Darryl Miles, M.D.

Pediatrics - Critical Care
Traumatic Brain Injury

Biography

Dr. Darryl Miles’ academic aim is to investigate the pathophysiology and long-term neurodevelopmental outcome after acquired brain injury in children. During his fellowship and as a junior faculty member, he used a transgenic mouse model to investigate the endogenous capability of neural stem and progenitor cells to remodel the brain after injury. Research found that progenitor cells within the hippocampus, a central structure for learning and memory, could recover and replace damaged neurons after hypoxic-ischemic injury.

Dr. Miles has transitioned to a clinical and translational approach to understanding CNS injury and recovery. He is the lead investigator for a five-year prospective cohort study sponsored by the Perot Center for Brain and Nerve Injury. This study is investigating the genetic and clinical factors affecting neurodevelopmental outcome in children after traumatic brain injury (TBI). Researchers are currently analyzing how the injury patterns on acute magnetic resonance imaging (MRI) and computed tomography (CT) imaging can help predict long-term cognitive function. Hopefully, this will lead to a better understanding of TBI in children and how the childhood brain responds and recovers after acute injury.

Dr. Miles is also involved in improving the clinical care of pediatric neurocritical care disorders and is a member of the Pediatric Neurocritical Care Research Group (PNCRG).

Education & Training

Residency - University of California at San Francisco (1998-2000), Pediatrics
Internship - University of California at San Francisco (1997-1998), Pediatrics
Medical School - University of California at San Francisco (1993-1997)
Fellowship - UT Southwestern Medical Center (2002-2005), Pediatric Critical Care Medicine

Professional Associations & Affiliations

Pediatric Neurocritical Care Research Group (2009)
Society of Critical Care Medicine
Perot Center for Brain and Nerve Injury (2008-2014)
National Neurotrauma Society
Society of Neuroscience

Honors & Awards

D Magazine Best Doctor 2022
D Magazine Best Pediatric Specialist 2021
Dean’s Prize for Research 1996, Presented by the University of California San Francisco
Conferred Thesis Dissertation 1996, Presented by the University of California San Francisco
Western Society of Pediatric Research Lowell Glasgow Award 1995, Presented by the University of California San Francisco
Minority Access to Research Careers Fellowship 1993, San Jose State University
Magna cum Laude 1993, San Jose State University

Books & Publications

Books
- Pediatric Neurocritical Care in Agrawal A, Britz G, eds. Pediatric Vascular Neurosurgery.
  Cruz-Navarro J, Miles DK, McDonagh DL. (2016), Springer International Publishing; 57-76.
Publications
- Use of magnetic resonance imaging in severe pediatric traumatic brain injury: assessment of current practice.
  Ferrazzano PA, Rosario BL, Wisniewski SR, Shafi NI, Siefkes HM, Miles DK, Alexander AL, Bell MJ Journal of neurosurgery. Pediatrics 2019 Feb 1-9
- Age and Mortality in Pediatric Severe Traumatic Brain Injury: Results from an International Study.
  Sarnaik A, Ferguson NM, O'Meara AMI, Agrawal S, Deep A, Buttram S, Bell MJ, Wisniewski SR, Luther JF, Hartman AL, Vavilala MS Neurocritical care 2018 Jun 28 3 302-313
- Assessment of Recovery Following Pediatric Traumatic Brain Injury.
  Slovis JC, Gupta N, Li NY, Kernie SG, Miles DK Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2018 Feb
- Extubation Failure and Tracheostomy Placement in Children with Acute Neurocritical Illness.
  Cohn EC, Robertson TS, Scott SA, Finley AM, Huang R, Miles DK Neurocritical care 2017 Jul
- Abusive Head Trauma and Mortality-An Analysis From an International Comparative Effectiveness Study of Children With Severe Traumatic Brain Injury.
  Miller Ferguson N, Sarnaik A, Miles D, Shafi N, Peters MJ, Truemper E, Vavilala MS, Bell MJ, Wisniewski SR, Luther JF, Hartman AL, Kochanek PM Critical care medicine 2017 Apr
- Therapeutic Hypothermia after In-Hospital Cardiac Arrest in Children.
  Moler FW, Silverstein FS, Holubkov R, Slomine BS, Christensen JR, Nadkarni VM, Meert KL, Browning B, Pemberton VL, Page K, Gildea MR, Scholefield BR, Shankaran S, Hutchison JS, Berger JT, Ofori-Amanfo G, Newth CJ, Topjian A, Bennett KS, Koch JD, Pham N, Chanani NK, Pineda JA, Harrison R, Dalton HJ, Alten J, Schleien CL, Goodman DM, Zimmerman JJ, Bhalala US, Schwarz AJ, Porter MB, Shah S, Fink EL, McQuillen P, Wu T, Skellett S, Thomas NJ, Nowak JE, Baines PB, Pappachan J, Mathur M, Lloyd E, van der Jagt EW, Dobyns EL, Meyer MT, Sanders RC, Clark AE, Dean JM The New England journal of medicine 2017 01 376 4 318-329
- Regional cerebral abnormalities measured by frequency-domain near-infrared spectroscopy in pediatric patients during extracorporeal membrane oxygenation.
  Tian F, Jenks C, Potter D, Miles D, Raman L ASAIO journal (American Society for Artificial Internal Organs : 1992) 2016 Dec
- Variation in Anticonvulsant Selection and Electroencephalographic Monitoring Following Severe Traumatic Brain Injury in Children-Understanding Resource Availability in Sites Participating in a Comparative Effectiveness Study.
  Kurz JE, Poloyac SM, Abend NS, Fabio A, Bell MJ, Wainwright MS Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2016 Jul 17 7 649-57
- Predicting Outcome After Pediatric Head Injury by Early Magnetic Resonance Imaging Lesion Location and Volume.
  Miles DK, Smitherman E, Hernandez A, Stavinoha PL, Huang R, Kernie S, Diaz-Arrastia R Journal of neurotrauma 2015 Mar
- Differences in medical therapy goals for children with severe traumatic brain injury-an international study.
  Bell MJ, Adelson PD, Hutchison JS, Kochanek PM, Tasker RC, Vavilala MS, Beers SR, Fabio A, Kelsey SF, Wisniewski SR Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2013 Oct 14 8 811-8
- The basic helix-loop-helix transcription factor olig2 is critical for reactive astrocyte proliferation after cortical injury.
  Chen Y, Miles DK, Hoang T, Shi J, Hurlock E, Kernie SG, Lu QR The Journal of neuroscience : the official journal of the Society for Neuroscience 2008 Oct 28 43 10983-9
- Brief exposure to hyperoxia depletes the glial progenitor pool and impairs functional recovery after hypoxic-ischemic brain injury.
  Koch JD, Miles DK, Gilley JA, Yang CP, Kernie SG Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2008 Jul 28 7 1294-306
- Hypoxic-ischemic brain injury activates early hippocampal stem/progenitor cells to replace vulnerable neuroblasts.
  Miles DK, Kernie SG Hippocampus 2008 18 8 793-806
- Injury-induced neurogenesis in Bax-deficient mice: evidence for regulation by voltage-gated potassium channels.
  Shi J, Miles DK, Orr BA, Massa SM, Kernie SG The European journal of neuroscience 2007 Jun 25 12 3499-512
- Activation of neural stem and progenitor cells after brain injury.
  Miles DK, Kernie SG Progress in brain research 2006 157 187-197
- Patterns of hematopoietic lineage involvement in children with neurofibromatosis type 1 and malignant myeloid disorders.
  Miles DK, Freedman MH, Stephens K, Pallavicini M, Sievers EL, Weaver M, Grunberger T, Thompson P, Shannon KM Blood 1996 Dec 88 11 4314-20

Research

Traumatic brain injury
MRI imaging biomarkers of neuronal injury
Neural stem cells

Clinical Focus

Traumatic Brain Injury

Links

New Patient Appointment