conservation and divergence of metabolic phenotypes between patient tumours and matched xenografts
  Rao AD, Cai L, Snyman M, Walsdorf RE, Li X, Wix SN, Gard G, Brown AB, Kim J, Santos Patricio J, Muh S, Martin Sandoval M, Zacharias LG, Heimdal KA, Gu W, Homsi J, Tillman B, Sharma R, Vandergriff TW, Solmonson A, Faubert B, Mathews TP, Morrison SJ, DeBerardinis RJ, Gill JG Nature Metabolism 2025 Aug 7 1703-1713
- High KYNU Expression Is Associated with Poor Prognosis, KEAP1/STK11 Mutations, and Immunosuppressive Metabolism in Patient-Derived but Not Murine Lung Adenocarcinomas
  Cai L, Rogers TJ, Mousavi Jafarabad R, Vu H, Yang C, Novaresi N, Galán-Cobo A, Girard L, Ostrin EJ, Fahrmann JF, Kim J, Heymach JV, O’Donnell KA, Xiao G, Xie Y, DeBerardinis RJ, Minna JD Cancers 2025 May 17
- The Lung Cancer Autochthonous Model Gene Expression Database Enables Cross-Study Comparisons of the Transcriptomic Landscapes Across Mouse Models
  Cai L, Wu F, Zhou Q, Gao Y, Yao B, DeBerardinis RJ, Acquaah-Mensah GK, Aidinis V, Beane JE, Biswal S, Chen T, Concepcion-Crisol CP, Grüner BM, Jia D, Jones RA, Kurie JM, Lee MG, Lindahl P, Lissanu Y, Lorz C, MacPherson D, Martinelli R, Mazur PK, Mazzilli SA, Mii S, Moll HP, Moorehead RA, Morrisey EE, Ng SR, Oser MG, Pandiri AR, Powell CA, Ramadori G, Santos M, Snyder EL, Sotillo R, Su KY, Taki T, Taparra K, Tran PT, Xia Y, van Veen JE, Winslow MM, Xiao G, Rudin CM, Oliver TG, Xie Y, Minna JD Cancer research 2025 May 85 1769-1783
- High Glucose Contribution to the TCA Cycle Is a Feature of Aggressive Non–Small Cell Lung Cancer in Patients
  Cai L, Hammond NG, Tasdogan A, Alsamraae M, Yang C, Cameron RB, Quan P, Solmonson A, Gu W, Pachnis P, Kaur M, Chang BK, Zhou Q, Hensley CT, Do QN, Melo LM, Ubellacker JM, Kaushik A, Clare MG, Alcazar IN, Kurylowicz K, Marcuccilli JD, Allies G, Kutritz A, Klode J, Ramesh V, Rogers TJ, Rao AD, Crentsil HE, Li H, Brister F, McDaniel P, Xu X, Evers BM, Zacharias LG, Sudderth J, Xu J, Mathews TP, Oliver D, Minna JD, Waters JK, Morrison SJ, Kernstine KH, Faubert B, Deberardinis RJ Cancer discovery 2025 Apr 15 702-716
- CD44-mediated metabolic rewiring is a targetable dependency of IDH-mutant leukemia
  Lyu J, Liu Y, Liu N, Vu HS, Cai F, Cao H, Kaphle P, Wu Z, Botten GA, Zhang Y, Wang J, Achyutuni S, Gao X, Iacobucci I, Mullighan CG, Chung SS, Ni M, DeBerardinis RJ, Xu J Blood 2025 Apr 145 1553-1567
- Lysosomal–Mitochondrial Interaction Promotes Tumor Growth in Squamous Cell Carcinoma of the Head and Neck
  Gopalkrishnan A, Wang N, Cruz-Rangel S, Yassin-Kassab A, Shiva S, Kurukulasuriya C, Monga SP, DeBerardinis RJ, Skinner HD, Kiselyov K, Duvvuri U Molecular Cancer Research 2025 Apr 23 339-349
- Lipoylation inhibition enhances radiation control of lung cancer by suppressing homologous recombination DNA damage repair
  Chiang JC, Shang Z, Rosales T, Cai L, Chen WM, Cai F, Vu H, Minna JD, Ni M, Davis AJ, Timmerman RD, DeBerardinis RJ, Zhang Y Science Advances 2025 Mar 11
- Assessing cancer therapeutic efficacy in vivo using [²H₇] glucose deuterium metabolic imaging
  Chang MC, Malut VR, Mahar R, Rushin A, McLeod MA, Pierre GL, Malut IR, Staklinski SJ, Glanz ME, Ragavan M, Sharma G, Madheswaran M, Badar A, Rao AD, Law BK, Kilberg MS, Collins JH, Kodibagkar VD, Bankson JA, DeBerardinis RJ, Merritt ME Science Advances 2025 Mar 11
- Nuclear GTPSCS functions as a lactyl-CoA synthetase to promote histone lactylation and gliomagenesis
  Liu R, Ren X, Park YE, Feng H, Sheng X, Song X, AminiTabrizi R, Shah H, Li L, Zhang Y, Abdullah KG, Dubois-Coyne S, Lin H, Cole PA, DeBerardinis RJ, McBrayer SK, Huang H, Zhao Y Cell Metabolism 2025 Feb 37 377-394.e9
- Glutaminase-2 Expression Induces Metabolic Changes and Regulates Pyruvate Dehydrogenase Activity in Glioblastoma Cells
  De los Santos-Jiménez J, Campos-Sandoval JA, Rosales T, Ko B, Alonso FJ, Márquez J, DeBerardinis RJ, Matés JM International journal of molecular sciences 2025 Jan 26
- Tryptophan fuels MYC-dependent liver tumorigenesis through indole 3-pyruvate synthesis
  Venkateswaran N, Garcia R, Lafita-Navarro MC, Hao YH, Perez-Castro L, Nogueira PA, Solmonson A, Mender I, Kilgore JA, Fang S, Brown IN, Li L, Parks E, Lopes dos Santos I, Bhaskar M, Kim J, Jia Y, Lemoff A, Grishin NV, Kinch L, Xu L, Williams NS, Shay JW, DeBerardinis RJ, Zhu H, Conacci-Sorrell M Nature communications 2024 Dec 15
- Navigating electronic health record accuracy by examination of sex incongruent conditions
  Cai L, DeBerardinis RJ, Zhan X, Xiao G, Xie Y Journal of the American Medical Informatics Association 2024 Dec 31 2849-2856
- A review of multiple diagnostic approaches in the undiagnosed diseases network to identify inherited metabolic diseases
  Author Collaboration TU, Furuta Y, Tinker RJ, Hamid R, Cogan JD, Ezell KM, Oglesbee D, DeBerardinis RJ, Phillips JA Orphanet Journal of Rare Diseases 2024 Dec 19
- Pathogenic mitochondrial DNA mutations inhibit melanoma metastasis
  Shelton SD, House S, Melo LM, Ramesh V, Chen Z, Wei T, Wang X, Llamas CB, Venigalla SS, Menezes CJ, Allies G, Krystkiewicz J, Rösler J, Meckelmann SW, Zhao P, Rambow F, Schadendorf D, Zhao Z, Gill JG, DeBerardinis RJ, Morrison SJ, Tasdogan A, Mishra P Science Advances 2024 Nov 10
- A glutamine metabolic switch supports erythropoiesis
  Lyu J, Gu Z, Zhang Y, Vu HS, Lechauve C, Cai F, Cao H, Keith J, Brancaleoni V, Granata F, Motta I, Cappellini MD, Huang LJ, DeBerardinis RJ, Weiss MJ, Ni M, Xu J Science 2024 Nov 386
- The redox sensor KEAP1 facilitates adaptation of T cells to chronic antigen stimulation by preventing hyperactivation
  Zhu Z, Luo Y, Lou G, Yihunie K, Wizzard S, DeVilbiss AW, Muh S, Ma C, Shinde SS, Hoar J, Hu T, Zhang N, Biswal S, DeBerardinis RJ, Wu T, Yao C Science Immunology 2024 Nov 9
- Niacin supplementation in a child with novel MTTN variant m.5670A>G causing early onset mitochondrial myopathy and NAD⁺ deficiency
  Aaltio J, Euro L, Tynninen O, Vu HS, Ni M, DeBerardinis RJ, Suomalainen A, Isohanni P Neuromuscular Disorders 2024 Oct 43 14-19
- Mitochondrial complex I promotes kidney cancer metastasis
  Bezwada D, Perelli L, Lesner NP, Cai L, Brooks B, Wu Z, Vu H, Sondhi V, Cassidy DL, Kasitinon SY, Kelekar S, Cai F, Aurora AB, Patrick M, Leach A, Ghandour R, Zhang Y, Do D, McDaniel P, Sudderth JA, Dumesnil D, House S, Rosales TI, Poole AM, Lotan Y, Woldu S, Bagrodia A, Meng X, Cadeddu JA, Mishra P, Garcia Bermudez J, Pedrosa I, Kapur P, Courtney KD, Malloy CR, Genovese G, Margulis V, DeBerardinis RJ Nature 2024 Aug 633 923-931
- De novo and salvage purine synthesis pathways across tissues and tumors
  Tran DH, Kim D, Kesavan R, Brown H, Dey T, Soflaee MH, Vu HS, Tasdogan A, Guo J, Bezwada D, Al Saad H, Cai F, Solmonson A, Rion H, Chabatya R, Merchant S, Manales NJ, Tcheuyap VT, Mulkey M, Mathews TP, Brugarolas J, Morrison SJ, Zhu H, DeBerardinis RJ, Hoxhaj G Cell 2024 Jul 187 3602-3618.e20
- Electron transport chain inhibition increases cellular dependence on purine transport and salvage
  Wu Z, Bezwada D, Cai F, Harris RC, Ko B, Sondhi V, Pan C, Vu HS, Nguyen PT, Faubert B, Cai L, Chen H, Martin-Sandoval M, Do D, Gu W, Zhang Y, Zhang Y, Brooks B, Kelekar S, Zacharias LG, Oaxaca KC, Patricio JS, Mathews TP, Garcia-Bermudez J, Ni M, DeBerardinis RJ Cell Metabolism 2024 Jul 36 1504-1520.e9
- Metabolic inflexibility promotes mitochondrial health during liver regeneration
  Wang X, Menezes CJ, Jia Y, Xiao Y, Venigalla SS, Cai F, Hsieh MH, Gu W, Du L, Sudderth J, Kim D, Shelton SD, Llamas CB, Lin YH, Zhu M, Merchant S, Bezwada D, Kelekar S, Zacharias LG, Mathews TP, Hoxhaj G, Wynn RM, Tambar UK, DeBerardinis RJ, Zhu H, Mishra P Science 2024 Jun 384
- Severely polarized extracellular acidity around tumour cells
  Feng Q, Bennett Z, Grichuk A, Pantoja R, Huang T, Faubert B, Huang G, Chen M, DeBerardinis RJ, Sumer BD, Gao J Nature Biomedical Engineering 2024 Jun 8 787-799
- Glutamine antagonists may KEAP lung cancer in check
  Blatt EB, DeBerardinis RJ Science Advances 2024 Mar 10
- Metabolic signatures of thymomas: potential biomarkers and treatment targets
  Miller JW, Faubert BM, Mathews TP, Waters JK, DeBerardinis RJ, Kernstine KH European Journal of Cardio-thoracic Surgery 2024 Feb 65
- Proteolytic activation of fatty acid synthase signals pan-stress resolution
  Wei H, Weaver YM, Yang C, Zhang Y, Hu G, Karner CM, Sieber M, DeBerardinis RJ, Weaver BP Nature Metabolism 2024 Jan 6 113-126
- Evaluation of the clinical, biochemical, and molecular spectrum of Cobalamin C (CblC) defect in 33 patients from Pakistan
  Ahmed S, Cai L, Akbar F, Siddiqui A, DeBerardinis RJ, Ni M, Vu H, Afroze B Scandinavian Journal of Clinical and Laboratory Investigation 2024 84 391-397
- Metabolic pathway analysis using stable isotopes in patients with cancer
  Bartman CR, Faubert B, Rabinowitz JD, DeBerardinis RJ Nature Reviews Cancer 2023 Dec 23 863-878
- IL-1β mediates the induction of immune checkpoint regulators IDO1 and PD-L1 in lung adenocarcinoma cells
  Nawas AF, Solmonson A, Gao B, DeBerardinis RJ, Minna JD, Conacci-Sorrell M, Mendelson CR Cell Communication and Signaling 2023 Dec 21
- New insights in the targets of action of dimethyl fumarate in endothelial cells: effects on energetic metabolism and serine synthesis in vitro and in vivo
  Ocaña Mª, Bernal M, Yang C, Caro C, Domínguez A, Vu HS, Cárdenas C, García-Martín ML, DeBerardinis RJ, Quesada AR, Martínez-Poveda B, Medina MÁ Communications Biology 2023 Dec 6
- Partial N-acetyl glutamate synthase deficiency presenting as postpartum hyperammonemia: Diagnosis and subsequent pregnancy management
  Abou Haidar L, Pachnis P, Gotway GK, Ni M, DeBerardinis RJ, McNutt MC JIMD Reports 2023 Nov 64 403-409
- Comprehensive isotopomer analysis of glutamate and aspartate in small tissue samples
  Cai F, Bezwada D, Cai L, Mahar R, Wu Z, Chang MC, Pachnis P, Yang C, Kelekar S, Gu W, Brooks B, Ko B, Vu HS, Mathews TP, Zacharias LG, Martin-Sandoval M, Do D, Oaxaca KC, Jin ES, Margulis V, Malloy CR, Merritt ME, DeBerardinis RJ Cell Metabolism 2023 Oct 35 1830-1843.e5
- Adipocytes reprogram cancer cell metabolism by diverting glucose towards glycerol-3-phosphate thereby promoting metastasis
  Mukherjee A, Bezwada D, Greco F, Zandbergen M, Shen T, Chiang CY, Tasdemir M, Fahrmann J, Grapov D, La Frano MR, Vu HS, Faubert B, Newman JW, McDonnell LA, Nezi L, Fiehn O, DeBerardinis RJ, Lengyel E Nature Metabolism 2023 Sep 5 1563-1577
- A comparative study of neuroendocrine heterogeneity in small cell lung cancer and neuroblastoma
  Cai L, De Berardinis RJ, Xie Y, Minna JD, Xiao G Molecular Cancer Research 2023 Aug 21 795-807
- Evaluation of the clinical, biochemical, and genetic presentation of neonatal and adult-onset 5,10-methylene tetrahydrofolate reductase (MTHFR) deficiency in patients from Pakistan
  Ahmed S, Akbar F, Deberardinis RJ, Ni M, Afroze B Journal of Pediatric Endocrinology and Metabolism 2023 Aug 36 761-771
- FASN deficiency induces a cytosol-to-mitochondria citrate flux to mitigate detachment-induced oxidative stress
  Dai W, Wang Z, Wang G, Wang QA, DeBerardinis R, Jiang L Cell Reports 2023 Aug 42
- Critical role of antioxidant programs in enzalutamide-resistant prostate cancer
  Blatt EB, Parra K, Neeb A, Buroni L, Bogdan D, Yuan W, Gao Y, Gilbreath C, Paschalis A, Carreira S, DeBerardinis RJ, Mani RS, de Bono JS, Raj GV Oncogene 2023 Jul 42 2347-2359
- MCT4-dependent lactate secretion suppresses antitumor immunity in LKB1-deficient lung adenocarcinoma
  Qian Y, Galan-Cobo A, Guijarro I, Dang M, Molkentine D, Poteete A, Zhang F, Wang Q, Wang J, Parra E, Panda A, Fang J, Skoulidis F, Wistuba II, Verma S, Merghoub T, Wolchok JD, Wong KK, DeBerardinis RJ, Minna JD, Vokes NI, Meador CB, Gainor JF, Wang L, Reuben A, Heymach JV Cancer Cell 2023 Jul 41 1363-1380.e7
- Dissecting molecular, pathological, and clinical features associated with tumor neural/neuroendocrine heterogeneity
  Cai L, DeBerardinis RJ, Xiao G, Minna JD, Xie Y iScience 2023 Jun 26
- FDA approved drugs with antiviral activity against SARS-CoV-2: From structure-based repurposing to host-specific mechanisms
  Ahmed MS, Farag AB, Boys IN, Wang P, Menendez-Montes I, Nguyen NU, Eitson JL, Ohlson MB, Fan W, McDougal MB, Mar K, Thet S, Ortiz F, Kim SY, Solmonson A, Williams NS, Lemoff A, DeBerardinis RJ, Schoggins JW, Sadek HA Biomedicine and Pharmacotherapy 2023 Jun 162
- Limiting mitochondrial plasticity by targeting DRP1 induces metabolic reprogramming and reduces breast cancer brain metastases
  Parida PK, Marquez-Palencia M, Ghosh S, Khandelwal N, Kim K, Nair V, Liu XZ, Vu HS, Zacharias LG, Gonzalez-Ericsson PI, Sanders ME, Mobley BC, McDonald JG, Lemoff A, Peng Y, Lewis C, Vale G, Halberg N, Arteaga CL, Hanker AB, DeBerardinis RJ, Malladi S Nature Cancer 2023 Jun 4 893-907
- Apoptotic cell death in disease—Current understanding of the NCCD 2023
  Vitale I, Pietrocola F, Guilbaud E, Aaronson SA, Abrams JM, Adam D, Agostini M, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Aqeilan RI, Arama E, Baehrecke EH, Balachandran S, Bano D, Barlev NA, Bartek J, Bazan NG, Becker C, Bernassola F, Bertrand MJ, Bianchi ME, Blagosklonny MV, Blander JM, Blandino G, Blomgren K, Borner C, Bortner CD, Bove P, Boya P, Brenner C, Broz P, Brunner T, Damgaard RB, Calin GA, Campanella M, Candi E, Carbone M, Carmona-Gutierrez D, Cecconi F, Chan FK, Chen GQ, Chen Q, Chen YH, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Ciliberto G, Conrad M, Cubillos-Ruiz JR, Czabotar PE, D’Angiolella V, Daugaard M, Dawson TM, Dawson VL, De Maria R, De Strooper B, Debatin KM, Deberardinis RJ, Degterev A, Del Sal G, Deshmukh M, Di Virgilio F, Diederich M, Dixon SJ, Dynlacht BD, El-Deiry WS, Elrod JW, Engeland K, Fimia GM, Galassi C, Ganini C, Garcia-Saez AJ, Garg AD, Garrido C, Gavathiotis E, Gerlic M, Ghosh S, Green DR, Greene LA, Gronemeyer H, Häcker G, Hajnóczky G, Hardwick JM, Haupt Y, He S, Heery DM, Hengartner MO, Hetz C, Hildeman DA, Ichijo H, Inoue S, Jäättelä M, Janic A, Joseph B, Jost PJ, Kanneganti TD, Karin M, Kashkar H, Kaufmann T, Kelly GL, Kepp O, Kimchi A, Kitsis RN, Klionsky DJ, Kluck R, Krysko DV, Kulms D, Kumar S, Lavandero S, Lavrik IN, Lemasters JJ, Liccardi G, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Luedde T, MacFarlane M, Madeo F, Malorni W, Manic G, Mantovani R, Marchi S, Marine JC, Martin SJ, Martinou JC, Mastroberardino PG, Medema JP, Mehlen P, Meier P, Melino G, Melino S, Miao EA, Moll UM, Muñoz-Pinedo C, Murphy DJ, Niklison-Chirou MV, Novelli F, Núñez G, Oberst A, Ofengeim D, Opferman JT, Oren M, Pagano M, Panaretakis T, Pasparakis M, Penninger JM, Pentimalli F, Pereira DM, Pervaiz S, Peter ME, Pinton P, Porta G, Prehn JH, Puthalakath H, Rabinovich GA, Rajalingam K, Ravichandran KS, Rehm M, Ricci JE, Rizzuto R, Robinson N, Rodrigues CM, Rotblat B, Rothlin CV, Rubinsztein DC, Rudel T, Rufini A, Ryan KM, Sarosiek KA, Sawa A, Sayan E, Schroder K, Scorrano L, Sesti F, Shao F, Shi Y, Sica GS, Silke J, Simon HU, Sistigu A, Stephanou A, Stockwell BR, Strapazzon F, Strasser A, Sun L, Sun E, Sun Q, Szabadkai G, Tait SW, Tang D, Tavernarakis N, Troy CM, Turk B, Urbano N, Vandenabeele P, Vanden Berghe T, Vander Heiden MG, Vanderluit JL, Verkhratsky A, Villunger A, von Karstedt S, Voss AK, Vousden KH, Vucic D, Vuri D, Wagner EF, Walczak H, Wallach D, Wang R, Wang Y, Weber A, Wood W, Yamazaki T, Yang HT, Zakeri Z, Zawacka-Pankau JE, Zhang L, Zhang H, Zhivotovsky B, Zhou W, Piacentini M, Kroemer G, Galluzzi L Cell Death and Differentiation 2023 May 30 1097-1154
- L-2-hydroxyglutaric aciduria – review of literature and case series
  Ahmed S, Siddiqui A, DeBerardinis RJ, Ni M, Lai WG, Cai F, Vu HS, Afroze B Annals of Medicine and Surgery 2023 Apr 85 712-717
- Recessive pathogenic variants in MCAT cause combined oxidative phosphorylation deficiency
  Webb BD, Nowinski SM, Solmonson A, Ganesh J, Rodenburg RJ, Leandro J, Evans A, Vu HS, Naidich TP, Gelb BD, DeBerardinis RJ, Rutter J, Houten SM eLife 2023 Mar 12
- Obesity Is Associated with Altered Tumor Metabolism in Metastatic Melanoma
  Hahn AW, Menk AV, Rivadeneira DB, Augustin RC, Xu M, Li J, Wu X, Mishra AK, Gide TN, Quek C, Zang Y, Spencer CN, Menzies AM, Daniel CR, Hudgens CW, Nowicki T, Haydu LE, Khan MA, Gopalakrishnan V, Burton EM, Malke J, Simon JM, Bernatchez C, Putluri N, Woodman SE, Gopal YN, Guerrieri R, Fischer GM, Wang J, Wani KM, Thompson JF, Lee JE, Hwu P, Ajami N, Gershenwald JE, Long GV, Scolyer RA, Tetzlaff MT, Lazar AJ, Schadendorf D, Wargo JA, Kirkwood JM, DeBerardinis RJ, Liang H, Futreal A, Zhang J, Wilmott JS, Peng W, Davies MA, Delgoffe GM, Najjar YG, McQuade JL Clinical Cancer Research 2023 Jan 29 154-164
- Disabling Uncompetitive Inhibition of Oncogenic IDH Mutations Drives Acquired Resistance
  Lyu J, Liu Y, Gong L, Chen M, Madanat YF, Zhang Y, Cai F, Gu Z, Cao H, Kaphle P, Kim YJ, Kalkan FN, Stephens H, Dickerson KE, Ni M, Chen W, Patel P, Mims AS, Borate U, Burd A, Cai SF, Yin CC, You MJ, Chung SS, Collins RH, Deberardinis RJ, Liu X, Xu J Cancer discovery 2023 Jan 13 170-193
- Novel pathogenic UQCRC2 variants in a female with normal neurodevelopment
  Haidar LA, Harris RC, Pachnis P, Chen H, Gotway GK, Ni M, DeBerardinis RJ Cold Spring Harbor Molecular Case Studies 2023 9
- Metabolic Adjustments following Glutaminase Inhibition by CB-839 in Glioblastoma Cell Lines
  De los Santos-Jiménez J, Rosales T, Ko B, Campos-Sandoval JA, Alonso FJ, Márquez J, DeBerardinis RJ, Matés JM Cancers 2023 Jan 15
- Glucocorticoid mediated inhibition of LKB1 mutant non-small cell lung cancers
  Huffman KE, Li LS, Carstens R, Park H, Girard L, Avila K, Wei S, Kollipara R, Timmons B, Sudderth J, Bendris N, Kim J, Villalobos P, Fujimoto J, Schmid S, Deberardinis RJ, Wistuba I, Heymach J, Kittler R, Akbay EA, Posner B, Wang Y, Lam S, Kliewer SA, Mangelsdorf DJ, Minna JD Frontiers in Oncology 2023 13
- Lactate metabolism is essential in early-onset mitochondrial myopathy
  Chen Z, Bordieanu B, Kesavan R, Lesner NP, Venigalla SS, Shelton SD, DeBerardinis RJ, Mishra P Science Advances 2023 Jan 9
- Metabolon formation regulates branched-chain amino acid oxidation and homeostasis
  Patrick MK, Gu Z, Zhang G, Wynn RM, Kaphle P, Cao H, Vu H, Cai F, Gao X, Zhang Y, Chen M, Ni M, Chuang DT, DeBerardinis RJ, Xu J Nature Metabolism 2022 Dec 4 1775-1791
- Principles of reproducible metabolite profiling of enriched lymphocytes in tumors and ascites from human ovarian cancer
  Kilgour MK, MacPherson S, Zacharias LG, LeBlanc J, Babinszky S, Kowalchuk G, Parks S, Sheldon RD, Jones RG, DeBerardinis RJ, Hamilton PT, Watson PH, Lum JJ Nature Protocols 2022 Nov 17 2668-2698
- Targeting acetylcholine signaling modulates persistent drug tolerance in EGFR-mutant lung cancer and impedes tumor relapse
  Nie M, Chen N, Pang H, Jiang T, Jiang W, Tian P, Yao LA, Chen Y, DeBerardinis RJ, Li W, Yu Q, Zhou C, Hu Z Journal of Clinical Investigation 2022 Oct 132
- In vivo isotope tracing reveals a requirement for the electron transport chain in glucose and glutamine metabolism by tumors
  Pachnis P, Wu Z, Faubert B, Tasdogan A, Gu W, Shelton S, Solmonson A, Rao AD, Kaushik AK, Rogers TJ, Ubellacker JM, LaVigne CA, Yang C, Ko B, Ramesh V, Sudderth J, Zacharias LG, Martin-Sandoval MS, Do D, Mathews TP, Zhao Z, Mishra P, Morrison SJ, DeBerardinis RJ Science Advances 2022 Sep 8
- De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma
  Shi DD, Savani MR, Levitt MM, Wang AC, Endress JE, Bird CE, Buehler J, Stopka SA, Regan MS, Lin YF, Puliyappadamba VT, Gao W, Khanal J, Evans L, Lee JH, Guo L, Xiao Y, Xu M, Huang B, Jennings RB, Bonal DM, Martin-Sandoval MS, Dang T, Gattie LC, Cameron AB, Lee S, Asara JM, Kornblum HI, Mak TW, Looper RE, Nguyen QD, Signoretti S, Gradl S, Sutter A, Jeffers M, Janzer A, Lehrman MA, Zacharias LG, Mathews TP, Losman JA, Richardson TE, Cahill DP, DeBerardinis RJ, Ligon KL, Xu L, Ly P, Agar NY, Abdullah KG, Harris IS, Kaelin WG, McBrayer SK Cancer Cell 2022 Sep 40 939-956.e16
- Differential requirements for mitochondrial electron transport chain components in the adult murine liver
  Lesner NP, Wang X, Chen Z, Frank A, Menezes C, House S, Shelton SD, Lemoff A, McFadden DG, Wansapura J, Deberardinis RJ, Mishra P eLife 2022 Sep 11
- Mitochondrial pyruvate supports lymphoma proliferation by fueling a glutamate pyruvate transaminase 2–dependent glutaminolysis pathway
  Wei P, Bott AJ, Cluntun AA, Morgan JT, Cunningham CN, Schell JC, Ouyang Y, Ficarro SB, Marto JA, Danial NN, DeBerardinis RJ, Rutter J Science Advances 2022 Sep 8
- A Pan-Cancer Assessment of RB1/TP53 Co-Mutations
  Cai L, DeBerardinis RJ, Xiao G, Minna JD, Xie Y Cancers 2022 Sep 14
- Carbon source availability drives nutrient utilization in CD8⁺ T cells
  Kaymak I, Luda KM, Duimstra LR, Ma EH, Longo J, Dahabieh MS, Faubert B, Oswald BM, Watson MJ, Kitchen-Goosen SM, DeCamp LM, Compton SE, Fu Z, DeBerardinis RJ, Williams KS, Sheldon RD, Jones RG Cell Metabolism 2022 Sep 34 1298-1311.e6
- Cellular signals converge at the NOX2-SHP-2 axis to induce reductive carboxylation in cancer cells
  Zhang R, Chen D, Fan H, Wu R, Tu J, Zhang FQ, Wang M, Zheng H, Qu CK, Elf SE, Faubert B, He YY, Bissonnette MB, Gao X, DeBerardinis RJ, Chen J Cell Chemical Biology 2022 Jul 29 1200-1208.e6
- Metabolic analysis as a driver for discovery, diagnosis, and therapy
  DeBerardinis RJ, Keshari KR Cell 2022 Jul 185 2678-2689
- Targeting BCAT1 Combined with a-Ketoglutarate Triggers Metabolic Synthetic Lethality in Glioblastoma
  Zhang B, Peng H, Zhou M, Bao L, Wang C, Cai F, Zhang H, Wang JE, Niu Y, Chen Y, Wang Y, Hatanpaa KJ, Copland JA, DeBerardinis RJ, Wang Y, Luo W Cancer research 2022 Jul 82 2388-2402
- Optimized protocol for stable isotope tracing and steady-state metabolomics in mouse HER2+ breast cancer brain metastasis
  Parida PK, Marquez-Palencia M, Kaushik AK, Kim K, Nair V, Sudderth J, Vu H, Zacharias L, DeBerardinis R, Malladi S STAR Protocols 2022 Jun 3
- SNAT7 regulates mTORC1 via macropinocytosis
  Meng D, Yang Q, Jeong MH, Curukovic A, Tiwary S, Melick CH, Lama-Sherpa TD, Wang H, Huerta-Rosario M, Urquhart G, Zacharias LG, Lewis C, DeBerardinis RJ, Jewell JL Proceedings of the National Academy of Sciences of the United States of America 2022 May 119
- A male-derived nonribosomal peptide pheromone controls female schistosome development
  Chen R, Wang J, Gradinaru I, Vu HS, Geboers S, Naidoo J, Ready JM, Williams NS, DeBerardinis RJ, Ross EM, Collins JJ Cell 2022 Apr 185 1506-1520.e17
- Compartmentalized metabolism supports midgestation mammalian development
  Solmonson A, Faubert B, Gu W, Rao A, Cowdin MA, Menendez-Montes I, Kelekar S, Rogers TJ, Pan C, Guevara G, Tarangelo A, Zacharias LG, Martin-Sandoval MS, Do D, Pachnis P, Dumesnil D, Mathews TP, Tasdogan A, Pham A, Cai L, Zhao Z, Ni M, Cleaver O, Sadek HA, Morrison SJ, DeBerardinis RJ Nature 2022 Apr 604 349-353
- Clinically relevant T cell expansion media activate distinct metabolic programs uncoupled from cellular function
  MacPherson S, Keyes S, Kilgour MK, Smazynski J, Chan V, Sudderth J, Turcotte T, Devlieger A, Yu J, Huggler KS, Cantor JR, DeBerardinis RJ, Siatskas C, Lum JJ Molecular Therapy Methods and Clinical Development 2022 Mar 24 380-393
- Mitochondrial enzyme GPT2 regulates metabolic mechanisms required for neuron growth and motor function in vivo
  Baytas O, Davidson SM, Deberardinis RJ, Morrow EM Human molecular genetics 2022 Feb 31 587-603
- Integrated Metabolic Profiling and Transcriptional Analysis Reveals Therapeutic Modalities for Targeting Rapidly Proliferating Breast Cancers
  Liao C, Glodowski CR, Fan C, Liu J, Mott KR, Kaushik A, Vu H, Locasale JW, McBrayer SK, DeBerardinis RJ, Perou CM, Zhang Q Cancer research 2022 Feb 82 665-680
- Loss of glucose 6-phosphate dehydrogenase function increases oxidative stress and glutaminolysis in metastasizing melanoma cells
  Aurora AB, Khivansara V, Leach A, Gill JG, Martin-Sandoval M, Yang C, Kasitinon SY, Bezwada D, Tasdogan A, Gu W, Mathews TP, Zhao Z, DeBerardinis RJ, Morrison SJ Proceedings of the National Academy of Sciences of the United States of America 2022 Feb 119
- Metabolic diversity within breast cancer brain-tropic cells determines metastatic fitness
  Parida PK, Marquez-Palencia M, Nair V, Kaushik AK, Kim K, Sudderth J, Quesada-Diaz E, Cajigas A, Vemireddy V, Gonzalez-Ericsson PI, Sanders ME, Mobley BC, Huffman K, Sahoo S, Alluri P, Lewis C, Peng Y, Bachoo RM, Arteaga CL, Hanker AB, DeBerardinis RJ, Malladi S Cell Metabolism 2022 Jan 34 90-105.e7
- In vivo characterization of glutamine metabolism identifies therapeutic targets in clear cell renal cell carcinoma
  Kaushik AK, Tarangelo A, Boroughs LK, Ragavan M, Zhang Y, Wu CY, Li X, Ahumada K, Chiang JC, Tcheuyap VT, Saatchi F, Do QN, Yong C, Rosales T, Stevens C, Rao AD, Faubert B, Pachnis P, Zacharias LG, Vu H, Cai F, Mathews TP, Genovese G, Slusher BS, Kapur P, Sun X, Merritt M, Brugarolas J, DeBerardinis RJ Science Advances 2022 8
- Cell-autonomous immune gene expression is repressed in pulmonary neuroendocrine cells and small cell lung cancer
  Cai L, Liu H, Huang F, Fujimoto J, Girard L, Chen J, Li Y, Zhang YA, Deb D, Stastny V, Pozo K, Kuo CS, Jia G, Yang C, Zou W, Alomar A, Huffman K, Papari-Zareei M, Yang L, Drapkin B, Akbay EA, Shames DS, Wistuba II, Wang T, Johnson JE, Xiao G, DeBerardinis RJ, Minna JD, Xie Y, Gazdar AF Communications Biology 2021 Dec 4
- Assessing consistency across functional screening datasets in cancer cells
  Cai L, Liu H, Minna JD, Deberardinis RJ, Xiao G, Xie Y Bioinformatics 2021 Dec 37 4540-4547
- Glutaminase isoforms expression switches microRNA levels and oxidative status in glioblastoma cells
  de los Santos-Jiménez J, Campos-Sandoval JA, Márquez-Torres C, Urbano-Polo N, Brøndegaard D, Martín-Rufián M, Lobo C, Peñalver A, Gómez-García MC, Martín-Campos J, Cardona C, Castilla L, da Costa Souza F, Cheng T, Segura JA, Alonso FJ, Curi R, Colquhoun A, DeBerardinis RJ, Márquez J, Matés JM Journal of biomedical science 2021 Dec 28
- Stable isotope tracing to assess tumor metabolism in vivo
  Faubert B, Tasdogan A, Morrison SJ, Mathews TP, DeBerardinis RJ Nature Protocols 2021 Nov 16 5123-5145
- Profiling Carbohydrate Metabolism in Liver and Hepatocellular Carcinoma with [¹³C]-Glycerate Probes
  Chen J, LaGue E, Li J, Yang C, Hackett EP, Mendoza M, Alger JR, DeBerardinis RJ, Corbin IR, Billingsley KL, Park JM Analysis and Sensing 2021 Nov 1 196-202
- A renal cell carcinoma tumorgraft platform to advance precision medicine
  Elias R, Tcheuyap VT, Kaushik AK, Singla N, Gao M, Reig Torras O, Christie A, Mulgaonkar A, Woolford L, Stevens C, Kettimuthu KP, Pavia-Jimenez A, Boroughs LK, Joyce A, Dakanali M, Notgrass H, Margulis V, Cadeddu JA, Pedrosa I, Williams NS, Sun X, DeBerardinis RJ, Öz OK, Zhong H, Seshagiri S, Modrusan Z, Cantarel BL, Kapur P, Brugarolas J Cell Reports 2021 Nov 37
- Metabolic Plasticity of Neutrophils: Relevance to Pathogen Responses and Cancer
  Rogers T, DeBerardinis RJ Trends in Cancer 2021 Aug 7 700-713
- Metabolic impact of pathogenic variants in the mitochondrial glutamyl-tRNA synthetase EARS2
  Ni M, Black LF, Pan C, Vu H, Pei J, Ko B, Cai L, Solmonson A, Yang C, Nugent KM, Grishin NV, Xing C, Roeder E, DeBerardinis RJ Journal of Inherited Metabolic Disease 2021 Jul 44 949-960
- A pathogenic UFSP2 variant in an autosomal recessive form of pediatric neurodevelopmental anomalies and epilepsy
  Ni M, Afroze B, Xing C, Pan C, Shao Y, Cai L, Cantarel BL, Pei J, Grishin NV, Hewson S, Knight D, Mahida S, Michel D, Tarnopolsky M, Poduri A, Rotenberg A, Sondheimer N, DeBerardinis RJ Genetics in Medicine 2021 May 23 900-908
- Mitochondrial NADP⁺ is essential for proline biosynthesis during cell growth
  Tran DH, Kesavan R, Rion H, Soflaee MH, Solmonson A, Bezwada D, Vu HS, Cai F, Phillips JA, DeBerardinis RJ, Hoxhaj G Nature Metabolism 2021 Apr 3 571-585
- Isotope tracing reveals glycolysis and oxidative metabolism in childhood tumors of multiple histologies
  Johnston K, Pachnis P, Tasdogan A, Faubert B, Zacharias LG, Vu HS, Rodgers-Augustyniak L, Johnson A, Huang F, Ricciardo S, Zhao Z, Mathews TP, Watt T, Leavey P, DeBerardinis RJ Med 2021 Apr 2 395-410.e4
- The major cap-binding protein eIF4E regulates lipid homeostasis and diet-induced obesity
  Conn CS, Yang H, Tom HJ, Ikeda K, Oses-Prieto JA, Vu H, Oguri Y, Nair S, Gill RM, Kajimura S, DeBerardinis RJ, Burlingame AL, Ruggero D Nature Metabolism 2021 Feb 3 244-257
- 1-Methylnicotinamide is an immune regulatory metabolite in human ovarian cancer
  Kilgour MK, MacPherson S, Zacharias LG, Ellis AE, Sheldon RD, Liu EY, Keyes S, Pauly B, Carleton G, Allard B, Smazynski J, Williams KS, Watson PH, Stagg J, Nelson BH, DeBerardinis RJ, Jones RG, Hamilton PT, Lum JJ Science Advances 2021 Jan 7
- Clinico-pathological and molecular spectrum of biotinidase deficiency- experience from a lower middle-income country
  Ahmed S, Ni M, DeBerardinis RJ, Habib A, Akbar F, Afroze B Clinical Laboratory 2021 67 1429-1439
- Guanosine triphosphate links MYC-dependent metabolic and ribosome programs in small-cell lung cancer
  Huang F, Huffman KE, Wang Z, Wang X, Li K, Cai F, Yang C, Cai L, Shih TS, Zacharias LG, Chung A, Yang Q, Chalishazar MD, Ireland AS, Stewart CA, Cargill K, Girard L, Liu Y, Ni M, Xu J, Wu X, Zhu H, Drapkin B, Byers LA, Oliver TG, Gazdar AF, Minna JD, DeBerardinis RJ Journal of Clinical Investigation 2021 Jan 131
- Regulation of branched-chain amino acid metabolism by hypoxia-inducible factor in glioblastoma
  Zhang B, Chen Y, Shi X, Zhou M, Bao L, Hatanpaa KJ, Patel T, DeBerardinis RJ, Wang Y, Luo W Cellular and Molecular Life Sciences 2021 Jan 78 195-206
- Using arterial–venous analysis to characterize cancer metabolic consumption in patients
  Xiong N, Gao X, Zhao H, Cai F, Zhang Fc, Yuan Y, Liu W, He F, Zacharias LG, Lin H, Vu HS, Xing C, Yao DX, Chen F, Luo B, Sun W, DeBerardinis RJ, Xu H, Ge Wp Nature communications 2020 Dec 11
- The hexosamine biosynthesis pathway is a targetable liability in KRAS/LKB1 mutant lung cancer
  Kim J, Lee HM, Cai F, Ko B, Yang C, Lieu EL, Muhammad N, Rhyne S, Li K, Haloul M, Gu W, Faubert B, Kaushik AK, Cai L, Kasiri S, Marriam U, Nham K, Girard L, Wang H, Sun X, Kim J, Minna JD, Unsal-Kacmaz K, DeBerardinis RJ Nature Metabolism 2020 Dec 2 1401-1412
- Vitamin B6-dependent epilepsy due to pyridoxal phosphate-binding protein (PLPBP) defect – First case report from Pakistan and review of literature
  Ahmed S, DeBerardinis RJ, Ni M, Afroze B Annals of Medicine and Surgery 2020 Dec 60 721-727
- Concentration-dependent early antivascular and antitumor effects of itraconazole in non-small cell lung cancer
  Gerber DE, Putnam WC, Fattah FJ, Kernstine KH, Brekken RA, Pedrosa I, Skelton R, Saltarski JM, Lenkinski RE, Leff RD, Ahn C, Padmanabhan C, Chembukar V, Kasiri S, Kallem RR, Subramaniyan I, Yuan Q, Do QN, Xi Y, Reznik SI, Pelosof L, Faubert B, DeBerardinis RJ, Kim J Clinical Cancer Research 2020 Nov 26 6017-6027
- Delaying surgery for patients with a previous SARS-CoV-2 infection
  Author Collaboration CC, Glasbey JC, Nepogodiev D, Omar O, Simoes JF, Ademuyiwa A, Fiore M, Minaya-Bravo A, Shaw R, Vidya R, Bhangu A, Omar O, Bhangu AA, Siaw-Acheampong K, Benson R, Bywater E, Chaudhry D, Dawson BE, Evans JP, Gujjuri RR, Heritage E, Jones CS, Kamarajah SK, Khatri C, Khaw RA, Keatley JM, Knight A, Lawday S, Li E, Mann HS, Marson EJ, McLean KA, Mckay SC, Mills EC, Nepogodiev D, Pellino G, Picciochi M, Taylor EH, Tiwari A, Simoes JF, Trout IM, Venn ML, Wilkin RJ, Bhangu A, Evans JP, Moug S, Vimalchandran D, Vallance A, Pockney PG, Aoun S, Batjer HH British Journal of Surgery 2020 Nov 107 e601-e602
- N-Acetyl cysteine abrogates silver-induced reactive oxygen species in human cells without altering silver-based antimicrobial activity
  Shah KN, Shah PN, Mullen AR, Chen Q, Southerland MR, Chirra B, DeBerardinis RJ, Cannon CL Toxicology Letters 2020 Oct 332 118-129
- The transcription factors aryl hydrocarbon receptor and MYC cooperate in the regulation of cellular metabolism
  Lafita-Navarro MC, Perez-Castro L, Zacharias LG, Barnes S, DeBerardinis RJ, Conacci-Sorrell M Journal of Biological Chemistry 2020 Aug 295
- Mitochondrial fatty acid synthesis coordinates oxidative metabolism in mammalian mitochondria
  Nowinski SM, Solmonson A, Rusin SF, Maschek JA, Bensard CL, Fogarty S, Jeong MY, Lettlova S, Berg JA, Morgan JT, Ouyang Y, Naylor BC, Paulo JA, Funai K, Cox JE, Gygi SP, Winge DR, Deberardinis RJ, Rutter J eLife 2020 Aug 9 1-35
- Glycine by MR spectroscopy is an imaging biomarker of glioma aggressiveness
  Vivek T, Elena VD, Kimmo JH, Ang G, Song Z, Zhongxu A, Sandeep KG, Jack MR, Cheryl ML, Pegah A, Jeannie B, Michael L, Ivan D, Binu PT, Marco CP, Christopher JM, Pan E, Toral RP, Ralph JD, Sherry AD, Bruce EM, Craig RM, Elizabeth AM, Choi C Neuro-oncology 2020 Jul 22 1018-1029
- EWS-FLI1-regulated serine synthesis and exogenous serine are necessary for ewing sarcoma cellular proliferation and tumor growth
  Issaq SH, Mendoza A, Kidner R, Rosales TI, Duveau DY, Heske CM, Rohde JM, Boxer MB, Thomas CJ, DeBerardinis RJ, Helman LJ Molecular Cancer Therapeutics 2020 Jul 19 1520-1529
- α-ketobutyrate links alterations in cystine metabolism to glucose oxidation in mtDNA mutant cells
  Lesner NP, Gokhale AS, Kota K, DeBerardinis RJ, Mishra P Metabolic Engineering 2020 Jul 60 157-167
- Does Tumor FDG-PET Avidity Represent Enhanced Glycolytic Metabolism in Non-Small Cell Lung Cancer?
  Kernstine KH, Faubert B, Do QN, Rogers TJ, Hensley CT, Cai L, Torrealba J, Oliver D, Wachsmann JW, Lenkinski RE, Malloy CR, Deberardinis RJ Annals of Thoracic Surgery 2020 Apr 109 1019-1025
- Metabolic reprogramming and cancer progression
  Faubert B, Solmonson A, DeBerardinis RJ Science 2020 Apr 368
- Assessment of Rapid Hepatic Glycogen Synthesis in Humans Using Dynamic ¹³C Magnetic Resonance Spectroscopy
  Stender S, Zaha VG, Malloy CR, Sudderth J, DeBerardinis RJ, Park JM Hepatology Communications 2020 Mar 4 425-433
- Tumor microenvironment, metabolism, and immunotherapy
  DeBerardinis RJ New England Journal of Medicine 2020 Feb 382 869-871
- Mechanical regulation of glycolysis via cytoskeleton architecture
  Park JS, Burckhardt CJ, Lazcano R, Solis LM, Isogai T, Li L, Chen CS, Gao B, Minna JD, Bachoo R, DeBerardinis RJ, Danuser G Nature 2020 Feb 578 621-626
- We need to talk about the Warburg effect
  DeBerardinis RJ, Chandel NS Nature Metabolism 2020 Feb 2 127-129
- Leveraging insights into cancer metabolism—a symposium report
  Cable J, Finley L, Tu BP, Patti GJ, Oliver TG, Vardhana S, Mana M, Ericksen R, Khare S, DeBerardinis R, Stockwell BR, Edinger A, Haigis M, Kaelin W Annals of the New York Academy of Sciences 2020 1462 5-13
- Metabolic heterogeneity confers differences in melanoma metastatic potential
  Tasdogan A, Faubert B, Ramesh V, Ubellacker JM, Shen B, Solmonson A, Murphy MM, Gu Z, Gu W, Martin M, Kasitinon SY, Vandergriff T, Mathews TP, Zhao Z, Schadendorf D, DeBerardinis RJ, Morrison SJ Nature 2020 Jan 577 115-120
- p53 deficiency triggers dysregulation of diverse cellular processes in physiological oxygen
  Valente LJ, Tarangelo A, Li AM, Naciri M, Raj N, Boutelle AM, Li Y, Mello SS, Bieging-Rolett K, Deberardinis RJ, Ye J, Dixon SJ, Attardi LD Journal of Cell Biology 2020 219
- Metabolic Diversity in Human Non-Small Cell Lung Cancer Cells
  Chen PH, Cai L, Huffman K, Yang C, Kim J, Faubert B, Boroughs L, Ko B, Sudderth J, McMillan EA, Girard L, Chen D, Peyton M, Shields MD, Yao B, Shames DS, Kim HS, Timmons B, Sekine I, Britt R, Weber S, Byers LA, Heymach JV, Chen J, White MA, Minna JD, Xiao G, DeBerardinis RJ Molecular cell 2019 Dec 76 838-851.e5
- Active pyruvate dehydrogenase and impaired gluconeogenesis in orthotopic hepatomas of rats
  Lee MH, DeBerardinis RJ, Wen X, Corbin IR, Sherry AD, Malloy CR, Jin ES Metabolism: clinical and experimental 2019 Dec 101
- γ-6-Phosphogluconolactone, a Byproduct of the Oxidative Pentose Phosphate Pathway, Contributes to AMPK Activation through Inhibition of PP2A
  Gao X, Zhao L, Liu S, Li Y, Xia S, Chen D, Wang M, Wu S, Dai Q, Vu H, Zacharias L, DeBerardinis R, Lim E, Metallo C, Boggon TJ, Lonial S, Lin R, Mao H, Pan Y, Shan C, Chen J Molecular cell 2019 Dec 76 857-871.e9
- Reactive metabolite production is a targetable liability of glycolytic metabolism in lung cancer
  Luengo A, Abbott KL, Davidson SM, Hosios AM, Faubert B, Chan SH, Freinkman E, Zacharias LG, Mathews TP, Clish CB, DeBerardinis RJ, Lewis CA, Vander Heiden MG Nature communications 2019 Dec 10
- Metabolic vulnerability in tumours illuminated
  Rao AD, DeBerardinis RJ Nature 2019 Nov 575 296-297
- A novel mitochondrial inhibitor blocks MAPK pathway and overcomes MAPK inhibitor resistance in melanoma
  Gopal YN, Gammon S, Prasad R, Knighton B, Pisaneschi F, Roszik J, Feng N, Johnson S, Pramanik S, Sudderth J, Sui D, Hudgens C, Fischer GM, Deng W, Reuben A, Peng W, Wang J, McQuade JL, Tetzlaff MT, Di Francesco ME, Marszalek J, Piwnica-Worms D, DeBerardinis RJ, Davies MA Clinical Cancer Research 2019 Nov 25 6429-6442
- Metabolic Profiling Using Stable Isotope Tracing Reveals Distinct Patterns of Glucose Utilization by Physiologically Activated CD8⁺ T Cells
  Ma EH, Verway MJ, Johnson RM, Roy DG, Steadman M, Hayes S, Williams KS, Sheldon RD, Samborska B, Kosinski PA, Kim H, Griss T, Faubert B, Condotta SA, Krawczyk CM, DeBerardinis RJ, Stewart KM, Richer MJ, Chubukov V, Roddy TP, Jones RG Immunity 2019 Nov 51 856-870.e5
- Induction of LEF1 by MYC activates the WNT pathway and maintains cell proliferation
  Hao YH, Lafita-Navarro MC, Zacharias L, Borenstein-Auerbach N, Kim M, Barnes S, Kim J, Shay J, Deberardinis RJ, Conacci-Sorrell M Cell Communication and Signaling 2019 Oct 17
- MYC promotes tryptophan uptake and metabolism by the kynurenine pathway in colon cancer
  Venkateswaran N, Lafita-Navarro MC, Hao YH, Kilgore JA, Perez-Castro L, Braverman J, Borenstein-Auerbach N, Kim M, Lesner NP, Mishra P, Brabletz T, Shay JW, DeBerardinis RJ, Williams NS, Yilmaz OH, Conacci-Sorrell M Genes and Development 2019 Sep 33 1236-1251
- Mechanisms and Implications of Metabolic Heterogeneity in Cancer
  Kim J, DeBerardinis RJ Cell Metabolism 2019 Sep 30 434-446
- IMP dehydrogenase-2 drives aberrant nucleolar activity and promotes tumorigenesis in glioblastoma
  Kofuji S, Hirayama A, Eberhardt AO, Kawaguchi R, Sugiura Y, Sampetrean O, Ikeda Y, Warren M, Sakamoto N, Kitahara S, Yoshino H, Yamashita D, Sumita K, Wolfe K, Lange L, Ikeda S, Shimada H, Minami N, Malhotra A, Morioka S, Ban Y, Asano M, Flanary VL, Ramkissoon A, Chow LM, Kiyokawa J, Mashimo T, Lucey G, Mareninov S, Ozawa T, Onishi N, Okumura K, Terakawa J, Daikoku T, Wise-Draper T, Majd N, Kofuji K, Sasaki M, Mori M, Kanemura Y, Smith EP, Anastasiou D, Wakimoto H, Holland EC, Yong WH, Horbinski C, Nakano I, DeBerardinis RJ, Bachoo RM, Mischel PS, Yasui W, Suematsu M, Saya H, Soga T, Grummt I, Bierhoff H, Sasaki AT Nature cell biology 2019 Aug 21 1003-1014
- AIF: an acquired metabolic liability in lung cancer
  Faubert B, DeBerardinis RJ, Minna JD Cell Research 2019 Aug 29 607-608
- MYC-driven small-cell lung cancer is metabolically distinct and vulnerable to arginine depletion
  Chalishazar MD, Wait SJ, Huang F, Ireland AS, Mukhopadhyay A, Lee Y, Schuman SS, Guthrie MR, Berrett KC, Vahrenkamp JM, Hu Z, Kudla M, Modzelewska K, Wang G, Ingolia NT, Gertz J, Lum DH, Cosulich SC, Bomalaski JS, DeBerardinis RJ, Oliver TG Clinical Cancer Research 2019 Aug 25 5107-5121
- p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas
  Hsieh MH, Choe JH, Gadhvi J, Kim YJ, Arguez MA, Palmer M, Gerold H, Nowak C, Do H, Mazambani S, Knighton JK, Cha M, Goodwin J, Kang MK, Jeong JY, Lee SY, Faubert B, Xuan Z, Abel ED, Scafoglio C, Shackelford DB, Minna JD, Singh PK, Shulaev V, Bleris L, Hoyt K, Kim J, Inoue M, DeBerardinis RJ, Kim TH, Kim Jw Cell Reports 2019 Aug 28 1860-1878.e9
- Systematic analysis of gene expression in lung adenocarcinoma and squamous cell carcinoma with a case study of FAM83A and FAM83B
  Cai L, Luo D, Yao B, Yang D, Lin S, Girard L, Deberardinis RJ, Minna JD, Xie Y, Xiao G Cancers 2019 Jun 11
- Molecular profiling reveals unique immune and metabolic features of melanoma brain metastases
  Fischer GM, Jalali A, Kircher DA, Lee WC, McQuade JL, Haydu LE, Joon AY, Reuben A, de Macedo MP, Carapeto FC, Yang C, Srivastava A, Ambati CR, Sreekumar A, Hudgens CW, Knighton B, Deng W, Ferguson SD, Tawbi HA, Glitza IC, Gershenwald JE, Vashisht Gopal YN, Hwu P, Huse JT, Wargo JA, Andrew Futreal P, Putluri N, Lazar AJ, Deberardinis RJ, Marszalek JR, Zhang J, Holmen SL, Tetzlaff MT, Davies MA Cancer discovery 2019 May 9 628-645
- Author Correction: CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells (Nature, (2017), 546, 7656, (168-172), 10.1038/nature22359)
  Kim J, Hu Z, Cai L, Li K, Choi E, Faubert B, Bezwada D, Rodriguez-Canales J, Villalobos P, Lin YF, Ni M, Huffman KE, Girard L, Byers LA, Unsal-Kacmaz K, Peña CG, Heymach JV, Wauters E, Vansteenkiste J, Castrillon DH, Chen BP, Wistuba I, Lambrechts D, Xu J, Minna JD, DeBerardinis RJ Nature 2019 May 569 E4
- Autophagy Regulation of Metabolism Is Required for CD8 ⁺ T Cell Anti-tumor Immunity
  DeVorkin L, Pavey N, Carleton G, Comber A, Ho C, Lim J, McNamara E, Huang H, Kim P, Zacharias LG, Mizushima N, Saitoh T, Akira S, Beckham W, Lorzadeh A, Moksa M, Cao Q, Murthy A, Hirst M, DeBerardinis RJ, Lum JJ Cell Reports 2019 Apr 27 502-513.e5
- Functional Assessment of Lipoyltransferase-1 Deficiency in Cells, Mice, and Humans
  Ni M, Solmonson A, Pan C, Yang C, Li D, Notzon A, Cai L, Guevara G, Zacharias LG, Faubert B, Vu HS, Jiang L, Ko B, Morales NM, Pei J, Vale G, Rakheja D, Grishin NV, McDonald JG, Gotway GK, McNutt MC, Pascual JM, DeBerardinis RJ Cell Reports 2019 Apr 27 1376-1386.e6
- Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity
  Vriens K, Christen S, Parik S, Broekaert D, Yoshinaga K, Talebi A, Dehairs J, Escalona-Noguero C, Schmieder R, Cornfield T, Charlton C, Romero-Pérez L, Rossi M, Rinaldi G, Orth MF, Boon R, Kerstens A, Kwan SY, Faubert B, Méndez-Lucas A, Kopitz CC, Chen T, Fernandez-Garcia J, Duarte JA, Schmitz AA, Steigemann P, Najimi M, Hägebarth A, Van Ginderachter JA, Sokal E, Gotoh N, Wong KK, Verfaillie C, Derua R, Munck S, Yuneva M, Beretta L, DeBerardinis RJ, Swinnen JV, Hodson L, Cassiman D, Verslype C, Christian S, Grünewald S, Grünewald TG, Fendt SM Nature 2019 Feb 566 403-406
- Loss of EZH2 reprograms BCAA metabolism to drive leukemic transformation
  Gu Z, Liu Y, Cai F, Patrick M, Zmajkovic J, Cao H, Zhang Y, Tasdogan A, Chen M, Qi L, Liu X, Li K, Lyu J, Dickerson KE, Chen W, Ni M, Merritt ME, Morrison SJ, Skoda RC, Deberardinis RJ, Xu J Cancer discovery 2019 9 1228-1247
- LKB1 and KEAP1/NRF2 pathways cooperatively promote metabolic reprogramming with enhanced glutamine dependence inKRAS-mutant lung adenocarcinoma
  Galan-Cobo A, Sitthideatphaiboon P, Qu X, Poteete A, Pisegna MA, Tong P, Chen PH, Boroughs LK, Rodriguez ML, Zhang W, Parlati F, Wang J, Gandhi V, Skoulidis F, DeBerardinis RJ, Minna JD, Heymach JV Cancer research 2019 79 3251-3267
- Gain-of-function variants in the ODC1 gene cause a syndromic neurodevelopmental disorder associated with macrocephaly, alopecia, dysmorphic features, and neuroimaging abnormalities
  Rodan LH, Anyane-Yeboa K, Chong K, Klein Wassink-Ruiter JS, Wilson A, Smith L, Kothare SV, Rajabi F, Blaser S, Ni M, DeBerardinis RJ, Poduri A, Berry GT American Journal of Medical Genetics, Part A 2018 Dec 176 2554-2560
- Lkb1 deficiency confers glutamine dependency in polycystic kidney disease
  Flowers EM, Sudderth J, Zacharias L, Mernaugh G, Zent R, Deberardinis RJ, Carroll TJ Nature communications 2018 Dec 9
- Transmembrane Protease TMPRSS11B Promotes Lung Cancer Growth by Enhancing Lactate Export and Glycolytic Metabolism
  Updegraff BL, Zhou X, Guo Y, Padanad MS, Chen PH, Yang C, Sudderth J, Rodriguez-Tirado C, Girard L, Minna JD, Mishra P, DeBerardinis RJ, O'Donnell-Mendell KA Cell Reports 2018 Nov 25 2223-2233.e6
- Isotope Tracing of Human Clear Cell Renal Cell Carcinomas Demonstrates Suppressed Glucose Oxidation In Vivo
  Courtney KD, Bezwada D, Mashimo T, Pichumani K, Vemireddy V, Funk AM, Wimberly J, McNeil SS, Kapur P, Lotan Y, Margulis V, Cadeddu JA, Pedrosa I, DeBerardinis RJ, Malloy CR, Bachoo R, Maher EA Cell Metabolism 2018 Nov 28 793-800.e2
- Inosine Monophosphate Dehydrogenase Dependence in a Subset of Small Cell Lung Cancers
  Huang F, Ni M, Chalishazar MD, Huffman KE, Kim J, Cai L, Shi X, Cai F, Zacharias LG, Ireland AS, Li K, Gu W, Kaushik AK, Liu X, Gazdar AF, Oliver TG, Minna JD, Hu Z, DeBerardinis RJ Cell Metabolism 2018 Sep 28 369-382.e5
- Applications of metabolomics to study cancer metabolism
  Kaushik AK, DeBerardinis RJ Biochimica et Biophysica Acta - Reviews on Cancer 2018 Aug 1870 2-14
- Chemistry-First Approach for Nomination of Personalized Treatment in Lung Cancer
  McMillan EA, Ryu MJ, Diep CH, Mendiratta S, Clemenceau JR, Vaden RM, Kim JH, Motoyaji T, Covington KR, Peyton M, Huffman K, Wu X, Girard L, Sung Y, Chen PH, Mallipeddi PL, Lee JY, Hanson J, Voruganti S, Yu Y, Park S, Sudderth J, DeSevo C, Muzny DM, Doddapaneni HV, Gazdar A, Gibbs RA, Hwang TH, Heymach JV, Wistuba I, Coombes KR, Williams NS, Wheeler DA, MacMillan JB, Deberardinis RJ, Roth MG, Posner BA, Minna JD, Kim HS, White MA Cell 2018 May 173 864-878.e29
- Loss of a Negative Regulator of mTORC1 Induces Aerobic Glycolysis and Altered Fiber Composition in Skeletal Muscle
  Dutchak PA, Estill-Terpack SJ, Plec AA, Zhao X, Yang C, Chen J, Ko B, Deberardinis RJ, Yu Y, Tu BP Cell Reports 2018 May 23 1907-1914
- Metabolic regulation of transcription through compartmentalized NAD⁺ biosynthesis
  Ryu KW, Nandu T, Kim J, Challa S, DeBerardinis RJ, Lee Kraus W Science 2018 May 360
- Differential glucose requirement in skin homeostasis and injury identifies a therapeutic target for psoriasis article
  Zhang Z, Zi Z, Lee EE, Zhao J, Contreras DC, South AP, Abel ED, Chong BF, Vandergriff T, Hosler GA, Scherer PE, Mettlen M, Rathmell JC, DeBerardinis RJ, Wang RC Nature medicine 2018 May 24 617-627
- Lipoic acid metabolism and mitochondrial redox regulation
  Solmonson A, DeBerardinis RJ Journal of Biological Chemistry 2018 May 293 7522-7530
- RIPK1-mediated induction of mitophagy compromises the viability of extracellular-matrix-detached cells
  Hawk MA, Gorsuch CL, Fagan P, Lee C, Kim SE, Hamann JC, Mason JA, Weigel KJ, Tsegaye MA, Shen L, Shuff S, Zuo J, Hu S, Jiang L, Chapman S, Leevy WM, Deberardinis RJ, Overholtzer M, Schafer ZT Nature cell biology 2018 Mar 20 272-284
- Molecular mechanisms of cell death: Recommendations of the Nomenclature Committee on Cell Death 2018
  Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Annicchiarico-Petruzzelli M, Antonov AV, Arama E, Baehrecke EH, Barlev NA, Bazan NG, Bernassola F, Bertrand MJ, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Boya P, Brenner C, Campanella M, Candi E, Carmona-Gutierrez D, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Cohen GM, Conrad M, Cubillos-Ruiz JR, Czabotar PE, D'Angiolella V, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, Deberardinis RJ, Deshmukh M, Di Daniele N, Di Virgilio F, Dixit VM, Dixon SJ, Duckett CS, Dynlacht BD, El-Deiry WS, Elrod JW, Fimia GM, Fulda S, García-Sáez AJ, Garg AD, Garrido C, Gavathiotis E, Golstein P, Gottlieb E, Green DR, Greene LA, Gronemeyer H, Gross A, Hajnoczky G, Hardwick JM, Harris IS, Hengartner MO, Hetz C, Ichijo H, Jäättelä M, Joseph B, Jost PJ, Juin PP, Kaiser WJ, Karin M, Kaufmann T, Kepp O, Kimchi A, Kitsis RN, Klionsky DJ, Knight RA, Kumar S, Lee SW, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lowe SW, Luedde T, Lugli E, MacFarlane M, Madeo F, Malewicz M, Malorni W, Manic G, Marine JC, Martin SJ, Martinou JC, Medema JP, Mehlen P, Meier P, Melino S, Miao EA, Molkentin JD, Moll UM, Muñoz-Pinedo C, Nagata S, Nuñez G, Oberst A, Oren M, Overholtzer M, Pagano M, Panaretakis T, Pasparakis M, Penninger JM, Pereira DM, Pervaiz S, Peter ME, Piacentini M, Pinton P, Prehn JH, Puthalakath H, Rabinovich GA, Rehm M, Rizzuto R, Rodrigues CM, Rubinsztein DC, Rudel T, Ryan KM, Sayan E, Scorrano L, Shao F, Shi Y, Silke J, Simon HU, Sistigu A, Stockwell BR, Strasser A, Szabadkai G, Tait SW, Tang D, Tavernarakis N, Thorburn A, Tsujimoto Y, Turk B, Vanden Berghe T, Vandenabeele P, Vander Heiden MG, Villunger A, Virgin HW, Vousden KH, Vucic D, Wagner EF, Walczak H, Wallach D, Wang Y, Wells JA, Wood W, Yuan J, Zakeri Z, Zhivotovsky B, Zitvogel L, Melino G, Kroemer G Cell Death and Differentiation 2018 Mar 25 486-541
- Metabolic strategies of melanoma cells: Mechanisms, interactions with the tumor microenvironment, and therapeutic implications
  Fischer GM, Vashisht Gopal YN, McQuade JL, Peng W, DeBerardinis RJ, Davies MA Pigment Cell and Melanoma Research 2018 Jan 31 11-30
- Genomic regression analysis of coordinated expression
  Cai L, Li Q, Du Y, Yun J, Xie Y, Deberardinis RJ, Xiao G Nature communications 2017 Dec 8
- Oxidation of [U-¹³C]glucose in the human brain at 7T under steady state conditions
  Cheshkov S, Dimitrov IE, Jakkamsetti V, Good L, Kelly D, Rajasekaran K, Deberardinis RJ, Pascual JM, Sherry AD, Malloy CR Magnetic resonance in medicine 2017 Dec 78 2065-2071
- The NQO1 bioactivatable drug, β-lapachone, alters the redox state of NQO1 pancreatic cancer cells, causing perturbation in central carbon metabolism
  Silvers MA, Deja S, Singh N, Egnatchik RA, Sudderth J, Luo X, Beg MS, Burgess SC, DeBerardinis RJ, Boothman DA, Merritt ME Journal of Biological Chemistry 2017 Nov 292 18203-18216
- Lactate Metabolism in Human Lung Tumors
  Faubert B, Li KY, Cai L, Hensley CT, Kim J, Zacharias LG, Yang C, Do QN, Doucette S, Burguete D, Li H, Huet G, Yuan Q, Wigal T, Butt Y, Ni M, Torrealba J, Oliver D, Lenkinski RE, Malloy CR, Wachsmann JW, Young JD, Kernstine K, DeBerardinis RJ Cell 2017 Oct 171 358-371.e9
- Ascorbate regulates haematopoietic stem cell function and leukaemogenesis
  Agathocleous M, Meacham CE, Burgess RJ, Piskounova E, Zhao Z, Crane GM, Cowin BL, Bruner E, Murphy MM, Chen W, Spangrude GJ, Hu Z, DeBerardinis RJ, Morrison SJ Nature 2017 Sep 549 476-481
- Engineering approaches to study cancer metabolism
  Metallo CM, Deberardinis RJ Metabolic Engineering 2017 Sep 43 93
- Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism
  Schell JC, Wisidagama DR, Bensard C, Zhao H, Wei P, Tanner J, Flores A, Mohlman J, Sorensen LK, Earl CS, Olson KA, Miao R, Waller TC, Delker D, Kanth P, Jiang L, DeBerardinis RJ, Bronner MP, Li DY, Cox JE, Christofk HR, Lowry WE, Thummel CS, Rutter J Nature cell biology 2017 Sep 19 1027-1036
- Quantitative metabolic flux analysis reveals an unconventional pathway of fatty acid synthesis in cancer cells deficient for the mitochondrial citrate transport protein
  Jiang L, Boufersaoui A, Yang C, Ko B, Rakheja D, Guevara G, Hu Z, DeBerardinis RJ Metabolic Engineering 2017 Sep 43 198-207
- Addressing metabolic heterogeneity in clear cell renal cell carcinoma with quantitative Dixon MRI
  Zhang Y, Udayakumar D, Cai L, Hu Z, Kapur P, Kho EY, Pavía-Jiménez A, Fulkerson M, de Leon AD, Yuan Q, Dimitrov IE, Yokoo T, Ye J, Mitsche MA, Kim H, McDonald JG, Xi Y, Madhuranthakam AJ, Dwivedi DK, Lenkinski RE, Cadeddu JA, Margulis V, Brugarolas J, DeBerardinis RJ, Pedrosa I JCI Insight 2017 Aug 2
- Using a novel NQO1 bioactivatable drug, beta-lapachone (ARQ761), to enhance chemotherapeutic effects by metabolic modulation in pancreatic cancer
  Beg MS, Huang X, Silvers MA, Gerber DE, Bolluyt J, Sarode V, Fattah F, Deberardinis RJ, Merritt ME, Xie XJ, Leff R, Laheru D, Boothman DA Journal of Surgical Oncology 2017 Jul 116 83-88
- Cytochrome c Oxidase Activity Is a Metabolic Checkpoint that Regulates Cell Fate Decisions During T Cell Activation and Differentiation
  Tarasenko TN, Pacheco SE, Koenig MK, Gomez-Rodriguez J, Kapnick SM, Diaz F, Zerfas PM, Barca E, Sudderth J, DeBerardinis RJ, Covian R, Balaban RS, DiMauro S, McGuire PJ Cell Metabolism 2017 Jun 25 1254-1268.e7
- CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells
  Kim J, Hu Z, Cai L, Li K, Choi E, Faubert B, Bezwada D, Rodriguez-Canales J, Villalobos P, Lin YF, Ni M, Huffman KE, Girard L, Byers LA, Unsal-Kacmaz K, Peña CG, Heymach JV, Wauters E, Vansteenkiste J, Castrillon DH, Chen BP, Wistuba I, Lambrechts D, Xu J, Minna JD, Deberardinis RJ Nature 2017 Jun 546 168-172
- Regulation of mitochondrial biogenesis in erythropoiesis by mTORC1-mediated protein translation
  Liu X, Zhang Y, Ni M, Cao H, Signer RA, Li D, Li M, Gu Z, Hu Z, Dickerson KE, Weinberg SE, Chandel NS, Deberardinis RJ, Zhou F, Shao Z, Xu J Nature cell biology 2017 May 19 626-638
- Lipid sensing by mTOR complexes via de novo synthesis of phosphatidic acid
  Menon D, Salloum D, Bernfeld E, Gorodetsky E, Akselrod A, Frias MA, Sudderth J, Chen PH, DeBerardinis R, Foster DA Journal of Biological Chemistry 2017 Apr 292 6303-6311
- Understanding the Intersections between Metabolism and Cancer Biology
  Vander Heiden MG, DeBerardinis RJ Cell 2017 Feb 168 657-669
- Hypoxia induces heart regeneration in adult mice
  Nakada Y, Canseco DC, Thet S, Abdisalaam S, Aroumougame A, Santos CX, Shah AM, Zhang H, Faber JE, Kinter MT, Szweda LI, Xing C, Hu Z, DeBerardinis RJ, Schiattarella G, Hill JA, Oz OK, Lu Z, Zhang C, Kimura W, Sadek HA Nature 2017 Jan 541 222-227
- Chronic innate immune activation of TBK1 suppresses mTORC1 activity and dysregulates cellular metabolism
  Hasan M, Gonugunta VK, Dobbs N, Ali A, Palchik G, Calvaruso MA, DeBerardinis RJ, Yan N Proceedings of the National Academy of Sciences of the United States of America 2017 Jan 114 746-751
- Biomarker accessible and chemically addressable mechanistic subtypes of braf melanoma
  Eskiocak B, McMillan EA, Mendiratta S, Kollipara RK, Zhang H, Humphries CG, Wang C, Garcia-Rodriguez J, Ding M, Zaman A, Rosales TI, Eskiocak U, Smith MP, Sudderth J, Komurov K, Deberardinis RJ, Wellbrock C, Davies MA, Wargo JA, Yu Y, De Brabander JK, Williams NS, Chin L, Rizos H, Long GV, Kittler R, White MA Cancer discovery 2017 7 832-851
- Analyzing tumor metabolism in vivo
  Faubert B, Deberardinis RJ Annual Review of Cancer Biology 2017 1 99-117
- The abundance of metabolites related to protein methylation correlates with the metastatic capacity of human melanoma xenografts
  Shi X, Tasdogan A, Huang F, Hu Z, Morrison SJ, DeBerardinis RJ Science Advances 2017 3
- Tetrameric Acetyl-CoA Acetyltransferase 1 Is Important for Tumor Growth
  Fan J, Lin R, Xia S, Chen D, Elf SE, Liu S, Pan Y, Xu H, Qian Z, Wang M, Shan C, Zhou L, Lei QY, Li Y, Mao H, Lee BH, Sudderth J, DeBerardinis RJ, Zhang G, Owonikoko T, Gaddh M, Arellano ML, Khoury HJ, Khuri FR, Kang S, Doetsch PW, Lonial S, Boggon TJ, Curran WJ, Chen J Molecular cell 2016 Dec 64 859-874
- Meta-analysis of clinical metabolic profiling studies in cancer: challenges and opportunities
  Goveia J, Pircher A, Conradi LC, Kalucka J, Lagani V, Dewerchin M, Eelen G, DeBerardinis RJ, Wilson ID, Carmeliet P EMBO Molecular Medicine 2016 Oct 8 1134-1142
- Blocking fatty acid synthesis reduces lung tumor growth in mice
  Kim J, Deberardinis RJ Nature medicine 2016 Oct 22 1077-1078
- Evidence of Glycolysis Up-Regulation and Pyruvate Mitochondrial Oxidation Mismatch During Mechanical Unloading of the Failing Human Heart: Implications for Cardiac Reloading and Conditioning
  Diakos NA, Navankasattusas S, Abel ED, Rutter J, McCreath L, Ferrin P, McKellar SH, Miller DV, Park SY, Richardson RS, Deberardinis R, Cox JE, Kfoury AG, Selzman CH, Stehlik J, Fang JC, Li DY, Drakos SG JACC: Basic to Translational Science 2016 Oct 1 432-444
- AACR Cancer Progress Report 2016
  Davidson NE, Armstrong SA, Coussens LM, Cruz-Correa MR, DeBerardinis RJ, Doroshow JH, Foti M, Hwu P, Kensler TW, Morrow M, Mulligan CG, Pao W, Platz EA, Smith TJ, Willman CL Clinical cancer research : an official journal of the American Association for Cancer Research 2016 Oct 22 S1-S137
- Glutathione depletion, pentose phosphate pathway activation, and hemolysis in erythrocytes protecting cancer cells from vitamin C-induced oxidative stress
  Zhang ZZ, Lee EE, Sudderth J, Yue Y, Zia A, Glass D, Deberardinis RJ, Wang RC Journal of Biological Chemistry 2016 Oct 291 22861-22867
- Mutations in mitochondrial enzyme GPT2 cause metabolic dysfunction and neurological disease with developmental and progressive features
  Ouyang Q, Nakayama T, Baytas O, Davidson SM, Yang C, Schmidt M, Lizarraga SB, Mishra S, Ei-Quessny M, Niaz S, Butt MG, Murtaza SI, Javed A, Chaudhry HR, Vaughan DJ, Hill RS, Partlow JN, Yoo SY, Lam AT, Nasir R, Al-Saffar M, Barkovich AJ, Schwede M, Nagpal S, Rajab A, DeBerardinis RJ, Housman DE, Mochida GH, Morrow EM Proceedings of the National Academy of Sciences of the United States of America 2016 Sep 113 E5598-E5607
- Glucose-dependent anaplerosis in cancer cells is required for cellular redox balance in the absence of glutamine
  Cetinbas NM, Sudderth J, Harris RC, Cebeci A, Negri GL, Yllmaz ÖH, Deberardinis RJ, Sorensen PH Scientific reports 2016 Sep 6
- Synergistic effects of ion transporter and MAP kinase pathway inhibitors in melanoma
  Eskiocak U, Ramesh V, Gill JG, Zhao Z, Yuan SW, Wang M, Vandergriff T, Shackleton M, Quintana E, Johnson TM, Deberardinis RJ, Morrison SJ Nature communications 2016 Aug 7
- Fatty Acid Oxidation Mediated by Acyl-CoA Synthetase Long Chain 3 Is Required for Mutant KRAS Lung Tumorigenesis
  Padanad MS, Konstantinidou G, Venkateswaran N, Melegari M, Rindhe S, Mitsche M, Yang C, Batten K, Huffman KE, Liu J, Tang X, Rodriguez-Canales J, Kalhor N, Shay JW, Minna JD, McDonald J, Wistuba II, DeBerardinis RJ, Scaglioni PP Cell Reports 2016 Aug 16 1614-1628
- Hepatic gluconeogenesis influences ¹³C enrichment in lactate in human brain tumors during metabolism of [1,2-¹³C]acetate
  Pichumani K, Mashimo T, Vemireddy V, Kovacs Z, Ratnakar J, Mickey B, Malloy CR, DeBerardinis RJ, Bachoo RM, Maher EA Neurochemistry International 2016 Jul 97 133-136
- Targeting Disease through Metabolism
  Green D, DeBerardinis R, Febbraio M Cell 2016 Jun 165 1561-1562
- Proliferating Cells Conserve Nitrogen to Support Growth
  DeBerardinis RJ Cell Metabolism 2016 Jun 23 957-958
- Fundamentals of cancer metabolism
  DeBerardinis RJ, Chandel NS Science Advances 2016 May 2
- Liposuction: Extracellular Fat Removal Promotes Proliferation
  Egnatchik RA, DeBerardinis RJ Cell Chemical Biology 2016 Apr 23 431-432
- Reductive carboxylation supports redox homeostasis during anchorage-independent growth
  Jiang L, Shestov AA, Swain P, Yang C, Parker SJ, Wang QA, Terada LS, Adams ND, McCabe MT, Pietrak B, Schmidt S, Metallo CM, Dranka BP, Schwartz B, Deberardinis RJ Nature 2016 Apr 532 255-258
- Cutting Edge: Critical role of glycolysis in human plasmacytoid dendritic cell antiviral responses
  Bajwa G, DeBerardinis RJ, Shao B, Hall B, Farrar JD, Gill MA Journal of Immunology 2016 Mar 196 2004-2009
- Erratum: NRF2 regulates serine biosynthesis in non-small cell lung cancer (Nat. Genet. (2015) 47 (1475-1481))
  Denicola GM, Chen PH, Mullarky E, Sudderth JA, Hu Z, Wu D, Tang H, Xie Y, Asara JM, Huffman KE, Wistuba II, Minna JD, Deberardinis RJ, Cantley LC Nature genetics 2016 Mar 48 473
- Metabolic Heterogeneity in Human Lung Tumors
  Hensley CT, Faubert B, Yuan Q, Lev-Cohain N, Jin E, Kim J, Jiang L, Ko B, Skelton R, Loudat L, Wodzak M, Klimko C, McMillan E, Butt Y, Ni M, Oliver D, Torrealba J, Malloy CR, Kernstine K, Lenkinski RE, DeBerardinis RJ Cell 2016 Feb 164 681-694
- Cancer-specific production of n-acetylaspartate via nat8l overexpression in non-small cell lung cancer and its potential as a circulating biomarker
  Lou TF, Sethuraman D, Dospoy P, Srivastva P, Kim HS, Kim J, Ma X, Chen PH, Huffman KE, Frink RE, Larsen JE, Lewis C, Um SW, Kim DH, Ahn JM, DeBerardinis RJ, White MA, Minna JD, Yoo H Cancer Prevention Research 2016 Jan 9 43-52
- TCA Cycle and Mitochondrial Membrane Potential Are Necessary for Diverse Biological Functions
  Martínez-Reyes I, Diebold LP, Kong H, Schieber M, Huang H, Hensley CT, Mehta MM, Wang T, Santos JH, Woychik R, Dufour E, Spelbrink JN, Weinberg SE, Zhao Y, DeBerardinis RJ, Chandel NS Molecular cell 2016 Jan 61 199-209
- Metformin Antagonizes Cancer Cell Proliferation by Suppressing Mitochondrial-Dependent Biosynthesis
  Griss T, Vincent EE, Egnatchik R, Chen J, Ma EH, Faubert B, Viollet B, DeBerardinis RJ, Jones RG PLoS biology 2015 Dec 13
- NRF2 regulates serine biosynthesis in non-small cell lung cancer
  DeNicola GM, Chen PH, Mullarky E, Sudderth JA, Hu Z, Wu D, Tang H, Xie Y, Asara JM, Huffman KE, Wistuba II, Minna JD, DeBerardinis RJ, Cantley LC Nature genetics 2015 Dec 47 1475-1481
- Dysregulated metabolism contributes to oncogenesis
  Author Collaboration TV, Hirschey MD, DeBerardinis RJ, Diehl AM, Drew JE, Frezza C, Green MF, Jones LW, Ko YH, Le A, Lea MA, Locasale JW, Longo VD, Lyssiotis CA, McDonnell E, Mehrmohamadi M, Michelotti G, Muralidhar V, Murphy MP, Pedersen PL, Poore B, Raffaghello L, Rathmell JC, Sivanand S, Vander Heiden MG, Wellen KE, Amedei A, Amin A, Salman Ashraf S, Azmi AS, Bhakta D, Bisland A, Boosani CS, Chen S, Fujii H, Georgakilas A, Guha G, Halicka D, Helferich B, Honoki K, Keith WN, Mohammed S, Niccolai E, Nowsheen S, Yang X Seminars in Cancer Biology 2015 Dec 35 S129-S150
- 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling
  Lin R, Elf S, Shan C, Kang HB, Ji Q, Zhou L, Hitosugi T, Zhang L, Zhang S, Seo JH, Xie J, Tucker M, Gu TL, Sudderth J, Jiang L, Mitsche M, DeBerardinis RJ, Wu S, Li Y, Mao H, Chen PR, Wang D, Chen GZ, Hurwitz SJ, Lonial S, Arellano ML, Khoury HJ, Khuri FR, Lee BH, Lei Q, Brat DJ, Ye K, Boggon TJ, He C, Kang S, Fan J, Chen J Nature cell biology 2015 Nov 17 1484-1496
- Tumor-selective use of DNA base excision repair inhibition in pancreatic cancer using the NQO1 bioactivatable drug, β-lapachone
  Chakrabarti G, Silvers MA, Ilcheva M, Liu Y, Moore ZR, Luo X, Gao J, Anderson G, Liu L, Sarode V, Gerber DE, Burma S, DeBerardinis RJ, Gerson SL, Boothman DA Scientific reports 2015 Nov 5
- PEPCK Coordinates the Regulation of Central Carbon Metabolism to Promote Cancer Cell Growth
  Montal ED, Dewi R, Bhalla K, Ou L, Hwang BJ, Ropell AE, Gordon C, Liu WJ, DeBerardinis RJ, Sudderth J, Twaddel W, Boros LG, Shroyer KR, Duraisamy S, Drapkin R, Powers RS, Rohde JM, Boxer MB, Wong KK, Girnun GD Molecular cell 2015 Nov 60 571-583
- Oxidative stress inhibits distant metastasis by human melanoma cells
  Piskounova E, Agathocleous M, Murphy MM, Hu Z, Huddlestun SE, Zhao Z, Leitch AM, Johnson TM, DeBerardinis RJ, Morrison SJ Nature 2015 Nov 527 186-191
- LKB1 loss promotes endometrial cancer progression via CCL2-dependent macrophage recruitment
  Peña CG, Nakada Y, Saatcioglu HD, Aloisio GM, Cuevas I, Zhang S, Miller DS, Lea JS, Wong KK, DeBerardinis RJ, Amelio AL, Brekken RA, Castrillon DH Journal of Clinical Investigation 2015 Nov 125 4063-4076
- A nanobuffer reporter library for fine-scale imaging and perturbation of endocytic organelles
  Wang C, Wang Y, Li Y, Bodemann B, Zhao T, Ma X, Huang G, Hu Z, Deberardinis RJ, White MA, Gao J Nature communications 2015 Oct 6
- Metabolic reprogramming induces resistance to anti-NOTCH1 therapies in T cell acute lymphoblastic leukemia
  Herranz D, Ambesi-Impiombato A, Sudderth J, Sánchez-Martín M, Belver L, Tosello V, Xu L, Wendorff AA, Castillo M, Haydu JE, Márquez J, Matés JM, Kung AL, Rayport S, Cordon-Cardo C, Deberardinis RJ, Ferrando AA Nature medicine 2015 Oct 21 1182-1189
- Hyperpolarized <sup>13</sup>C Magnetic Resonance and Its Use in Metabolic Assessment of Cultured Cells and Perfused Organs
  Lumata L, Yang C, Ragavan M, Carpenter N, DeBerardinis RJ, Merritt ME Methods in Enzymology 2015 Sep 561 73-106
- A roadmap for interpreting ¹³C metabolite labeling patterns from cells
  Buescher JM, Antoniewicz MR, Boros LG, Burgess SC, Brunengraber H, Clish CB, DeBerardinis RJ, Feron O, Frezza C, Ghesquiere B, Gottlieb E, Hiller K, Jones RG, Kamphorst JJ, Kibbey RG, Kimmelman AC, Locasale JW, Lunt SY, Maddocks OD, Malloy C, Metallo CM, Meuillet EJ, Munger J, Nöh K, Rabinowitz JD, Ralser M, Sauer U, Stephanopoulos G, St-Pierre J, Tennant DA, Wittmann C, Vander Heiden MG, Vazquez A, Vousden K, Young JD, Zamboni N, Fendt SM Current Opinion in Biotechnology 2015 Aug 34 189-201
- Metabolic dysregulation in monogenic disorders and cancer-finding method in madness
  Erez A, Deberardinis RJ Nature Reviews Cancer 2015 Jul 15 440-448
- Metabolic reprogramming during TGFβ1-induced epithelial-to-mesenchymal transition
  Jiang L, Xiao L, Sugiura H, Huang X, Ali A, Kuro-O M, DeBerardinis RJ, Boothman DA Oncogene 2015 Jul 34 3908-3916
- Loss of the tumor suppressor Hace1 leads to ROS-dependent glutamine addiction
  Cetinbas N, Daugaard M, Mullen AR, Hajee S, Rotblat B, Lopez A, Li A, DeBerardinis RJ, Sorensen PH Oncogene 2015 Jul 34 4005-4010
- Hypoxic metabolism in human hematopoietic stem cells
  Kocabas F, Xie L, Xie J, Yu Z, DeBerardinis RJ, Kimura W, Thet SW, Elshamy AF, Abouellail H, Muralidhar S, Liu X, Chen C, Sadek HA, Zhang CC, Zheng J Cell and Bioscience 2015 Jul 5
- D2HGDH regulates alpha-ketoglutarate levels and dioxygenase function by modulating IDH2
  Lin AP, Abbas S, Kim SW, Ortega M, Bouamar H, Escobedo Y, Varadarajan P, Qin Y, Sudderth J, Schulz E, Deutsch A, Mohan S, Ulz P, Neumeister P, Rakheja D, Gao X, Hinck A, Weintraub ST, DeBerardinis RJ, Sill H, Dahia PL, Aguiar RC Nature communications 2015 Jul 6
- The cancer cell ‘energy grid’: TGF-β1 signaling coordinates metabolism for migration
  Jiang L, Deberardinis R, Boothman DA Molecular and Cellular Oncology 2015 Jul 2
- Conditions for ¹³C NMR detection of 2-hydroxyglutarate in tissue extracts from isocitrate dehydrogenase-mutated gliomas
  Pichumani K, Mashimo T, Baek HM, Ratnakar J, Mickey B, DeBerardinis RJ, Maher EA, Bachoo RM, Malloy CR, Kovacs Z Analytical biochemistry 2015 Jun 481 4-6
- Metabolism: Growth in the fat lane
  Egnatchik RA, Deberardinis RJ Nature 2015 Apr 520 165-166
- Metabolic pathways promoting cancer cell survival and growth
  Boroughs LK, Deberardinis RJ Nature cell biology 2015 Apr 17 351-359
- Glutamate Dehydrogenase 1 Signals through Antioxidant Glutathione Peroxidase 1 to Regulate Redox Homeostasis and Tumor Growth
  Jin L, Li D, Alesi GN, Fan J, Kang HB, Lu Z, Boggon TJ, Jin P, Yi H, Wright ER, Duong D, Seyfried NT, Egnatchik R, DeBerardinis RJ, Magliocca KR, He C, Arellano ML, Khoury JH, Shin DM, Khuri FR, Kang S Cancer Cell 2015 Feb 27 257-270
- In vivo analysis of lung cancer metabolism: Nothing like the real thing
  Hensley CT, De Berardinis RJ Journal of Clinical Investigation 2015 Feb 125 495-497
- NAMPT inhibition sensitizes pancreatic adenocarcinoma cells to tumor-selective, PAR-independent metabolic catastrophe and cell death induced by β-lapachone
  Moore Z, Chakrabarti G, Luo X, Ali A, Hu Z, Fattah FJ, Vemireddy R, DeBerardinis RJ, Brekken RA, Boothman DA Cell Death and Disease 2015 Jan 6
- Mechanism by which a recently discovered allosteric inhibitor blocks glutamine metabolism in transformed cells
  Stalnecker CA, Ulrich SM, Li Y, Ramachandran S, McBrayer MK, De Berardinis RJ, Cerione RA, Erickson JW Proceedings of the National Academy of Sciences of the United States of America 2015 Jan 112 394-399
- Designing a broad-spectrum integrative approach for cancer prevention and treatment
  Block KI, Gyllenhaal C, Lowe L, Amedei A, Ruhul Amin AR, Amin A, Aquilano K, Arbiser J, Arreola A, Arzumanyan A, Salman Ashraf S, Azmi AS, Benencia F, Bhakta D, Bilsland A, Bishayee A, Blain SW, Block PB, Boosani CS, Carey TE, Carnero A, Carotenuto M, Casey SC, Chakrabarti M, Chaturvedi R, Chen GZ, Chen H, Chen S, Chen YC, Choi BK, Ciriolo MR, Coley HM, Collins AR, Connell M, Crawford S, Curran CS, Dabrosin C, Damia G, Dasgupta S, DeBerardinis RJ, Decker WK, Dhawan P, Diehl AM, Dong JT, Dou QP, Drewa JE, Elkord E, El-Rayes B, Feitelson MA, Felsheru DW, Ferguson LR, Fimognari C, Firestone GL, Frezza C, Fujii H, Fuster MM, Generali D, Georgakilas AG, Gieseler F, Gilbertson M, Green MF, Grue B, Guhal G, Halicka D, Helferich WG, Heneberg P, Hentosh P, Hirschey MD, Hofseth LJ, Holcombe RF, Honoki K, Hsu HY, Huang GS, Jensen LD, Jiang WG, Jones LW, Karpowicz PA, Keith WN, Kerkar SP, Khan GN, Khatami M, Ko YH, Kucuk O, Kulathinal RJ, Kumar NB, Kwon BS, Leb A, Leab MA, Lee HY, Lichtor T, Lin LT, Locasale JW, Lokeshwar BL, Longo VD, Lyssiotis CA, MacKenzie KL, Malhotra M, Marino M, Martinez-Chantar ML, Matheu A, Maxwellx C, McDonnell E, Meeker AK, Mehrmohamadi M, Mehta K, Michelotti GA, Mohammad RM, Mohammed SI, Morre DJ, Muqbil I, Muralidharcq V, Murphy MP, Nagaraju GP, Nahta R, Niccolai E, Nowsheen S, Panis C, Pantano F, Parslow VR, Pawelec G, Pedersen PL, Poore B, Poudyal D, Prakash S, Prince M, Raffaghello L, Rathmell JC, Rathmell WK, Ray SK, Reichrath J, Rezazadeh S, Ribatti D, Ricciardiello L, Robeydf RB, Rodierdh F, Rupasinghe HP, Russo GL, Ryan EP, Samadi AK, Sanchez-Garcia I, Sanders AJ, Santini D, Sarkar M, Sasada T, Saxena NK, Shackelford RE, Shantha Kumara HM, Sharma D, Shin DM, Sidransky D, Siegelin MD, Signori E, Singh N, Sivanand S, Sliva D, Smythe C, Spagnuolo C, Stafforini DM, Stagg J, Subbarayan PR, Sundin T, Talib WH, Thompson SK, Tran PT, Ungefroren H, Vander Heiden MG, Venkateswaran V, Vinay DS, Vlachostergios PJ, Wang Z, Wellen KE, Whelan RL, Yang ES, Yang H, Yang X, Yaswen P, Yedjou C, Yin X, Zhu J, Zollo M Seminars in Cancer Biology 2015 35 S276-S304
- Acetate is a bioenergetic substrate for human glioblastoma and brain metastases
  Mashimo T, Pichumani K, Vemireddy V, Hatanpaa KJ, Singh DK, Sirasanagandla S, Nannepaga S, Piccirillo SG, Kovacs Z, Foong C, Huang Z, Barnett S, Mickey BE, Deberardinis RJ, Tu BP, Maher EA, Bachoo RM Cell 2014 Dec 159 1603-1614
- MAVS, cGAS, and endogenous retroviruses in T-independent B cell responses
  Zeng M, Hu Z, Shi X, Li X, Zhan X, Li XD, Wang J, Choi JH, Wang Kw, Purrington T, Tang M, Fina M, DeBerardinis RJ, Moresco EM, Pedersen G, McInerney GM, Hedestam GB, Chen ZJ, Beutler B Science 2014 Dec 346 1486-1492
- The gut commensal bacteroides thetaiotaomicron exacerbates enteric infection through modification of the metabolic landscape
  Curtis MM, Hu Z, Klimko C, Narayanan S, Deberardinis R, Sperandio V Cell Host and Microbe 2014 Dec 16 759-769
- MAVS, cGAS, and endogenous retroviruses in T-independent B cell responses
  Zeng M, Hu Z, Shi X, Li X, Zhan X, Li XD, Wang J, Choi JH, Wang KW, Purrington T, Tang M, Fina M, DeBerardinis RJ, Moresco EM, Pedersen G, McInerney GM, Hedestam GB, Chen ZJ, Beutler B Science 2014 Dec 346 1486-1492
- Real-time detection of hepatic gluconeogenic and glycogenolytic states using hyperpolarized [2-13c]dihydroxyacetone
  Moreno KX, Satapati S, DeBerardinis RJ, Burgess SC, Malloy CR, Merritt ME Journal of Biological Chemistry 2014 Dec 289 35859-35867
- MCT4 Defines a Glycolytic Subtype of Pancreatic Cancer with Poor Prognosis and Unique Metabolic Dependencies
  Baek GH, Tse YF, Hu Z, Cox D, Buboltz N, McCue P, Yeo CJ, White MA, DeBerardinis RJ, Knudsen ES, Witkiewicz AK Cell Reports 2014 Dec 9 2233-2249
- Inhibition of cancer cell proliferation by PPARγ is mediated by a metabolic switch that increases reactive oxygen species levels
  Srivastava N, Kollipara RK, Singh DK, Sudderth J, Hu Z, Nguyen H, Wang S, Humphries CG, Carstens R, Huffman KE, Deberardinis RJ, Kittler R Cell Metabolism 2014 Oct 20 650-661
- Lysine acetylation activates 6-phosphogluconate dehydrogenase to promote tumor growth
  Shan C, Elf S, Ji Q, Kang HB, Zhou L, Hitosugi T, Jin L, Lin R, Zhang L, Seo JH, Xie J, Tucker M, Gu TL, Sudderth J, Jiang L, DeBerardinis RJ, Wu S, Li Y, Mao H, Chen PR, Wang D, Chen G, Lonial S, Arellano ML, Khoury HJ, Khuri FR, Lee BH, Brat DJ, Ye K, Boggon TJ, He C, Kang S, Fan J, Chen J Molecular cell 2014 Aug 55 552-565
- In vivo detection of citrate in brain tumors by ¹H magnetic resonance spectroscopy at 3T
  Choi C, Ganji SK, Madan A, Hulsey KM, An Z, Zhang S, Pinho MC, Deberardinis RJ, Bachoo RM, Maher EA Magnetic resonance in medicine 2014 Aug 72 316-323
- Oxidation of alpha-ketoglutarate is required for reductive carboxylation in cancer cells with mitochondrial defects
  Mullen AR, Hu Z, Shi X, Jiang L, Boroughs LK, Kovacs Z, Boriack R, Rakheja D, Sullivan LB, Linehan WM, Chandel NS, DeBerardinis RJ Cell Reports 2014 Jun 7 1679-1690
- A novel radiotracer to image glycogen metabolism in tumors by positron emission tomography
  Witney TH, Carroll L, Alam IS, Chandrashekran A, De Nguyen Q, Sala R, Harris R, De Berardinis RJ, Agarwal R, Aboagye EO Cancer research 2014 Mar 74 1319-1328
- Both GLS silencing and GLS2 overexpression synergize with oxidative stress against proliferation of glioma cells
  Martín-Rufián M, Nascimento-Gomes R, Higuero A, Crisma AR, Campos-Sandoval JA, Gómez-García MC, Cardona C, Cheng T, Lobo C, Segura JA, Alonso FJ, Szeliga M, Albrecht J, Curi R, Márquez J, Colquhoun A, Deberardinis RJ, Matés JM Journal of Molecular Medicine 2014 Mar 92 277-290
- A nanoparticle-based strategy for the imaging of a broad range of tumours by nonlinear amplification of microenvironment signals
  Wang Y, Zhou K, Huang G, Hensley C, Huang X, Ma X, Zhao T, Sumer BD, Deberardinis RJ, Gao J Nature Materials 2014 Feb 13 204-212
- Simultaneous steady-state and dynamic¹³C NMR can differentiate alternative routes of pyruvate metabolism in living cancer cells
  Yang C, Harrison C, Jin ES, Chuang DT, Sherry AD, Malloy CR, Merritt ME, DeBerardinis RJ Journal of Biological Chemistry 2014 Feb 289 6212-6224
- Profilin 1 is essential for retention and metabolism of mouse hematopoietic stem cells in bone marrow
  Zheng J, Lu Z, Kocabas F, Böttcher RT, Costell M, Kang X, Liu X, DeBerardinis RJ, Wang Q, Chen GQ, Sadek HA, Zhang C Blood 2014 Feb 123 992-1001
- A Mitochondrial RNAi Screen Defines Cellular Bioenergetic Determinants and Identifies an Adenylate Kinase as a Key Regulator of ATP Levels
  Lanning NJ, Looyenga BD, Kauffman AL, Niemi NM, Sudderth J, DeBerardinis RJ, MacKeigan JP Cell Reports 2014 7 907-917
- A role for the mitochondrial pyruvate carrier as a repressor of the warburg effect and colon cancer cell growth
  Schell JC, Olson KA, Jiang L, Hawkins AJ, VanVranken JG, Xie J, Egnatchik RA, Earl EG, DeBerardinis RJ, Rutter J Molecular cell 2014 56 400-413
- Glutamine oxidation maintains the TCA cycle and cell survival during impaired mitochondrial pyruvate transport
  Yang C, Ko B, Hensley CT, Jiang L, Wasti AT, Kim J, Sudderth J, Calvaruso M, Lumata L, Mitsche M, Rutter J, Merritt ME, DeBerardinis RJ Molecular cell 2014 56 414-424
- Analysis of hypoxia-induced metabolic reprogramming
  Yang C, Jiang L, Zhang H, Shimoda LA, Deberardinis RJ, Semenza GL 2014 425-455
- Hydrophilic interaction liquid chromatography coupled with MS/MS to detect and quantify dicarboxyethyl glutathione, a metabolic biomarker of the fumarate hydratase deficient cancer cell
  Nguyen HP, Chandel NS, Deberardinis RJ, Schug KA Journal of Separation Science 2013 Oct 36 3303-3309
- XSystematic identification of molecular subtype-selective vulnerabilities in non-small-cell lung cancer
  Kim HS, Mendiratta S, Kim J, Pecot CV, Larsen JE, Zubovych I, Seo BY, Kim J, Eskiocak B, Chung H, McMillan E, Wu S, De Brabander J, Komurov K, Toombs JE, Wei S, Peyton M, Williams N, Gazdar AF, Posner BA, Brekken RA, Sood AK, Deberardinis RJ, Roth MG, Minna JD, White MA Cell 2013 Oct 155 552
- A comparative study of short- and long-TE ¹H MRS at 3 T for in vivo detection of 2-hydroxyglutarate in brain tumors
  Choi C, Ganji S, Hulsey K, Madan A, Kovacs Z, Dimitrov I, Zhang S, Pichumani K, Mendelsohn D, Mickey B, Malloy C, Bachoo R, Deberardinis R, Maher E NMR in biomedicine 2013 Oct 26 1242-1250
- Glutamine and cancer: Cell biology, physiology, and clinical opportunities
  Hensley CT, Wasti AT, DeBerardinis RJ Journal of Clinical Investigation 2013 Sep 123 3678-3684
- XRole of PFKFB3-driven glycolysis in vessel sprouting
  De Bock K, Georgiadou M, Schoors S, Kuchnio A, Wong BW, Cantelmo AR, Quaegebeur A, Ghesquière B, Cauwenberghs S, Eelen G, Phng LK, Betz I, Tembuyser B, Brepoels K, Welti J, Geudens I, Segura I, Cruys B, Bifari F, Decimo I, Blanco R, Wyns S, Vangindertael J, Rocha S, Collins RT, Munck S, Daelemans D, Imamura H, Devlieger R, Rider M, Van Veldhoven PP, Schuit F, Bartrons R, Hofkens J, Fraisl P, Telang S, Deberardinis RJ, Schoonjans L, Vinckier S, Chesney J, Gerhardt H, Dewerchin M, Carmeliet P Cell 2013 Aug 154 X651-663
- The Proto-oncometabolite Fumarate Binds Glutathione to Amplify ROS-dependent signaling
  Sullivan L, Martinez-Garcia E, Nguyen H, Mullen A, Dufour E, Sudarshan S, Licht J, Deberardinis R, Chandel N Molecular cell 2013 Jul 51 236-248
- The Proto-oncometabolite Fumarate Binds Glutathione to amplify ROS-dependent signaling
  Sullivan L, Martinez-Garcia E, Nguyen H, Mullen A, Dufour E, Sudarshan S, Licht J, Deberardinis R, Chandel N Molecular cell 2013 Jul 51 273
- Mitochondrial reactive oxygen species promote epidermal differentiation and hair follicle development
  Hamanaka RB, Glasauer A, Hoover P, Yang S, Blatt H, Mullen AR, Getsios S, Gottardi CJ, DeBerardinis RJ, Lavker RM, Chandel NS Science Signaling 2013 Feb 6
- Silencing a metabolic oncogene
  Kim J, DeBerardinis RJ Science 2013 340 558-559
- AMPK is a negative regulator of the warburg effect and suppresses tumor growth in vivo
  Faubert B, Boily G, Izreig S, Griss T, Samborska B, Dong Z, Dupuy F, Chambers C, Fuerth BJ, Viollet B, Mamer OA, Avizonis D, Deberardinis RJ, Siegel PM, Jones RG Cell Metabolism 2013 Jan 17 113-124
- Meis1 regulates the metabolic phenotype and oxidant defense of hematopoietic stem cells
  Kocabas F, Zheng J, Thet S, Copeland NG, Jenkins NA, DeBerardinis RJ, Zhang C, Sadek HA Blood 2012 Dec 120 4963-4972
- Phosphoglycerate Mutase 1 Coordinates Glycolysis and Biosynthesis to Promote Tumor Growth
  Hitosugi T, Zhou L, Elf S, Fan J, Kang HB, Seo JH, Shan C, Dai Q, Zhang L, Xie J, Gu TL, Jin P, Alečković M, LeRoy G, Kang Y, Sudderth JA, DeBerardinis RJ, Luan CH, Chen GZ, Muller S, Shin DM, Owonikoko TK, Lonial S, Arellano ML, Khoury HJ, Khuri FR, Lee BH, Ye K, Boggon TJ, Kang S, He C, Chen J Cancer Cell 2012 Nov 22 585-600
- Metabolism of [U-¹³C]glucose in human brain tumors in vivo
  Maher EA, Marin-Valencia I, Bachoo RM, Mashimo T, Raisanen J, Hatanpaa KJ, Jindal A, Jeffrey FM, Choi C, Madden C, Mathews D, Pascual JM, Mickey BE, Malloy CR, Deberardinis RJ NMR in biomedicine 2012 Nov 25 1234-1244
- Comparison of kinetic models for analysis of pyruvate-to-lactate exchange by hyperpolarized ¹³C NMR
  Harrison C, Yang C, Jindal A, Deberardinis RJ, Hooshyar MA, Merritt M, Dean Sherry A, Malloy CR NMR in biomedicine 2012 Nov 25 1286-1294
- Genetically-defined metabolic reprogramming in cancer
  Mullen AR, DeBerardinis RJ Trends in Endocrinology and Metabolism 2012 Nov 23 552-559
- Erratum: Analysis of tumor metabolism reveals mitochondrial glucose oxidation in genetically diverse human glioblastomas in the mouse brain in vivo (Cell Metabolism (2012) 16 (394-406))
  Marin-Valencia I, Yang C, Mashimo T, Cho S, Baek H, Yang XL, Rajagopalan KN, Maddie M, Vemireddy V, Zhao Z, Cai L, Good L, Tu BP, Hatanpaa KJ, Mickey BE, Matés JM, Pascual JM, Maher EA, Malloy CR, DeBerardinis RJ, Bachoo RM Cell Metabolism 2012 Nov 16 686
- A Mitochondrial Power Play in Lymphoma
  DeBerardinis RJ Cancer Cell 2012 Oct 22 423-424
- Glucose metabolism via the pentose phosphate pathway, glycolysis and Krebs cycle in an orthotopic mouse model of human brain tumors
  Marin-Valencia I, Cho SK, Rakheja D, Hatanpaa KJ, Kapur P, Mashimo T, Jindal A, Vemireddy V, Good LB, Raisanen JM, Sun X, Mickey BE, Choi C, Takahashi M, Togao O, Pascual JM, DeBerardinis RJ, Maher EA, Malloy CR, Bachoo R NMR in biomedicine 2012 Oct 25 1177-1186
- The hypoxic epicardial and subepicardial microenvironment
  Kocabas F, Mahmoud AI, Sosic D, Porrello ER, Chen R, Garcia JA, Deberardinis RJ, Sadek HA Journal of cardiovascular translational research 2012 Oct 5 654-665
- Erratum: The hypoxic epicardial and subepicardial microenvironment (J. of Cardiovasc. Trans. Res. DOI 10.1007/s12265-012-9366-7)
  Kocabas F, Mahmoud AI, Sosic D, Porrello ER, Chen R, Garcia JA, Deberardinis RJ, Sadek HA Journal of cardiovascular translational research 2012 Oct 5 666
- The G Protein-Coupled Taste Receptor T1R1/T1R3 Regulates mTORC1 and Autophagy
  Wauson EM, Zaganjor E, Lee AY, Guerra ML, Ghosh AB, Bookout AL, Chambers CP, Jivan A, McGlynn K, Hutchison MR, Deberardinis RJ, Cobb MH Molecular cell 2012 Sep 47 851-862
- Cancer metabolism: When more is less
  Jiang L, Deberardinis RJ Nature 2012 Sep 489 511-512
- Analysis of tumor metabolism reveals mitochondrial glucose oxidation in genetically diverse human glioblastomas in the mouse brain in vivo
  Marin-Valencia I, Yang C, Mashimo T, Cho S, Baek H, Yang XL, Rajagopalan KN, Maddie M, Vemireddy V, Zhao Z, Cai L, Good L, Tu BP, Hatanpaa KJ, Mickey BE, Matés JM, Pascual JM, Maher EA, Malloy CR, DeBerardinis RJ, Bachoo RM Cell Metabolism 2012 Jun 15 827-837
- 2-Hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas
  Choi C, Ganji SK, DeBerardinis RJ, Hatanpaa KJ, Rakheja D, Kovacs Z, Yang XL, Mashimo T, Raisanen JM, Marin-Valencia I, Pascual JM, Madden CJ, Mickey BE, Malloy CR, Bachoo R, Maher EA Nature medicine 2012 Apr 18 624-629
- Good neighbours in the tumour stroma reduce oxidative stress
  Deberardinis RJ Nature cell biology 2012 Mar 14 235-236
- Cellular metabolism and disease: What do metabolic outliers teach us?
  Deberardinis RJ, Thompson CB Cell 2012 Mar 148 1132-1144
- Spectrum of mutations in the renin-angiotensin system genes in autosomal recessive renal tubular dysgenesis
  Gribouval O, Morinière V, Pawtowski A, Arrondel C, Sallinen SL, Saloranta C, Clericuzio C, Viot G, Tantau J, Blesson S, Cloarec S, Machet MC, Chitayat D, Thauvin C, Laurent N, Sampson JR, Bernstein JA, Clemenson A, Prieur F, Daniel L, Levy-Mozziconacci A, Lachlan K, Alessandri JL, Cartault F, Rivière JP, Picard N, Baumann C, Delezoide AL, Ortega MB, Chassaing N, Labrune P, Yu S, Firth H, Wellesley D, Bitzan M, Alfares A, Braverman N, Krogh L, Tolmie J, Gaspar H, Doray B, Majore S, Bonneau D, Triau S, Loirat C, David A, Bartholdi D, Peleg A, Brackman D, Stone R, DeBerardinis R, Corvol P, Michaud A, Antignac C, Gubler MC Human mutation 2012 Feb 33 316-326
- Reductive carboxylation supports growth in tumour cells with defective mitochondria
  Mullen AR, Wheaton WW, Jin ES, Chen PH, Sullivan LB, Cheng T, Yang Y, Linehan WM, Chandel NS, Deberardinis RJ Nature 2012 Jan 481 385-388
- Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase
  Frezza C, Zheng L, Folger O, Rajagopalan KN, MacKenzie ED, Jerby L, Micaroni M, Chaneton B, Adam J, Hedley A, Kalna G, Tomlinson IP, Pollard PJ, Watson DG, Deberardinis RJ, Shlomi T, Ruppin E, Gottlieb E Nature 2011 Sep 477 225-228
- Serine metabolism: Some tumors take the road less traveled
  Deberardinis RJ Cell Metabolism 2011 Sep 14 285-286
- Measurement of glycine in the human brain in vivo by ¹H-MRS at 3 T: Application in brain tumors
  Choi C, Ganji SK, Deberardinis RJ, Dimitrov IE, Pascual JM, Bachoo R, Mickey BE, Malloy CR, Maher EA Magnetic resonance in medicine 2011 Sep 66 609-618
- Role of glutamine in cancer: Therapeutic and imaging implications
  Rajagopalan KN, DeBerardinis RJ Journal of Nuclear Medicine 2011 Jul 52 1005-1008
- Uncoupling hypoxia signaling from oxygen sensing in the liver results in hypoketotic hypoglycemic death
  Kucejova B, Sunny NE, Nguyen AD, Hallac R, Fu X, Pẽa-Llopis S, Mason RP, Deberardinis RJ, Xie XJ, Debose-Boyd R, Kodibagkar VD, Burgess SC, Brugarolas J Oncogene 2011 May 30 2147-2160
- Pyruvate carboxylase is required for glutamine-independent growth of tumor cells
  Cheng T, Sudderth J, Yang C, Mullen AR, Jin ES, Matés JM, DeBerardinis RJ Proceedings of the National Academy of Sciences of the United States of America 2011 May 108 8674-8679
- Exploring a glycolytic inhibitor for the treatment of an FH-deficient type-2 papillary RCC
  Yamasaki T, Tran TA, Oz OK, Raj GV, Schwarz RE, DeBerardinis RJ, Zhang X, Brugarolas J Nature Reviews Urology 2011 Apr 8 165-171
- Isocitrate dehydrogenase 1/2 mutational analyses and 2-hydroxyglutarate measurements in Wilms tumors
  Rakheja D, Mitui M, Boriack RL, DeBerardinis RJ Pediatric Blood and Cancer 2011 Mar 56 379-383
- Glutamine: Pleiotropic roles in tumor growth and stress resistance
  Shanware NP, Mullen AR, DeBerardinis RJ, Abraham RT Journal of Molecular Medicine 2011 Mar 89 229-236
- Analysis of cancer metabolism by imaging hyperpolarized nuclei: Prospects for translation to clinical research
  Kurhanewicz J, Vigneron DB, Brindle K, Chekmenev EY, Comment A, Cunningham CH, DeBerardinis RJ, Green GG, Leach MO, Rajan SS, Rizi RR, Ross BD, Warren WS, Malloy CR Neoplasia 2011 Feb 13 81-97
- Targeting the metabolic flexibility of cancer cells: Straighten up and die right
  Marin-Valencia I, DeBerardinis RJ Cell Cycle 2011 Jan 10 191-190
- The distinct metabolic profile of hematopoietic stem cells reflects their location in a hypoxic niche
  Simsek T, Kocabas F, Zheng J, DeBerardinis RJ, Mahmoud AI, Olson EN, Schneider JW, Zhang C, Sadek HA Cell Stem Cell 2010 Sep 7 380-390
- Wilms tumor in a child with L-2-hydroxyglutaric aciduria
  Rogers RE, DeBerardinis RJ, Klesse LJ, Boriack RL, Margraf LR, Rakheja D Pediatric and Developmental Pathology 2010 Sep 13 408-411
- 2010 Keystone Symposium: Metabolism and Cancer Progression.
  DeBerardinis RJ Future oncology (London, England) 2010 Jun 6 893-895
- Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation
  Krawczyk CM, Holowka T, Sun J, Blagih J, Amiel E, DeBerardinis RJ, Cross JR, Jung E, Thompson CB, Jones RG, Pearce EJ Blood 2010 Jun 115 4742-4749
- Glioblastoma cellsrequire glutamate dehydrogenase to survive impairments of glucose metabolism or akt signaling (Cancer Research (2009) 69, (7986-7993))
  Yang C, Sudderth J, Dang T, Bachoo RM, McDonald JG, DeBerardinis RJ Cancer research 2010 Feb 70 1275
- Carbon-13 nuclear magnetic resonance for analysis of metabolic pathways
  Malloy CR, Maher E, Marin-Valencia I, Mickey B, Deberardinis RJ, Dean Sherry A 2010 Jan 415-445
- Q's next: The diverse functions of glutamine in metabolism, cell biology and cancer
  Deberardinis RJ, Cheng T Oncogene 2010 Jan 29 313-324
- Glioblastoma cells require glutamate dehydrogenase to survive impairments of glucose metabolism or Akt signaling
  Chendong Y, Sudderth J, Tuyen D, Bachoo RG, McDonald JG, DeBerardinis RJ Cancer research 2009 Oct 69 7986-7993
- Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction
  Wise DR, Deberardinis RJ, Mancuso A, Sayed N, Zhang XY, Pfeiffer HK, Nissim I, Daikhin E, Yudkoff M, McMahon SB, Thompson CB Proceedings of the National Academy of Sciences of the United States of America 2008 Dec 105 18782-18787
- Penicillamine Therapy for Pediatric Cystinuria: Experience From a Cohort of American Children
  DeBerardinis RJ, Coughlin CR, Kaplan P Journal of Urology 2008 Dec 180 2620-2623
- Is cancer a disease of abnormal cellular metabolism? New angles on an old idea
  DeBerardinis RJ Genetics in Medicine 2008 Nov 10 767-777
- Metabolism of cell growth and proliferation
  DeBerardinis RJ, Thompson CB 2008 Mar 189-203
- Brick by brick: metabolism and tumor cell growth
  DeBerardinis RJ, Sayed N, Ditsworth D, Thompson CB Current Opinion in Genetics and Development 2008 Feb 18 54-61
- The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation
  DeBerardinis RJ, Lum JJ, Hatzivassiliou G, Thompson CB Cell Metabolism 2008 Jan 7 11-20
- Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
  DeBerardinis RJ, Mancuso A, Daikhin E, Nissim I, Yudkoff M, Wehrli S, Thompson CB Proceedings of the National Academy of Sciences of the United States of America 2007 Dec 104 19345-19350
- Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth
  Buzzai M, Jones RG, Amaravadi RK, Lum JJ, DeBerardinis RJ, Zhao F, Viollet B, Thompson CB Cancer research 2007 Jul 67 6745-6752
- The transcription factor HIF-1 plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis
  Lum JJ, Bui T, Gruber M, Gordan JD, DeBerardinis RJ, Covello KL, Simon MC, Thompson CB Genes and Development 2007 May 21 1037-1049
- Phosphatidylinositol 3-kinase-dependent modulation of carnitine palmitoyltransferase 1A expression regulates lipid metabolism during hematopoietic cell growth
  DeBerardinis RJ, Lum JJ, Thompson CB Journal of Biological Chemistry 2006 Dec 281 37372-37380
- DiGeorge anomaly in a patient with isochromosome 18p born to a diabetic mother
  DeBerardinis RJ, Medne L, Spinner NB, Zackai EH American Journal of Medical Genetics 2005 Oct 138 A 155-159
- The glucose dependence of Akt-transformed cells can be reversed by pharmacologic activation of fatty acid β-oxidation
  Buzzai M, Bauer DE, Jones RG, DeBerardinis RJ, Hatzivassiliou G, Elstrom RL, Thompson CB Oncogene 2005 Jun 24 4165-4173
- Autophagy in metazoans: Cell survival in the land of plenty
  Lum JJ, DeBerardinis RJ, Thompson CB Nature Reviews Molecular Cell Biology 2005 Jun 6 439-448
- Myoclonus in a patient with a deletion of the ε-sarcoglycan locus on chromosome 7q21
  DeBerardinis RJ, Conforto D, Russell K, Kaplan J, Kollros PR, Zackai EH, Emanuel BS American Journal of Medical Genetics 2003 Aug 121 A 31-36
- A mouse model of human L1 retrotransposition
  Ostertag EM, DeBerardinis RJ, Goodier JL, Zhang Y, Yang N, Gerton GL, Kazazian HH Nature genetics 2002 Dec 32 655-660
- Erratum: An actively retrotransposing, novel subfamily of mouse L1 elements (The EMBO Journal (1998) 17 (590-597))
  Naas TP, DeBerardinis RJ, Moran JV, Ostertag EM, Kingsmore SF, Seldin MF, Hayashizaki Y, Martin SL, Kazazian H.H. J EMBO Journal 2001 May 20 2608
- Determination of L1 retrotransposition kinetics in cultured cells
  Ostertag EM, Luning Prak ET, DeBerardinis RJ, Moran JV, Kazazian HH Nucleic acids research 2000 Mar 28 1418-1423
- Exon shuffling by L1 retrotransposition
  Moran JV, DeBerardinis RJ, Kazazian HH Science 1999 Mar 283 1530-1534
- Analysis of the promoter from an expanding mouse retrotransposon subfamily
  Deberardinis RJ, Kazazian HH Genomics 1999 Mar 56 317-323
- Full-length L1 elements have arisen recently in the same 1-kb region of the gorilla and human genomes
  DeBerardinis RJ, Kazazian HH Journal of Molecular Evolution 1998 Oct 47 292-301
- Rapid amplification of a retrotransposon subfamily is evolving the mouse genome
  DeBerardinis RJ, Goodier JL, Ostertag EM, Kazazian HH Nature genetics 1998 20 288-290
- An actively retrotransposing, novel subfamily of mouse L1 elements
  Naas TP, Deberardinis RJ, Moran JV, Ostertag EM, Kingsmore SF, Seldin MF, Hayashizaki Y, Martin SL, Kazazian HH EMBO Journal 1998 Jan 17 590-597
- Many human L1 elements are capable of retrotransposition
  Sassaman DM, Dombroski BA, Moran JV, Kimberland ML, Naas TP, DeBerardinis RJ, Gabriel A, Swergold GD, Kazazian HH Nature genetics 1997 May 16 37-43
- High frequency retrotransposition in cultured mammalian cells
  Moran JV, Holmes SE, Naas TP, DeBerardinis RJ, Boeke JD, Kazazian HH Cell 1996 Nov 87 917-927
- Human enteric defensins: Gene structure and developmental expression
  Mallow EB, Harris A, Salzman N, Russell JP, DeBerardinis RJ, Ruchelli E, Bevins CL Journal of Biological Chemistry 1996 Feb 271 4038-4045

Research

Metabolism
Inborn errors of metabolism
Genetic disorders in children
Cancer

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Ralph DeBerardinis, M.D., Ph.D.

Biography

About His Laboratory

Education & Training

Professional Associations & Affiliations

Honors & Awards

Books & Publications

Research

Links

Ralph DeBerardinis, M.D., Ph.D.

Biography

About His Laboratory

Education & Training

Professional Associations & Affiliations

Honors & Awards

Books & Publications

Research

Links

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