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Publications
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PEX39 facilitates the peroxisomal import of PTS2-containing proteins
Chen WW, Rodrigues TA, Wendscheck D, Pedrosa AG, Yang C, Francisco T, Möcklinghoff T, Zografakis A, Nunes-Silva B, Avraham RE, Silva AR, Ferreira MJ, Das H, Koster J, Neuwirth S, Bender J, Oeljeklaus S, Sondhi V, Gatsogiannis C, Schuldiner M, Zalckvar E, Hofmann K, Waterham HR, DeBerardinis RJ, Azevedo JE, Warscheid B Nature cell biology 2025 Aug 27 1256-1271 -
Technologies for Decoding Cancer Metabolism with Spatial Resolution
Chen WW, Pacold ME, Sabatini DM, Kanarek N Cold Spring Harbor Perspectives in Medicine 2025 Jul 15 -
MFSD7C switches mitochondrial ATP synthesis to thermogenesis in response to heme
Li Y, Ivica NA, Dong T, Papageorgiou DP, He Y, Brown DR, Kleyman M, Hu G, Chen WW, Sullivan LB, Del Rosario A, Hammond PT, Vander Heiden MG, Chen J Nature communications 2020 Dec 11 -
A PEROXO-Tag Enables Rapid Isolation of Peroxisomes from Human Cells
Ray GJ, Boydston EA, Shortt E, Wyant GA, Lourido S, Chen WW, Sabatini DM iScience 2020 May 23 -
MITO-Tag Mice enable rapid isolation and multimodal profiling of mitochondria from specific cell types in vivo
Bayraktar EC, Baudrier L, Özerdem C, Lewis CA, Chan SH, Kunchok T, Abu-Remaileh M, Cangelosi AL, Sabatini DM, Birsoy K, Chen WW Proceedings of the National Academy of Sciences of the United States of America 2019 Jan 116 303-312 -
mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient
Wyant GA, Abu-Remaileh M, Wolfson RL, Chen WW, Freinkman E, Danai LV, Vander Heiden MG, Sabatini DM Cell 2017 Oct 171 642-654.e12 -
Rapid immunopurification of mitochondria for metabolite profiling and absolute quantification of matrix metabolites
Chen WW, Freinkman E, Sabatini DM Nature Protocols 2017 Oct 12 2215-2231 -
Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras
Wang T, Yu H, Hughes NW, Liu B, Kendirli A, Klein K, Chen WW, Lander ES, Sabatini DM Cell 2017 Feb 168 890-903.e15 -
Absolute Quantification of Matrix Metabolites Reveals the Dynamics of Mitochondrial Metabolism
Chen WW, Freinkman E, Wang T, Birsoy K, Sabatini DM Cell 2016 Aug 166 1324-1337.e11 -
A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate
Pacold ME, Brimacombe KR, Chan SH, Rohde JM, Lewis CA, Swier LJ, Possemato R, Chen WW, Sullivan LB, Fiske BP, Cho S, Freinkman E, Birsoy K, Abu-Remaileh M, Shaul YD, Liu CM, Zhou M, Koh MJ, Chung H, Davidson SM, Luengo A, Wang AQ, Xu X, Yasgar A, Liu L, Rai G, Westover KD, Vander Heiden MG, Shen M, Gray NS, Boxer MB, Sabatini DM Nature chemical biology 2016 Jun 12 452-458 -
An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis
Birsoy K, Wang T, Chen WW, Freinkman E, Abu-Remaileh M, Sabatini DM Cell 2015 Aug 162 540-551 -
Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness
Katajisto P, Döhla J, Chaffer CL, Pentinmikko N, Marjanovic N, Iqbal S, Zoncu R, Chen W, Weinberg RA, Sabatini DM Science 2015 Apr 348 340-343 -
SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance
Kim D, Fiske BP, Birsoy K, Freinkman E, Kami K, Possemato RL, Chudnovsky Y, Pacold ME, Chen WW, Cantor JR, Shelton LM, Gui DY, Kwon M, Ramkissoon SH, Ligon KL, Kang SW, Snuderl M, Vander Heiden MG, Sabatini DM Nature 2015 Apr 520 363-367 -
Inhibition of ATPIF1 ameliorates severe mitochondrial respiratory chain dysfunction in mammalian cells
Chen WW, Birsoy K, Mihaylova MM, Snitkin H, Stasinski I, Yucel B, Bayraktar EC, Carette JE, Clish CB, Brummelkamp TR, Sabatini DD, Sabatini DM Cell Reports 2014 Oct 7 27-34 -
Dihydropyrimidine accumulation is required for the epithelial-mesenchymal transition
Shaul YD, Freinkman E, Comb WC, Cantor JR, Tam WL, Thiru P, Kim D, Kanarek N, Pacold ME, Chen WW, Bierie B, Possemato R, Reinhardt F, Weinberg RA, Yaffe MB, Sabatini DM Cell 2014 Aug 158 1094-1109 -
Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides
Birsoy K, Possemato R, Lorbeer FK, Bayraktar EC, Thiru P, Yucel B, Wang T, Chen WW, Clish CB, Sabatini DM Nature 2014 508 108-112 -
A tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1
Bar-Peled L, Chantranupong L, Cherniack AD, Chen WW, Ottina KA, Grabiner BC, Spear ED, Carter SL, Meyerson M, Sabatini DM Science 2013 May 340 1100-1106 -
MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors
Birsoy K, Wang T, Possemato R, Yilmaz OH, Koch CE, Chen WW, Hutchins AW, Gultekin Y, Peterson TR, Carette JE, Brummelkamp TR, Clish CB, Sabatini DM Nature genetics 2013 Jan 45 104-108 -
Beaming and droplet digital pcr analysis of mutant idh1 mrna in glioma patient serum and cerebrospinal fluid extracellular vesicles
Chen WW, Balaj L, Liau LM, Samuels ML, Kotsopoulos SK, Maguire CA, LoGuidice L, Soto H, Garrett M, Zhu LD, Sivaraman S, Chen C, Wong ET, Carter BS, Hochberg FH, Breakefield XO, Skog J Molecular Therapy Nucleic Acids 2013 2 e109 -
Functional genomics reveal that the serine synthesis pathway is essential in breast cancer
Possemato R, Marks KM, Shaul YD, Pacold ME, Kim D, Birsoy K, Sethumadhavan S, Woo HK, Jang HG, Jha AK, Chen WW, Barrett FG, Stransky N, Tsun ZY, Cowley GS, Barretina J, Kalaany NY, Hsu PP, Ottina K, Chan AM, Yuan B, Garraway LA, Root DE, Mino-Kenudson M, Brachtel EF, Driggers EM, Sabatini DM Nature 2011 Aug 476 346-350
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PEX39 facilitates the peroxisomal import of PTS2-containing proteins
Walter Chen, M.D., Ph.D.
- Pediatrics - Neonatal-Perinatal
Education & Training
- Other - MIT (2009-2016), Doctor of Philosophy
- Medical Education - Harvard Medical School (2009-2018)
- Fellowship - UT Southwestern Medical Center (2021-2024), Neonatal-Perinatal Medicine
- Residency - Boston Children's Hospital (2018-2021), Pediatrics