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Richard Wang, M.D., Ph.D.

Harold C. Simmons Comprehensive Cancer Center

Dr. J.B. Shelmire Professorship in Dermatology

Dermatology - General
Melanoma
Skin Cancer

New Patient Appointment Accepting Virtual Visits or 214-645-8300

New Patient Appointment or 214-645-8300

See Dr. Wang's Locations

Biography

Richard Wang, M.D., Ph.D., is an Associate Professor in the Department of Dermatology at UT Southwestern Medical Center. He specializes in general medical dermatology and is an expert at treating non-melanoma skin cancer, including Merkel cell carcinoma, viral skin infections, and psoriasis.

Dr. Wang earned his combined medical and doctoral degree in cell biology and genetics through the Tri-Institutional M.D.-Ph.D. Program, a collaboration between Weill Cornell Medical College, The Rockefeller University, and Memorial Sloan Kettering. He completed an internship in internal medicine and a residency in dermatology, both at UT Southwestern. He then received advanced training in cancer biology through a research fellowship in the lab of UT Southwestern’s Beth Levine, M.D., with the support of the UTSW Physician Scientist Training Program and the Dermatology Foundation.

Certified by the American Board of Dermatology, Dr. Wang joined the UT Southwestern faculty in 2010.

Dr. Wang’s research focuses on pathways central to the development of both normal skin and non-melanoma skin cancer. His specific areas of interest include viruses that cause cancer and the transport and metabolism of glucose. His research is supported by a Research Project Grant (R01) from the National Institutes of Health, the American Cancer Society, and the Burroughs Wellcome Fund.

He is a member of the Society for Investigative Dermatology, the Texas Dermatological Society, and the Leaders Society of the Dermatology Foundation.

Education & Training

Residency - UT Southwestern Medical Center (2007-2010), Dermatology
Internship - UT Southwestern Medical Center (2006-2007), Internal Medicine
Medical School - Weill Cornell Medical College (1998-2006)
Graduate School - Rockefeller University (2000-2005)
Other Post Graduate Training - Rockefeller University (2000-2005)

Professional Associations & Affiliations

Society of Investigative Dermatology (2007)
American Academy of Dermatology (2011), Fellow

Honors & Awards

Stanford University President’s Scholar 1998
The Dermatology Foundation Physician Scientist Career Development Award 2011
Burroughs Wellcome Fund Career Award for Medical Scientists 2012

Books & Publications

Publications
- Viral-associated trichodysplasia spinulosa: a case with electron microscopic and molecular detection of the trichodysplasia spinulosa-associated human polyomavirus.
  Matthews MR, Wang RC, Reddick RL, Saldivar VA, Browning JC Journal of cutaneous pathology 2011 May 38 5 420-31
- Human polyomavirus 6 and 7 are associated with pruritic and dyskeratotic dermatoses.
  Nguyen KD, Lee EE, Yue Y, Stork J, Pock L, North JP, Vandergriff T, Cockerell C, Hosler GA, Pastrana DV, Buck CB, Wang RC Journal of the American Academy of Dermatology 2016 Dec
- Subclinical Lung Disease, Macrocytosis and Premature Graying in Kindreds with Telomerase (TERT) Mutations.
  Diaz de Leon A, Cronkhite JT, Yilmaz C, Brewington C, Wang R, Xing C, Hsia CC, Garcia CK Chest 2011 Feb 753-63
- Mitochondrial dysregulation and glycolytic insufficiency functionally impair CD8 T cells infiltrating human renal cell carcinoma.
  Siska PJ, Beckermann KE, Mason FM, Andrejeva G, Greenplate AR, Sendor AB, Chiang YJ, Corona AL, Gemta LF, Vincent BG, Wang RC, Kim B, Hong J, Chen CL, Bullock TN, Irish JM, Rathmell WK, Rathmell JC JCI insight 2017 Jun 2 12
- Glutathione Depletion, Pentose Phosphate Pathway Activation, and Hemolysis in Erythrocytes Protecting Cancer Cells from Vitamin C Induced Oxidative Stress.
  Zhang ZZ, Lee EE, Sudderth J, Yue Y, Zia A, Glass D, DeBerardinis RJ, Wang RC The Journal of biological chemistry 2016 Sep
- Tel2 regulates the stability of PI3K-related protein kinases.
  Takai H, Wang RC, Takai KK, Yang H, de Lange T Cell 2007 Dec 131 7 1248-59
- DNA polymerase-a regulates the activation of type I interferons through cytosolic RNA:DNA synthesis.
  Starokadomskyy P, Gemelli T, Rios JJ, Xing C, Wang RC, Li H, Pokatayev V, Dozmorov I, Khan S, Miyata N, Fraile G, Raj P, Xu Z, Xu Z, Ma L, Lin Z, Wang H, Yang Y, Ben-Amitai D, Orenstein N, Mussaffi H, Baselga E, Tadini G, Grunebaum E, Sarajlija A, Krzewski K, Wakeland EK, Yan N, de la Morena MT, Zinn AR, Burstein E Nature immunology 2016 Mar
- Differential glucose requirement in skin homeostasis and injury identifies a therapeutic target for psoriasis.
  Zhang Z, Zi Z, Lee EE, Zhao J, Contreras DC, South AP, Abel ED, Chong BF, Vandergriff T, Hosler GA, Scherer PE, Mettlen M, Rathmell JC, DeBerardinis RJ, Wang RC Nature medicine 2018 Apr
- Somatic mutations in telomerase promoter counterbalance germline loss-of-function mutations.
  Maryoung L, Yue Y, Young A, Newton CA, Barba C, van Oers NS, Wang RC, Garcia CK The Journal of clinical investigation 2017 Mar 127 3 982-986
- Polyomavirus-Associated Trichodysplasia Spinulosa Involves Hyperproliferation, pRB Phosphorylation and Upregulation of p16 and p21.
  Kazem S, van der Meijden E, Wang RC, Rosenberg AS, Pope E, Benoit T, Fleckman P, Feltkamp MC PloS one 2014 9 10 e108947
- The Biology and Clinical Features of Cutaneous Polyomaviruses.
  Nguyen KD, Chamseddin BH, Cockerell CJ, Wang RC The Journal of investigative dermatology 2019 Feb 139 2 285-292
- Autophagy in cellular growth control.
  Wang RC, Levine B FEBS letters 2010 Apr 584 7 1417-26
- A Primary Melanoma and its Asynchronous Metastasis Highlight the Role of BRAF, CDKN2A, and TERT.
  Hosler GA, Davoli T, Mender I, Litzner B, Choi J, Kapur P, Shay JW, Wang RC Journal of cutaneous pathology 2014 Nov
- A case of disseminated follicular spicules in human immunodeficiency virus-associated follicular syndrome in the absence of the seven known human polyomaviruses, suggesting that this disorder is distinct from trichodysplasia spinulosa.
  Maddy AJ, Lee EE, Maderal AD, Wang RC, Tosti A, Cho-Vega JH The British journal of dermatology 2018 Mar
- Trichodysplasia Spinulosa in a 7-Year-Old Boy Managed Using Physical Extraction of Keratin Spicules.
  Barton M, Lockhart S, Sidbury R, Wang R, Brandling-Bennett H Pediatric dermatology 2016 Dec
- Calcipotriol induces autophagy in HeLa cells and keratinocytes.
  Wang RC, Levine B The Journal of investigative dermatology 2011 Apr 131 4 990-3
- A Protein Kinase C Phosphorylation Motif in GLUT1 Affects Glucose Transport and is Mutated in GLUT1 Deficiency Syndrome.
  Lee EE, Ma J, Sacharidou A, Mi W, Salato VK, Nguyen N, Jiang Y, Pascual JM, North PE, Shaul PW, Mettlen M, Wang RC Molecular cell 2015 May
- Glucose Uptake in Heterologous Expression Systems.
  Lee EE, Wang RC Methods in molecular biology (Clifton, N.J.) 2018 1713 57-67
- Engineered telomere degradation models dyskeratosis congenita.
  Hockemeyer D, Palm W, Wang RC, Couto SS, de Lange T Genes & development 2008 Jul 22 13 1773-85
- Transforming activity of an oncoprotein-encoding circular RNA from human papillomavirus.
  Zhao J, Lee EE, Kim J, Yang R, Chamseddin B, Ni C, Gusho E, Xie Y, Chiang CM, Buszczak M, Zhan X, Laimins L, Wang RC, Nature communications 2019 05 10 1 2300
- Akt-mediated regulation of autophagy and tumorigenesis through Beclin 1 phosphorylation.
  Wang RC, Wei Y, An Z, Zou Z, Xiao G, Bhagat G, White M, Reichelt J, Levine B Science (New York, N.Y.) 2012 Nov 338 6109 956-9
- Two cases of trichodysplasia spinulosa responsive to compounded topical cidofovir 3% cream.
  Leitenberger JJ, Abdelmalek M, Wang RC, Strasfeld L, Hopkins RS JAAD case reports 2015 Nov 1 6 S33-5
- Homologous recombination generates T-loop-sized deletions at human telomeres.
  Wang RC, Smogorzewska A, de Lange T Cell 2004 Oct 119 3 355-68
- The Cause of Follicular Spicules in Multiple Myeloma.
  Hosler GA, Weibel L, Wang RC JAMA dermatology 2014 Dec
- Trichodysplasia spinulosa in a child: Identification of trichodysplasia spinulosa-associated polyomavirus in skin, serum, and urine.
  Chamseddin BH, Tran BAPD, Lee EE, Pastrana DV, Buck CB, Wang RC, Kirkorian AY, Pediatric dermatology 2019 Jun

Research

Glucose Transport and Metabolism
Skin Cancer
Polyomaviruses
Merkel Cell Carcinoma

Clinical Focus

Melanoma
Skin Cancer

New Patient Appointment Accepting Virtual Visits or 214-645-8300 or 817-882-2400