Robert Bachoo, M.D., Ph.D.

Miller Family Professorship in Neuro-Oncology

Neurology

New Patient Appointment or 214-645-8800

Education & Training

Graduate School - McGill University Faculty of Medicine, Experimental Medicine
Internship - Brigham and Women's Hospital/The Faulkner Hospital (1996-1997), Neurology
Residency - Tufts University (1997-2000), Neurology
Medical School - University of Toronto (1992-1996), Medicine

Professional Associations & Affiliations

American Society of Neuro-Oncology (2002)
American Society of Neurology (2000)
American Association for Cancer Research (2006)
American Academy of Neurology (2011)

Honors & Awards

McGill University 1989, Ph.D. with Honors
American Society of Clinical Investigation 2002, Poster presentation award
Medical Research Council of Canada Medical Scientist 1994-1996
Chief Resident 1999-2000, Tufts University Neurology Program
Heart and Stroke Foundation of Canada Medical Scientist 1992-1994

Books & Publications

Books
- Glioblastoma in Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease
  Maher E, Bachoo, R (2014), San Diego, Elsevier
Publications
- Corrigendum: Identification of a PTEN-regulated STAT₃ brain tumor suppressor pathway
  de la Iglesia N, Konopka G, Puram SV, Chan JA, Bachoo RM, You MJ, Levy DE, DePinho RA, Bonni A Genes & development 2025 Feb 39 299
- Editorial Expression of Concern: Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing(Nature, 10.1038/nature01385)
  Wong KK, Maser RS, Bachoo RM, Menon J, Carrasco DR, Gu Y, Alt FW, DePinho RA Nature 2025
- Spatially Precise and Minimally Invasive Delivery of Peptides to the Spinal Cord for Behavior Modulation
  Leong TW, Gao Z, David ET, Li X, Cai Q, Mwirigi JM, Zhang T, Giannotta M, Dejana E, Wiggins J, Krishnagiri S, Bachoo RM, Ge X, Price TJ, Qin Z ACS Nano 2024 Dec 18 34720-34729
- Transcription factors ASCL1 and OLIG2 drive glioblastoma initiation and co-regulate tumor cell types and migration
  Myers BL, Brayer KJ, Paez-Beltran LE, Villicana E, Keith MS, Suzuki H, Newville J, Anderson RH, Lo Y, Mertz CM, Kollipara RK, Borromeo MD, Lu QR, Bachoo RM, Johnson JE, Vue TY Nature communications 2024 Dec 15
- Erratum: Epidermal growth factor receptor and Ink4a/Arf: Convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis (Epidermal growth factor receptor and Ink4a/Arf (2002) 1(3) (269–277), (S1535610802000466), (10.1016/S1535-6108(02)00046-6))
  Bachoo RM, Maher EA, Ligon KL, Sharpless NE, Chan SS, You MJ, Tang Y, DeFrances J, Stover E, Weissleder R, Rowitch DH, Louis DN, DePinho RA Cancer Cell 2024 Dec 42 2124
- Glioblastoma Margin as a Diffusion Barrier Revealed by Photoactivation of Plasmonic Nanovesicles
  Xiong H, Wilson BA, Ge X, Gao X, Cai Q, Xu X, Bachoo R, Qin Z Nano Letters 2024 Feb 24 1570-1578
- Glioblastoma
  Maher EA, Bachoo RM 2024 Jan 2 215-227
- Live Mapping of the Brain Extracellular Matrix and Remodeling in Neurological Disorders
  Ge X, Xu X, Cai Q, Xiong H, Xie C, Hong Y, Gao X, Yao Y, Bachoo R, Qin Z Small Methods 2024 Jan 8
- Optical Modulation of the Blood–Brain Barrier for Glioblastoma Treatment
  Cai Q, Fan H, Li X, Giannotta M, Bachoo R, Qin Z Bio-protocol 2024 Jan 14
- Optical blood-brain-tumor barrier modulation expands therapeutic options for glioblastoma treatment
  Cai Q, Li X, Xiong H, Fan H, Gao X, Vemireddy V, Margolis R, Li J, Ge X, Giannotta M, Hoyt K, Maher E, Bachoo R, Qin Z Nature communications 2023 Dec 14
- Systematic investigation of mitochondrial transfer between cancer cells and T cells at single-cell resolution
  Zhang H, Yu X, Ye J, Li H, Hu J, Tan Y, Fang Y, Akbay E, Yu F, Weng C, Sankaran VG, Bachoo RM, Maher E, Minna J, Zhang A, Li B Cancer Cell 2023 Oct 41 1788-1802.e10
- ALK Amplification and Rearrangements Are Recurrent Targetable Events in Congenital and Adult Glioblastoma
  Blandin AF, Giglio R, Graham MS, Garcia G, Malinowski S, Woods JK, Ramkissoon S, Ramkissoon L, Dubois F, Schoolcraft K, Tsai J, Wang D, Jones R, Vogelzang J, Pelton K, Becker S, Watkinson F, Sinai C, Cohen EF, Booker MA, Tolstorukov MY, Haemels V, Goumnerova L, Wright K, Kieran M, Fehnel K, Reardon D, Tauziede-Espariat A, Lulla R, Carcamo B, Chaleff S, Charest A, De Smet F, Ligon AH, Dubuc A, Pages M, Varlet P, Wen PY, Alexander BM, Chi S, Alexandrescu S, Kittler R, Bachoo R, Bandopadhayay P, Beroukhim R, Ligon KL Clinical Cancer Research 2023 Jul 29 2651-2667
- Mechanobiological modulation of blood-brain barrier permeability by laser stimulation of endothelial-targeted nanoparticles
  Li X, Cai Q, Wilson BA, Fan H, Dave H, Giannotta M, Bachoo R, Qin Z Nanoscale 2023 Jan 15 3387-3397
- Glutamine anaplerosis is required for amino acid biosynthesis in human meningiomas
  Ijare OB, Hambarde S, Brasil Da Costa FH, Lopez S, Sharpe MA, Helekar SA, Hangel G, Bogner W, Widhalm G, Bachoo RM, Baskin DS, Pichumani K Neuro-oncology 2022 Apr 24 556-568
- Metabolic diversity within breast cancer brain-tropic cells determines metastatic fitness
  Parida PK, Marquez-Palencia M, Nair V, Kaushik AK, Kim K, Sudderth J, Quesada-Diaz E, Cajigas A, Vemireddy V, Gonzalez-Ericsson PI, Sanders ME, Mobley BC, Huffman K, Sahoo S, Alluri P, Lewis C, Peng Y, Bachoo RM, Arteaga CL, Hanker AB, DeBerardinis RJ, Malladi S Cell Metabolism 2022 Jan 34 90-105.e7
- SI-MOIRAI: A new method to identify and quantify the metabolic fate of nucleotides
  Ikeda Y, Hirayama A, Kofuji S, Hirota Y, Kamata R, Osaka N, Fujii Y, Sasaki M, Ikeda S, Smith EP, Bachoo R, Soga T, Sasaki AT Journal of Biochemistry 2021 Dec 170 699-711
- Reversibly Modulating the Blood-Brain Barrier by Laser Stimulation of Molecular-Targeted Nanoparticles
  Li X, Vemireddy V, Cai Q, Xiong H, Kang P, Li X, Giannotta M, Hayenga HN, Pan E, Sirsi SR, Mateo C, Kleinfeld D, Greene C, Campbell M, Dejana E, Bachoo R, Qin Z Nano Letters 2021 Nov 21 9805-9815
- Large animal models of glioma: Current status and future prospects
  HICKS WH, BIRD CE, PERNIK MN, HAIDER AS, DOBARIYA A, ABDULLAH KG, AOUN SG, BENTLEY RT, COHEN-GADOL AA, BACHOO RM, MICKEY BE, PASCUAL JM, EL AHMADIEH TY Anticancer Research 2021 Nov 41 5343-5353
- Probing Cerebral Metabolism with Hyperpolarized ¹³C Imaging after Opening the Blood-Brain Barrier with Focused Ultrasound
  Hackett EP, Shah BR, Cheng B, Lague E, Vemireddy V, Mendoza M, Bing C, Bachoo RM, Billingsley KL, Chopra R, Park JM ACS Chemical Neuroscience 2021 Aug 12 2820-2828
- Identification of tetracycline combinations as EphB1 tyrosine kinase inhibitors for treatment of neuropathic pain
  Ahmed MS, Wang P, Nhi Nguyen NU, Nakada Y, Menendez-Montes I, Ismail M, Bachoo R, Henkemeyer M, Sadek HA, Kandil ES Proceedings of the National Academy of Sciences of the United States of America 2021 Mar 118
- Preoperative imaging of glioblastoma patients using hyperpolarized ¹³C pyruvate: Potential role in clinical decision making
  Chen J, Patel TR, Pinho MC, Choi C, Harrison CE, Baxter JD, Derner K, Pena S, Liticker J, Raza J, Hall RG, Reed GD, Cai C, Hatanpaa KJ, Bankson JA, Bachoo RM, Malloy CR, Mickey BE, Park JM Neuro-Oncology Advances 2021 Jan 3
- ASCL1 regulates neurodevelopmental transcription factors and cell cycle genes in brain tumors of glioma mouse models
  Vue TY, Kollipara RK, Borromeo MD, Smith T, Mashimo T, Burns DK, Bachoo RM, Johnson JE GLIA 2020 Dec 68 2613-2630
- In vivo MRS measurement of 2-hydroxyglutarate in patient-derived IDH-mutant xenograft mouse models versus glioma patients
  Tiwari V, Mashimo T, An Z, Vemireddy V, Piccirillo S, Askari P, Hulsey KM, Zhang S, de Graaf RA, Patel TR, Pan E, Mickey BE, Maher EA, Bachoo RM, Choi C Magnetic resonance in medicine 2020 Sep 84 1152-1160
- Mechanical regulation of glycolysis via cytoskeleton architecture
  Park JS, Burckhardt CJ, Lazcano R, Solis LM, Isogai T, Li L, Chen CS, Gao B, Minna JD, Bachoo R, DeBerardinis RJ, Danuser G Nature 2020 Feb 578 621-626
- Gliomas Interact with Non-glioma Brain Cells via Extracellular Vesicles
  Gao X, Zhang Z, Mashimo T, Shen B, Nyagilo J, Wang H, Wang Y, Liu Z, Mulgaonkar A, Hu XL, Piccirillo SG, Eskiocak U, Davé DP, Qin S, Yang Y, Sun X, Fu YX, Zong H, Sun W, Bachoo RM, Ge Wp Cell Reports 2020 Feb 30 2489-2500.e5
- Glioblastoma
  Maher EA, Bachoo RM 2020 Jan 173-182
- Differences in creep response of GBM cells migrating in confinement
  Khan I, Bui L, Bachoo R, Kim YT, Chuong CJ International Biomechanics 2020 Jan 7 44-57
- IMP dehydrogenase-2 drives aberrant nucleolar activity and promotes tumorigenesis in glioblastoma
  Kofuji S, Hirayama A, Eberhardt AO, Kawaguchi R, Sugiura Y, Sampetrean O, Ikeda Y, Warren M, Sakamoto N, Kitahara S, Yoshino H, Yamashita D, Sumita K, Wolfe K, Lange L, Ikeda S, Shimada H, Minami N, Malhotra A, Morioka S, Ban Y, Asano M, Flanary VL, Ramkissoon A, Chow LM, Kiyokawa J, Mashimo T, Lucey G, Mareninov S, Ozawa T, Onishi N, Okumura K, Terakawa J, Daikoku T, Wise-Draper T, Majd N, Kofuji K, Sasaki M, Mori M, Kanemura Y, Smith EP, Anastasiou D, Wakimoto H, Holland EC, Yong WH, Horbinski C, Nakano I, DeBerardinis RJ, Bachoo RM, Mischel PS, Yasui W, Suematsu M, Saya H, Soga T, Grummt I, Bierhoff H, Sasaki AT Nature cell biology 2019 Aug 21 1003-1014
- Brain metabolism modulates neuronal excitability in a mouse model of pyruvate dehydrogenase deficiency
  Jakkamsetti V, Marin-Valencia I, Ma Q, Good LB, Terrill T, Rajasekaran K, Pichumani K, Khemtong C, Hooshyar MA, Sundarrajan C, Patel MS, Bachoo RM, Malloy CR, Pascual JM Science translational medicine 2019 11
- Radiation-induced DNA damage cooperates with heterozygosity of TP53 and PTEN to generate high-grade gliomas
  Todorova PK, Fletcher-Sananikone E, Mukherjee B, Kollipara R, Vemireddy V, Xie XJ, Guida PM, Story MD, Hatanpaa K, Habib AA, Kittler R, Bachoo R, Hromas R, Floyd JR, Burma S Cancer research 2019 79 3749-3761
- Isotope Tracing of Human Clear Cell Renal Cell Carcinomas Demonstrates Suppressed Glucose Oxidation In Vivo
  Courtney KD, Bezwada D, Mashimo T, Pichumani K, Vemireddy V, Funk AM, Wimberly J, McNeil SS, Kapur P, Lotan Y, Margulis V, Cadeddu JA, Pedrosa I, DeBerardinis RJ, Malloy CR, Bachoo R, Maher EA Cell Metabolism 2018 Nov 28 793-800.e2
- Measurement of ¹³C turnover into glutamate and glutamine pools in brain tumor patients
  Pichumani K, Mashimo T, Vemireddy V, Ijare OB, Mickey BE, Malloy CR, Marin-Valencia I, Baskin DS, Bachoo RM, Maher EA FEBS Letters 2017 Nov 591 3548-3554
- Label-free optical detection of action potential in mammalian neurons
  Batabyal S, Satpathy S, Bui L, Kim YT, Mohanty S, Bachoo R, Davé DP Biomedical Optics Express 2017 Aug 8 3700-3713
- Rapid progression to glioblastoma in a subset of IDH-mutated astrocytomas: a genome-wide analysis
  Richardson TE, Snuderl M, Serrano J, Karajannis MA, Heguy A, Oliver D, Raisanen JM, Maher EA, Pan E, Barnett S, Cai C, Habib AA, Bachoo RM, Hatanpaa KJ Journal of Neuro-Oncology 2017 May 133 183-192
- Targeting orthotopic gliomas with renal-clearable luminescent gold nanoparticles
  Peng C, Gao X, Xu J, du B, Ning X, Tang S, Bachoo RM, Yu M, Ge WP, Zheng J Nano Research 2017 Apr 10 1366-1376
- Oncogenes Activate an Autonomous Transcriptional Regulatory Circuit That Drives Glioblastoma
  Singh DK, Kollipara RK, Vemireddy V, Yang XL, Sun Y, Regmi N, Klingler S, Hatanpaa KJ, Raisanen J, Cho SK, Sirasanagandla S, Nannepaga S, Piccirillo S, Mashimo T, Wang S, Humphries CG, Mickey B, Maher EA, Zheng H, Kim RS, Kittler R, Bachoo RM Cell Reports 2017 Jan 18 961-976
- Prospective longitudinal analysis of 2-hydroxyglutarate magnetic resonance spectroscopy identifies broad clinical utility for the management of patients with IDH-mutant glioma
  Choi C, Raisanen JM, Ganji SK, Zhang S, McNeil SS, An Z, Madan A, Hatanpaa KJ, Vemireddy V, Sheppard CA, Oliver D, Hulsey KM, Tiwari V, Mashimo T, Battiste J, Barnett S, Madden CJ, Patel TR, Pan E, Malloy CR, Mickey BE, Bachoo RM, Maher EA Journal of Clinical Oncology 2016 Nov 34 4030-4039
- Hepatic gluconeogenesis influences ¹³C enrichment in lactate in human brain tumors during metabolism of [1,2-¹³C]acetate
  Pichumani K, Mashimo T, Vemireddy V, Kovacs Z, Ratnakar J, Mickey B, Malloy CR, DeBerardinis RJ, Bachoo RM, Maher EA Neurochemistry International 2016 Jul 97 133-136
- Brain Tumor Genetic Modification Yields Increased Resistance to Paclitaxel in Physical Confinement
  Bui L, Hendricks A, Wright J, Chuong CJ, Davé D, Bachoo R, Kim YT Scientific reports 2016 May 6
- Conditions for ¹³C NMR detection of 2-hydroxyglutarate in tissue extracts from isocitrate dehydrogenase-mutated gliomas
  Pichumani K, Mashimo T, Baek HM, Ratnakar J, Mickey B, DeBerardinis RJ, Maher EA, Bachoo RM, Malloy CR, Kovacs Z Analytical biochemistry 2015 Jun 481 4-6
- Proton T₂ measurement and quantification of lactate in brain tumors by MRS at 3 Tesla in vivo
  Madan A, Ganji SK, An Z, Choe KS, Pinho MC, Bachoo RM, Maher EM, Choi C Magnetic resonance in medicine 2015 Jun 73 2094-2099
- SOX2 reprograms resident astrocytes into neural progenitors in the adult brain
  Niu W, Zang T, Smith DK, Vue TY, Zou Y, Bachoo R, Johnson JE, Zhang CL Stem Cell Reports 2015 May 4 780-794
- DNA double-strand breaks cooperate with loss of Ink4 and Arf tumor suppressors to generate glioblastomas with frequent Met amplification
  Camacho CV, Todorova PK, Hardebeck MC, Tomimatsu N, Gil del Alcazar CR, Ilcheva M, Mukherjee B, McEllin B, Vemireddy V, Hatanpaa K, Story MD, Habib AA, Murty VV, Bachoo R, Burma S Oncogene 2015 Feb 34 1064-1072
- ¹H MRS characterization of neurochemical profiles in orthotopic mouse models of human brain tumors
  Hulsey KM, Mashimo T, Banerjee A, Soesbe TC, Spence JS, Vemireddy V, Maher EA, Bachoo RM, Choi C NMR in biomedicine 2015 Jan 28 108-115
- Acetate is a bioenergetic substrate for human glioblastoma and brain metastases
  Mashimo T, Pichumani K, Vemireddy V, Hatanpaa KJ, Singh DK, Sirasanagandla S, Nannepaga S, Piccirillo SG, Kovacs Z, Foong C, Huang Z, Barnett S, Mickey BE, Deberardinis RJ, Tu BP, Maher EA, Bachoo RM Cell 2014 Dec 159 1603-1614
- Glioblastoma
  Maher EA, Bachoo RM 2014 Nov 909-917
- In vivo detection of citrate in brain tumors by ¹H magnetic resonance spectroscopy at 3T
  Choi C, Ganji SK, Madan A, Hulsey KM, An Z, Zhang S, Pinho MC, Deberardinis RJ, Bachoo RM, Maher EA Magnetic resonance in medicine 2014 Aug 72 316-323
- High expression of the stem cell marker nestin is an adverse prognostic factor in WHO grade II-III astrocytomas and oligoastrocytomas
  Hatanpaa KJ, Hu T, Vemireddy V, Foong C, Raisanen JM, Oliver D, Hiemenz MC, Burns DK, White CL, Whitworth LA, Mickey B, Stegner M, Habib AA, Fink K, Maher EA, Bachoo RM Journal of Neuro-Oncology 2014 Mar 117 183-189
- In vivo chemical exchange saturation transfer imaging allows early detection of a therapeutic response in glioblastoma
  Sagiyama K, Mashimo T, Togao O, Vemireddy V, Hatanpaa KJ, Maher EA, Mickey BE, Pan E, Sherry AD, Bachoo RM, Takahashi M Proceedings of the National Academy of Sciences of the United States of America 2014 Mar 111 4542-4547
- Inhibition of DNA double-strand break repair by the dual PI3K/mTOR inhibitor NVP-BEZ235 as a strategy for radiosensitization of glioblastoma
  Gil Del Alcazar CR, Hardebeck MC, Mukherjee B, Tomimatsu N, Gao X, Yan J, Xie XJ, Bachoo R, Li L, Habib AA, Burma S Clinical Cancer Research 2014 20 1235-1248
- A comparative study of short- and long-TE ¹H MRS at 3 T for in vivo detection of 2-hydroxyglutarate in brain tumors
  Choi C, Ganji S, Hulsey K, Madan A, Kovacs Z, Dimitrov I, Zhang S, Pichumani K, Mendelsohn D, Mickey B, Malloy C, Bachoo R, Deberardinis R, Maher E NMR in biomedicine 2013 Oct 26 1242-1250
- In vivo reprogramming of astrocytes to neuroblasts in the adult brain
  Niu W, Zang T, Zou Y, Fang S, Smith DK, Bachoo R, Zhang CL Nature cell biology 2013 Oct 15 1164-1175
- Proliferation and migration of tumor cells in tapered channels
  Wan Y, Tamuly D, Allen PB, Kim YT, Bachoo R, Ellington AD, Iqbal SM Biomedical Microdevices 2013 Aug 15 635-643
- In vivo contribution of nestin- and GLAST-lineage cells to adult hippocampal neurogenesis
  Decarolis NA, Mechanic M, Petrik D, Carlton A, Ables JL, Malhotra S, Bachoo R, Götz M, Lagace DC, Eisch AJ Hippocampus 2013 Aug 23 708-719
- Progenitor Cell Line (hPheo1) Derived from a Human Pheochromocytoma Tumor
  Ghayee HK, Bhagwandin VJ, Stastny V, Click A, Ding LH, Mizrachi D, Zou YS, Chari R, Lam WL, Bachoo RM, Smith AL, Story MD, Sidhu S, Robinson BG, Nwariaku FE, Gazdar AF, Auchus RJ, Shay JW PloS one 2013 Jun 8
- Lamin A/C depletion enhances DNA damage-induced stalled replication fork arrest
  Singh M, Hunt CR, Pandita RK, Kumar R, Yang CR, Horikoshi N, Bachoo R, Serag S, Story MD, Shay JW, Powell SN, Gupta A, Jeffery J, Pandita S, Chen BP, Deckbar D, Löbrich M, Yang Q, Khanna KK, Worman HJ, Panditaa TK Molecular and cellular biology 2013 Mar 33 1210-1222
- Lamin A/C depletion enhances DNA damage-induced stalled replication fork arrest
  Singh M, Hunt CR, Pandita RK, Kumar R, Yang CR, Horikoshi N, Bachoo R, Serag S, Story MD, Shay JW, Powell SN, Gupta A, Jeffery J, Pandita S, Chen BP, Deckbar D, Löbrich M, Yang Q, Khanna KK, Worman HJ, Pandita TK Molecular and cellular biology 2013 33 3390
- Erratum: Analysis of tumor metabolism reveals mitochondrial glucose oxidation in genetically diverse human glioblastomas in the mouse brain in vivo (Cell Metabolism (2012) 16 (394-406))
  Marin-Valencia I, Yang C, Mashimo T, Cho S, Baek H, Yang XL, Rajagopalan KN, Maddie M, Vemireddy V, Zhao Z, Cai L, Good L, Tu BP, Hatanpaa KJ, Mickey BE, Matés JM, Pascual JM, Maher EA, Malloy CR, DeBerardinis RJ, Bachoo RM Cell Metabolism 2012 Nov 16 686
- Metabolism of [U-¹³C]glucose in human brain tumors in vivo
  Maher EA, Marin-Valencia I, Bachoo RM, Mashimo T, Raisanen J, Hatanpaa KJ, Jindal A, Jeffrey FM, Choi C, Madden C, Mathews D, Pascual JM, Mickey BE, Malloy CR, Deberardinis RJ NMR in biomedicine 2012 Nov 25 1234-1244
- Glucose metabolism via the pentose phosphate pathway, glycolysis and Krebs cycle in an orthotopic mouse model of human brain tumors
  Marin-Valencia I, Cho SK, Rakheja D, Hatanpaa KJ, Kapur P, Mashimo T, Jindal A, Vemireddy V, Good LB, Raisanen JM, Sun X, Mickey BE, Choi C, Takahashi M, Togao O, Pascual JM, DeBerardinis RJ, Maher EA, Malloy CR, Bachoo R NMR in biomedicine 2012 Oct 25 1177-1186
- Resistance to EGF receptor inhibitors in glioblastoma mediated by phosphorylation of the PTEN tumor suppressor at tyrosine 240
  Fenton TR, Nathanson D, Ponte De Albuquerque C, Kuga D, Iwanami A, Dang J, Yang H, Tanaka K, Oba-Shinjo S, Uno M, Del Mar Inda M, Wykosky J, Bachoo RM, James CD, DePinho RA, Vandenberg SR, Zhou H, Marie SK, Mischel PS, Cavenee WK, Furnari FB Proceedings of the National Academy of Sciences of the United States of America 2012 Aug 109 14164-14169
- Electrical fingerprinting, 3D profiling and detection of tumor cells with solid-state micropores
  Asghar W, Wan Y, Ilyas A, Bachoo R, Kim YT, Iqbal SM Lab on a Chip 2012 Jul 12 2345-2352
- Analysis of tumor metabolism reveals mitochondrial glucose oxidation in genetically diverse human glioblastomas in the mouse brain in vivo
  Marin-Valencia I, Yang C, Mashimo T, Cho S, Baek H, Yang XL, Rajagopalan KN, Maddie M, Vemireddy V, Zhao Z, Cai L, Good L, Tu BP, Hatanpaa KJ, Mickey BE, Matés JM, Pascual JM, Maher EA, Malloy CR, DeBerardinis RJ, Bachoo RM Cell Metabolism 2012 Jun 15 827-837
- 2-Hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas
  Choi C, Ganji SK, DeBerardinis RJ, Hatanpaa KJ, Rakheja D, Kovacs Z, Yang XL, Mashimo T, Raisanen JM, Marin-Valencia I, Pascual JM, Madden CJ, Mickey BE, Malloy CR, Bachoo R, Maher EA Nature medicine 2012 Apr 18 624-629
- Nanotextured substrates with immobilized aptamers for cancer cell isolation and cytology
  Wan Y, Mahmood MA, Li N, Allen PB, Kim YT, Bachoo R, Ellington AD, Iqbal SM Cancer 2012 Feb 118 1145-1154
- Leukocyte common antigen-related phosphatase is a functional receptor for chondroitin sulfate proteoglycan axon growth inhibitors
  Fisher D, Xing B, Dill J, Li H, Hoang HH, Zhao Z, Yang XL, Bachoo R, Cannon S, Longo FM, Sheng M, Silver J, Li S Journal of Neuroscience 2011 Oct 31 14051-14066
- ATM-dependent IGF-1 induction regulates secretory clusterin expression after DNA damage and in genetic instability
  Goetz EM, Shankar B, Zou Y, Morales JC, Luo X, Araki S, Bachoo R, Mayo LD, Boothman DA Oncogene 2011 Sep 30 3745-3754
- MicroRNA-146a inhibits glioma development by targeting Notch1
  Mei J, Bachoo R, Zhang CL Molecular and cellular biology 2011 Sep 31 3584-3592
- Measurement of glycine in the human brain in vivo by ¹H-MRS at 3 T: Application in brain tumors
  Choi C, Ganji SK, Deberardinis RJ, Dimitrov IE, Pascual JM, Bachoo R, Mickey BE, Malloy CR, Maher EA Magnetic resonance in medicine 2011 Sep 66 609-618
- Small-molecule blocks malignant astrocyte proliferation and induces neuronal gene expression
  Zhang L, Li P, Hsu T, Aguilar HR, Frantz DE, Schneider JW, Bachoo R, Hsieh J Differentiation 2011 Apr 81 233-242
- SHP-2/PTPN11 mediates gliomagenesis driven by PDGFRA and INK4A/ARF aberrations in mice and humans
  Liu KW, Feng H, Bachoo R, Kazlauskas A, Smith EM, Symes K, Hamilton RL, Nagane M, Nishikawa R, Hu B, Cheng SY Journal of Clinical Investigation 2011 Mar 121 905-917
- Purkinje cell-specific males absent on the first (mMof) gene deletion results in an ataxia-telangiectasia-like neurological phenotype and backward walking in mice
  Kumar R, Hunt CR, Gupta A, Nannepaga S, Pandita RK, Shay JW, Bachoo R, Ludwig T, Burns DK, Pandita TK Proceedings of the National Academy of Sciences of the United States of America 2011 Mar 108 3636-3641
- Erratum: Surface-immobilized aptamers for cancer cell isolation and microscopic cytology (Cancer Research (2010) 70 (9371-80))
  Wan Y, Kim YT, Li N, Cho SK, Bachoo R, Ellington AD, Iqbal SM Cancer research 2011 Jan 71 626
- Surface-immobilized aptamers for cancer cell isolation and microscopic cytology
  Wan Y, Kim YT, Li N, Cho SK, Bachoo R, Ellington AD, Iqbal SM Cancer research 2010 Nov 70 9371-9380
- Tumor heterogeneity is an active process maintained by a mutant EGFR-induced cytokine circuit in glioblastoma
  Inda MD, Bonavia R, Mukasa A, Narita Y, Sah DW, Vandenberg S, Brennan C, Johns TG, Bachoo R, Hadwiger P, Tan P, DePinho RA, Cavenee W, Furnari F Genes and Development 2010 Aug 24 1731-1745
- PTEN loss compromises homologous recombination repair in astrocytes: Implications for glioblastoma therapy with temozolomide or poly(ADP-Ribose) polymerase inhibitors
  McEllin B, Camacho CV, Mukherjee B, Hahm B, Tomimatsu N, Bachoo RM, Burma S Cancer research 2010 Jul 70 5457-5464
- Loss of p15/Ink4b accompanies tumorigenesis triggered by complex DNA double-strand breaks
  Camacho CV, Mukherjee B, McEllin B, Ding LH, Hu B, Habib AA, Xie XJ, Nirodi CS, Saha D, Story MD, Balajee AS, Bachoo RM, Boothman DA, Burma S Carcinogenesis 2010 Jul 31 1889-1896
- Glioblastoma cellsrequire glutamate dehydrogenase to survive impairments of glucose metabolism or akt signaling (Cancer Research (2009) 69, (7986-7993))
  Yang C, Sudderth J, Dang T, Bachoo RM, McDonald JG, DeBerardinis RJ Cancer research 2010 Feb 70 1275
- A molecular mechanism for ibuprofen-mediated RhoA inhibition in neurons
  Dill J, Patel AR, Yang XL, Bachoo R, Powell CM, Li S Journal of Neuroscience 2010 Jan 30 963-972
- The telomerase antagonist, imetelstat, efficiently targets glioblastoma tumor-initiating cells leading to decreased proliferation and tumor growth
  Marian CO, Cho SK, Mcellin BM, Maher EA, Hatanpaa KJ, Madden CJ, Mickey BE, Wright WE, Shay JW, Bachoo RM Clinical Cancer Research 2010 Jan 16 154-163
- Glioblastoma cells require glutamate dehydrogenase to survive impairments of glucose metabolism or Akt signaling
  Chendong Y, Sudderth J, Tuyen D, Bachoo RG, McDonald JG, DeBerardinis RJ Cancer research 2009 Oct 69 7986-7993
- EGFRvIII and DNA double-strand break repair: A molecular mechanism for radioresistance in glioblastoma
  Mukherjee B, McEllin B, Camacho CV, Tomimatsu N, Sirasanagandala S, Nannepaga S, Hatanpaa KJ, Mickey B, Madden C, Maher E, Boothman DA, Furnari F, Cavenee WK, Bachoo RM, Burma S Cancer research 2009 May 69 4252-4259
- The receptor interacting protein 1 inhibits p53 induction through NF-KB activation and confers a worse prognosis in glioblastoma
  Park S, Hatanpaa KJ, Xie Y, Mickey BE, Madden CJ, Raisanen JM, Ramnarain DB, Xiao G, Saha D, Boothman DA, Zhao D, Bachoo RM, Pieper RO, Habib AA Cancer research 2009 Apr 69 2809-2816
- Functional skeletal muscle regeneration from differentiating embryonic stem cells
  Darabi R, Gehlbach K, Bachoo RM, Kamath S, Osawa M, Kamm KE, Kyba M, Perlingeiro RC Nature medicine 2008 Feb 14 134-143
- Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway
  De La Iglesia N, Konopka G, Puram SV, Chan JA, Bachoo RM, You MJ, Levy DE, DePinho RA, Bonni A Genes and Development 2008 Feb 22 449-462
- Malignant astrocytic glioma: Genetics, biology, and paths to treatment
  Furnari FB, Fenton T, Bachoo RM, Mukasa A, Stommel JM, Stegh A, Hahn WC, Ligon KL, Louis DN, Brennan C, Chin L, DePinho RA, Cavenee WK Genes and Development 2007 Nov 21 2683-2710
- Erratum: Bcl2L12 inhibits post-mitochondrial apoptosis signaling in glioblastoma (Ecography (2007) 21 (98-111))
  Stegh AH, Kim H, Bachoo RM, Forloney KL, Zhang J, Schulze H, Park K, Hannon GJ, Yuan J, Louis DN, DePinho RA, Chin L Genes and Development 2007 Feb 21 481
- Olig2-Regulated Lineage-Restricted Pathway Controls Replication Competence in Neural Stem Cells and Malignant Glioma
  Ligon KL, Huillard E, Mehta S, Kesari S, Liu H, Alberta JA, Bachoo RM, Kane M, Louis DN, DePinho RA, Anderson DJ, Stiles CD, Rowitch DH Neuron 2007 Feb 53 503-517
- Bcl2L12 inhibits post-mitochondrial apoptosis signaling in glioblastoma
  Stegh AH, Kim H, Bachoo RM, Forloney KL, Zhang J, Schulze H, Park K, Hannon GJ, Yuan J, Louis DN, DePinho RA, Chin L Genes and Development 2007 Jan 21 98-111
- Suppression of Reactive Oxygen Species and Neurodegeneration by the PGC-1 Transcriptional Coactivators
  St-Pierre J, Drori S, Uldry M, Silvaggi JM, Rhee J, Jäger S, Handschin C, Zheng K, Lin J, Yang W, Simon DK, Bachoo R, Spiegelman BM Cell 2006 Oct 127 397-408
- PCAF modulates PTEN activity
  Okumura K, Mendoza M, Bachoo RM, DePinho RA, Cavenee WK, Furnari FB Journal of Biological Chemistry 2006 Sep 281 26562-26568
- Three-dimensional visualization of microvessel architecture of whole-mount tissue by confocal microscopy
  Dickie R, Bachoo RM, Rupnick MA, Dallabrida SM, DeLoid GM, Lai J, DePinho RA, Rogers RA Microvascular Research 2006 Jul 72 20-26
- Erratum: Molecular diversity of astrocytes with implications for neurological disorders (Proceedings of the National Academy of Sciencs of the United States of America (June 1, 2004) 101, 22 (8384-8389))
  Bachoo RM, Kim RS, Ligon KL, Maher EA, Brennan C, Billings N, Chan S, Li C, Rowitch DH, Wong WH, DePinho RA Proceedings of the National Academy of Sciences of the United States of America 2004 Jul 101
- Molecular diversity of astrocytes with implications for neurological disorders
  Bachoo RM, Kim RS, Ligon KL, Maher EA, Brennan C, Billings N, Chan S, Li C, Rowitch DH, Wong WH, DePinho RA Proceedings of the National Academy of Sciences of the United States of America 2004 Jun 101 8384-8389
- Ectopic Expression of the Catalytic Subunit of Telomerase Protects against Brain Injury Resulting from Ischemia and NMDA-Induced Neurotoxicity
  Kang HJ, Choi YS, Hong SB, Kim KW, Woo RS, Won SJ, Kim EJ, Jeon HK, Jo SY, Kim TK, Bachoo R, Reynolds IJ, Gwag BJ, Lee HW Journal of Neuroscience 2004 Feb 24 1280-1287
- Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing
  Wong KK, Maser RS, Bachoo RM, Menon J, Carrasco DR, Gu Y, Alt FW, DePinho RA Nature 2003 Feb 421 643-648
- Epidermal growth factor receptor and Ink4a/Arf: Convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis
  Bachoo RM, Maher EA, Ligon KL, Sharpless NE, Chan SS, You MJ, Tang Y, DeFrances J, Stover E, Weissleder R, Rowitch DH, Louis DN, DePinho RA Cancer Cell 2002 Apr 1 269-277
- Malignant glioma: Genetics and biology of a grave matter
  Maher EA, Furnari FB, Bachoo RM, Rowitch DH, Louis DN, Cavenee WK, DePinho RA Genes and Development 2001 15 1311-1333
- Microsurgical C-2 ganglionectomy for chronic intractable occipital pain
  Lozano AM, Vanderlinden G, Bachoo R, Rothbart P Journal of neurosurgery 1998 Sep 89 359-365
- Role of neuron soma firing in the restoration of neurotensin store in sympathetic preganglionic neuron terminals after stimulus-evoked depletion
  Maher E, Bachoo B, Polosa C Brain Research 1994 Mar 640 126-130
- In vitro and in vivo evidence of neurotensin release from preganglionic axon terminals in the stellate ganglion of the cat
  Maher E, Bachoo B, Polosa C Brain Research 1994 Mar 640 131-135

Research

Tumor Cell Migration
Tumor Microenvironment
Brain Tumor Metabolism
Malignant Transformation
Stem Cell Biology

Robert Bachoo, M.D., Ph.D.

Education & Training

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