- Residency - Columbia University/New York Presbyterian Hospital (2005-2008), Pediatrics
- Fellowship - Yale University School of Medicine (2008-2011), Pediatric Infectious Diseases
- Medical School - Washington University School of Medicine (1998-2005)
Dawn Wetzel, M.D., Ph.D.
- Pediatrics - Infectious Disease
Dr. Dawn Wetzel is an early-career physician-scientist who cares for children with infectious diseases and conducts basic and translational research in medically relevant parasitic diseases. She has been performing biological research throughout her undergraduate and medical training. She earned a Ph.D. in Microbiology by demonstrating that actin polymerization and calcium secretion regulate a unique form of motility and cell invasion by the Apicomplexa phylum of parasites. When she became a Pediatric Infectious Diseases Fellow, she began to characterize the molecular mechanisms that regulate Leishmania uptake by macrophages. Her work demonstrated that preventing Leishmania entry into macrophages through genetic or chemical inhibition of the Abl family kinases decreases disease manifestations in the mouse model of leishmaniasis. This work resulted in invitations to speak at national meetings, publications, and multiple competitive grants, including a Mentored Clinical Scientist Development Award (K08) from the NIH.
Dr. Wetzel's research career will focus on elucidating the molecular pathogenesis of leishmaniasis, which may lead to novel therapies to prevent infection with this important pathogen. She will also continue her clinical work in Pediatric Infectious Diseases, and have a particular interest in patients with parasitic infections.
- Eastern Society for Pediatric Research (2013)
- American Society for Microbiology (2012)
- American Medical Association (2009)
- Infectious Diseases Society of America (2009)
- Pediatric Infectious Diseases Society of America (2009)
- American Academy of Pediatrics (2005)
- Young Physician-Scientist Award 2013, American Society of Clinical Investigation
- IDSA Fellow's Research Award and Travel Grant 2010, Top abstracts by infectious disease fellows-in-training - Infectious Diseases Society of America
- Alexander Berg Prize 2005, Graduating medical student presenting the best research in molecular microbiology - Washington University School of Medicine
- William A. McElroy Award for Undergraduate Research in Biology 1998, Graduating student with th emost promise in biological research - Johns Hopkins University
Chemotherapy of Protozoal Infections in Goodman and Gilman?s The Pharmacological Basis of Therapeutics
Wetzel DM, Phillips MA (2017), New York, NY, McGraw-Hill Medical
- Chemotherapy of Protozoal Infections in Goodman and Gilman?s The Pharmacological Basis of Therapeutics
Calcium-mediated protein secretion potentiates motility in Toxoplasma gondii.
Wetzel DM, Chen LA, Ruiz FA, Moreno SN, Sibley LD Journal of cell science 2004 Nov 117 Pt 24 5739-48
Erratum to: An Outbreak of Brucellosis: An Adult and Pediatric Case Series.
Hassouneh L, Quadri S, Reto PP, Chaisavaneeyakorn S, Cutrell JB, Wetzel DM, Nijhawan AE, Open forum infectious diseases 2019 Dec 6 12 ofz527
The relative rate of kill of the MMV Malaria Box compounds provides links to the mode of antimalarial action and highlights scaffolds of medicinal chemistry interest.
Ullah I, Sharma R, Mete A, Biagini GA, Wetzel DM, Horrocks PD, The Journal of antimicrobial chemotherapy 2020 Feb 75 2 362-370
The Src kinases Hck, Fgr, and Lyn activate Abl2/Arg to facilitate IgG-mediated phagocytosis and Leishmania infection.
Wetzel DM, Rhodes EL, Li S, McMahon-Pratt D, Koleske AJ Journal of cell science 2016 Jun
An Antiparasitic Compound from the Medicines for Malaria Venture Pathogen Box Promotes Leishmania Tubulin Polymerization.
Ullah I, Gahalawat S, Booshehri LM, Niederstrasser H, Majumdar S, Leija C, Bradford JM, Hu B, Ready JM, Wetzel DM, ACS infectious diseases 2020 Jul
An Outbreak of Brucellosis: An Adult and Pediatric Case Series.
Hassouneh L, Quadri S, Reto PP, Chaisavaneeyakorn S, Cutrell JB, Wetzel DM, Nijhawan AE, Open forum infectious diseases 2019 Oct 6 10 ofz384
The Abl-1 kinase is dispensable for NK cell inhibitory signaling and is not involved in murine NK cell education.
Ganesan S, Thanh TL, Kadri N, Chambers BJ, Meinke S, Brodin P, Vivier E, Wetzel DM, Koleske AJ, Höglund P Scandinavian journal of immunology 2017 Jun
Role of dynactin in endocytic traffic: effects of dynamitin overexpression and colocalization with CLIP-170.
Valetti C, Wetzel DM, Schrader M, Hasbani MJ, Gill SR, Kreis TE, Schroer TA Molecular biology of the cell 1999 Dec 10 12 4107-20
Actin filament polymerization regulates gliding motility by apicomplexan parasites.
Wetzel DM, Håkansson S, Hu K, Roos D, Sibley LD Molecular biology of the cell 2003 Feb 14 2 396-406
Evidence that the cADPR signalling pathway controls calcium-mediated microneme secretion in Toxoplasma gondii.
Chini EN, Nagamune K, Wetzel DM, Sibley LD The Biochemical journal 2005 Jul 389 Pt 2 269-77
Gliding motility leads to active cellular invasion by Cryptosporidium parvum sporozoites.
Wetzel DM, Schmidt J, Kuhlenschmidt MS, Dubey JP, Sibley LD Infection and immunity 2005 Sep 73 9 5379-87
Staphylococcus aureus activates type I IFN signaling in mice and humans through the Xr repeated sequences of protein A.
Martin FJ, Gomez MI, Wetzel DM, Memmi G, O'Seaghdha M, Soong G, Schindler C, Prince A The Journal of clinical investigation 2009 Jul 119 7 1931-9
The Abl and Arg kinases mediate distinct modes of phagocytosis and are required for maximal Leishmania infection.
Wetzel DM, McMahon-Pratt D, Koleske AJ Molecular and cellular biology 2012 Aug 32 15 3176-86
- Calcium-mediated protein secretion potentiates motility in Toxoplasma gondii.
- Host-pathogen interactions
- Development of novel antiparasitics
- Cellular and molecular pathogenesis of leishmaniasis and other parasitic infections