- Medical School - USF Health Morsani College of Medicine (1984-1988)
- Residency - University of Cincinnati/Children's Hospital Medical Center (1988-1991), Pediatrics
- Fellowship - Baylor College of Medicine/Texas Children's Hospital (1991-1995), Medical Genetics
Angela Scheuerle, M.D.
- Pediatrics - Genetics & Metabolism
Dr. Angela Scheuerle fell in love with genetics as a sophomore in high school and never looked back. She now has the career that she wanted at the age of 15 – even though such a profession didn’t exist at the time. Learning the intricacies of the science is like learning the secret of a magic trick. Remember the “ah hah!” moment when you suddenly mastered a two-wheeler? Genetics is like that.
Dr. Scheuerle graduated Magna Cum Laude as a biology major from Sewanee: The University of the South. She received her M.D. from The University of South Florida Morsani College of Medicine. Dr. Scheuerle completed a Pediatric Residency at Children’s Hospital Medical Center in Cincinnati, Ohio, and Medical Genetics Fellowship at Baylor College of Medicine. Her fellowship started just at the beginning of the Human Genome Project, so she got to “grow up” in genetics at a very exciting time: when it was possible to keep up with gene discoveries because it was about one every two weeks. She has also completed a fellowship in Clinical Ethics at the University of Chicago. Dr. Scheuerle is board certified in Clinical Genetics, Clinical Molecular Genetics, and Pediatrics.
She started shadowing in a craniofacial clinic during high school, where she developed a specific interest in craniofacial malformations. She has practiced Clinical Genetics in Houston and then Dallas since 1995. From 2003 to 2014 she was in private practice at Tesserae Genetics at Medical City Dallas. She has been adjunct faculty at UT Southwestern in the Program of Ethics in Science and Medicine and the Eugene McDermott Center for Human Development since 2000. She joined the Pediatric Division of Genetics and Metabolism as full faculty in September 2014. She holds secondary appointments as Professor in the McDermott Center and in the Department of Pathology, where she is also co-director of the Fellowship in Laboratory Genetics and Genomics.
In addition to clinical practice, Dr. Scheuerle does extensive work in public health and drug safety. She has worked with the Texas Department of State Health Services Birth Defects Epidemiology and Surveillance Branch since 1994. This Branch operates the Texas Birth Defect Registry, an active state surveillance system that monitors birth prevalence of congenital anomalies and genetic conditions. This has become particularly important in 2016 with the Zika virus epidemic. She is part of the birth defect surveillance group monitoring for Zika-related birth defects. In July 2016, she attended and participated in a workshop at the Centers for Disease Control and Prevention to define guidelines for evaluation and management of infants and children exposed to Zika virus.
The Birth Defects Epidemiology and Surveillance Branch also manages the Texas Center for Birth Defects Research and Prevention (TCBDRP), which performs and supports investigation into causes of birth defects. The TCBDRP participated in the 15-year, 10-state National Birth Defects Prevention Study, and Dr. Scheuerle served as the Geneticist for Texas’ contribution to that Study. She continues her involvement with research generated from both the state and national programs.
In 1997, Dr. Scheuerle joined the Antiretroviral Pregnancy Registry (APR). This is an FDA-mandated, post-marketing exposure registry that began in 1989 as the Zidovudine in Pregnancy Registry. This multi-drug registry is one of the largest of its kind, monitoring pregnancy exposure of now over 40 HIV and Hepatitis medications. Dr. Scheuerle’s role as teratologist is to identify those cases in which exposure to one or more medications temporally associates with embryopathogenesis of the anomaly. She also serves on the scientific advisory and steering committees for the APR. Her Organ System Classification schema for categorizing birth defects is one of two recommended by the FDA for use in pharmaceutical pregnancy registry work. Dr. Scheuerle now participates in other pregnancy registries and provides similar consultative services to US- and European-based pharmaceutical companies.
In 2018, Dr. Scheuerle was included in D Magazine's Best Doctors list, and was named a Super Doctor by Texas Monthly.
- AAP - Section Executive Committee (2013-2015), Elected
- AAP - ListServ Working Group (2011), Chair
- North Texas Bioethics Network (2005)
- Pediatric Society of Greater Dallas (2004), Vice President, 2006; President, 2007
- Bioethics Committee, Medical City Dallas Hospital (2003-2014), Co-chair, 2007-2011; Chair, 2011-2014
- National Birth Defects Prevention Network (1998)
- Houston Bioethics Network (1997-1998)
- AAP - Section of Genetics and Birth Defects (1995)
- American College of Medical Genetics and Genomics (1995), Fellow
- American Society of Human Genetics (1990), Social Issues Committee (2000-2005)
- American Academy of Pediatrics (AAP) (1988)
- Distinguished Service Award 2010, National Birth Defect Prevention Network
- First place poster award 2009, National Birth Defect Prevention Network
- Best Pediatric Specialists 2004-2017, D Magazine
- Phi Beta Kappa 1994
Appendix III: Syndromes Glossary in Cabana MD, ed. The 5-Minute Pediatric Consult. 7th ed.
Scheuerle AE. (2015), Wolters Kluwer; 1027-1033.
Genetics in the Clinic: Clinical, Ethical and Social Implications for Primary Care.
(2001), St. Louis: Mosby
Understanding Genetics: A Guide for Couples and Families.
(2005), Westport, CT: Greenwood Publishing.
Clinical Genetics and Dysmorphology in Cabana M, ed. Rudolph's Pediatrics Self-Assessment and Board Review. 22nd ed.
Scheuerle A. (2014), San Francisco: McGraw Hill; 220-236.
Review of Embryology and Clinical Genetics in Advances in Plastic Surgery.
Scheuerle A. (1998)
- Appendix III: Syndromes Glossary in Cabana MD, ed. The 5-Minute Pediatric Consult. 7th ed.
Some Intensification and Refining.
Scheuerle AE The Journal of craniofacial surgery 2017 Jan
Enamel Pit Defects and Taurodontism in a Patient with Ring Chromosome 14 and 47,XXX.
Townsend JA, Lacour L, Scheuerle AE Journal of dentistry for children (Chicago, Ill.) 2017 Jan 84 1 39-43
Update: Interim Guidance for the Evaluation and Management of Infants with Possible Congenital Zika Virus Infection - United States, August 2016.
Russell K, Oliver SE, Lewis L, Barfield WD, Cragan J, Meaney-Delman D, Staples JE, Fischer M, Peacock G, Oduyebo T, Petersen EE, Zaki S, Moore CA, Rasmussen SA MMWR. Morbidity and mortality weekly report 2016 Aug 65 33 870-878
Birth defects and neonatal morbidity caused by teratogen exposure after the embryonic period.
Scheuerle AE, Aylsworth AS Birth defects research. Part A, Clinical and molecular teratology 2016 Aug
Mandibulofacial Dysostosis with Microcephaly: Mutation and Database Update.
Huang L, Vanstone MR, Hartley T, Osmond M, Barrowman N, Allanson J, Baker L, Dabir TA, Dipple KM, Dobyns WB, Estrella J, Faghfoury H, Favaro FP, Goel H, Gregersen PA, Gripp KW, Grix A, Guion-Almeida ML, Harr MH, Hudson C, Hunter AG, Johnson J, Joss SK, Kimball A, Kini U, Kline AD, Lauzon J, Lildballe DL, López-González V, Martinezmoles J, Meldrum C, Mirzaa GM, Morel CF, Morton JE, Pyle LC, Quintero-Rivera F, Richer J, Scheuerle AE, Schönewolf-Greulich B, Shears DJ, Silver J, Smith AC, Temple IK, van de Kamp JM, van Dijk FS, Vandersteen AM, White SM, Zackai EH, Zou R, Consortium CC, Bulman DE, Boycott KM, Lines MA Human mutation 2015 Oct
Population-based birth defects data in the United States, 2008 to 2012: Presentation of state-specific data and descriptive brief on variability of prevalence.
Mai CT, Isenburg J, Langlois PH, Alverson CJ, Gilboa SM, Rickard R, Canfield MA, Anjohrin SB, Lupo PJ, Jackson DR, Stallings EB, Scheuerle AE, Kirby RS Birth defects research. Part A, Clinical and molecular teratology 2015 Nov 103 11 972-93
Prenatal exposure to zidovudine and risk for ventricular septal defects and congenital heart defects: data from the Antiretroviral Pregnancy Registry.
Vannappagari V, Albano JD, Koram N, Tilson H, Scheuerle AE, Napier MD European journal of obstetrics, gynecology, and reproductive biology 2015 Nov 197 6-10
De novo mutations in NALCN cause a syndrome characterized by congenital contractures of the limbs and face, hypotonia, and developmental delay.
Chong JX, McMillin MJ, Shively KM, Beck AE, Marvin CT, Armenteros JR, Buckingham KJ, Nkinsi NT, Boyle EA, Berry MN, Bocian M, Foulds N, Uzielli ML, Haldeman-Englert C, Hennekam RC, Kaplan P, Kline AD, Mercer CL, Nowaczyk MJ, Klein Wassink-Ruiter JS, McPherson EW, Moreno RA, Scheuerle AE, Shashi V, Stevens CA, Carey JC, Monteil A, Lory P, Tabor HK, Smith JD, Shendure J, Nickerson DA, Bamshad MJ American journal of human genetics 2015 Mar 96 3 462-73
Maternal occupational exposure to polycyclic aromatic hydrocarbons and craniosynostosis among offspring in the national birth defects prevention study.
O'Brien JL, Langlois PH, Lawson CC, Scheuerle A, Rocheleau CM, Waters MA, Symanski E, Romitti PA, Agopian AJ, Lupo PJ Birth defects research. Part A, Clinical and molecular teratology 2015 Jun
Descriptive epidemiology of birth defects thought to arise by new mutation.
Langlois PH, Scheuerle AE Birth defects research. Part A, Clinical and molecular teratology 2015 Jul
High Incidence of Noonan Syndrome Features Including Short Stature and Pulmonic Stenosis in Patients carrying NF1 Missense Mutations Affecting p.Arg1809: Genotype-Phenotype Correlation.
Rojnueangnit K, Xie J, Gomes A, Sharp A, Callens T, Chen Y, Liu Y, Cochran M, Abbott MA, Atkin J, Babovic-Vuksanovic D, Barnett CP, Crenshaw M, Bartholomew DW, Basel L, Bellus G, Ben-Shachar S, Bialer MG, Bick D, Blumberg B, Cortes F, David KL, Destree A, Duat-Rodriguez A, Earl D, Escobar L, Eswara M, Ezquieta B, Frayling IM, Frydman M, Gardner K, Gripp KW, Hernández-Chico C, Heyrman K, Ibrahim J, Janssens S, Keena BA, Llano-Rivas I, Leppig K, McDonald M, Misra VK, Mulbury J, Narayanan V, Orenstein N, Galvin-Parton P, Pedro H, Pivnick EK, Powell CM, Randolph L, Raskin S, Rosell J, Rubin K, Seashore M, Schaaf CP, Scheuerle A, Schultz M, Schorry E, Schnur R, Siqveland E, Tkachuk A, Tonsgard J, Upadhyaya M, Verma IC, Wallace S, Williams C, Zackai E, Zonana J, Lazaro C, Claes K, Korf B, Martin Y, Legius E, Messiaen L Human mutation 2015 Jul
The Xolair Pregnancy Registry (EXPECT): the safety of omalizumab use during pregnancy.
Namazy J, Cabana MD, Scheuerle AE, Thorp JM, Chen H, Carrigan G, Wang Y, Veith J, Andrews EB The Journal of allergy and clinical immunology 2015 Feb 135 2 407-12
Expanding the Molecular and Clinical Phenotype of SSR4-CDG.
Ng BG, Raymond K, Kircher M, Buckingham KJ, Wood T, Shendure J, Nickerson DA, Bamshad MJ, Wong JT, Monteiro FP, Graham BH, Jackson S, Sparkes R, Scheuerle AE, Cathey S, Kok F, Gibson JB, Freeze HH Human mutation 2015 Aug
A modified panel of sentinel congenital anomalies for potential use in mutation epidemiology based on birth defects registry data.
Langlois PH, Moffitt KB, Scheuerle AE American journal of medical genetics. Part A 2014 Sep 164A 9 2187-99
Birth defects, causal attributions, and ethnicity in the national birth defects prevention study.
Case AP, Royle M, Scheuerle AE, Carmichael SL, Moffitt K, Ramadhani T Journal of genetic counseling 2014 Oct 23 5 860-73
Loss-of-function HDAC8 mutations cause a phenotypic spectrum of Cornelia de Lange syndrome-like features, ocular hypertelorism, large fontanelle and X-linked inheritance.
Kaiser FJ, Ansari M, Braunholz D, Concepción Gil-Rodríguez M, Decroos C, Wilde JJ, Fincher CT, Kaur M, Bando M, Amor DJ, Atwal PS, Bahlo M, Bowman CM, Bradley JJ, Brunner HG, Clark D, Del Campo M, Di Donato N, Diakumis P, Dubbs H, Dyment DA, Eckhold J, Ernst S, Ferreira JC, Francey LJ, Gehlken U, Guillén-Navarro E, Gyftodimou Y, Hall BD, Hennekam R, Hudgins L, Hullings M, Hunter JM, Yntema H, Innes AM, Kline AD, Krumina Z, Lee H, Leppig K, Lynch SA, Mallozzi MB, Mannini L, McKee S, Mehta SG, Micule I, Mohammed S, Moran E, Mortier GR, Moser JA, Noon SE, Nozaki N, Nunes L, Pappas JG, Penney LS, Pérez-Aytés A, Petersen MB, Puisac B, Revencu N, Roeder E, Saitta S, Scheuerle AE, Schindeler KL, Siu VM, Stark Z, Strom SP, Thiese H, Vater I, Willems P, Williamson K, Wilson LC, Hakonarson H, Quintero-Rivera F, Wierzba J, Musio A, Gillessen-Kaesbach G, Ramos FJ, Jackson LG, Shirahige K, Pié J, Christianson DW, Krantz ID, Fitzpatrick DR, Deardorff MA Human molecular genetics 2014 Jun 23 11 2888-900
Sociodemographic and hispanic acculturation factors and isolated anotia/microtia.
Hoyt AT, Canfield MA, Shaw GM, Waller DK, Polen KN, Ramadhani T, Anderka MT, Scheuerle AE Birth defects research. Part A, Clinical and molecular teratology 2014 Jul
Insight into IKBKG/NEMO locus: report of new mutations and complex genomic rearrangements leading to incontinentia pigmenti disease.
Conte MI, Pescatore A, Paciolla M, Esposito E, Miano MG, Lioi MB, McAleer MA, Giardino G, Pignata C, Irvine AD, Scheuerle AE, Royer G, Hadj-Rabia S, Bodemer C, Bonnefont JP, Munnich A, Smahi A, Steffann J, Fusco F, Ursini MV Human mutation 2014 Feb 35 2 165-77
Mortality in babies with achondroplasia: revisited.
Simmons K, Hashmi SS, Scheuerle A, Canfield M, Hecht JT Birth defects research. Part A, Clinical and molecular teratology 2014 Apr 100 4 247-9
Prenatal diagnosis and cesarean section in a large, population-based birth defects registry.
Case AP, Colpitts LR, Langlois PH, Scheuerle AE The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2012 Apr 25 4 395-402
Birth defects among a cohort of infants born to HIV-infected women on antiretroviral medication.
Watts DH, Huang S, Culnane M, Kaiser KA, Scheuerle A, Mofenson L, Stanley K, Newell ML, Mandelbrot L, Delfraissy JF, Cunningham CK Journal of perinatal medicine 2011 Mar 39 2 163-70
PARK2 copy number aberrations in two children presenting with autism spectrum disorder: further support of an association and possible evidence for a new microdeletion/microduplication syndrome.
Scheuerle A, Wilson K American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2011 Jun 156B 4 413-20
Descriptive epidemiology of selected heritable birth defects in Texas.
Moffitt KB, Abiri OO, Scheuerle AE, Langlois PH Birth defects research. Part A, Clinical and molecular teratology 2011 Dec 91 12 990-4
Clinical differentiation of patent foramen ovale and secundum atrial septal defect: a survey of pediatric cardiologists in Dallas, Texas, USA.
Scheuerle A Journal of registry management 2011 38 1 4-8
A physician survey regarding diagnostic variability among birth defects.
Langlois PH, Sheu SU, Scheuerle AE American journal of medical genetics. Part A 2010 Jun 152A 6 1594-8
A case of Asian Indian OCA3 patient.
Chiang PW, Spector E, Scheuerle A American journal of medical genetics. Part A 2009 Jul 149A 7 1578-80
Clinical review procedures for the Antiretroviral Pregnancy Registry.
Scheuerle A, Covington D Pharmacoepidemiology and drug safety 2004 Aug 13 8 529-36
Birth defect classification by organ system: a novel approach to heighten teratogenic signalling in a pregnancy registry.
Scheuerle A, Tilson H Pharmacoepidemiology and drug safety 2002 Sep 11 6 465-75
Male cases of incontinentia pigmenti: Case report and review
Scheuerle AE American Journal of Medical Genetics 1998 77 201-218
Pre-Zika descriptive epidemiology of microcephaly in Texas, 2008-2012.
Hoyt AT, Canfield MA, Langlois PH, Waller DK, Agopian AJ, Shumate CJ, Hall NB, Marengo LK, Ethen MK, Scheuerle AE Birth defects research 2017 Nov
Mutations in PIGS, Encoding a GPI Transamidase, Cause a Neurological Syndrome Ranging from Fetal Akinesia to Epileptic Encephalopathy.
Nguyen TTM, Murakami Y, Wigby KM, Baratang NV, Rousseau J, St-Denis A, Rosenfeld JA, Laniewski SC, Jones J, Iglesias AD, Jones MC, Masser-Frye D, Scheuerle AE, Perry DL, Taft RJ, Le Deist F, Thompson M, Kinoshita T, Campeau PM American journal of human genetics 2018 Oct 103 4 602-611
An additional case of Hennekam lymphangiectasia-lymphedema syndrome caused by loss-of-function mutation in ADAMTS3.
Scheuerle AE, Sweed NT, Timmons CF, Smith ED, Alcaraz WA, Shinde DN American journal of medical genetics. Part A 2018 Dec 176 12 2858-2861
Expanding the clinical and molecular findings in RASA1 capillary malformation-arteriovenous malformation.
Wooderchak-Donahue WL, Johnson P, McDonald J, Blei F, Berenstein A, Sorscher M, Mayer J, Scheuerle AE, Lewis T, Grimmer JF, Richter GT, Steeves MA, Lin AE, Stevenson DA, Bayrak-Toydemir P European journal of human genetics : EJHG 2018 Jun
Pregnancy Outcomes after Exposure to Certolizumab Pegol: Updated Results from a Pharmacovigilance Safety Database.
Clowse MEB, Scheuerle AE, Chambers C, Afzali A, Kimball AB, Cush JJ, Cooney M, Shaughnessy L, Vanderkelen M, Förger F Arthritis & rheumatology (Hoboken, N.J.) 2018 Apr
- Some Intensification and Refining.
- Teratogenic risks of prescription medication/drug safety
- Syndrome definition
- Public health genetics and birth defect surveillance