The focus of the Reimold lab's research program is to understand how transcription factors control the expression of genes involved in inflammation. Insights into how these proteins turn genes on and off may lead to new treatments for rheumatic diseases. They have studied transcription factors binding to DNA at cyclic AMP response elements, a sequence of widespread importance in the regulation of proinflammatory genes. To determine the precise functions of these transcription factors, mice with targeted disruptions of the genes under study were generated and have revealed defects in embryonic growth and development, as well as impaired activation of inflammatory pathways. Recently they have identified a block in the pathway of B lymphocyte terminal differentiation in one of our knockout mouse models. Further work will help to elucidate how the interaction of transcription factors with each other and with their target genes regulates the production of immunoglobulin-secreting plasma cells.

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Education & Training
  • Fellowship - Harvard Medical School (1991-1993), Immunology
  • Fellowship - Harvard Medical School (1988-1991), Rheumatology
  • Internship/Residency - Washington University School of Medicine (1984-1987), Internal Medicine
  • Medical School - Columbia University College of Physicians and Surgeons
Professional Associations & Affiliations
  • Arthritis Foundation
  • American College of Rheumatology
  • American Association of Immunologists
Honors & Awards
  • Arthritis Investigator Award 1997, American College of Rheumatology
  • Lyndon Baines Johnson Research Award 2002, American Heart Association
Books & Publications
  • Transcriptional regulation of lymphocyte function
  • Mechanisms of B cell differentiation

Clinical Focus

  • Myositis
  • Crystalline Arthropathies
  • Sarcoidosis
  • Interstitial Lung Disease (Pulmonary Fibrosis)
  • Osteoarthritis
  • Spondyloarthropathy
  • Relapsing Polychondritis
  • Vasculitis
  • Sjogren's Syndrome
  • Systemic Sclerosis
  • Polymyalgia Rheumatic
  • Rheumatoid Arthritis
  • Systemic Lupus Erythematosus
  • IGG4 Related Disease

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Internal Medicine Subspecialties Clinic

at West Campus Building 3 2001 Inwood Road, 8th and 9th Floor
Dallas, Texas 75390
214-645-2800 Directions Parking Info