Rolando Garcia, Ph.D.

Pathology

Biography

Education:

Rutgers University 2011-2015 Biomedical Informatics PhD

Fellowship:

UT Southwestern 2016-2018 Clinical Genetics and Genomics

UT Southwestern 2018-2019 Laboratory Genetics and Genomics

Education & Training

Fellowship - Pathology - Clinical Cytogenetics (2016-2018), Cytogenetics
Undergraduate School - University of Texas at San Antonio (1986-1990)
Graduate School - Rutgers University, the State University of New Jersey (2013-2015)
Graduate School - Rutgers University, the State University of New Jersey (2007-2009)

Books & Publications

Publications
- Structural screening and molecular simulation identify potential ligands against the K700E hot spot variant and functional pockets of SF3B1 to modulate splicing in myelodysplastic syndrome.
  García R, Atis M, Cox A, Koduru P, Heliyon 2024 Jun 10 12 e32729
- RNASeq Analysis for Accurate Identification of Fusion Partners in Tumor Specific Translocations Detected by Standard FISH Probes in Hematologic Malignancies.
  Koduru P, Chen W, Fuda F, Kaur G, Awan F, John S, Garcia R, Gagan J, Clinical pathology (Thousand Oaks, Ventura County, Calif.) 2024 17 2632010X241230262
- Automated prediction of acute promyelocytic leukemia from flow cytometry data using a graph neural network pipeline.
  Cox AM, Kim D, García R, Fuda FS, Weinberg OK, Chen W, American journal of clinical pathology 2023 Oct
- A t(11;14)(q13;q32)/CCND1::IGH carrying progenitor germinal B-cell with subsequent cytogenetic aberrations contributes to the development of classic Hodgkin lymphoma.
  García R, Timmons C, Luu H, Miller V, Fuda F, Chen W, Koduru P, Cancer genetics 2022 Oct 268-269 97-102
- An artificial intelligence system applied to recurrent cytogenetic aberrations and genetic progression scores predicts MYC rearrangements in large B-cell lymphoma.
  García R, Hussain A, Chen W, Wilson K, Koduru P, EJHaem 2022 Aug 3 3 707-721
- Rhabdomyosarcoma With Epithelioid Features And NSD3::FOXO1 Fusion: Evidence For Reconsideration Of Previously Reported FOXO1::FGFR1 Fusion.
  Rakheja D, Park JY, Yang MS, Martinez DP, Koduru P, Wilson KS, Garcia R, Uddin N, International journal of surgical pathology 2022 May 10668969221098084
- A Combined Biomarker of Bright CD38 and MYC =55% Is Highly Predictive of Double-/Triple-Hit High-Grade B-Cell Lymphoma.
  Alsuwaidan A, Koduru P, Fuda F, Manuel Jaso J, Chen M, Rosado F, Luu HS, Sweed N, Garcia R, Doucet M, Desai NB, Kumar KA, Awan FT, Ramakrishnan Geethakumari P, Chen W, American journal of clinical pathology 2022 May
- Automated classification of cytogenetic abnormalities in hematolymphoid neoplasms.
  Cox A, Park C, Koduru P, Wilson K, Weinberg O, Chen W, García R, Kim D, Bioinformatics (Oxford, England) 2021 Dec
- Identification of potential antiviral compounds against SARS-CoV-2 structural and non structural protein targets: A pharmacoinformatics study of the CAS COVID-19 dataset.
  García R, Hussain A, Koduru P, Atis M, Wilson K, Park JY, Toby I, Diwa K, Vu L, Ho S, Adnan F, Nguyen A, Cox A, Kirtek T, García P, Li Y, Jones H, Shi G, Green A, Rosenbaum D, Computers in biology and medicine 2021 06 133 104364
- Development and Clinical Validation of a Multiplex Gene Fusion Assay
  Rolando García, PhD, Nirav Patel, PhD,Naseem Uddin, MD, Jason Y. Park,MD, PhD Laboratory Medicine 2020 1-7
- Bright CD38 Expression by Flow Cytometric Analysis Is a Biomarker for Double/Triple Hit Lymphomas with a Moderate Sensitivity and High Specificity.
  Alsuwaidan A, Pirruccello E, Jaso J, Koduru P, Garcia R, Krueger J, Doucet M, Chaudhry R, Fuda F, Chen W Cytometry. Part B, Clinical cytometry 2019 Feb
- Clinical impact of MYC abnormalities in plasma cell myeloma.
  García R, Chen W, Koduru P Cancer genetics 2018 Dec 228-229 115-126
- Cytogenetic and Cytogenomic Microarray Characterization of Chromothripsis in Chromosome 8 Affecting MOZ/NCOA2 (TIF2), FGFR1, RUNX1T1, and RUNX1 in a Pediatric Acute Myeloid Leukemia.
  Koduru PR, Wilson K, Wen J, Garcia R, Patel S, Monaghan SA Journal of pediatric hematology/oncology 2017 Jan
- Acquisition of a t(11;14)(q13;q32) in clonal evolution in a follicular lymphoma with a t(14;18)(q32;q21) and t(3;22)(q27;q11.2).
  Koduru PR, Chen W, Garcia R, Fuda F Cancer genetics 2015 Mar
- Myeloid neoplasm with t(3;8)(q26;q24): report of six cases and review of the literature.
  Xu X, Su M, Levy NB, Mohtashamian A, Monaghan S, Kaur P, Zaremba C, Garcia R, Broome HE, Dell'aquila ML, Wang HY Leukemia & lymphoma 2014 Feb
- A case of pediatric B-Lymphoblastic leukemia presenting with a t(9;12)(p24;q11.2) involving JAK2 and concomitant MLL rearrangement with apparent insertion at 6q27.
  Tirado CA, Shabsovich D, DeNicola M, Rao D, Yang L, Garcia R, Rao N, Biomarker research 2013 Nov 1 1 31
- Atypical rearrangement involving 3'-IGH@ and a breakpoint at least 400 Kb upstream of an intact MYC in a CLL patient with an apparently balanced t(8;14)(q24.1;q32) and negative MYC expression.
  Amarillo I, Bui PH, Kantarci S, Rao N, Shackley BS, García R, Tirado CA, Molecular cytogenetics 2013 Feb 6 1 5
- A Chronic Myelogenous Leukemia (CML) Case with a Cryptic Insertion of the ABL1 Gene of Chromosome 9 into 22 Resulting in a Fusion Signal on the Derivative 22: 46,XY.ish ins(22;9)(q11.2;q34q34)BCR+,ABL1.
  Boles J, DeNicola M, Collins R, Garcia R, Patel S, Satayasoontorn K, Tirado CA, Journal of the Association of Genetic Technologists 2013 39 1 21-2
- Recombinant chromosome 7 in a mosaic 45,X/47,XXX patient.
  Tirado CA, Gotway G, Torgbe E, Iyer S, Dallaire S, Appleberry T, Suterwala M, Garcia R, Valdez F, Patel S, Koduru P American journal of medical genetics. Part A 2012 Jan 158A 1 206-14
- Genomic profiling using array comparative genomic hybridization define distinct subtypes of diffuse large B-cell lymphoma: a review of the literature.
  Tirado CA, Chen W, García R, Kohlman KA, Rao N Journal of hematology & oncology 2012 5 54
- Erythroblastic sarcoma presenting as bilateral ovarian masses in an infant with pure erythroid leukemia.
  Wang HY, Huang LJ, Liu Z, Garcia R, Li S, Galliani CA, Human pathology 2011 May 42 5 749-58
- Coexistence of t(12;21)(p13;q22)/ETV6-RUNX1 and 11q23/MLL Rearrangement in B Acute Lymphoblastic Leukemia: A Case Report and Review of the Literature.
  Hiemenz MC, Chen W, Winick N, Garcia R, Tirado CA Journal of the Association of Genetic Technologists 2011 37 4 213-5
- Acute myeloid leukemia with inv(16) with CBFB-MYH11, 3'CBFB deletion, variant t(9;22) with BCR-ABL1, and del(7)(q22q32) in a pediatric patient: case report and literature review.
  Tirado CA, Valdez F, Klesse L, Karandikar NJ, Uddin N, Arbini A, Fustino N, Collins R, Patel S, Smart RL, Garcia R, Doolittle J, Chen W Cancer genetics and cytogenetics 2010 Jul 200 1 54-9
- Simple karyotype and bcl-6 expression predict a diagnosis of Burkitt lymphoma and better survival in IG-MYC rearranged high-grade B-cell lymphomas.
  Seegmiller AC, Garcia R, Huang R, Maleki A, Karandikar NJ, Chen W Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2010 Jul 23 7 909-20
- Unusual presentation of myeloid sarcoma in a case of acute promyelocytic leukemia with a cryptic PML-RARA rearrangement involving multiple sites including the atrium.
  Tirado CA, Chen W, Valdez F, Karandikar N, Arbini A, Acevedo I, Garcia R, Davila O, Smart RL, Matthews E, Kirk A, Collins RH Cancer genetics and cytogenetics 2010 Jul 200 1 47-53
- JAK2 Translocations in hematological malignancies: Review of the literature.
  Ho K, Valdez F, Garcia R, Tirado CA Journal of the Association of Genetic Technologists 2010 36 3 107-9
- Cytogenetic and molecular characterization of a partial trisomy 2p arising from inverted duplication of 2p with terminal deletion of 2pter.
  Tirado CA, Henderson S, Uddin N, Stewart E, Iyer S, Ratner IM, Matthews E, Doolittle J, Garcia R, Valdez F, Dallaire S, Appleberry T, Payne D, Collins R American journal of medical genetics. Part A 2009 Nov 149A 11 2507-12
- Plasmablastic lymphomas with MYC/IgH rearrangement: report of three cases and review of the literature.
  Bogusz AM, Seegmiller AC, Garcia R, Shang P, Ashfaq R, Chen W American journal of clinical pathology 2009 Oct 132 4 597-605
- Acute myeloid leukemia (M2) with a cryptic RUNX1/RUNX1T1 t(1;21;8)(p36;q22;q22) variant.
  Tirado CA, Chen W, Valdez FJ, Henderson S, Doolittle J, Garcia R, Patel S, Holdridge S, Chastain C, Collins RH Cancer genetics and cytogenetics 2009 Aug 193 1 67-9
- A Cryptic t(1;21;8)(p36;q22;q22) in a Case of Acute Myeloid Leukemia with Maturation.
  Tirado CA, Chena W, Valdez FJ, Henderson S, Smart RL, Doolittle J, Garcia R, Patel S, Holdridge S, Chastain C, Auchus M, Collins RH Journal of the Association of Genetic Technologists 2009 35 3 88-92