- Fellowship - UT Southwestern Medical Center (2011-2014), Endocrinology & Metabolism
- Medical School - Albert Ludwigs Universitat (1995-2003)
- Residency - UT Southwestern Medical Center (2009-2011), Internal Medicine
Christoph Zechner, M.D., Ph.D.
- Internal Medicine - Endocrinology
- Type 1 and 2 diabetes mellitus
- General endocrinology
Biography
Christoph Zechner, M.D., Ph.D., is an Instructor in the Department of Internal Medicine, the Department of Pharmacology, and the Charles and Jane Pak Center for Mineral Metabolism and Clinical Research at UT Southwestern Medical Center. He specializes in Type 1 and 2 diabetes mellitus, general endocrinology, and disorders of phosphate metabolism.
Dr. Zechner earned his medical degree and research doctorate at the University of Freiburg, combined with a research fellowship at Yale University School of Medicine. After a medical internship at the University of Würzburg, he completed a postdoctoral fellowship at Washington University in St. Louis and the Sanford-Burnham Medical Research Institute at Lake Nona. Subsequently, he moved to UT Southwestern to complete his clinical training in internal medicine and endocrinology and research training in energy and solute metabolism in the laboratory of Drs. David Mangelsdorf and Steven Kliewer as a member of the Physician-Scientist Training Program.
Certified by the American Board of Internal Medicine in internal medicine and the subspecialty of endocrinology, diabetes, and metabolism, he joined the UT Southwestern faculty in 2014.
Dr. Zechner’s research is focused on phosphate balance and energy metabolism.
In 2014, he received the Research Productivity and Accomplishment Award from UT Southwestern’s Division of Endocrinology.
Personal Note
In his spare time, Dr. Zechner enjoys biking in the Texas heat, watching soccer, and taking advantage of the great cultural opportunities that Dallas offers, especially the symphony.
Education & Training
Professional Associations & Affiliations
- Dallas County Medical Society
- Texas Medical Association (2009), Member
- American Medical Association (2010), Member
- Endocrine Society (2011), Member
- American Diabetes Association (2011), Member
- American Society for Bone and Mineral Research (2013), Member
- International Academy of Life Sciences
Honors & Awards
- Biomedical Sciences Exchange Program (BMEP) 2000-2001, Scholarship of the German Academic Exchange Service (DAAD)
- Research Scholarship 2006-2008, German Research Foundation
- Trainee, T32 Endocrine and Metabolism Training Grant 2012-2014, NIH
- Best Presentation by an Endocrinology Fellow 2013, UT Southwestern, Department of Internal Medicine, Division of Endocrinology
- Research Productivity and Accomplishment Award 2014, UT Southwestern, Department of Internal Medicine, Division of Endocrinology
- Physician-Scientist Training Program 2009-2015, Department of Internal Medicine, UT Southwestern Medical Center
Books & Publications
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Publications
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The Hormone FGF21 Stimulates Water Drinking in Response to Ketogenic Diet and Alcohol.
Song P, Zechner C, Hernandez G, Cánovas J, Xie Y, Sondhi V, Wagner M, Stadlbauer V, Horvath A, Leber B, Hu MC, Moe OW, Mangelsdorf DJ, Kliewer SA Cell metabolism 2018 Apr -
Structural insights into gene repression by the orphan nuclear receptor SHP.
Zhi X, Zhou XE, He Y, Zechner C, Suino-Powell KM, Kliewer SA, Melcher K, Mangelsdorf DJ, Xu HE Proceedings of the National Academy of Sciences of the United States of America 2014 Jan 111 2 839-44 -
Uncoupling protein downregulation in doxorubicin-induced heart failure improves mitochondrial coupling but increases reactive oxygen species generation.
Bugger H, Guzman C, Zechner C, Palmeri M, Russell KS, Russell RR Cancer chemotherapy and pharmacology 2011 Jun 67 6 1381-8 -
Total skeletal muscle PGC-1 deficiency uncouples mitochondrial derangements from fiber type determination and insulin sensitivity.
Zechner C, Lai L, Zechner JF, Geng T, Yan Z, Rumsey JW, Collia D, Chen Z, Wozniak DF, Leone TC, Kelly DP Cell metabolism 2010 Dec 12 6 633-42 -
Functional protein expression of multiple sodium channel alpha- and beta-subunit isoforms in neonatal cardiomyocytes.
Kaufmann SG, Westenbroek RE, Zechner C, Maass AH, Bischoff S, Muck J, Wischmeyer E, Scheuer T, Maier SK Journal of molecular and cellular cardiology 2010 Jan 48 1 261-9 -
Transcriptional coactivators PGC-1alpha and PGC-lbeta control overlapping programs required for perinatal maturation of the heart.
Lai L, Leone TC, Zechner C, Schaeffer PJ, Kelly SM, Flanagan DP, Medeiros DM, Kovacs A, Kelly DP Genes & development 2008 Jul 22 14 1948-61 -
A role for the transcriptional coactivator PGC-1alpha in muscle refueling.
Wende AR, Schaeffer PJ, Parker GJ, Zechner C, Han DH, Chen MM, Hancock CR, Lehman JJ, Huss JM, McClain DA, Holloszy JO, Kelly DP The Journal of biological chemistry 2007 Dec 282 50 36642-51 -
Discrepancy between GLUT4 translocation and glucose uptake after ischemia.
Zaha V, Nitschke R, Göbel H, Fischer-Rasokat U, Zechner C, Doenst T Molecular and cellular biochemistry 2005 Oct 278 1-2 129-37 -
Hyperglycemia during cardiopulmonary bypass is an independent risk factor for mortality in patients undergoing cardiac surgery.
Doenst T, Wijeysundera D, Karkouti K, Zechner C, Maganti M, Rao V, Borger MA The Journal of thoracic and cardiovascular surgery 2005 Oct 130 4 1144 -
AMP-activated protein kinase mediates ischemic glucose uptake and prevents postischemic cardiac dysfunction, apoptosis, and injury.
Russell RR, Li J, Coven DL, Pypaert M, Zechner C, Palmeri M, Giordano FJ, Mu J, Birnbaum MJ, Young LH The Journal of clinical investigation 2004 Aug 114 4 495-503 -
The role of calcium in the regulation of glucose uptake in isolated working rat heart.
Zechner C, Beyersdorf F, Doenst T Molecular and cellular biochemistry 2002 Mar 232 1-2 75-80
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The Hormone FGF21 Stimulates Water Drinking in Response to Ketogenic Diet and Alcohol.
Research
- Phosphate Metabolism
- Energy Metabolism
Clinical Focus
- Type 1 and 2 diabetes mellitus
- General endocrinology
- Disorders of phosphate metabolism
Results: 1 Locations
Mineral Metabolism and Clinical Research Clinic
at Professional Office Building 2 5939 Harry Hines Blvd., 9th Floor, Suite 925Dallas, Texas 75390 214-645-2870 Directions to Mineral Metabolism and Clinical Research Clinic Parking Info for Mineral Metabolism and Clinical Research Clinic