Andreas Reimold, M.D.

Internal Medicine - Rheumatology Diseases
Polymyalgia Rheumatica
Myositis

Biography

The focus of the Reimold lab's research program is to understand how transcription factors control the expression of genes involved in inflammation. Insights into how these proteins turn genes on and off may lead to new treatments for rheumatic diseases. They have studied transcription factors binding to DNA at cyclic AMP response elements, a sequence of widespread importance in the regulation of proinflammatory genes. To determine the precise functions of these transcription factors, mice with targeted disruptions of the genes under study were generated and have revealed defects in embryonic growth and development, as well as impaired activation of inflammatory pathways. Recently they have identified a block in the pathway of B lymphocyte terminal differentiation in one of our knockout mouse models. Further work will help to elucidate how the interaction of transcription factors with each other and with their target genes regulates the production of immunoglobulin-secreting plasma cells.

Education & Training

Fellowship - Harvard Medical School (1991-1993), Immunology
Fellowship - Harvard Medical School (1988-1991), Rheumatology
Internship/Residency - Washington University School of Medicine (1984-1987), Internal Medicine
Medical School - Columbia University College of Physicians and Surgeons

Professional Associations & Affiliations

Arthritis Foundation
American College of Rheumatology
American Association of Immunologists

Honors & Awards

Arthritis Investigator Award 1997, American College of Rheumatology
Lyndon Baines Johnson Research Award 2002, American Heart Association

Books & Publications

Publications
- New indications for treatment of chronic inflammation by TNFa blockade
  Reimold, A.M. American Journal of Medical Science 2003 325 75-92
- Plasma cell differentiation requires the trasncription factor XBP-1
  Reimold A.M., N.N. Iwakoshi, J. Manis, P. Vallabhajosyula, E. Szomolanyi-Tsuda, E.M. Gravallese, D. Friend, M.J. Grusby, F. Alt, L.H. Glimcher Nature 2001 412 300-307
- An essential role in liver development for transcription factor XBP-1
  Reimold A.M., A. Etkin, I Clauss, A. Perkins, D.S. Friend, J. Zhang, H.F. Horton, A. Scott, S. Orkin, M.C. Byrne, M.J. Grusby, L.H. Glimcher Genes and Development 2000 14 152-157

Research

Transcriptional regulation of lymphocyte function
Mechanisms of B cell differentiation

Clinical Focus

Polymyalgia Rheumatica
Myositis
Sjogren's Syndrome
Crystalline Arthropathies
Relapsing Polychondritis
Spondyloarthropathy
Vasculitis
IGG4 Related Disease
Interstitial Lung Disease (Pulmonary Fibrosis)
Rheumatoid Arthritis
Systemic Lupus Erythematosus
Osteoarthritis
Sarcoidosis
Systemic Sclerosis