Weina Chen, M.D., Ph.D.

Director, Hematopathology; Co-director, Flow Cytometry;

Pathology
Pathology/Diagnosis of Hematologic Cancers

Education & Training

Medical School - Shanghai Medical University (1980-1985)
Fellowship - UT Southwestern Medical Center (2002-2004), Hematopathology
Fellowship - National Institute of Environmental Health Science (1993-1995), Research
Graduate School - Shanghai Medical University (1985-1988), Clinical Pharmacology
Graduate School - Ecole Polytechnique (1989-1993), Biophysics
Other Post Graduate Training - Shanghai Medical University (1985-1988)
Other Post Graduate Training - Ecole Polytechnique (1989-1993)
Residency - UT Southwestern Medical Center (1998-2002), Anatomic & Clinical Pathology
Fellowship - Duke University Medical Center (1995-1998), Research

Honors & Awards

Dr. Janet Caldwell Memorial Award for Research in Pathology Fellowship (Faculty mentor/Senior author) 2016
Graduation with Honor, MD (ranked 2nd in a class of 300), Shanghai Medical University 1985
Graduation with Highest Honor, Ph.D in Biophysics, Ecole Polytechnique, France 1993
Dr. Arthur Weinberg UTSW Pathology Resident Research Article Award (Faculty mentor/Senior author) 2008

Books & Publications

Books
- Immunophenotyping by Flow Cytometry for Acute Myeloid Leukemia in Methods and Protocols in Series Title: Methods in Molecular Biology
  Weina Chen, Hung Luu (2016), New York 2016, Springer, Science+Business, LLC
Publications
- Clinical and molecular characteristics associated with Vitamin C deficiency in myeloid malignancies; real world data from a prospective cohort.
  Premnath N, Chung SS, Weinberg OK, Ikpefan R, Pandey M, Kaur G, Geethakumari PR, Afrough A, Awan FT, Anderson LD, Vusirikala M, Collins RH, Chen W, Agathocleous M, Madanat YF, Leukemia research 2022 Dec 125 107001
- Rare circulating lymphoblasts with striking eosinophilia: A rare case of B-lymphoblastic leukemia with PAX5::ZCCHC7.
  Kwon A, Fuda F, Gagan J, John S, Aquino V, Chen W, American journal of hematology 2022 Dec
- Monkeypox virus: A new etiology for reactive lymphocytes in peripheral blood.
  Neeley J, Glogowski S, Chen W, EJHaem 2022 Nov 3 4 1388-1389
- Adult mixed phenotype acute leukemia (MPAL): B/myeloid MPAL^isoMPO is distinct from other MPAL subtypes.
  Weinberg OK, Dennis J, Zia H, Chen P, Chu A, Koduru P, Luu HS, Fuda F, Chen W, International journal of laboratory hematology 2022 Nov
- Distinct mutational and clinicopathologic profiles characterize acute myeloid leukemia with cup-like nuclei.
  Oertling E, Fuda F, Koduru P, Chen M, Weinberg O, Juntilla M, Jaso J, Vusirikala M, Chung S, Geethakumari PR, Madanat YF, Collins R, Gagan J, Chen W, Leukemia research 2022 Nov 124 106995
- Optimizing Palliative Focal Radiation Therapy Dose in Cutaneous T-Cell Lymphoma: How Low Can You Go?
  Patel AM, West L, Atluri PS, Yi SF, Rizvi S, Geethakumari PR, Awan FT, Chen W, Shah JL, Desai NB, Goff HW, Kumar KA, Practical radiation oncology 2022 Oct
- A t(11;14)(q13;q32)/CCND1::IGH carrying progenitor germinal B-cell with subsequent cytogenetic aberrations contributes to the development of classic Hodgkin lymphoma.
  García R, Timmons C, Luu H, Miller V, Fuda F, Chen W, Koduru P, Cancer genetics 2022 Oct 268-269 97-102
- Disabling Uncompetitive Inhibition of Oncogenic IDH Mutations Drives Acquired Resistance.
  Lyu J, Liu Y, Gong L, Chen M, Madanat YF, Zhang Y, Cai F, Gu Z, Cao H, Kaphle P, Kim YJ, Kalkan FN, Stephens H, Dickerson KE, Ni M, Chen W, Patel P, Mims AS, Borate U, Burd A, Cai SF, Yin CC, You MJ, Chung SS, Collins RH, DeBerardinis RJ, Liu X, Xu J, Cancer discovery 2022 Oct
- Genomic profile of TdT^positive MYC/BCL2 rearranged high-grade B-cell lymphoma supporting its diagnosis as mature aggressive lymphoma.
  Hamdan H, Luu L, Opsahl M, Weinberg O, Fuda F, Koduru P, Wilson K, Gagan J, Ramakrishnan Geethakumari P, Collins R, Chen W, Cytometry. Part B, Clinical cytometry 2022 Sep
- The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic/Dendritic Neoplasms.
  Khoury JD, Solary E, Abla O, Akkari Y, Alaggio R, Apperley JF, Bejar R, Berti E, Busque L, Chan JKC, Chen W, Chen X, Chng WJ, Choi JK, Colmenero I, Coupland SE, Cross NCP, De Jong D, Elghetany MT, Takahashi E, Emile JF, Ferry J, Fogelstrand L, Fontenay M, Germing U, Gujral S, Haferlach T, Harrison C, Hodge JC, Hu S, Jansen JH, Kanagal-Shamanna R, Kantarjian HM, Kratz CP, Li XQ, Lim MS, Loeb K, Loghavi S, Marcogliese A, Meshinchi S, Michaels P, Naresh KN, Natkunam Y, Nejati R, Ott G, Padron E, Patel KP, Patkar N, Picarsic J, Platzbecker U, Roberts I, Schuh A, Sewell W, Siebert R, Tembhare P, Tyner J, Verstovsek S, Wang W, Wood B, Xiao W, Yeung C, Hochhaus A, Leukemia 2022 Jun
- A Combined Biomarker of Bright CD38 and MYC =55% Is Highly Predictive of Double-/Triple-Hit High-Grade B-Cell Lymphoma.
  Alsuwaidan A, Koduru P, Fuda F, Manuel Jaso J, Chen M, Rosado F, Luu HS, Sweed N, Garcia R, Doucet M, Desai NB, Kumar KA, Awan FT, Ramakrishnan Geethakumari P, Chen W, American journal of clinical pathology 2022 May
- NCCN Guidelines® Insights: Hodgkin Lymphoma, Version 2.2022.
  Hoppe RT, Advani RH, Ai WZ, Ambinder RF, Armand P, Bello CM, Benitez CM, Chen W, Dabaja B, Daly ME, Gordon LI, Hansen N, Herrera AF, Hochberg EP, Johnston PB, Kaminski MS, Kelsey CR, Kenkre VP, Khan N, Lynch RC, Maddocks K, McConathy J, Metzger M, Morgan D, Mulroney C, Pullarkat ST, Rabinovitch R, Rosenspire KC, Seropian S, Tao R, Torka P, Winter JN, Yahalom J, Yang JC, Burns JL, Campbell M, Sundar H, Journal of the National Comprehensive Cancer Network : JNCCN 2022 04 20 4 322-334
- SARS-CoV-2 Infection Associated with Aplastic Anemia and Pure Red Cell Aplasia.
  Lee NC, Patel BA, Etra AM, Bat T, Ibrahim IF, Vusirikala M, Chen M, Rosado F, Jaso JM, Young NS, Chen W, Blood advances 2022 Apr
- Polar/villous lymphocytes in peripheral blood and exclusively intrasinusoidal lymphoma infiltrate in bone marrow: A clue to splenic diffuse red pulp lymphoma.
  Parmley M, Gagan J, Imam M, Chen W, International journal of laboratory hematology 2022 Mar
- CSF3R T618I mutated chronic myelomonocytic leukemia: A proliferative subtype with a distinct mutational profile.
  Kwon A, Ibrahim I, Le T, Jaso JM, Weinberg O, Fuda F, Chen W, Leukemia research reports 2022 17 100323
- Green-blue inclusions in neutrophils and monocytes: a critical finding.
  Welder D, Chen W, International journal of hematology 2022 Jan
- Evaluation of multiple myeloma measurable residual disease by high sensitivity flow cytometry: An international harmonized approach for data analysis.
  Soh KT, Came N, Otteson GE, Jevremovic D, Shi M, Olteanu H, Natoni A, Lagoo A, Theakston E, Óskarsson JÞ, Gorniak M, Grigoriadis G, Arroz M, Fletcher M, Lin P, Ludwig P, Tembhare P, Matuzeviciene R, Radzevicius M, Kay S, Chen W, Cabrita C, Wallace PK, Cytometry. Part B, Clinical cytometry 2022 Jan
- EBV-positive high-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements: a multi-institutional study.
  Liu H, Xu-Monette ZY, Tang G, Wang W, Kim Y, Yuan J, Li Y, Chen W, Li Y, Fedoriw GY, Zhu F, Fang X, Luedke C, Medeiros LJ, Young KH, Hu S, Histopathology 2021 Oct
- Restricted TRBC1 expression: a clonality marker for circulating Sezary cells.
  Tintle S, Fuda F, Chen W, American journal of hematology 2021 Aug
- Blister and bite cells in G6PD deficiency.
  Opsahl M, Chen W, International journal of laboratory hematology 2021 Aug
- MYC protein expression does not correlate with MYC abnormalities detected by FISH but predicts an unfavorable prognosis in de novo acute myeloid leukemia.
  Chen P, Redd L, Schmidt Y, Koduru P, Fuda F, Montgomery-Goecker C, Kumar K, Xu-Monette Z, Young K, Collins R, Chen W, Leukemia research 2021 Jul 106 106584
- Immature platelets as a biomarker for disease severity and mortality in COVID-19 patients.
  Welder D, Jeon-Slaughter H, Ashraf B, Choi SH, Chen W, Ibrahim I, Bat T, British journal of haematology 2021 Jun
- LILRB1: A Novel Diagnostic B-Cell Marker to Distinguish Neoplastic B Lymphoblasts From Hematogones
  Saumell Tutusaus S, Pirruccello E, Fuda F, Churchill H, Chen D, Zhang CC, Chen W, American journal of clinical pathology 2021 Jun
- Combined immune checkpoint blockade and radiotherapy induces durable remission in relapsed natural killer/T-cell lymphoma: a case report and review of the literature.
  McGehee E, Patel H, Pearson C, Clements K, Jaso JM, Chen W, Callan A, Desai N, Ramakrishnan Geethakumari P, Journal of medical case reports 2021 Apr 15 1 221
- PD1/PD-L1 Expressions in Plasmablastic Lymphoma with Clinicopathological Correlation.
  Rosado FG, Coberly J, Gupta A, John G, Naina H, Koduru P, Chen W, Annals of clinical and laboratory science 2021 Mar 51 2 174-181
- Primary Effusion Lymphoma: A Clinicopathological Study of 70 Cases.
  Hu Z, Pan Z, Chen W, Shi Y, Wang W, Yuan J, Wang E, Zhang S, Kurt H, Mai B, Zhang X, Liu H, Rios AA, Ma HY, Nguyen ND, Medeiros LJ, Hu S, Cancers 2021 Feb 13 4
- Salmon-coloured granules in residual acute myeloid leukaemia with t(8;21)(q22;q22.1); RUNX1-RUNX1T1.
  Chen D, Chen W, British journal of haematology 2021 Jan
- The association of leukocyte immunoglobulin-like receptor subfamily B-4 expression in acute myeloid leukemia and central nervous system involvement.
  Bergstrom CP, Dahiya S, Chen W, Zhang CC, Zhu H, Yan J, Madanat Y, Patel P, Vusirkala M, Ramakrishnan P, Rizvi S, Chung S, Awan F, Anderson LD, Collins R, Kansagra A, Leukemia research 2020 Nov 100 106480
- Mixed Phenotype Acute Leukemia, B/Myeloid (Bilineal and Biphenotypic), With t(2;22)(q35;q12);EWSR1-FEV.
  Montgomery-Goecker C, Koduru P, Botten G, Xu J, Ghisoli M, Goldman SC, Krueger J, Bhushan V, Fuda F, Chen W, Journal of pediatric hematology/oncology 2020 Sep
- Leukocyte immunoglobulin-like receptor B1 and B4 (LILRB1 and LILRB4): Highly sensitive and specific markers of acute myeloid leukemia with monocytic differentiation.
  Churchill HRO, Fuda FS, Xu J, Deng M, Zhang CC, An Z, Zhang N, Chen P, Bergstrom C, Kansagra A, Collins R, John S, Koduru P, Chen W, Cytometry. Part B, Clinical cytometry 2020 Sep
- Lenalidomide-Associated Secondary B-Lymphoblastic Leukemia/Lymphoma-A Unique Entity.
  Germans SK, Kulak O, Koduru P, Oliver D, Gagan J, Patel P, Anderson LD, Fuda FS, Chen W, Jaso JM, American journal of clinical pathology 2020 Sep
- Antagonistic anti-LILRB1 monoclonal antibody regulates antitumor functions of natural killer cells.
  Chen H, Chen Y, Deng M, John S, Gui X, Kansagra A, Chen W, Kim J, Lewis C, Wu G, Xie J, Zhang L, Huang R, Liu X, Arase H, Huang Y, Yu H, Luo W, Xia N, Zhang N, An Z, Zhang CC, Journal for immunotherapy of cancer 2020 Aug 8 2
- Application of flow cytometry in the analysis of lymphoid disease in the lung and pleural space.
  May F, Malary M, Jaclyn B, Weina C, Mingyi C, Franklin F, Seminars in diagnostic pathology 2020 Jun
- Myeloid diseases in the lung and pleura.
  Khoury JD, Chen W, Seminars in diagnostic pathology 2020 Jun
- Non-Coding Variants Connect Enhancer Dysregulation with Nuclear Receptor Signaling in Hematopoietic Malignancies.
  Li K, Zhang Y, Liu X, Liu Y, Gu Z, Cao H, Dickerson KE, Chen M, Chen W, Shao Z, Ni M, Xu J, Cancer discovery 2020 Mar
- Cytogenomic characterization of double minute heterogeneity in therapy related acute myeloid leukemia.
  Koduru P, Chen W, Haley B, Ho K, Oliver D, Wilson K, Cancer genetics 2019 Aug 238 69-75
- Flow Cytometric Features in Double/Triple Hit Lymphomas: Dim CD45 Expression of Limited Diagnostic Utility.
  Xu X, Fuda F, Alsuwaidan A, Jaso J, Chen W, Cytometry. Part B, Clinical cytometry 2019 Jul 96 4 321-322
- Conjunctival lymphoma.
  Li JJ, Chen W, Sadeghi N, BMJ case reports 2019 Jul 12 7
- Breast Implant-associated Plasmablastic Lymphoma: A Case Report and Discussion of the Literature.
  Geethakumari PR, Markantonis J, Shah JL, Alsuwaidan A, Shahab I, Chen W, Jaso JM, Clinical lymphoma, myeloma & leukemia 2019 Jun
- Loss of EZH2 Reprograms BCAA Metabolism to Drive Leukemic Transformation.
  Gu Z, Liu Y, Cai F, Patrick M, Zmajkovic J, Cao H, Zhang Y, Tasdogan A, Chen M, Qi L, Liu X, Li K, Lyu J, Dickerson KE, Chen W, Ni M, Merritt ME, Morrison SJ, Skoda RC, DeBerardinis RJ, Xu J, Cancer discovery 2019 Jun
- PD1/PD-L1 Expression in Blastic Plasmacytoid Dendritic Cell Neoplasm.
  Aung PP, Sukswai N, Nejati R, Loghavi S, Chen W, Torres-Cabala CA, Yin CC, Konopleva M, Zheng X, Wang J, Tang Z, Medeiros LJ, Prieto VG, Pemmaraju N, Khoury JD, Cancers 2019 May 11 5
- Bright CD38 Expression by Flow Cytometric Analysis Is a Biomarker for Double/Triple Hit Lymphomas with a Moderate Sensitivity and High Specificity.
  Alsuwaidan A, Pirruccello E, Jaso J, Koduru P, Garcia R, Krueger J, Doucet M, Chaudhry R, Fuda F, Chen W Cytometry. Part B, Clinical cytometry 2019 Feb
- Enumeration of Plasmacytoid Dendritic Cells in Peripheral Blood and Bone Marrow by Flow-Cytometric Analysis.
  Alsuwaidan A, Fuda F, Chen W, Chen M, Methods in molecular biology (Clifton, N.J.) 2019 2032 193-201
- Clinical impact of MYC abnormalities in plasma cell myeloma.
  García R, Chen W, Koduru P Cancer genetics 2018 Dec 228-229 115-126
- Minimal/Measurable Residual Disease Detection in Acute Leukemias by Multiparameter Flow Cytometry.
  Fuda F, Chen W Current hematologic malignancy reports 2018 Nov
- LILRB4 signalling in leukaemia cells mediates T cell suppression and tumour infiltration.
  Deng M, Gui X, Kim J, Xie L, Chen W, Li Z, He L, Chen Y, Chen H, Luo W, Lu Z, Xie J, Churchill H, Xu Y, Zhou Z, Wu G, Yu C, John S, Hirayasu K, Nguyen N, Liu X, Huang F, Li L, Deng H, Tang H, Sadek AH, Zhang L, Huang T, Zou Y, Chen B, Zhu H, Arase H, Xia N, Jiang Y, Collins R, You MJ, Homsi J, Unni N, Lewis C, Chen GQ, Fu YX, Liao XC, An Z, Zheng J, Zhang N, Zhang CC Nature 2018 Oct 562 7728 605-609
- A Novel Anti-LILRB4 CAR-T Cell for the Treatment of Monocytic AML.
  John S, Chen H, Deng M, Gui X, Wu G, Chen W, Li Z, Zhang N, An Z, Zhang CC Molecular therapy : the journal of the American Society of Gene Therapy 2018 Aug
- Utility and proposed algorithm of CSF flow cytometry in hematologic malignancies.
  Tawfik B, Brown L, Fuda F, Chen W, Niu S, Sailors J, Sadeghi N Annals of hematology 2018 Apr
- Patterns of Failure in Patients With Double Hit or Double Expressor Lymphomas: Implications for Radiation Therapy.
  Tumati V, Trivedi L, Li HC, Patel P, Scaglioni PP, Vusirikala M, Sadeghi N, Rizvi S, Chen W, Wachsmann J, Collins R, Desai NB International journal of radiation oncology, biology, physics 2018 Apr 100 5 1126-1132
- Acute Myeloid Leukemia With a Rare t(7;14)(q21;q32) and Trisomy 4 With Poor Clinical Outcome: A Case Report.
  Jabbar SB, Monaghan S, Chen W, Koduru P, Kumar K Laboratory medicine 2017 Oct
- Cytokeratin-positive primary effusion lymphoma: a diagnostic challenge.
  Yamani F, Chen W British journal of haematology 2017 Sep
- Ascorbate regulates haematopoietic stem cell function and leukaemogenesis.
  Agathocleous M, Meacham CE, Burgess RJ, Piskounova E, Zhao Z, Crane GM, Cowin BL, Bruner E, Murphy MM, Chen W, Spangrude GJ, Hu Z, DeBerardinis RJ, Morrison SJ Nature 2017 Aug
- Immunophenotyping by Multiparameter Flow Cytometry.
  Chen W, Luu HS Methods in molecular biology (Clifton, N.J.) 2017 1633 51-73
- Fasting selectively blocks development of acute lymphoblastic leukemia via leptin-receptor upregulation.
  Lu Z, Xie J, Wu G, Shen J, Collins R, Chen W, Kang X, Luo M, Zou Y, Huang LJ, Amatruda JF, Slone T, Winick N, Scherer PE, Zhang CC Nature medicine 2016 Dec
- CD25 Expression in B Lymphoblastic Leukemia/Lymphoma Predicts t(9;22)(q34;q11)/Philadelphia Chromosome Translocation (Ph) and Is Associated With Residual Disease in Ph-Negative Patients.
  Chen P, Chu A, Zia H, Koduru P, Collins R, Winick N, Fuda F, Chen W American journal of clinical pathology 2016 Nov 146 5 632-638
- Distinguishing Between Hepatosplenic T-cell Lymphoma and ?d T-cell Large Granular Lymphocytic Leukemia: A Clinicopathologic, Immunophenotypic, and Molecular Analysis.
  Yabe M, Medeiros LJ, Wang SA, Tang G, Bueso-Ramos CE, Jorgensen JL, Bhagat G, Chen W, Li S, Young KH, Miranda RN The American journal of surgical pathology 2016 Oct
- Myelofibrosis secondary to renal osteodystrophy.
  Butt YM, Chen W Blood 2016 Oct 128 16 2104
- Mantle Cell Lymphoma With MYC Rearrangement: A Report of 17 Patients.
  Hu Z, Medeiros LJ, Chen Z, Chen W, Li S, Konoplev SN, Lu X, Pham LV, Young KH, Wang W, Hu S The American journal of surgical pathology 2016 Oct
- Blastic plasmacytoid dendritic cell neoplasm with t(11;19)(q23;p13.3);KMT2A(MLL) rearranged: a diagnostic challenge.
  Gehlbach D, Koduru P, John G, Fuda F, Frankel AE, Chen W British journal of haematology 2016 Oct
- Management and Outcomes of HIV-Associated Primary Effusion Lymphoma: A Single Center Experience.
  Gupta A, Sen S, Marley E, Chen W, Naina HV Clinical lymphoma, myeloma & leukemia 2016 Aug 16 Suppl S175-80
- Hyaline-Vascular Type Castleman's Disease, Sarcoidosis, and Crohns Disease.
  Gupta A, Ayyar B, Zia H, Chen W, Harris S, Naina HV Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion 2016 Jun 32 Suppl 1 335-9
- PIAS1 Promotes Lymphomagenesis through MYC Upregulation.
  Rabellino A, Melegari M, Tompkins VS, Chen W, Van Ness BG, Teruya-Feldstein J, Conacci-Sorrell M, Janz S, Scaglioni PP Cell reports 2016 May
- Dyspoietic changes associated with hepatosplenic T-cell lymphoma are not a manifestation of a myelodysplastic syndrome: analysis of 25 patients.
  Yabe M, Medeiros LJ, Tang G, Wang SA, P Patel K, Routbort M, Bhagat G, Bueso-Ramos CE, Jorgensen JL, Luthra R, Chen W, Muzzafar T, Kanagal-Shamanna R, Khoury JD, Daneshbod Y, Davanlou M, Li S, Young KH, Miranda RN Human pathology 2016 Apr 50 109-17
- Haematogone hyperplasia in copper deficiency.
  Pirruccello E, Luu HS, Chen W British journal of haematology 2016 Mar
- Prognostic Factors of Hepatosplenic T-cell Lymphoma: Clinicopathologic Study of 28 Cases.
  Yabe M, Medeiros LJ, Tang G, Wang SA, Ahmed S, Nieto Y, Hu S, Bhagat G, Oki Y, Patel KP, Routbort M, Luthra R, Fanale MA, Bueso-Ramos CE, Jorgensen JL, Vega F, Chen W, Hoehn D, Konoplev S, Milton DR, Wistuba I, Li S, You MJ, Young KH, Miranda RN The American journal of surgical pathology 2016 Feb
- Diagnosing Lymphomatosis Cerebri-Reply.
  Hatanpaa KJ, Chen W JAMA neurology 2015 Dec 72 12 1536
- Lymphadenopathy following cardiac resuscitation in a patient with a previous lymphoma.
  Gupta A, Chen W, Naina HV British journal of haematology 2015 Dec
- The importance of plasma D-2HG measurement in screening for IDH mutations in acute myeloid leukaemia.
  McGehee E, Rakheja D, Oliver D, Chen W, Boriack R, Collins RH British journal of haematology 2015 Jul
- Lymphomatosis Cerebri: A Diagnostic Challenge.
  Hatanpaa KJ, Fuda F, Koduru P, Young K, Lega B, Chen W JAMA neurology 2015 Jul
- Myeloid and Lymphoid Neoplasm With Abnormalities of FGFR1 Presenting With Trilineage Blasts and RUNX1 Rearrangement: A Case Report and Review of Literature.
  Kumar KR, Chen W, Koduru PR, Luu HS American journal of clinical pathology 2015 May 143 5 738-48
- Acquisition of a t(11;14)(q13;q32) in clonal evolution in a follicular lymphoma with a t(14;18)(q32;q21) and t(3;22)(q27;q11.2).
  Koduru PR, Chen W, Garcia R, Fuda F Cancer genetics 2015 Mar
- Increased plasma d-2-hydroxyglutarate in isocitrate dehydrogenase 2-mutated blastic plasmacytoid dendritic cell neoplasm.
  Rakheja D, Fuda F, Vandergriff T, Boriack R, Medeiros BC, Frankel AE, Chen W Human pathology 2015 Feb 46 2 322-6
- Immunophenotypic characteristics of breast implant-associated anaplastic large-cell lymphoma by flow cytometry.
  Montgomery-Goecker C, Fuda F, Krueger JE, Chen W Cytometry. Part B, Clinical cytometry 2015 Jan
- Discordant intracellular and plasma D-2-hydroxyglutarate levels in a patient with IDH2 mutated angioimmunoblastic T-cell lymphoma.
  Churchill H, Naina H, Boriack R, Rakheja D, Chen W International journal of clinical and experimental pathology 2015 8 9 11753-9
- Identification of CREB3L1 as a Biomarker Predicting Doxorubicin Treatment Outcome.
  Denard B, Pavia-Jimenez A, Chen W, Williams NS, Naina H, Collins R, Brugarolas J, Ye J PloS one 2015 10 6 e0129233
- Consensus guidelines on plasma cell myeloma minimal residual disease analysis and reporting.
  Arroz M, Came N, Lin P, Chen W, Yuan C, Lagoo A, Monreal M, de Tute R, Vergilio JA, Rawstron AC, Paiva B Cytometry. Part B, Clinical cytometry 2015 Jan
- Acute megakaryoblastic leukemia associated with trisomy 21 demonstrates a distinct immunophenotype.
  Wang L, Peters JM, Fuda F, Li L, Karandikar NJ, Koduru P, Wang HY, Chen W Cytometry. Part B, Clinical cytometry 2014 Oct
- Submicroscopic deletion of 5q involving tumor suppressor genes (CTNNA1, HSPA9) and copy neutral loss of heterozygosity associated with TET2 and EZH2 mutations in a case of MDS with normal chromosome and FISH results.
  Hemmat M, Chen W, Anguiano A, Naggar ME, Racke FK, Jones D, Wang Y, Strom CM, Chang K, Boyar FZ Molecular cytogenetics 2014 7 35
- Lineage determination in mixed phenotype acute leukemia: Response to marcondes et al.
  Fuda F, Chen W Cytometry. Part B, Clinical cytometry 2014 Jan
- Case study interpretation-New Orleans: case 2. Mixed phenotype acute leukemia, T/myeloid.
  Chen W Cytometry. Part B, Clinical cytometry 2013 Sep-Oct 84 5 342-5
- MYC/BCL2 protein co-expression contributes to the inferior survival of activated B-cell subtype of diffuse large B-cell lymphoma and demonstrates high-risk gene expression signatures: a report from The International DLBCL Rituximab-CHOP Consortium Program Study.
  Hu S, Xu-Monette ZY, Tzankov A, Green T, Wu L, Balasubramanyam A, Liu WM, Visco C, Li Y, Miranda RN, Montes-Moreno S, Dybkær K, Chiu A, Orazi A, Zu Y, Bhagat G, Richards KL, Hsi ED, Choi WW, Zhao X, van Krieken JH, Huang Q, Huh J, Ai W, Ponzoni M, Ferreri AJ, Zhou F, Slack GW, Gascoyne RD, Tu M, Variakojis D, Chen W, Go RS, Piris MA, Møller MB, Medeiros LJ, Young KH Blood 2013 Feb
- The emerging role of d-2-hydroxyglutarate as an oncometabolite in hematolymphoid and central nervous system neoplasms.
  Rakheja D, Medeiros LJ, Bevan S, Chen W Frontiers in oncology 2013 3 169
- Human immunodeficiency virus-associated plasmablastic lymphoma: poor prognosis in the era of highly active antiretroviral therapy.
  Castillo JJ, Furman M, Beltrán BE, Bibas M, Bower M, Chen W, Díez-Martín JL, Liu JJ, Miranda RN, Montoto S, Nanaji NM, Navarro JT, Seegmiller AC, Vose JM Cancer 2012 Nov 118 21 5270-7
- IDH mutations in acute myeloid leukemia.
  Rakheja D, Konoplev S, Medeiros LJ, Chen W Human pathology 2012 Oct 43 10 1541-51
- CD5-positive mucosa-associated lymphoid tissue (MALT) lymphoma: a clinicopathologic study of 14 cases.
  Jaso J, Chen L, Li S, Lin P, Chen W, Miranda RN, Konoplev S, Medeiros LJ, Yin CC Human pathology 2012 Sep 43 9 1436-43
- The first case of Philadelphia chromosome-negative acute promyelocytic leukemia following imatinib for chronic myelogenous leukemia.
  Wakim JJ, Tirado CA, Dowell J, Chen W Cancer genetics 2012 Mar 205 3 124-7
- Genomic profiling using array comparative genomic hybridization define distinct subtypes of diffuse large B-cell lymphoma: a review of the literature.
  Tirado CA, Chen W, García R, Kohlman KA, Rao N Journal of hematology & oncology 2012 5 54
- Distinct immunophenotype of early T-cell progenitors in T lymphoblastic leukemia/lymphoma may predict FMS-like tyrosine kinase 3 mutations.
  Zaremba CM, Oliver D, Cavalier M, Fuda F, Karandikar NJ, Chen W Annals of diagnostic pathology 2012 Jan 16 1 16-20
- Uniform expression of Notch1, suppressor of B-cell-specific gene expression, in plasmablastic lymphoma.
  Seegmiller AC, Wang HY, Hladik C, Chen W Archives of pathology & laboratory medicine 2011 Jun 135 6 770-5
- t(8;22)/BCR-FGFR1 myeloproliferative disorder presenting as B-acute lymphoblastic leukemia: Report of a case treated with sorafenib and review of the literature.
  Wakim JJ, Tirado CA, Chen W, Collins R Leukemia research 2011 May e151-3
- High incidence of IDH mutations in acute myeloid leukaemia with cuplike nuclei.
  Rakheja D, Konoplev S, Su M, Wheeler D, Muzny DM, Ruvolo VR, Collins R, Karandikar NJ, Andreeff M, Medeiros LJ, Chen W British journal of haematology 2011 Apr 125-8
- Coexistence of t(12;21)(p13;q22)/ETV6-RUNX1 and 11q23/MLL Rearrangement in B Acute Lymphoblastic Leukemia: A Case Report and Review of the Literature.
  Hiemenz MC, Chen W, Winick N, Garcia R, Tirado CA Journal of the Association of Genetic Technologists 2011 37 4 213-5
- Novel JAK2 rearrangement resulting from a t(9;22)(p24;q11.2) in B-acute lymphoblastic leukemia.
  Tirado CA, Chen W, Huang LJ, Laborde C, Hiemenz MC, Valdez F, Ho K, Winick N, Lou Z, Koduru P Leukemia research 2010 Dec 34 12 1674-6
- Infantile mixed phenotype acute leukemia (bilineal and biphenotypic) with t(10;11)(p12;q23);MLL-MLLT10.
  Lou Z, Zhang CC, Tirado CA, Slone T, Zheng J, Zaremba CM, Oliver D, Chen W Leukemia research 2010 Aug 34 8 1107-9
- Acute myeloid leukemia with inv(16) with CBFB-MYH11, 3'CBFB deletion, variant t(9;22) with BCR-ABL1, and del(7)(q22q32) in a pediatric patient: case report and literature review.
  Tirado CA, Valdez F, Klesse L, Karandikar NJ, Uddin N, Arbini A, Fustino N, Collins R, Patel S, Smart RL, Garcia R, Doolittle J, Chen W Cancer genetics and cytogenetics 2010 Jul 200 1 54-9
- Unusual presentation of myeloid sarcoma in a case of acute promyelocytic leukemia with a cryptic PML-RARA rearrangement involving multiple sites including the atrium.
  Tirado CA, Chen W, Valdez F, Karandikar N, Arbini A, Acevedo I, Garcia R, Davila O, Smart RL, Matthews E, Kirk A, Collins RH Cancer genetics and cytogenetics 2010 Jul 200 1 47-53
- Simple karyotype and bcl-6 expression predict a diagnosis of Burkitt lymphoma and better survival in IG-MYC rearranged high-grade B-cell lymphomas.
  Seegmiller AC, Garcia R, Huang R, Maleki A, Karandikar NJ, Chen W Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2010 Jul 23 7 909-20
- Notch1 in primary effusion lymphoma: a clinicopathological study.
  Wang HY, Fuda FS, Chen W, Karandikar NJ Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2010 Jun 23 6 773-80
- mTOR signaling is activated by FLT3 kinase and promotes survival of FLT3-mutated acute myeloid leukemia cells.
  Chen W, Drakos E, Grammatikakis I, Schlette EJ, Li J, Leventaki V, Staikou-Drakopoulou E, Patsouris E, Panayiotidis P, Medeiros LJ, Rassidakis GZ Molecular cancer 2010 9 292
- Cuplike nuclei (prominent nuclear invaginations) in acute myeloid leukemia are highly associated with FLT3 internal tandem duplication and NPM1 mutation.
  Chen W, Konoplev S, Medeiros LJ, Koeppen H, Leventaki V, Vadhan-Raj S, Jones D, Kantarjian HM, Falini B, Bueso-Ramos CE Cancer 2009 Dec 115 23 5481-9
- Significant CD5 expression on normal stage 3 hematogones and mature B Lymphocytes in bone marrow.
  Fuda FS, Karandikar NJ, Chen W American journal of clinical pathology 2009 Nov 132 5 733-7
- Plasmablastic lymphomas with MYC/IgH rearrangement: report of three cases and review of the literature.
  Bogusz AM, Seegmiller AC, Garcia R, Shang P, Ashfaq R, Chen W American journal of clinical pathology 2009 Oct 132 4 597-605
- Cytoplasmic localization of nucleophosmin in bone marrow blasts of acute myeloid leukemia patients is not completely concordant with NPM1 mutation and is not predictive of prognosis.
  Konoplev S, Huang X, Drabkin HA, Koeppen H, Jones D, Kantarjian HM, Garcia-Manero G, Chen W, Medeiros LJ, Bueso-Ramos CE Cancer 2009 Oct 115 20 4737-44
- Segmental tandem triplication of the MLL gene in an intravascular large B-cell lymphoma with multisystem involvement: a comprehensive morphologic, immunophenotypic, cytogenetic, and molecular cytogenetic antemortem study.
  Deisch J, Fuda FB, Chen W, Karandikar N, Arbini AA, Zhou XJ, Wang HY Archives of pathology & laboratory medicine 2009 Sep 133 9 1477-82
- Acute myeloid leukemia (M2) with a cryptic RUNX1/RUNX1T1 t(1;21;8)(p36;q22;q22) variant.
  Tirado CA, Chen W, Valdez FJ, Henderson S, Doolittle J, Garcia R, Patel S, Holdridge S, Chastain C, Collins RH Cancer genetics and cytogenetics 2009 Aug 193 1 67-9
- Hematogone hyperplasia in copper deficiency.
  Sutton L, Vusirikala M, Chen W American journal of clinical pathology 2009 Aug 132 2 191-9; quiz 307
- Bright CD38 expression is an indicator of MYC rearrangement.
  Maleki A, Seegmiller AC, Uddin N, Karandikar NJ, Chen W Leukemia & lymphoma 2009 Jun 50 6 1054-7
- Hereditary haemorrhagic telangiectasia involving the bone marrow and liver.
  Willis J, Mayo MJ, Rogers TE, Chen W British journal of haematology 2009 Apr 145 2 150
- Immunophenotypic study of basophils by multiparameter flow cytometry.
  Han X, Jorgensen JL, Brahmandam A, Schlette E, Huh YO, Shi Y, Awagu S, Chen W Archives of pathology & laboratory medicine 2008 May 132 5 813-9
- Multiparameter flow cytometric analysis reveals low percentage of bone marrow hematogones in myelodysplastic syndromes.
  Maftoun-Banankhah S, Maleki A, Karandikar NJ, Arbini AA, Fuda FS, Wang HY, Chen W American journal of clinical pathology 2008 Feb 129 2 300-8
- Immunophenotypic studies of monoclonal gammopathy of undetermined significance.
  Olteanu H, Wang HY, Chen W, McKenna RW, Karandikar NJ BMC clinical pathology 2008 8 13
- Unusual expression of CD94 on CD8+ TCR-alpha beta T cells in infectious mononucleosis.
  Ren Y, Medeiros LJ, Amin HM, Rytting ME, Jorgensen JL, Chen W Annals of diagnostic pathology 2007 Feb 11 1 55-60
- Stability of leukemia-associated immunophenotypes in precursor B-lymphoblastic leukemia/lymphoma: a single institution experience.
  Chen W, Karandikar NJ, McKenna RW, Kroft SH American journal of clinical pathology 2007 Jan 127 1 39-46
- Nucleophosmin gene mutations in acute myeloid leukemia.
  Chen W, Rassidakis GZ, Medeiros LJ Archives of pathology & laboratory medicine 2006 Nov 130 11 1687-92
- Activating FLT3 mutations are detectable in chronic and blast phase of chronic myeloproliferative disorders other than chronic myeloid leukemia.
  Lin P, Jones D, Medeiros LJ, Chen W, Vega-Vazquez F, Luthra R American journal of clinical pathology 2006 Oct 126 4 530-3
- High frequency of NPM1 gene mutations in acute myeloid leukemia with prominent nuclear invaginations ("cuplike" nuclei).
  Chen W, Rassidakis GZ, Li J, Routbort M, Jones D, Kantarjian H, Medeiros LJ, Bueso-Ramos CE Blood 2006 Sep 108 5 1783-4
- Flow cytometric features of angioimmunoblastic T-cell lymphoma.
  Chen W, Kesler MV, Karandikar NJ, McKenna RW, Kroft SH Cytometry. Part B, Clinical cytometry 2006 May 70 3 142-8
- Myeloid sarcoma involving the gynecologic tract: a report of 11 cases and review of the literature.
  Garcia MG, Deavers MT, Knoblock RJ, Chen W, Tsimberidou AM, Manning JT, Medeiros LJ American journal of clinical pathology 2006 May 125 5 783-90
- Mycosis fungoides with tinea pseudoimbricata owing to Trichophyton rubrum infection.
  Poonawalla T, Chen W, Duvic M Journal of cutaneous medicine and surgery 2006 Jan-Feb 10 1 52-6
- Acute myeloid leukaemia with FLT3 gene mutations of both internal tandem duplication and point mutation type.
  Chen W, Jones D, Medeiros LJ, Luthra R, Lin P British journal of haematology 2005 Sep 130 5 726-8
- Characterization of incidentally identified minute clonal B-lymphocyte populations in peripheral blood and bone marrow.
  Chen W, Asplund SL, McKenna RW, Kroft SH American journal of clinical pathology 2004 Oct 122 4 588-95
- Inhibition of p38 MAPK alpha/beta reduces ischemic injury and does not block protective effects of preconditioning.
  Schneider S, Chen W, Hou J, Steenbergen C, Murphy E American journal of physiology. Heart and circulatory physiology 2001 Feb 280 2 H499-508
- Ischemic preconditioning activates phosphatidylinositol-3-kinase upstream of protein kinase C.
  Tong H, Chen W, Steenbergen C, Murphy E Circulation research 2000 Aug 87 4 309-15
- Preconditioning enhanced glucose uptake is mediated by p38 MAP kinase not by phosphatidylinositol 3-kinase.
  Tong H, Chen W, London RE, Murphy E, Steenbergen C The Journal of biological chemistry 2000 Apr 275 16 11981-6
- Lipoxygenase metabolism of arachidonic acid in ischemic preconditioning and PKC-induced protection in heart.
  Chen W, Glasgow W, Murphy E, Steenbergen C The American journal of physiology 1999 Jun 276 6 Pt 2 H2094-101
- Regulation of the Ca2+ gradient across the sarcoplasmic reticulum in perfused rabbit heart. A 19F nuclear magnetic resonance study.
  Chen W, London R, Murphy E, Steenbergen C Circulation research 1998 Nov 83 9 898-907
- Molecular cloning, expression, and functional significance of a cytochrome P450 highly expressed in rat heart myocytes.
  Wu S, Chen W, Murphy E, Gabel S, Tomer KB, Foley J, Steenbergen C, Falck JR, Moomaw CR, Zeldin DC The Journal of biological chemistry 1997 May 272 19 12551-9
- A comparison of AMP degradation in the perfused rat heart during 2-deoxy-D-glucose perfusion and anoxia. Part I: The release of adenosine and inosine.
  Chen W, Hoerter J, Guéron M Journal of molecular and cellular cardiology 1996 Oct 28 10 2163-74
- AMP degradation in the perfused rat heart during 2-deoxy-D-glucose perfusion and anoxia. Part II: The determination of the degradation pathways using an adenosine deaminase inhibitor.
  Chen W, Guéron M Journal of molecular and cellular cardiology 1996 Oct 28 10 2175-82
- Effect of ischemic preconditioning and PKC activation on acidification during ischemia in rat heart.
  Chen W, Wetsel W, Steenbergen C, Murphy E Journal of molecular and cellular cardiology 1996 May 28 5 871-80
- Measurement of free Ca2+ in sarcoplasmic reticulum in perfused rabbit heart loaded with 1,2-bis(2-amino-5,6-difluorophenoxy)ethane-N,N,N',N'-tetraacetic acid by 19F NMR.
  Chen W, Steenbergen C, Levy LA, Vance J, London RE, Murphy E The Journal of biological chemistry 1996 Mar 271 13 7398-403
- A redox-based mechanism for cardioprotection induced by ischemic preconditioning in perfused rat heart.
  Chen W, Gabel S, Steenbergen C, Murphy E Circulation research 1995 Aug 77 2 424-9
- The inhibition of bovine heart hexokinase by 2-deoxy-D-glucose-6-phosphate: characterization by 31P NMR and metabolic implications.
  Chen W, Guéron M Biochimie 1992 Sep-Oct 74 9-10 867-73

Research

Hematopathology (Leukemias and lymphomas)
Flow Cytometry

Clinical Focus

Pathology/Diagnosis of Hematologic Cancers