- Fellowship - Brown University Woman & Infant Hospital (1995-1996), Gynecologic Pathology
- Residency - Cornell New York Presbyterian Hospital (1992-1995), Pathology
- Fellowship - Columbia University Medical Center (1986-1989), Molecular Reproduction
- Residency - Hospital of Obstetrics and Gynecology (1983-1986), Obstetrics & Gynecology
- Internship - Hospital of Obstetrics and Gynecology (1982-1983), Obstetrics & Gynecology
- Medical School - Shanghai Medical College of Fudan University (1978-1982)
Wenxin Zheng, M.D.
- Mark and Jane Gibson Distinguished Professorship in Cancer Research
- Pathology
Biography
Wenxin Zheng, M.D., is a Professor with dual appointments in the Department of Pathology and the Department of Obstetrics and Gynecology at UT Southwestern Medical Center. An internationally recognized gynecologic pathologist, he specializes in all aspects of gynecologic pathology. Dr. Zheng is the Director of the Gynecologic Pathology Service and Director of the Gynecologic Pathology Fellowship at UT Southwestern.
Dr. Zheng earned his medical degree at Shanghai Medical College Fudan University. He completed a residency in obstetrics and gynecology at the Hospital of Obstetrics and Gynecology in Shanghai and, later, a residency in anatomic and clinical pathology at New York Hospital-Cornell Medical Center. He received advanced training through a gynecologic pathology fellowship at Women & Infants Hospital of Rhode Island.
Dr. Zheng also received advanced training through a postdoctoral fellowship in molecular reproduction at Columbia University College of Physicians and Surgeons.
Certified by the American Board of Pathology in combined anatomic pathology and clinical pathology, he joined the UT Southwestern faculty in 2015.
His main research contributions include endometrial serous carcinogenesis and precancerous lesion endometrial glandular dysplasia, cell origin of low-grade ovarian serous carcinoma, hormonal etiology of ovarian epithelial cancers, and tubal contribution of ovarian endometriosis and its associated ovarian cancers. In addition, he has created a novel approach called one-stop cervical care (OSCC) to diagnose and treat cervical precancers.
Dr. Zheng is a member of the United States and Canadian Academy of Pathology, the College of American Pathologists, the American Society for Colposcopy and Cervical Pathology, the Chinese Society of Colposcopy and Cervical Pathology, and the Gynecologic Oncology Group of NRG Oncology.
In 2013, he was selected by U.S. News & World Report as one of America's top pathologists.
Education & Training
Books & Publications
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Books
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Many chapters as leading or co-authors in Gynecologic and Obstetrics Pathology
Wenxin Zheng et al., (2013), Beijing,China, Science Press
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Many chapters as leading or co-authors in Gynecologic and Obstetrics Pathology
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Publications
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Morules But Not Squamous Differentiation are a Reliable Indicator of CTNNB1 (ß-catenin) Mutations in Endometrial Carcinoma and Precancers
Niu S, Lucas E, Molberg K, Strickland A, Wang Y, Carrick K, Rivera-Colon G, Gwin K, SoRelle JA, Castrillon DH, Zheng W, Chen H, The American journal of surgical pathology 2022 Jul -
The Prognostic Values of HPV Genotypes and Tumor PD-L1 Expression in Patients With HPV-associated Endocervical Adenocarcinoma.
Zhou F, Chen H, Li M, Strickland AL, Zheng W, Zhang X, The American journal of surgical pathology 2022 03 46 3 300-308 -
Endometrial stromal tumors: Diagnostic updates and challenges.
Niu S, Zheng W, Seminars in diagnostic pathology 2022 Jan -
High-grade endometrial carcinomas: Morphologic spectrum and molecular classification.
Zhang C, Zheng W, Seminars in diagnostic pathology 2021 Nov -
The IVF-generated human embryonic microenvironment reverses progestin resistance in endometrial cancer cells by inducing cancer stem cell differentiation.
Sun D, Qin Z, Xu Y, Xiao Q, Xu Y, Bai M, Li W, Liu Y, Zheng W, Zhang Z, Cancer letters 2021 Nov -
Tumoral Morphologic Features From Cervical Biopsies That Are Predictive of a Negligible Risk for Nodal Metastasis and Tumor Recurrence in Usual-type Cervical Adenocarcinomas: A Multi-institutional Study.
Wang Y, Chang RJ, Luo RZ, Yu J, Zhang X, Yang X, Quddus MR, Li L, Yang W, Liu A, Jiang Q, Zhao R, Zhu H, Zhou F, Wang Y, Sheng X, Liu LL, Wen YL, Banet N, Sung CJ, Qi Y, Bi R, Li M, Wang Y, Li J, Lin W, Wang Y, Rivera G, Chen H, Holloway SB, Fadare O, Liu J, Wang J, Lea J, Kong B, Zheng W, The American journal of surgical pathology 2021 Nov -
Navigating through perplex morphologic changes after exogenous hormone usage.
Chang RJ, Rivera-Colon G, Chen H, Niu S, Carrick K, Lucas E, Gwin K, Zheng W, Seminars in diagnostic pathology 2021 Oct -
Reliable Identification of Endometrial Precancers Through Combined Pax2, ß-Catenin, and Pten Immunohistochemistry
Aguilar M, Chen H, Rivera-Colon G, Niu S, Carrick K, Gwin K, Cuevas IC, Sahoo SS, Li HD, Zhang S, Zheng W, Lucas E, Castrillon DH, The American journal of surgical pathology 2021 Sep -
Tumor Necrotic Debris and High Nuclear Grade: Newly Identified High-risk Factors for Early-stage Endocervical Adenocarcinoma.
Holloway SB, Colon GR, Zheng W, Lea JS, American journal of clinical oncology 2021 04 44 4 162-168 -
LASS2 mediates Nrf2-driven progestin resistance in endometrial cancer.
Yang B, Hu M, Fu Y, Sun D, Zheng W, Liao H, Zhang Z, Chen X, American journal of translational research 2021 13 3 1280-1289 -
PD-L1 Expression in Endometrial Serous Carcinoma and Its Prognostic Significance.
Zhang T, Liu Q, Zhu Y, Zhang S, Peng Q, Strickland AL, Zheng W, Zhou F, Cancer management and research 2021 13 9157-9165 -
Serial genomic analysis of endometrium supports the existence of histologically indistinct endometrial cancer precursors.
Aguilar M, Zhang H, Zhang M, Cantarell B, Sahoo SS, Li HD, Cuevas IC, Lea J, Miller DS, Chen H, Zheng W, Gagan J, Lucas E, Castrillon DH, The Journal of pathology 2021 Jan -
PD-L1 Expression in Endocervical Adenocarcinoma: Correlation With Patterns of Tumor Invasion, CD8+ Tumor-infiltrating Lymphocytes, and Clinical Outcomes.
Rivera-Colon G, Chen H, Molberg K, Niu S, Strickland AL, Castrillon DH, Carrick K, Gwin K, Lea J, Zheng W, Lucas E, The American journal of surgical pathology 2020 Dec -
Specific Biomarker Expression Patterns in the Diagnosis of Residual and Recurrent Endometrial Precancers After Progestin Treatment: A Longitudinal Study.
Chen H, Lucas E, Strickland AL, Carrick K, Gwin K, Castrillon DH, Rivera-Colon G, Niu S, Molberg KH, Zheng W, The American journal of surgical pathology 2020 Oct 44 10 1429-1439 -
De novo prediction of cancer-associated T cell receptors for noninvasive cancer detection.
Beshnova D, Ye J, Onabolu O, Moon B, Zheng W, Fu YX, Brugarolas J, Lea J, Li B, Science translational medicine 2020 Aug 12 557 -
PD-L1 Expression and CD8+ Tumor-infiltrating Lymphocytes in Different Types of Tubo-Ovarian Carcinoma and Their Prognostic Value in High-grade Serous Carcinoma.
Chen H, Molberg K, Strickland AL, Castrillon DH, Carrick K, Jiang Q, Niu S, Rivera-Colon G, Gwin K, Hinson S, Lea J, Miller DS, Zheng W, Lucas E, The American journal of surgical pathology 2020 May -
Cervical Adenocarcinoma: Histopathologic Features From Biopsies to Predict Tumor Behavior.
Rivera-Colon G, Chen H, Niu S, Lucas E, Holloway S, Carrick K, Gwin K, Lea J, Zheng W, The American journal of surgical pathology 2020 Feb 44 2 247-254 -
Loss of tubal ciliated cells as a risk for "ovarian" or pelvic serous carcinoma.
Tao T, Lin W, Wang Y, Zhang J, Chambers SK, Li B, Lea J, Wang Y, Wang Y, Zheng W, American journal of cancer research 2020 10 11 3815-3827 -
Roles of follicle stimulating hormone and its receptor in human metabolic diseases and cancer.
Sun D, Bai M, Jiang Y, Hu M, Wu S, Zheng W, Zhang Z, American journal of translational research 2020 12 7 3116-3132 -
Dedifferentiated Endometrioid Carcinomas with Neuroendocrine Differentiation: A Clinicopathological and Immunohistochemical Study of Three Cases.
Zhou F, Zhang X, Chen H, Zheng W, Cancer management and research 2020 12 11623-11629 -
Stigmasterol sensitizes endometrial cancer cells to chemotherapy by repressing Nrf2 signal pathway.
Liao H, Zhu D, Bai M, Chen H, Yan S, Yu J, Zhu H, Zheng W, Fan G, Cancer cell international 2020 20 480 -
Randomized Trial of Intravenous Versus Intraperitoneal Chemotherapy Plus Bevacizumab in Advanced Ovarian Carcinoma: An NRG Oncology/Gynecologic Oncology Group Study.
Walker JL, Brady MF, Wenzel L, Fleming GF, Huang HQ, DiSilvestro PA, Fujiwara K, Alberts DS, Zheng W, Tewari KS, Cohn DE, Powell MA, Van Le L, Davidson SA, Gray HJ, Rose PG, Aghajanian C, Myers T, Alvarez Secord A, Rubin SC, Mannel RS, Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2019 Jun 37 16 1380-1390 -
Challenges in the Pap diagnosis of endocervical adenocarcinoma in situ.
Niu S, Molberg K, Thibodeaux J, Rivera-Colon G, Hinson S, Zheng W, Lucas E, Journal of the American Society of Cytopathology 2019 May - Jun 8 3 141-148 -
Metformin sensitizes endometrial cancer cells to progestin by targeting TET1 to downregulate glyoxalase I expression.
Jiang Y, Chen X, Wei Y, Feng Y, Zheng W, Zhang Z, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 May 113 108712 -
Effect of Progestin Usage on the Interpretation of Cervical High-grade Squamous Intraepithelial Lesion.
Wang Y, Chen H, Jiang Q, Luo R, Zhou P, Wang Y, Zhao R, Fadare O, Zheng W, The American journal of surgical pathology 2019 Apr -
Age cutoff for reporting of benign-appearing endometrial cells in Papanicolaou specimens; should it be raised? A 10-year retrospective study from a large county hospital.
Hinson S, Molberg K, Mir M, Flores M, Zheng W, Lucas E, Journal of the American Society of Cytopathology 2019 Mar - Apr 8 2 78-83 -
Clinical significance of HPV genotyping and viral load in cervical cancer screening
Yue Wang, Yiying Wang, Xin Xie, Wenxin Zheng, Beihua Kong Chinese Journal of Obstetrics and Gynecology 2019 54 350-353 -
Extended HPV genotyping and its application in cervical cancer screening
Yiying Wang, Yue Wang, Beihua Kong, Wenxin Zheng Advances of Modern Obstetrics and Gynecology 2019 28 79-81 -
Tubal Origin of "Ovarian" Low-Grade Serous Carcinoma: A Gene Expression Profile Study.
Wang Y, Hong S, Mu J, Wang Y, Lea J, Kong B, Zheng W, Journal of oncology 2019 2019 8659754 -
Aberrant expression of oxidative stress related proteins affects the pregnancy outcome of gestational diabetes mellitus patients.
Zhang C, Yang Y, Chen R, Wei Y, Feng Y, Zheng W, Liao H, Zhang Z American journal of translational research 2019 11 1 269-279 -
Human Papillomavirus Genotyping in 1,088 Anal Cancer Precursor Cases: Expected and Unexpected Results
Yuxin Liu, Keith Sigel, Melissa Gitman, Tamara Kalir, William Westra, Wenxin Zheng, Michael M Gaisa AIDS 2019 -
Targeted Molecular and Immunohistochemical Analyses of Endometrial Clear Cell Carcinoma Show that POLE Mutations and DNA Mismatch Repair Protein Deficiencies are Uncommon.
Baniak N, Fadare O, Köbel M, DeCoteau J, Parkash V, Hecht JL, Hanley KZ, Gwin K, Zheng W, Quick CM, Jarboe EA, Liang SX, Kinloch M The American journal of surgical pathology 2018 Dec -
Estrogen affects the negative feedback loop of PTENP1-miR200c to inhibit PTEN expression in the development of endometrioid endometrial carcinoma.
Chen R, Zhang M, Liu W, Chen H, Cai T, Xiong H, Sheng X, Liu S, Peng J, Wang F, Chen H, Lin W, Xu X, Zheng W, Jiang Q Cell death & disease 2018 Dec 10 1 4 -
Mismatch Repair Protein Expression in Endometrioid Intraepithelial Neoplasia/Atypical Hyperplasia: Should We Screen for Lynch Syndrome in Precancerous Lesions?
Lucas E, Chen H, Molberg K, Castrillon DH, Rivera Colon G, Li L, Hinson S, Thibodeaux J, Lea J, Miller DS, Zheng W International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 2018 Oct -
Metformin sensitizes endometrial cancer cells to chemotherapy through IDH1-induced Nrf2 expression via an epigenetic mechanism.
Bai M, Yang L, Liao H, Liang X, Xie B, Xiong J, Tao X, Chen X, Cheng Y, Chen X, Feng Y, Zhang Z, Zheng W Oncogene 2018 Jun -
Superficially invasive cervical squamous cell carcinoma metastatic to ovarian endometriotic cyst wall, a case report and brief review of the literature.
Zhang M, Lucas E, Xiong H, Liu S, Molberg K, Jiang Q, Zheng W Journal of ovarian research 2018 May 11 1 44 -
Combination of TP53 and AGR3 to distinguish ovarian high-grade serous carcinoma from low-grade serous carcinoma.
Qiu C, Wang Y, Wang X, Zhang Q, Li Y, Xu Y, Jin C, Bu H, Zheng W, Yang X, Lu N, Kong B International journal of oncology 2018 Apr -
Female adnexal tumor of probable Wolffian origin (FATWO)
Elena Lucas and Wenxin Zheng Pathology Outlines 2018 -
Primary Ovarian Pregnancy: A Case Series and Analysis.
Wang Y, Chen H, Zhao M, Fadare O, Zheng W International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 2018 Jan -
Clear Cell Renal Cell Carcinoma Metastatic to the Gynecologic Tract: A Clinicopathologic Analysis of 17 Cases.
Fadare O, Desouki MM, Gwin K, Hanley KZ, Jarboe EA, Liang SX, Quick CM, Rawish KR, Roma AA, Zheng W, Hecht JL, Parkash V, Osunkoya AO International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 2017 Nov -
Pathological findings in explanted vaginal mesh.
Li L, Wang X, Park JY, Chen H, Wang Y, Zheng W Human pathology 2017 Sep -
Gene expression profiles of ovarian low-grade serous carcinoma resemble those of fallopian tube epithelium.
Qiu C, Lu N, Wang X, Zhang Q, Yuan C, Yan S, Dongol S, Li Y, Sun X, Sun C, Zhang Z, Zheng W, Kong B Gynecologic oncology 2017 Sep -
The Significance of L1CAM Expression in Clear Cell Carcinoma of the Endometrium.
Fadare O, Roma AA, Desouki MM, Gwin K, Hanley KZ, Jarboe EA, Liang SX, Quick CM, Zheng W, Hecht JL, Parkash V, Wang XJ Histopathology 2017 Sep -
Does a p53 "Wild-type" Immunophenotype Exclude a Diagnosis of Endometrial Serous Carcinoma?
Fadare O, Roma AA, Parkash V, Zheng W, Walavalkar V Advances in anatomic pathology 2017 Sep -
Malignant Female Adnexal Tumor of Probable Wolffian Origin: Case Report and Literature Review.
Hong S, Cui J, Li L, Buscema J, Liggins C, Zheng W International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 2017 Jul -
Endometrial Carcinoma With Trophoblastic Components: Clinicopathologic Analysis of a Rare Entity.
Rawish KR, Buza N, Zheng W, Fadare O International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 2017 Jun -
BRCA1 expression, proliferative and apoptotic activities in ovarian epithelial inclusions.
Wang Y, Wang Y, Wei L, Hong S, Zhao M, Zhang X, Zheng W Journal of ovarian research 2017 Mar 10 1 12 -
Mechanism of progestin resistance in endometrial precancer/cancer through Nrf2-survivin pathway.
Fan R, Wang Y, Wang Y, Wei L, Zheng W American journal of translational research 2017 9 3 1483-1491 -
Association between human papillomavirus type 16 E6 and E7 variants with subsequent persistent infection and recurrence of cervical high-grade squamous intraepithelial lesion after conization.
Zhang L, Yang B, Zhang A, Zhou A, Yuan J, Wang Y, Sun L, Cao H, Wang J, Zheng W Journal of medical virology 2016 Apr -
Cytologic studies of the fallopian tube in patients undergoing salpingo-oophorectomy.
Chen H, Klein R, Arnold S, Chambers S, Zheng W Cancer cell international 2016 16 78 -
Overexpression and oncogenic function of HMGA2 in endometrial serous carcinogenesis.
Wei L, Liu X, Zhang W, Wei Y, Li Y, Zhang Q, Dong R, Kwon JS, Liu Z, Zheng W, Kong B American journal of cancer research 2016 6 2 249-59 -
Mechanism of progestin resistance in endometrial precancer/cancer through Nrf2-AKR1C1 pathway.
Wang Y, Wang Y, Zhang Z, Park JY, Guo D, Liao H, Yi X, Zheng Y, Zhang D, Chambers SK, Zheng W Oncotarget 2016 Jan -
Fallopian tube secretory cell expansion: a sensitive biomarker for ovarian serous carcinogenesis.
Wang Y, Li L, Wang Y, Tang SN, Zheng W American journal of translational research 2016 8 1 230-8 -
Ovarian serous carcinogenesis from tubal secretory cells.
Zhang W, Wei L, Li L, Yang B, Kong B, Yao G, Zheng W Histology and histopathology 2015 Jul 11645 -
Are clear cell carcinomas of the ovary and endometrium phenotypically identical? A proteomic analysis
Fata CR, Seeley EH, Desouki MM, Du L, Gwin K, Hanley KZ, Hecht JL, Jarboe EA, Liang SX, Parkash V, Quick CM, Zheng W, Shyr Y, Caprioli RM, Fadare O Human pathology 2015 Jun -
Tubal origin of ovarian endometriosis and clear cell and endometrioid carcinoma.
Wang Y, Mang M, Wang Y, Wang L, Klein R, Kong B, Zheng W American journal of cancer research 2015 5 3 869-79 -
Primary sources of pelvic serous cancer in patients with endometrial intraepithelial carcinoma.
Jia L, Yuan Z, Wang Y, Cragun JM, Kong B, Zheng W Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2015 Jan 28 1 118-27 -
Flutamide and biomarkers in women at high risk for ovarian cancer: preclinical and clinical evidence.
Gruessner C, Gruessner A, Glaser K, AbuShahin N, Zhou Y, Laughren C, Wright H, Pinkerton S, Yi X, Stoffer J, Azodi M, Zheng W, Chambers SK Cancer prevention research (Philadelphia, Pa.) 2014 Sep 7 9 896-905 -
Tubal origin of ovarian endometriosis.
Yuan Z, Wang L, Wang Y, Zhang T, Li L, Cragun JM, Chambers SK, Kong B, Zheng W Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2014 Aug 27 8 1154-62 -
IMP3 signatures of fallopian tube: a risk for pelvic serous cancers.
Wang Y, Wang Y, Li D, Li L, Zhang W, Yao G, Jiang Z, Zheng W Journal of hematology & oncology 2014 Jul 7 1 49 -
Secretory cell expansion with aging: risk for pelvic serous carcinogenesis.
Li J, Ning Y, Abushahin N, Yuan Z, Wang Y, Wang Y, Yuan B, Cragun JM, Chambers SK, Hatch K, Kong B, Zheng W Gynecologic oncology 2013 Dec 131 3 555-60 -
Tubal origin of ovarian low-grade serous carcinoma.
Chen C, Li J, Yao G, Chambers SK, Zheng W American journal of clinical and experimental obstetrics and gynecology 2013 Dec 1 1 13-36 -
Lynch syndrome related endometrial cancer: clinical significance beyond the endometrium.
Wang Y, Wang Y, Li J, Cragun J, Hatch K, Chambers SK, Zheng W Journal of hematology & oncology 2013 Mar 6 1 22 -
Detection of PAX8 and p53 is beneficial in recognizing metastatic carcinomas in pelvic washings, especially in cases with suspicious cytology.
Xiang L, Zheng W, Kong B Gynecologic oncology 2012 Dec 127 3 595-600 -
Fallopian tube as main source for ovarian and pelvic (non-endometrial) serous carcinomas.
Zheng W, Fadare O International journal of clinical and experimental pathology 2012 5 3 182-6 -
Endometrial serous carcinoma (uterine papillary serous carcinoma): precancerous lesions and the theoretical promise of a preventive approach.
Fadare O, Zheng W American journal of cancer research 2012 2 3 335-9 -
Ovarian serous carcinoma: recent concepts on its origin and carcinogenesis.
Li J, Fadare O, Xiang L, Kong B, Zheng W Journal of hematology & oncology 2012 5 8 -
Tubal origin of 'ovarian' low-grade serous carcinoma.
Li J, Abushahin N, Pang S, Xiang L, Chambers SK, Fadare O, Kong B, Zheng W Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2011 Nov 24 11 1488-99 -
Personal history of breast cancer as a significant risk factor for endometrial serous carcinoma in women aged 55 years old or younger.
Liang SX, Pearl M, Liang S, Xiang L, Jia L, Yang B, Fadare O, Schwartz PE, Chambers SK, Kong B, Zheng W International journal of cancer 2011 Feb 128 4 763-70 -
A proposed model for endometrial serous carcinogenesis.
Zheng W, Xiang L, Fadare O, Kong B The American journal of surgical pathology 2011 Jan 35 1 e1-e14 -
High levels of Nrf2 determine chemoresistance in type II endometrial cancer.
Jiang T, Chen N, Zhao F, Wang XJ, Kong B, Zheng W, Zhang DD Cancer research 2010 Jul 70 13 5486-96 -
Molecular identification of "latent precancers" for endometrial serous carcinoma in benign-appearing endometrium.
Zhang X, Liang SX, Jia L, Chen N, Fadare O, Schwartz PE, Kong B, Zheng W The American journal of pathology 2009 Jun 174 6 2000-6
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Morules But Not Squamous Differentiation are a Reliable Indicator of CTNNB1 (ß-catenin) Mutations in Endometrial Carcinoma and Precancers
Research
- Tubal secretory cell biology
- Tubal origin of ovarian endometriosis and its related cancer development
- Ovarian cancer early detection and prevention
- Endometrial serous carcinoma: carcinogenesis, early detection and prevention
- Cervical cancer: suitable model of cervical cancer screening, effective intervention, and prevention in developing countries.
- Biomarkers to aid the diagnosis of gynecologic cancers