- Pediatric Neurocritical Care Research Group (2009)
- Society of Critical Care Medicine
- Perot Center for Brain and Nerve Injury (2008-2014)
- National Neurotrauma Society
- Society of Neuroscience
Darryl Miles, M.D.
- Pediatrics - Critical Care
- Traumatic Brain Injury
Biography
Dr. Darryl Miles’ academic aim is to investigate the pathophysiology and long-term neurodevelopmental outcome after acquired brain injury in children. During his fellowship and as a junior faculty member, he used a transgenic mouse model to investigate the endogenous capability of neural stem and progenitor cells to remodel the brain after injury. Research found that progenitor cells within the hippocampus, a central structure for learning and memory, could recover and replace damaged neurons after hypoxic-ischemic injury.
Dr. Miles has transitioned to a clinical and translational approach to understanding CNS injury and recovery. He is the lead investigator for a five-year prospective cohort study sponsored by the Perot Center for Brain and Nerve Injury. This study is investigating the genetic and clinical factors affecting neurodevelopmental outcome in children after traumatic brain injury (TBI). Researchers are currently analyzing how the injury patterns on acute magnetic resonance imaging (MRI) and computed tomography (CT) imaging can help predict long-term cognitive function. Hopefully, this will lead to a better understanding of TBI in children and how the childhood brain responds and recovers after acute injury.
Dr. Miles is also involved in improving the clinical care of pediatric neurocritical care disorders and is a member of the Pediatric Neurocritical Care Research Group (PNCRG).
Education & Training
- Residency - University of California at San Francisco (1998-2000), Pediatrics
- Internship - University of California at San Francisco (1997-1998), Pediatrics
- Medical School - University of California at San Francisco (1993-1997)
- Fellowship - UT Southwestern Medical Center (2002-2005), Pediatric Critical Care Medicine
Professional Associations & Affiliations
Honors & Awards
- D Magazine Best Doctor 2022
- D Magazine Best Pediatric Specialist 2021
- Dean’s Prize for Research 1996, Presented by the University of California San Francisco
- Conferred Thesis Dissertation 1996, Presented by the University of California San Francisco
- Western Society of Pediatric Research Lowell Glasgow Award 1995, Presented by the University of California San Francisco
- Minority Access to Research Careers Fellowship 1993, San Jose State University
- Magna cum Laude 1993, San Jose State University
Books & Publications
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Books
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Pediatric Neurocritical Care in Agrawal A, Britz G, eds. Pediatric Vascular Neurosurgery.
Cruz-Navarro J, Miles DK, McDonagh DL. (2016), Springer International Publishing; 57-76.
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Pediatric Neurocritical Care in Agrawal A, Britz G, eds. Pediatric Vascular Neurosurgery.
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Publications
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Early Electroencephalogram to Predict Severity of Injury in Infants With Abusive Traumatic Brain Injury
Varughese NA, Hasan A, Cohen N, Smith D, Clarke RL, Grapsy J, Said R, Miles D, Raman L, Sirsi D Journal of child neurology 2026 May 41 704-714 -
The association between neurologic pupillary index (NPi) and functional outcomes in critically ill children
McGetrick M, Olson DW, Vashisht A, McCreary M, Kim R, Sinn C, Miles D BMC Pediatrics 2025 Dec 25 -
Social Environment and Neurobehavioral Outcomes 1 Year After Severe Pediatric TBI in the Intensive Care Unit
Author Collaboration TG, Miley AE, Patronick J, Zhang N, Bode RL, Fabio A, Treble-Barna A, Chima RS, Adlam AL, Bell MJ, Wisniewski SR, Beers SR, Wade SL, Kurowski BG, Adlam A, Agbeko R, Au A, Beers S, Butt W, Clark R, Deep A, Edwards R, Ferrazzano P, Figaji A, Kirkwood M, Kong M, LaRovere K, Macintosh I, Mahoney S, Martin LJ, McNally K, Miles D, Morris K, O'Brien N, Pilipenko V, Ramirez JB, Robertson C, Sarnaik A, Schober M, Soto JP, Telling A, Thangarajah H, Thomas NJ, Walson K, West AN, Willyerd A, Zimmerman J Journal of Head Trauma Rehabilitation 2025 May 40 147-156 -
Increased Intracranial Pressure in Pediatric Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease
Nguyen L, Miles DK, Harder L, Singh S, Whittemore BA, Greenberg BM, Wang CX Neurology: Neuroimmunology and NeuroInflammation 2023 Oct 11 -
Reducing central line-associated bloodstream infection in contaminated central venous catheters: Case studies of a pediatric contamination guideline
Chamblee TB, Patton LJ, Young VB, Marusich J, Bowens CD, Miles DK British Journal of Nursing 2021 Oct 30 S24-S29 -
A Prospective Study of Family Engagement for Prevention of Central Line-associated Blood Stream Infections
Chamblee TB, Miles DK Pediatric Quality and Safety 2021 Sep 6 E467 -
Automated Infrared Pupillometer Use in Assessing the Neurological Status in Pediatric Neurocritical Care Patients: Case Reports and Literature Review
McGetrick ME, Schneider N, Olson DW, Aiyagari V, Miles D Journal of Child Science 2021 Jun 11 E125-E132 -
Reducing Central Line-Associated Bloodstream Infection in Contaminated Central Venous Catheters: Case Studies of a Pediatric Contamination Guideline
Chamblee TB, Patton LJ, Young VB, Marusich J, Bowens CD, Miles DK JAVA - Journal of the Association for Vascular Access 2021 Jun 26 26-30 -
Clinical Features, Treatment Strategies, and Outcomes in Hospitalized Children With Immune-Mediated Encephalopathies
McGetrick ME, Varughese NA, Miles DK, Wang CX, McCreary M, Monson NL, Greenberg BM Pediatric Neurology 2021 Mar 116 20-26 -
Predictors of intracranial hypertension in children undergoing ICP monitoring after severe traumatic brain injury
Miles DK, Ponisio MR, Colvin R, Limbrick D, Greenberg JK, Brancato C, Leonard JR, Pineda JA Child's Nervous System 2020 Jul 36 1453-1460 -
Transcranial Doppler Ultrasound during Critical Illness in Children: Survey of Practices in Pediatric Neurocritical Care Centers
Author Collaboration tP, Larovere KL, Tasker RC, Wainwright M, Reuter-Rice K, Appavu B, Miles D, Lidsky K, Vittner P, Gundersen D, O'Brien NF, Schober M, Robertson C, Kurz J, Pineda J, Wainwright M, Bell M Pediatric Critical Care Medicine 2020 Jan 21 67-74 -
Use of magnetic resonance imaging in severe pediatric traumatic brain injury: Assessment of current practice
Ferrazzano PA, Rosario BL, Wisniewski SR, Shaf NI, Siefkes HM, Miles DK, Alexander AL, Bell MJ, Sarnaik A, Agrawal S, Mahoney S, Gupta D, Beca J, Loftis L, Morris K, Piper L, Slater A, Walson K, Bennett T, Kilbaugh T, Iqbal O'Meara AM, Dean N, Chima RS, Biagas K, Wildschut E, Peters M, LaRovere K, Balcells J, Robertson C, Gertz S, Deep A, Cooper S, Wainwright M, Murphy S, Kuluz J, Butt W, O'Brien N, Thomas N, Buttram S, Erickson S, Mahil Samuel J, Agbeko R, Edwards R, Ramakrishnan KA, Winkler M, Borasino S, Natale J, Giza C, Hilfiker M, Shellington D, Figaji A, Newell E, Truemper E, Clark R, Newth K, Shafi N, Schober M, Zimmerman J, Pineda J Journal of Neurosurgery: Pediatrics 2019 Apr 23 471-479 -
Age and Mortality in Pediatric Severe Traumatic Brain Injury: Results from an International Study
Author Collaboration Ft, Sarnaik A, Ferguson NM, O’Meara AI, Agrawal S, Deep A, Buttram S, Bell MJ, Wisniewski SR, Luther JF, Hartman AL, Vavilala MS, Mahoney S, Gupta D, Beca J, Loftis L, Morris K, Piper L, Slater A, Walson K, Bennett T, Kilbaugh T, O’Meara AM, Dean N, Chima RS, Biagas K, Wildschut E, Peters M, LaRovere K, Balcells J, Robertson C, Gertz S, Cooper S, Wainwright M, Murphy S, Kuluz J, Butt W, O’Brien N, Thomas N, Erickson S, Samuel JM, Agbeko R, Edwards R, Ramakrishnan KA, Winkler M, Borasino S, Natale J, Giza C, Hilfiker M, Shellington D, Miles D Neurocritical Care 2018 Jun 28 302-313 -
Assessment of recovery following pediatric traumatic brain injury
Slovis JC, Gupta N, Li NY, Kernie SG, Miles DK Pediatric Critical Care Medicine 2018 Apr 19 353-360 -
Extubation Failure and Tracheostomy Placement in Children with Acute Neurocritical Illness
Cohn EC, Robertson TS, Scott SA, Finley AM, Huang R, Miles DK Neurocritical Care 2018 Feb 28 83-92 -
Challenges and opportunities for pediatric severe TBI—review of the evidence and exploring a way forward
Author Collaboration ft, Bell MJ, Adelson PD, Wisniewski SR, Agrawal S, Mahoney S, Gupta D, Beca J, Loftis L, Morris K, Piper L, Slater A, Walson K, Bennett T, Kilbaugh T, O’Meara AM, Dean N, Chima RS, Biagas K, Wildschut E, Peters M, LaRovere K, Balcells J, Robertson C, Gertz S, Deep A, Cooper S, Wainwright M, Murphy S, Kuluz J, Butt W, O’Brien N, Thomas NJ, Buttram S, Erickson S, Samuel JM, Agbeko R, Edwards R, Ramakrishnan KA, Winkler M, Borasino S, Natale J, Giza C, Hilfiker M, Shellington D, Figaji A, Newell E, Truemper E, Clark R, Newth K, Schober M Child's Nervous System 2017 Oct 33 1663-1667 -
Abusive head trauma and mortality-an analysis from an international comparative effectiveness study of children with severe traumatic brain injury
Miller Ferguson N, Sarnaik A, Miles D, Shafi N, Peters MJ, Truemper E, Vavilala MS, Bell MJ, Wisniewski SR, Luther JF, Hartman AL, Kochanek PM Critical care medicine 2017 Aug 45 1398-1407 -
Pediatric neurocritical care
Cruz-Navarro J, Miles DK, McDonagh DL 2017 May 57-76 -
Regional Cerebral Abnormalities Measured by Frequency-Domain Near-Infrared Spectroscopy in Pediatric Patients during Extracorporeal Membrane Oxygenation
Tian F, Jenks C, Potter D, Miles D, Raman L ASAIO Journal 2017 63 e52-e59 -
Predicting outcome after pediatric traumatic brain injury by early magnetic resonance imaging lesion location and volume
Smitherman E, Hernandez A, Stavinoha PL, Huang R, Kernie SG, Diaz-Arrastia R, Miles DK Journal of neurotrauma 2016 Jan 33 35-48 -
Differences in medical therapy goals for children with severe traumatic brain injury - An international study
Bell MJ, Adelson PD, Hutchison JS, Kochanek PM, Tasker RC, Vavilala MS, Beers SR, Fabio A, Kelsey SF, Wisniewski SR, Loftis L, Morris K, LaRovere K, Meyer P, Walson K, Exo J, Sarnaik A, Kilbaugh T, Miles D, Wainwright M, Dean N, Chima R, Biagas K, Peters M, Balcells J, Del Toledo JS, Robertson C, Bailey D, Piper L, Tsai W, Ragheb J, Agbeko R, O'Brien N, Young A, Thomas N, Buttram S, Borasino S, Natale J, Giza C, Shellington D, Stein D, Clark R, Au A, Zimmerman J, Pineda J, Ferrazzano P Pediatric Critical Care Medicine 2013 Oct 14 811-818 -
The basic helix-loop-helix transcription factor Olig2 is critical for reactive astrocyte proliferation after cortical injury
Chen Y, Miles DK, Hoang T, Shi J, Hurlock E, Kernie SG, Lu QR Journal of Neuroscience 2008 Oct 28 10983-10989 -
Brief exposure to hyperoxia depletes the glial progenitor pool and impairs functional recovery after hypoxic-ischemic brain injury
Koch JD, Miles DK, Gilley JA, Yang CP, Kernie SG Journal of Cerebral Blood Flow and Metabolism 2008 Jul 28 1294-1306 -
Hypoxic-ischemic brain injury activates early hippocampal stem/progenitor cells to replace vulnerable neuroblasts
Miles DK, Kernie SG Hippocampus 2008 18 793-806 -
Injury-induced neurogenesis in Bax-deficient mice: Evidence for regulation by voltage-gated potassium channels
Shi J, Miles DK, Orr BA, Massa SM, Kernie SG European Journal of Neuroscience 2007 Jun 25 3499-3512 -
Chapter 12 Activation of neural stem and progenitor cells after brain injury
Miles DK, Kernie SG Progress in Brain Research 2006 157 187-198,395-396 -
Patterns of hematopoietic lineage involvement in children with neurofibromatosis type 1 and malignant myeloid disorders
Miles DK, Freedman MH, Stephens K, Pallavicini M, Sievers EL, Weaver M, Grunberger T, Thompson P, Shannon KM Blood 1996 Dec 88 4314-4320 -
Neurofibromatosis, type 1 (NF1) and childhood leukemia: Parent of origin effects and pattern of alleuc loss at the NF1 LOCUS in hematopoietic cells
Miles DK, Freedman MH, Pallavicini M, Sievers E, Thompson T, Shannon KM Journal of Investigative Medicine 1996 44 195A
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Early Electroencephalogram to Predict Severity of Injury in Infants With Abusive Traumatic Brain Injury
Research
- MRI imaging biomarkers of neuronal injury
- Neural stem cells
- Traumatic brain injury
Clinical Focus
- Traumatic Brain Injury
Results: 1 Locations
Children's Medical Center of Dallas
1935 Medical District DriveDallas, Texas 75235 214-730-5437 Directions to Children's Medical Center of Dallas at Children's Medical Center of Dallas, Dallas