Sarah Huen, M.D., Ph.D.

Internal Medicine - Nephrology

New Patient Appointment or 214-645-1919

Biography

Dr. Sarah Huen is originally from Chicago, IL. She received her initial medical training at Northwestern University. She completed her Internal Medicine residency training at New York University Medical Center. Intrigued by the pathophysiology of acute kidney injury and frustrated by the lack of any viable therapeutic options, she pursued a research nephrology fellowship and a Ph.D. degree in Investigative Medicine at Yale University in the laboratory of Dr. Lloyd Cantley studying the role of macrophages in ischemic kidney injury. She was a post doctoral fellow in the laboratory of Dr. Ruslan Medzhitov at Yale where she studied the mechanisms of tissue tolerance and changes in metabolism in systemic inflammation. Dr. Huen joined the faculty at UT Southwestern in 2017 as an Assistant Professor. Her research interests include investigating renal metabolism in sepsis and other states of inflammation. Outside of medicine and science, she enjoys cooking, photography and hiking.

Education & Training

Other Post Graduate Training - Yale University School of Medicine (2011-2013)
Graduate School - Yale University School of Medicine (2011-2013), Investigative Medicine
Fellowship - Yale University School of Medicine (2007-2012), Nephrology
Residency - New York University School of Medicine (2004-2007), Internal Medicine
Medical School - Northwestern University Feinberg School of Medicine (2000-2004)

Professional Associations & Affiliations

American Society of Nephrology (2008), Member
American Heart Association, Kidney Council (2012), Member

Honors & Awards

Phi Beta Kappa 2000, Northwestern University
Carl W. Gottschalk Research Scholar 2016, American Society of Nephrology
Iva Dostanic Physician-Scientist Trainee Award 2017, Yale University School of Medicine
Disease Oriented Clinical Scholar Award 2017, UT Southwestern

Books & Publications

Publications
- Alpha-melanocyte-stimulating hormone contributes to an anti-inflammatory response to lipopolysaccharide.
  Reynolds RP, Fan RR, Tinajero A, Luo X, Huen SC, Fujikawa T, Lee S, Lemoff A, Mountjoy KG, Elmquist JK, Molecular metabolism 2024 Jul 87 101986
- Hepatic ketogenesis is not required for starvation adaptation in mice.
  Feola K, Venable AH, Broomfield T, Villegas M, Fu X, Burgess S, Huen SC, Molecular metabolism 2024 Jun 86 101967
- Metabolism and Nutrition in Sepsis: In Need of a Paradigm Shift.
  Collins K, Huen SC, Nephron 2023 Sep
- When a calorie isn't just a calorie: a revised look at nutrition in critically ill patients with sepsis and acute kidney injury.
  Nadamuni M, Venable AH, Huen SC, Current opinion in nephrology and hypertension 2022 Jul 31 4 358-366
- Fasting-induced renal HMGCS2 expression does not contribute to circulating ketones.
  Venable AH, Lee LE, Feola K, Santoyo J, Broomfield T, Huen SC, American journal of physiology. Renal physiology 2022 Feb
- Hepatic FGF21 preserves thermoregulation and cardiovascular function during bacterial inflammation.
  Huen SC, Wang A, Feola K, Desrouleaux R, Luan HH, Hogg R, Zhang C, Zhang QJ, Liu ZP, Medzhitov R, The Journal of experimental medicine 2021 Oct 218 10
- Metabolism as Disease Tolerance: Implications for Sepsis-Associated Acute Kidney Injury.
  Huen SC, Nephron 2021 Jun 1-4
- Survey of Current Practices of Outpatient Hemodialysis for AKI Patients.
  Ortiz-Soriano V, Butler CR, Levy M, Huen SC, Castaneda JL, Sakhuja A, Basu RK, Liu KD, Cerda J, Neyra JA, Kidney international reports 2021 Apr 6 4 1156-1160
- Controversies in acute kidney injury: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Conference.
  Ostermann M, Bellomo R, Burdmann EA, Doi K, Endre ZH, Goldstein SL, Kane-Gill SL, Liu KD, Prowle JR, Shaw AD, Srisawat N, Cheung M, Jadoul M, Winkelmayer WC, Kellum JA, Kidney international 2020 Aug 98 2 294-309
- Renal tubular cell spliced X-box binding protein 1 (Xbp1s) has a unique role in sepsis-induced acute kidney injury and inflammation.
  Ferrè S, Deng Y, Huen SC, Lu CY, Scherer PE, Igarashi P, Moe OW, Kidney international 2019 12 96 6 1359-1373
- Targeting protein translation to prevent septic kidney injury.
  Huen SC The Journal of clinical investigation 2018 Dec
- Glucose metabolism mediates disease tolerance in cerebral malaria.
  Wang A, Huen SC, Luan HH, Baker K, Rinder H, Booth CJ, Medzhitov R Proceedings of the National Academy of Sciences of the United States of America 2018 Oct 115 43 11042-11047
- Acute Kidney Injury After Burn: A Cohort Study From the Parkland Burn Intensive Care Unit.
  Clark AT, Li X, Kulangara R, Adams-Huet B, Huen SC, Madni TD, Imran JB, Phelan HA, Arnoldo BD, Moe OW, Wolf SE, Neyra JA Journal of burn care & research : official publication of the American Burn Association 2018 Sep
- Macrophages in Renal Injury and Repair.
  Huen SC, Cantley LG Annual review of physiology 2017 Feb 79 449-469
- Opposing Effects of Fasting Metabolism on Tissue Tolerance in Bacterial and Viral Inflammation.
  Wang A, Huen SC, Luan HH, Yu S, Zhang C, Gallezot JD, Booth CJ, Medzhitov R Cell 2016 Sep 166 6 1512-1525.e12
- Molecular phenotyping of clinical AKI with novel urinary biomarkers.
  Huen SC, Parikh CR American journal of physiology. Renal physiology 2015 Sep 309 5 F406-13
- GM-CSF Promotes Macrophage Alternative Activation after Renal Ischemia/Reperfusion Injury.
  Huen SC, Huynh L, Marlier A, Lee Y, Moeckel GW, Cantley LG Journal of the American Society of Nephrology : JASN 2015 Jun 26 6 1334-45
- Macrophage-mediated injury and repair after ischemic kidney injury.
  Huen SC, Cantley LG Pediatric nephrology (Berlin, Germany) 2015 Feb 30 2 199-209
- Macrophage-specific deletion of transforming growth factor-β1 does not prevent renal fibrosis after severe ischemia-reperfusion or obstructive injury.
  Huen SC, Moeckel GW, Cantley LG American journal of physiology. Renal physiology 2013 Aug 305 4 F477-84
- Predicting acute kidney injury after cardiac surgery: a systematic review.
  Huen SC, Parikh CR The Annals of thoracic surgery 2012 Jan 93 1 337-47
- Macrophages promote cyst growth in polycystic kidney disease.
  Karihaloo A, Koraishy F, Huen SC, Lee Y, Merrick D, Caplan MJ, Somlo S, Cantley LG Journal of the American Society of Nephrology : JASN 2011 Oct 22 10 1809-14
- Distinct macrophage phenotypes contribute to kidney injury and repair.
  Lee S, Huen S, Nishio H, Nishio S, Lee HK, Choi BS, Ruhrberg C, Cantley LG Journal of the American Society of Nephrology : JASN 2011 Feb 22 2 317-26
- Successful use of intraperitoneal daptomycin in the treatment of vancomycin-resistant enterococcus peritonitis.
  Huen SC, Hall I, Topal J, Mahnensmith RL, Brewster UC, Abu-Alfa AK American journal of kidney diseases : the official journal of the National Kidney Foundation 2009 Sep 54 3 538-41
- Adverse metabolic side effects of thiazides: implications for patients with calcium nephrolithiasis.
  Huen SC, Goldfarb DS The Journal of urology 2007 Apr 177 4 1238-43

Research

Renal Metabolism
Inflammation and Sepsis
Acute Kidney Injury