- American Society of Nephrology
- American Society of Pediatric Nephrology
- International Society of Nephrology
Biography
Amanda Clark, M.D., is an Assistant Professor in the Department of Pediatrics at UT Southwestern Medical Center. She specializes in pediatric nephrology.
Dr. Clark earned her medical degree at the Albert Einstein College of Medicine in the Bronx. She completed a residency in pediatrics at the Monroe Carrell Jr. Children’s Hospital at Vanderbilt. She received advanced training through a pediatric nephrology clinical fellowship at Boston Children’s Hospital and Children’s Medical Center Dallas. She was also a postdoctoral researcher in the Samir Parikh Lab at both Beth Israel Deaconess Medical Center at Harvard and UT Southwestern.
Certified by the American Board of Pediatrics, she joined the UT Southwestern faculty in 2024.
Dr. Clark’s research focuses on how maternal and fetal metabolism affects fetal kidney development. She has served as Principal Investigator on research projects funded by the National Institutes of Health, the American Society of Nephrology, and the Pediatric Physician Scientist Development Program. She has delivered international and national invited lectures and published peer-reviewed academic articles related to her areas of expertise.
She is a member of the American Society of Nephrology, the American Society of Pediatric Nephrology, and the International Society of Nephrology.
Education & Training
- Medical School - Albert Einstein College of Medicine of Yeshiva University (2011-2015)
- Residency - Vanderbilt University Medical Center/Monroe Carell Jr. Children's Hospital (2015-2018), Pediatrics
- Fellowship - Boston Children's Hospital/Boston Medical Center (2018-2021), Pediatric Nephrology
- Fellowship - UT Southwestern Medical Center/Children's Medical Center (2021-2024), Pediatric Nephrology
Professional Associations & Affiliations
Honors & Awards
- Basic Science Award 2024, Donald W. Seldin Research Symposium, UT Southwestern
- Best Oral Presentation 2023, Basic Research Forum for Emerging Kidney Scientists, American Physiological Society
- David G. Nathan Award for Basic Research 2022, Society for Pediatric Research
- Trainee Award in Basic Science 2018, American Society of Pediatric Nephrology
- David Karzon Award for Research 2018, Vanderbilt Pediatrics Residency Program
Books & Publications
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Publications
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Therapeutic remodeling of the ceramide backbone prevents kidney injury
Nicholson RJ, Cedeño-Rosario L, Maschek JA, Lonergan T, Van Vranken JG, Kruse AR, Stubben CJ, Wang L, Stuart D, Alcantara QA, Revelo MP, Rutter K, Pahulu M, Taloa J, Wu X, Kim J, Kim J, Hall I, Clark AJ, Parikh S, Spraggins J, Romero D, Blitzer JT, Gygi SP, Rutter J, Holland WL, Ramkumar N, Summers SA Cell Metabolism 2026 Jan 38 135-156.e10 -
Acute kidney injury is associated with elevated urinary endotrophin
Clark AJ, Flores BM, Saade MC, Vu KQ, Pence IJ, Zhang N, An Z, Bu D, Scherer PE, Parikh SM American Journal of Physiology - Renal Physiology 2025 Nov 329 F685-F689 -
Reversible compromise of physiological resilience by accumulation of heteroplasmic mtDNA mutations
Huang H, Wang Y, Zsengeller ZK, Gorham JM, Vemireddy V, Clark AJ, Pan H, Dreyfuss JM, Jotwani V, Shlipak MG, Sarnak MJ, Parikh CR, Thiessen-Philbrook H, Katz R, Waikar SS, Lake NJ, Lek M, Shi W, Puiu D, Hong YS, Seidman JG, Arking DE, Parikh SM Science 2025 Oct 390 164-172 -
Pediatric acute kidney injury is associated with impairment in nicotinamide adenine dinucleotide (NAD+) metabolism
Clark AJ, Flores BM, Saade MC, Vu KQ, Pence IJ, Berg A, Parikh SM Pediatric Nephrology 2025 Sep 40 2967-2972 -
NAD+ metabolism in acute kidney injury and chronic kidney disease transition
Alhumaidi R, Huang H, Saade MC, Clark AJ, Parikh SM Trends in Molecular Medicine 2025 Jul 31 669-681 -
Cathepsin K cleavage of angiopoietin-2 creates detrimental Tie2 antagonist fragments in sepsis
Suzuki T, Loyde E, Chen S, Etzrodt V, Idowu TO, Clark AJ, Saade MC, Flores BM, Lu S, Birrane G, Vemireddy V, Seeliger B, David S, Parikh SM Journal of Clinical Investigation 2025 Apr 135 -
Hepatocyte nuclear factor 4α mediated quinolinate phosphoribosylltransferase (QPRT) expression in the kidney facilitates resilience against acute kidney injury
Clark AJ, Saade MC, Vemireddy V, Vu KQ, Flores BM, Etzrodt V, Ciampa EJ, Huang H, Takakura A, Zandi-Nejad K, Zsengellér ZK, Parikh SM Kidney international 2023 Dec 104 1150-1163 -
States of quinolinic acid excess in urine: A systematic review of human studies
Saade MC, Clark AJ, Parikh SM Frontiers in Nutrition 2022 Dec 9 -
Dicarbonyl-modified lipoproteins contribute to proteinuric kidney injury
Zhong J, Yang HC, Shelton EL, Matsusaka T, Clark AJ, Yermalitsky V, Mashhadi Z, May-Zhang LS, Linton MF, Fogo AB, Kirabo A, Davies SS, Kon V JCI Insight 2022 Nov 7 -
The Significance of NAD+ Biosynthesis Alterations in Acute Kidney Injury
Clark AJ, Saade MC, Parikh SM Seminars in nephrology 2022 May 42 -
Malaise, weight loss, and acute kidney injury in a 13-year-old girl
Clark AJ, Matevish L, Hernanz-Schulman M, Mason EF, Hunley TE Pediatrics in review 2021 Jul 42 E28-E32 -
Targeting energy pathways in kidney disease: the roles of sirtuins, AMPK, and PGC1α
Clark AJ, Parikh SM Kidney international 2021 Apr 99 828-840 -
Mitochondrial Metabolism in Acute Kidney Injury
Clark AJ, Parikh SM Seminars in nephrology 2020 Mar 40 101-113 -
Urinary apolipoprotein AI in children with kidney disease
Clark AJ, Jabs K, Hunley TE, Jones DP, VanDeVoorde RG, Anderson C, Du L, Zhong J, Fogo AB, Yang H, Kon V Pediatric Nephrology 2019 Nov 34 2351-2360 -
Urinary apoAl: novel marker of renal disease?
Clark AJ, Yang H, Kon V Pediatric Nephrology 2019 Nov 34 2425-2426 -
Factors associated with asthma diagnosis within five years of a bronchiolitis hospitalization: A retrospective cohort study in a high asthma prevalence population
Clark AJ, Dong N, Roth T, Douglas LC Hospital Pediatrics 2019 9 794-800 -
Priapism in a 13-year-old boy
Clark AJ, Hsu P, Darves-Bornoz A, Tanaka ST, Mason EF, Katzenstein HM Pediatrics in review 2018 Dec 39 617-619 -
Acute kidney injury and subsequent frailty status in survivors of critical illness: A secondary analysis
Abdel-Kader K, Girard TD, Brummel NE, Saunders CT, Blume JD, Clark AJ, Vincz AJ, Ely EW, Jackson JC, Bell SP, Archer KR, Ikizler TA, Pandharipande PP, Siew ED Critical care medicine 2018 May 46 e380-e388 -
Acute kidney injury as a risk factor for delirium and coma during critical illness
Siew ED, Fissell WH, Tripp CM, Blume JD, Wilson MD, Clark AJ, Vincz AJ, Ely EW, Pandharipande PP, Girard TD American Journal of Respiratory and Critical Care Medicine 2017 Jun 195 1597-1607 -
Urinary L-FABP predicts poor outcomes in critically ill patients with early acute kidney injury
Parr SK, Clark AJ, Bian A, Shintani AK, Wickersham NE, Ware LB, Ikizler TA, Siew ED Kidney international 2015 Mar 87 640-648
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Therapeutic remodeling of the ceramide backbone prevents kidney injury
Research
- Effects of maternal and fetal metabolism on the development of fetal kidneys
Children's Medical Center of Dallas
1935 Medical District DriveDallas, Texas 75235 214-730-5437 Directions to Children's Medical Center of Dallas at Children's Medical Center of Dallas, Dallas