David Fixler, M.D.

Dr. Fred S. Brooksaler Professorship in Pediatrics

Pediatrics - Cardiology
Congenital Heart Disease
Pediatric Blood Pressure Problems

Biography

David E. Fixler, M.D., is a Professor in the Department of Pediatrics at UT Southwestern Medical Center. He specializes in congenital heart disease.

Dr. Fixler earned his medical degree at the University of Chicago. He completed a residency in pediatrics at Northwestern University, where he also received advanced training through a fellowship in pediatric cardiology. He completed a research fellowship at the University of California Cardiovascular Research Institute. He also holds a master’s degree in epidemiology from the London School of Hygiene & Tropical Medicine.

Certified by the American Board of Pediatrics, he joined the UT Southwestern faculty in 1971.

Dr. Fixler’s clinical interests include blood pressure issues and heart murmurs in children. His research interests include the epidemiology of congenital heart disease and the environmental epidemiology of exposures associated with birth defects of the heart. He is the author of numerous scholarly articles and book chapters, and he has delivered lectures and other presentations all over the world.

Dr. Fixler is a member of the Alpha Omega Alpha Honor Medical Society, the American Academy of Pediatrics, the American College of Cardiology, the American Heart Association, the American Society of Transplantation, the International Society and Federation of Cardiology, the International Society for Heart and Lung Transplantation, and the Society for Pediatric Research.

Dr. Fixler holds the Dr. Fred S. Brooksaler Professorship in Pediatrics.

Education & Training

Medical School - University of Chicago (1960-1964)
Residency - Children's Memorial Medical Center - Chicago (1964-1967), Pediatrics
Fellowship - Children's Memorial Medical Center - Chicago (1964-1967), Pediatric Cardiology
Fellowship - University of California at San Francisco (1969-1971), Cardiovascular Medicine

Professional Associations & Affiliations

Alpha Omega Alpha Honor Medical Society
American Academy of Pediatrics
American College of Cardiology
American Heart Association
American Society of Transplantation
International Society and Federation of Cardiology
International Society for Heart and Lung Transplantation
Society for Pediatric Research

Honors & Awards

Robert L. Moore, MD 2000, Distinguished Service Award for Medicine, Children’s Medical Center
The Dr. Fred Brooksaler Pediatric Teaching Professorship 1999, UT Southwestern
Gladys Fashena Award in Pediatric Cardiology 1991, American Heart Association
Residents Teaching Awards, 1983-4, 1987-8, Awarded by Children’s Medical Center for teaching excellence
Variety Club of Texas Humanitarian of the Year Award 1985

Books & Publications

Books
- Epidemiology of Congenital Heart Disease in Oski's Pediatrics: Principles & Practice, 4th edition, McMillan JA, Feigin RD, DeAngelis C, Jones MD, eds.
  Fixler DE (2006), Lippincott Williams & Wilkins
- Atrioventricular septal defect in Surgery of Congenital Heart Disease: Perspectives in Pediatric Cardiology, Moller JH, ed.
  Fixler DE (1998), Wiley-Blackwell
- Acyanotic Heart Disease in Essentials of Pediatric Intensive Care, Levin DL, Morriss FC, eds.
  Kouatli AA, Fixler DE (1997), Churchill Livingstone
Publications
- Complement (C1q) Binding De Novo Donor Specific Antibodies and Cardiac-Allograft Vasculopathy in Pediatric Heart Transplant Recipients.
  Das BB, Lacelle C, Zhang S, Gao A, Fixler D Transplantation 2017 Sep
- Persistent Epstein-Barr viral load in Epstein-Barr viral naive pediatric heart transplant recipients: Risk of late-onset post-transplant lymphoproliferative disease.
  Das B, Morrow R, Huang R, Fixler D World journal of transplantation 2016 Dec 6 4 729-735
- Prenatal diagnosis, hospital characteristics, and mortality in transposition of the great arteries.
  Lara DA, Fixler DE, Ethen MK, Canfield MA, Nembhard WN, Morris SA Birth defects research. Part A, Clinical and molecular teratology 2016 Jun
- Health-Related Quality of Life and Functional Status Are Associated with Cardiac Status and Clinical Outcome in Children with Cardiomyopathy.
  Sleeper LA, Towbin JA, Colan SD, Hsu D, Orav EJ, Lemler MS, Clunie S, Messere J, Fountain D, Miller TL, Wilkinson JD, Lipshultz SE The Journal of pediatrics 2015 Dec
- Donor-specific HLA alloantibodies: Impact on cardiac allograft vasculopathy, rejection, and survival after pediatric heart transplantation.
  Tran A, Fixler D, Huang R, Meza T, Lacelle C, Das BB The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2015 Sep
- Age at referral and mortality from critical congenital heart disease.
  Fixler DE, Xu P, Nembhard WN, Ethen MK, Canfield MA Pediatrics 2014 Jul 134 1 e98-e105
- Late Detection of Critical Congenital Heart Disease Among US Infants: Estimation of the Potential Impact of Proposed Universal Screening Using Pulse Oximetry.
  Peterson C, Ailes E, Riehle-Colarusso T, Oster ME, Olney RS, Cassell CH, Fixler DE, Carmichael SL, Shaw GM, Gilboa SM JAMA pediatrics 2014 Feb
- Prenatal Diagnosis, Birth Location, Surgical Center, and Neonatal Mortality in Infants with Hypoplastic Left Heart Syndrome.
  Morris SA, Ethen MK, Penny DJ, Canfield MA, Minard CG, Fixler DE, Nembhard WN Circulation 2013 Oct
- Racial/ethnic disparities in timing of death during childhood among children with congenital heart defects.
  Nembhard WN, Xu P, Ethen MK, Fixler DE, Salemi JL, Canfield MA Birth defects research. Part A, Clinical and molecular teratology 2013 Oct 97 10 628-40
- The importance of the muscle and ventilatory blood pumps during exercise in patients without a subpulmonary ventricle (Fontan operation).
  Shafer KM, Garcia JA, Babb TG, Fixler DE, Ayers CR, Levine BD Journal of the American College of Cardiology 2012 Nov 60 20 2115-21
- Effect of acculturation and distance from cardiac center on congenital heart disease mortality.
  Fixler DE, Nembhard WN, Xu P, Ethen MK, Canfield MA Pediatrics 2012 Jun 129 6 1118-24
- Use of a highly sensitive assay for cardiac troponin T and N-terminal pro-brain natriuretic peptide to diagnose acute rejection in pediatric cardiac transplant recipients.
  Dyer AK, Barnes AP, Fixler DE, Shah TK, Sutcliffe DL, Hashim I, Drazner MH, de Lemos JA American heart journal 2012 Apr 163 4 595-600
- Racial/Ethnic disparities in risk of early childhood mortality among children with congenital heart defects.
  Nembhard WN, Salemi JL, Ethen MK, Fixler DE, Dimaggio A, Canfield MA Pediatrics 2011 May 127 5 e1128-38
- Mortality resulting from congenital heart disease among children and adults in the United States, 1999 to 2006.
  Gilboa SM, Salemi JL, Nembhard WN, Fixler DE, Correa A Circulation 2010 Nov 122 22 2254-63
- Mortality among infants with birth defects: Joint effects of size at birth, gestational age, and maternal race/ethnicity.
  Nembhard WN, Salemi JL, Ethen MK, Fixler DE, Canfield MA Birth defects research. Part A, Clinical and molecular teratology 2010 Sep 88 9 728-36
- Mortality in first 5 years in infants with functional single ventricle born in Texas, 1996 to 2003.
  Fixler DE, Nembhard WN, Salemi JL, Ethen MK, Canfield MA Circulation 2010 Feb 121 5 644-50
- Infliximab treatment of intravenous immunoglobulin-resistant Kawasaki disease.
  Burns JC, Best BM, Mejias A, Mahony L, Fixler DE, Jafri HS, Melish ME, Jackson MA, Asmar BI, Lang DJ, Connor JD, Capparelli EV, Keen ML, Mamun K, Keenan GF, Ramilo O The Journal of pediatrics 2008 Dec 153 6 833-8
- Pulse oximetry screening at 4 hours of age to detect critical congenital heart defects.
  Sendelbach DM, Jackson GL, Lai SS, Fixler DE, Stehel EK, Engle WD Pediatrics 2008 Oct 122 4 e815-20
- Aspirin resistance in children with heart disease at risk for thromboembolism: prevalence and possible mechanisms.
  Heistein LC, Scott WA, Zellers TM, Fixler DE, Ramaciotti C, Journeycake JM, Lemler MS Pediatric cardiology 2008 Mar 29 2 285-91
- Antibodies against donor human leukocyte antigens and the outcome of cardiac allografts in adults and children.
  Stastny P, Lavingia B, Fixler DE, Yancy CW, Ring WS Transplantation 2007 Sep 84 6 738-45
- Epidemiology of noncomplex left ventricular outflow tract obstruction malformations (aortic valve stenosis, coarctation of the aorta, hypoplastic left heart syndrome) in Texas, 1999-2001.
  McBride KL, Marengo L, Canfield M, Langlois P, Fixler D, Belmont JW Birth defects research. Part A, Clinical and molecular teratology 2005 Aug 73 8 555-61
- Relation between ambient air quality and selected birth defects, seven county study, Texas, 1997-2000.
  Gilboa SM, Mendola P, Olshan AF, Langlois PH, Savitz DA, Loomis D, Herring AH, Fixler DE American journal of epidemiology 2005 Aug 162 3 238-52
- Trisomy 21 and congenital heart disease: effect of timing of initial echocardiogram.
  Ghaffar S, Lemler MS, Fixler DE, Ramaciotti C Clinical pediatrics 2005 Jan-Feb 44 1 39-42
- Effect of proximity to hazardous waste sites on the development of congenital heart disease.
  Malik S, Schecter A, Caughy M, Fixler DE Archives of environmental health 2004 Apr 59 4 177-81
- Cardiopulmonary bypass to repair an atrial septal defect does not affect cognitive function in children.
  Stavinoha PL, Fixler DE, Mahony L Circulation 2003 Jun 107 21 2722-5
- The role of the right ventricle during hypobaric hypoxic exercise: insights from patients after the Fontan operation.
  Garcia JA, McMinn SB, Zuckerman JH, Fixler DE, Levine BD Medicine and science in sports and exercise 1999 Feb 31 2 269-76
- Prenatal exposures and congenital heart defects in Down syndrome infants.
  Fixler DE, Threlkeld N Teratology 1998 Jul 58 1 6-12
- Respiratory syncytial virus infection in children with congenital heart disease: a review.
  Fixler DE Pediatric cardiology 1996 May-Jun 17 3 163-8
- Ambulatory blood pressure in patients with occult recurrent coarctation of the aorta.
  Parrish MD, Torres E, Peshock R, Fixler DE Pediatric cardiology 1995 Jul-Aug 16 4 166-71
- Cognitive function in children who receive organ transplantation.
  Stewart SM, Kennard BD, Waller DA, Fixler D Health psychology : official journal of the Division of Health Psychology, American Psychological Association 1994 Jan 13 1 3-13
- Ethnicity and socioeconomic status: impact on the diagnosis of congenital heart disease.
  Fixler DE, Pastor P, Sigman E, Eifler CW Journal of the American College of Cardiology 1993 Jun 21 7 1722-6
- Limitations of an oscillometric ambulatory blood pressure monitor in physically active children.
  Jacoby AC, Fixler DE, Torres EJ The Journal of pediatrics 1993 Feb 122 2 231-6
- Ambulatory blood pressure monitoring in hypertensive adolescents.
  Fixler DE, Wallace JM, Thornton WE, Dimmitt P American journal of hypertension 1990 Apr 3 4 288-92
- Trends in congenital heart disease in Dallas County births. 1971-1984.
  Fixler DE, Pastor P, Chamberlin M, Sigman E, Eifler CW Circulation 1990 Jan 81 1 137-42
- Thrombolytic treatment with streptokinase for late intraatrial thrombosis after modified Fontan procedure.
  Mahony L, Nikaidoh H, Fixler DE The American journal of cardiology 1988 Aug 62 4 343-4
- Left ventricular dysfunction due to chronic right ventricular pressure overload. Resolution following percutaneous balloon valvuloplasty for pulmonic stenosis.
  Stenberg RG, Fixler DE, Taylor AL, Corbett JR, Firth BG The American journal of medicine 1988 Jan 84 1 157-61
- Global myocardial ischemia in the newborn, juvenile, and adult isolated isovolumic rabbit heart. Age-related differences in systolic function, diastolic stiffness, coronary resistance, myocardial oxygen consumption, and extracellular pH.
  Parrish MD, Payne A, Fixler DE Circulation research 1987 Nov 61 5 609-15
- Maturational differences in the isolated isovolumic rabbit heart.
  Parrish MD, Ayres NA, Kendrick BT, Fixler DE The American journal of physiology 1986 Dec 251 6 Pt 2 H1143-8
- Longitudinal blood pressures in blacks, whites, and Mexican Americans during adolescence and early adulthood.
  Barón AE, Freyer B, Fixler DE American journal of epidemiology 1986 May 123 5 809-17
- Usefulness of exercise stress testing for prediction of blood pressure trends.
  Fixler DE, Laird WP, Dana K Pediatrics 1985 Jun 75 6 1071-5
- Body size, composition, and fitness in adolescents with elevated blood pressures.
  Wilson SL, Gaffney FA, Laird WP, Fixler DE Hypertension 1985 May-Jun 7 3 Pt 1 417-22
- Aortic and mitral regurgitation in an infant with Kawasaki disease.
  Freij BJ, Gessouroun M, Fixler DE, Fink CW Pediatric cardiology 1985 6 2 95-8
- Validity of mass blood pressure screening in children.
  Fixler DE, Laird WP Pediatrics 1983 Oct 72 4 459-63
- Regional blood flows in newborn lambs during endotracheal continuous airway pressure and continuous negative pressure breathing.
  Furzan JA, Gabriele G, Wheeler JM, Fixler DE, Rosenfeld CR Pediatric research 1981 May 15 5 874-8
- Left ventricular hypertrophy in adolescents with elevated blood pressure: assessment by chest roentgenography, electrocardiography, and echocardiography.
  Laird WP, Fixler DE Pediatrics 1981 Feb 67 2 255-9
- Systolic blood pressure differences among pediatric epidemiological studies.
  Fixler DE, Kautz JA, Dana K Hypertension 1980 Jul-Aug 2 4 Pt 2 I3-7
- Response of hypertensive adolescents to dynamic and isometric exercise stress.
  Fixler DE, Laird WP, Browne R, Fitzgerald V, Wilson S, Vance R Pediatrics 1979 Nov 64 5 579-83
- Regional coronary blood flow in awake resting and pharmacologically stressed dogs.
  Archie JP, Fixler DE, Hoffman JI The Journal of surgical research 1979 Jul 27 1 41-9
- Management of the child with persistently elevated blood pressure.
  Fixler DE, Laird WP Comprehensive therapy 1979 Jun 5 6 20-5
- Cardiovascular response to isometric exercise in normal adolescents.
  Laird WP, Fixler DE, Huffines FD Circulation 1979 Apr 59 4 651-4
- Distribution of cardiac output during induced isometric exercise in dogs.
  Crayton SC, Aung-Din R, Fixler DE, Mitchell JH The American journal of physiology 1979 Feb 236 2 H218-24
- Hypertension screening in schools: results of the Dallas study.
  Fixler DE, Laird WP, Fitzgerald V, Stead S, Adams R Pediatrics 1979 Jan 63 1 32-6
- Morphologic analysis of the pulmonary vascular bed in infants exposed in utero to prostaglandin synthetase inhibitors.
  Levin DL, Fixler DE, Morriss FC, Tyson J The Journal of pediatrics 1978 Mar 92 3 478-83
- Influence of mannitol on maintaining coronary flows and salvaging myocardium during ventriculotomy and during prolonged coronary artery ligation.
  Fixler DE, Buja LM, Wheeler JM, Willerson JT Circulation 1977 Sep 56 3 340-6
- Coronary reserve and right ventricular function in awake newborn lambs with persistent right ventricular hypertension.
  Archie JP, Fixler DE, Hoffman JI Pediatric research 1977 Jul 11 7 867-70
- Continuous airway pressure breathing with the head-box in the newborn lamb: effects of regional blood flows.
  Gabriele G, Rosenfeld CR, Fixler DE, Wheeler JM Pediatrics 1977 Jun 59 6 858-64
- Echocardiography of premature infants with pulmonary disease: a noninvasive method for detecting large ductal left-to-right shunts.
  Laird WP, Fixler DE Radiology 1977 Feb 122 2 455-7
- Hemodynamic alterations during septal or right ventricular ischemia in dogs.
  Fixler DE, Monroe GA, Wheeler JM American heart journal 1977 Feb 93 2 210-5
- Blood flow to respiratory, cardiac, and limb muscles in dogs during graded exercise.
  Fixler DE, Atkins JM, Mitchell JH, Horwitz LD The American journal of physiology 1976 Nov 231 5 Pt. 1 1515-9
- Effect of hypertonic mannitol and isoproterenol on regional coronary flow following right ventriculotomy.
  Fixler DE, Watson JT, Wheeler JM, Willerson JT Circulation 1976 Jul 54 1 26-31
- The influence of combined intra-aortic balloon counterpulsation and hyperosomotic mannitol on regional myocardial blood flow in ischemic myocardium in the dog.
  Watson JT, Fixler DE, Platt MR, Nall BB, Jett GK, Willerson JT Circulation research 1976 Jun 38 6 506-13
- An unusual cause of recurrent chest pain.
  Fixler DE, Yousefzadeh DK, Monroe GA, Adam M JAMA : the journal of the American Medical Association 1975 Dec 234 12 1255-6
- Reduced myocardial reflow and increased coronary vascular resistance following prolonged myocardial ischemia in the dog.
  Willerson JT, Watson JT, Hutton I, Templeton GH, Fixler DE Circulation research 1975 Jun 36 6 771-81
- The influence of hypertonic mannitol on regional myocardial blood flow during acute and chronic myocardial ischemia in anesthetized and awake intact dogs.
  Willerson JT, Watson JT, Hutton I, Fixler DE, Curry GC, Templeton GH The Journal of clinical investigation 1975 May 55 5 892-902
- Changes in regional coronary blood flow with hypertonic mannitol in conscious dogs.
  Hutton I, Marynick SP, Fixler DE, Templeton GH, Willerson JT Cardiovascular research 1975 Jan 9 1 47-55
- Variable effects of heart rate on phasic and regional left ventricular muscle blood flow in anaesthetized dogs.
  Buckberg GD, Fixler DE, Archie JP, Henney RP, Hoffman JI Cardiovascular research 1975 Jan 9 1 1-11
- Oxygen consumption in infants and children during cardiac catheterization under different sedation regimens.
  Fixler DE, Carrell T, Browne R, Willis K, Miller WW Circulation 1974 Oct 50 4 788-94
- Temporal changes in collateral coronary blood flow in ischemic myocardium during intra-aortic balloon pumping.
  Watson JT, Willerson JT, Fixler DE, Sugg WL Circulation 1974 Aug 50 2 Suppl II249-54
- Extent of myocardial flow from luminal collateral circulation.
  Fixler DE, Wheeler M, Huffines D Journal of applied physiology 1974 Aug 37 2 282-5
- Subendocardial underperfusion during acute aorticopulmonary shunting in anesthetized dogs.
  Fixler DE, Saunders KW, Sugg WL American heart journal 1974 Apr 87 4 483-90
- Proceedings: Influence of hypertonic mannitol on regional myocardial blood flow during and in the absence of acute myocardial ischaemia in the conscious intact dog.
  Hutton I, Templeton GH, Fixler DE, Willerson JT British heart journal 1974 Apr 36 4 402
- Regional myocardial blood flow in lambs with concentric right ventricular hypertrophy.
  Archie JP, Fixler DE, Ullyot DJ, Buckberg GD, Hoffman JI Circulation research 1974 Feb 34 2 143-54
- Evaluation of a Doppler catheter probe to measure cardiac output.
  Fixler DE, Stage L, Rudolph AM, Buckberg GD, Archie JP The Journal of surgical research 1973 Oct 15 4 243-50
- Use of hemodialysis in the treatment of quinidine poisoning.
  Reimold EW, Reynolds WJ, Fixler DE, McElroy L Pediatrics 1973 Jul 52 1 95-9
- Measurement of cardiac output with and organ trapping of radioactive microspheres.
  Archie JP, Fixler DE, Ullyot DJ, Hoffman JI, Utley JR, Carlson EL Journal of applied physiology 1973 Jul 35 1 148-54
- Effects of acute right ventricular systolic hypertension on regional myocardial blood flow in anesthetized dogs.
  Fixler DE, Archie JP, Ullyot DJ, Buckberg GD, Hoffman JI American heart journal 1973 Apr 85 4 491-500
- Experimental subendocardial ischemia in dogs with normal coronary arteries.
  Buckberg GD, Fixler DE, Archie JP, Hoffman JI Circulation research 1972 Jan 30 1 67-81

Research

Epidemiology of Congenital Heart Disease

Clinical Focus

Congenital Heart Disease
Pediatric Blood Pressure Problems
Pediatric Cardiology
Pediatric Heart Murmurs

Links

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