- American Association for the Study of Liver Diseases
- North American Society for Pediatric Gastroenterology, Hepatology & Nutrition
- Texas Medical Association
Charina Ramirez, M.D.
- Pediatrics - Gastroenterology
- Pediatric Gastroenterology and Nutrition
- Pediatric Liver Disease
Biography
Charina Marie Ramirez, M.D., is a Professor in the Department of Pediatrics at UT Southwestern Medical Center. She serves as the Director of the Metabolic Associated Fatty Liver Disease Clinic at Children’s Medical Center Dallas and Medical Director of Pediatrics at Children’s Health Specialty Center in Park Cities. She specializes in pediatric gastroenterology, hepatology, and nutrition.
She is also the Co-Course Director of the Gastrointestinal System at UT Southwestern Medical School and serves as a Faculty Advisor for pediatric residents.
Dr. Ramirez earned her medical degree at the University of Texas Medical Branch at Galveston. She completed a residency in pediatrics at UT Southwestern, where she also received advanced training through a three-year fellowship in pediatric gastroenterology, hepatology, and nutrition. During her fellowship training, she was awarded the Ara Parseghian Medical Research Foundation fellowship grant.
Certified by the American Board of Pediatrics, she joined the UT Southwestern faculty in 2010.
Dr. Ramirez’s research interests include metabolic associated fatty liver disease, cystic fibrosis liver disease, and Niemann-Pick type C disease. She is a member of the American Association for the Study of Liver Diseases; the North American Society for Pediatric Gastroenterology, Hepatology & Nutrition; and the Texas Medical Association.
Education & Training
- Internship - Children's Medical Center Dallas (2003-2004), Pediatrics
- Residency - Children's Medical Center Dallas (2004-2006), Pediatric Medicine
- Fellowship - UT Southwestern/Children's Medical Center (2007-2010), Pediatric Gastroenterology
- Medical School - University of Texas Medical Branch at Galveston (1999-2003)
Professional Associations & Affiliations
Honors & Awards
- D Magazine Best Doctor 2022-2025
- D Magazine Best Pediatric Specialist 2019-2021
Books & Publications
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Publications
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Call to action—Pediatric MASLD requires immediate attention to curb health crisis
Hartmann P, Mouzaki M, Hassan S, Kehar M, Mysore KR, Mauney E, Nonga D, Karjoo S, Sood S, Tou A, Brichta C, Herdes RE, Pai N, Garner DK, Rinella ME, Noureddin M, Younossi Z, Allen AM, Sanyal A, Kohut T, Kohli R, Ramirez CM, Xanthakos S, Vos MB, Schwimmer JB, Ibrahim SH, Panganiban J Hepatology 2025 Nov 82 1341-1351 -
Metabolic dysfunction-associated steatotic liver disease (MASLD) in children with obesity: An Obesity Medicine Association (OMA) and expert joint perspective 2025
Panganiban J, Kehar M, Ibrahim SH, Hartmann P, Sood S, Hassan S, Ramirez CM, Kohli R, Censani M, Mauney E, Cuda S, Karjoo S Obesity Pillars 2025 Jun 14 -
Utilization and perspectives of weight loss medications in pediatric metabolic dysfunction-associated steatotic liver disease
Kehar M, Ibrahim SH, Ramirez CM, Amin SA, Diamond T, Mohammad S Journal of pediatric gastroenterology and nutrition 2024 Sep 79 661-666 -
Electronic phenotypes to distinguish clinician attention to high body mass index, hypertension, lipid disorders, fatty liver and diabetes in pediatric primary care: Diagnostic accuracy of electronic phenotypes compared to masked comprehensive chart review
Turer CB, Park JJ, Gupta OT, Ramirez C, Basit MA, Heitjan DF, Barlow SE Pediatric Obesity 2023 Oct 18 -
Update on glycogen storage disease: primary hepatic involvement
Wright TL, Umaña LA, Ramirez CM Current opinion in pediatrics 2022 Oct 34 496-502 -
Molecular markers of brain cholesterol homeostasis are unchanged despite a smaller brain mass in a mouse model of cholesteryl ester storage disease
Aqul AA, Ramirez CM, Lopez AM, Burns DK, Repa JJ, Turley SD Lipids 2022 Jan 57 3-16 -
The 21st Century Cures Act and Multiuser Electronic Health Record Access: Potential Pitfalls of Information Release
Arvisais-Anhalt S, Lau M, Lehmann CU, Holmgren AJ, Medford RJ, Ramirez CM, Chen CN Journal of medical Internet research 2022 24 -
Diagnostic challenges and disease management in patients with a mild Zellweger spectrum disorder phenotype
Enns GM, Ammous Z, Himes RW, Nogueira J, Palle S, Sullivan M, Ramirez C Molecular Genetics and Metabolism 2021 Nov 134 217-222 -
A Case of Dubin-Johnson Syndrome Presenting as Neonatal Cholestasis With Paucity of Interlobular Bile Ducts
Chan KL, Varughese N, Jones PM, Zwick DL, Rajaram V, Lee M, Ramirez CM Pediatric and Developmental Pathology 2021 Apr 24 154-158 -
Hepatic Steatosis in the Pediatric Population: An Overview of Pathophysiology, Genetics, and Diagnostic Workup
Phen C, Ramirez CM Clinical Liver Disease 2021 Mar 17 191-195 -
Delineation of metabolic responses of Npc1−/−nih mice lacking the cholesterol-esterifying enzyme SOAT2 to acute treatment with 2-hydroxypropyl-β-cyclodextrin
Ramirez CM, Taylor AM, Lopez AM, Repa JJ, Turley SD Steroids 2020 Dec 164 -
Ontogenesis and Modulation of Intestinal Unesterified Cholesterol Sequestration in a Mouse Model of Niemann–Pick C1 Disease
Lopez AM, Ramirez CM, Taylor AM, Jones RD, Repa JJ, Turley SD Digestive Diseases and Sciences 2020 Jan 65 158-167 -
Lysosomal Acid Lipase Activity: A Tool for the Detection and Management of Fatty Liver Disease?
Ramirez CM, Lopez AM, Turley SD EBioMedicine 2015 Jul 2 638-639 -
Systemic administration of 2-hydroxypropyl-β-cyclodextrin to symptomatic Npc1-deficient mice slows cholesterol sequestration in the major organs and improves liver function
Lopez AM, Terpack SJ, Posey KS, Liu B, Ramirez CM, Turley SD Clinical and Experimental Pharmacology and Physiology 2014 Oct 41 780-787 -
Impact of the loss of caveolin-1 on lung mass and cholesterol metabolism in mice with and without the lysosomal cholesterol transporter, Niemann-Pick type C1
Mundy DI, Lopez AM, Posey KS, Chuang JC, Ramirez CM, Scherer PE, Turley SD Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids 2014 Jul 1841 995-1002 -
Ontogenic changes in lung cholesterol metabolism, lipid content, and histology in mice with Niemann-Pick type C disease
Ramirez CM, Lopez AM, Le LQ, Posey KS, Weinberg AG, Turley SD Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids 2014 1841 54-61 -
Frequency of the cholesteryl ester storage disease common LIPA E8SJM mutation (c.894G>A) in various racial and ethnic groups
Scott SA, Liu B, Nazarenko I, Martis S, Kozlitina J, Yang Y, Ramirez C, Kasai Y, Hyatt T, Peter I, Desnick RJ Hepatology 2013 Sep 58 958-965 -
Unesterified cholesterol accumulation in late endosomes/lysosomes causes neurodegeneration and is prevented by driving cholesterol export from this compartment
Aqul A, Liu B, Ramirez CM, Pieper AA, Estill SJ, Burns DK, Liu B, Repa JJ, Turley SD, Dietschy JM Journal of Neuroscience 2011 Jun 31 9404-9413 -
Quantitative role of LAL, NPC2, and NPC1 in lysosomal cholesterol processing defined by genetic and pharmacological manipulations
Ramirez CM, Liu B, Aqul A, Taylor AM, Repa JJ, Turley SD, Dietschy JM Journal of lipid research 2011 Apr 52 688-698 -
Weekly cyclodextrin administration normalizes cholesterol metabolism in nearly every organ of the niemann-pick type C1 mouse and markedly prolongs life
Ramirez CM, Liu B, Taylor AM, Repa JJ, Burns DK, Weinberg AG, Turley SD, Dietschy JM Pediatric Research 2010 Oct 68 309-315 -
Cyclodextrin overcomes the transport defect in nearly every organ of NPC1 mice leading to excretion of sequestered cholesterol as bile acid
Liu B, Ramirez CM, Miller AM, Repa JJ, Turley SD, Dietschy JM Journal of lipid research 2010 May 51 933-944 -
Persistence of herpes simplex virus DNA in cerebrospinal fluid of neonates with herpes simplex virus encephalitis
Mejías A, Bustos R, Ardura MI, Ramírez C, Sánchez PJ Journal of Perinatology 2009 29 290-296
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Call to action—Pediatric MASLD requires immediate attention to curb health crisis
Research
- Metabolic-Associated Fatty Liver Disease in Pediatrics (Evaluation in Primary Care Setting, Effects of Low Carbohydrate Diet, Evaluation in Primary Care Setting, Genetics of Fatty Liver Disease, Cystic Fibrosis-Associated Liver Disease in Pediatrics, and Niemann-Pick Type C Disease)
Clinical Focus
- Pediatric Gastroenterology and Nutrition
- Pediatric Liver Disease
- Metabolic-Associated Fatty Liver Disease
- Rare Metabolic Liver Diseases
- Niemann-Pick Type C Disease
- Lysosomal Acid Lipase Deficiency
- Peroxisomal Disorder and Zellweger Spectrum Disorder
- Bile Acid Synthesis Defect
Children's Medical Center of Dallas
1935 Medical District DriveDallas, Texas 75235 214-730-5437 Directions to Children's Medical Center of Dallas at Children's Medical Center of Dallas, Dallas