- Graduate School - Rockefeller University (1995-1999)
- Fellowship - University of California at San Francisco (2003-2007), Nephrology
- Residency - University of California, San Francisco (2001-2004), Internal Medicine
- Medical School - Cornell University Medical College (1993-2001)
Denise Marciano, M.D., Ph.D.
- Carolyn R. Bacon Distinguished Professorship in Medical Science and Education
- Internal Medicine - Nephrology
Denise Marciano, M.D., Ph.D., is an Associate Professor in the Department of Internal Medicine at UT Southwestern Medical Center, and a member of its Division of Nephrology. She specializes in kidney disease.
Originally from Washington, D.C., Dr. Marciano holds a bachelor's degree in chemistry from Dartmouth College in Hanover, New Hampshire, where she graduated magna cum laude. She earned her doctorate in cellular biophysics from The Rockefeller University, and her medical degree from Weill Cornell University Medical College in New York. She completed internal medicine residency training, as well as fellowship training in nephrology, at the University of California San Francisco, where she also completed a postdoctoral research fellowship in the Louis F. Reichardt Lab.
Certified by the American Board of Internal Medicine in internal medicine and nephrology, she joined the UT Southwestern faculty in 2011.
Dr. Marciano focuses her research on understanding the cellular and molecular mechanisms that drive kidney development and regeneration. She uses a variety of cellular, genetic, and biochemical approaches to study these processes in renal tubules and the filtration units of the kidney, called glomeruli. She also studies the pathogenesis of human congenital kidney abnormalities. She has received several grant awards to support her research laboratory, including awards from the March of Dimes and the NIH. More details on her research program can be found at the Marciano Research Lab.
Education & Training
Professional Associations & Affiliations
- American Heart Association (2014)
- National Kidney Foundation
- American Society of Nephrology
Honors & Awards
- Fellow of the American Society of Nephrology 2017
- Janet M. Glasgow Memorial Achievement Award 2001, Graduated in top ten students at Cornell Univ Medical College
- Magna cum laude and Phi Beta Kappa, Dartmouth College 1993
- NRSA F32 grant 2005
- K08 and NKF Young Investigator Awards 2008
- Norman S. Coplon Extramural Grant 2013
- March of Dimes Basil O'Connor Scholar 2013
- American Society of Clinical Investigation (ASCI) 2020
Books & Publications
Assembling filamentous phage occlude pIV channels.
Marciano DK, Russel M, Simon SM Proceedings of the National Academy of Sciences of the United States of America 2001 Jul 98 16 9359-64
cor, a Novel Carbon Monoxide Resistance Gene, Is Essential for Mycobacterium tuberculosis Pathogenesis.
Zacharia VM, Manzanillo PS, Nair VR, Marciano DK, Kinch LN, Grishin NV, Cox JS, Shiloh MU mBio 2013 4 6
Mucin-1 Increases Renal TRPV5 Activity In Vitro, and Urinary Level Associates with Calcium Nephrolithiasis in Patients.
Nie M, Bal MS, Yang Z, Liu J, Rivera C, Wenzel A, Beck BB, Sakhaee K, Marciano DK, Wolf MT Journal of the American Society of Nephrology : JASN 2016 Apr
Spatiotemporal heterogeneity and patterning of developing renal blood vessels.
Daniel E, Azizoglu DB, Ryan AR, Walji TA, Chaney CP, Sutton GI, Carroll TJ, Marciano DK, Cleaver O Angiogenesis 2018 Apr
The basement membrane of hair follicle stem cells is a muscle cell niche.
Fujiwara H, Ferreira M, Donati G, Marciano DK, Linton JM, Sato Y, Hartner A, Sekiguchi K, Reichardt LF, Watt FM Cell 2011 Feb 144 4 577-89
p120 catenin is required for normal renal tubulogenesis and glomerulogenesis.
Marciano DK, Brakeman PR, Lee CZ, Spivak N, Eastburn DJ, Bryant DM, Beaudoin GM, Hofmann I, Mostov KE, Reichardt LF Development (Cambridge, England) 2011 May 138 10 2099-109
Heme Oxygenase-1 Regulates Inflammation and Mycobacterial Survival in Human Macrophages during Mycobacterium tuberculosis Infection.
Scharn CR, Collins AC, Nair VR, Stamm CE, Marciano DK, Graviss EA, Shiloh MU Journal of immunology (Baltimore, Md. : 1950) 2016 Jun 196 11 4641-9
Nephronectin Regulates Mesangial Cell Adhesion and Behavior in Glomeruli.
Zimmerman SE, Hiremath C, Tsunezumi J, Yang Z, Finney B, Marciano DK Journal of the American Society of Nephrology : JASN 2018 Jan
Heterozygous Mutation of Vegfr3 Reduces Renal Lymphatics without Renal Dysfunction.
Liu H, Hiremath C, Patterson Q, Vora S, Shang Z, Jamieson AR, Fiolka R, Dean KM, Dellinger MT, Marciano DK, Journal of the American Society of Nephrology : JASN 2021 Sep
A novel method that improves sensitivity of protein detection in PAGE and western blot.
Vallejo-Illarramendi A, Marciano DK, Reichardt LF Electrophoresis 2013 Feb
De novo lumen formation and elongation in the developing nephron: a central role for afadin in apical polarity.
Yang Z, Zimmerman S, Brakeman PR, Beaudoin GM, Reichardt LF, Marciano DK Development (Cambridge, England) 2013 Mar
Role of CD34 family members in lumen formation in the developing kidney.
Yang Z, Zimmerman SE, Tsunezumi J, Braitsch C, Trent C, Bryant DM, Cleaver O, González-Manchón C, Marciano DK Developmental biology 2016 Aug
Developing renal tubules orient cell division via Afadin to position the tubule lumen.
Gao L, Yang Z, Hiremath C, Zimmerman SE, Long B, Brakeman PR, Mostov KE, Bryant DM, Luby-Phelps K, Marciano DK Development (Cambridge, England) 2017 Aug
Listeria monocytogenes InlP interacts with afadin and facilitates basement membrane crossing.
Faralla C, Bastounis EE, Ortega FE, Light SH, Rizzuto G, Gao L, Marciano DK, Nocadello S, Anderson WF, Robbins JR, Theriot JA, Bakardjiev AI PLoS pathogens 2018 May 14 5 e1007094
Light-sheet microscopy of cleared tissues with isotropic, subcellular resolution.
Chakraborty T, Driscoll MK, Jeffery E, Murphy MM, Roudot P, Chang BJ, Vora S, Wong WM, Nielson CD, Zhang H, Zhemkov V, Hiremath C, De La Cruz ED, Yi Y, Bezprozvanny I, Zhao H, Tomer R, Heintzmann R, Meeks JP, Marciano DK, Morrison SJ, Danuser G, Dean KM, Fiolka R, Nature methods 2019 11 16 11 1109-1113
Cdc42 regulates epithelial cell polarity and cytoskeletal function in kidney tubule development.
Elias BC, Das A, Parekh DV, Mernaugh G, Adams R, Yang Z, Brakebusch C, Pozzi A, Marciano DK, Carroll TJ, Zent R Journal of cell science 2015 Oct
Afadin and RhoA control pancreatic endocrine mass via lumen morphogenesis.
Azizoglu DB, Braitsch C, Marciano DK, Cleaver O Genes & development 2017 12 31 23-24 2376-2390
A holey pursuit: lumen formation in the developing kidney.
Marciano DK Pediatric nephrology (Berlin, Germany) 2016 Feb
Trans-Seq maps a selective mammalian retinotectal synapse instructed by Nephronectin.
Tsai NY, Wang F, Toma K, Yin C, Takatoh J, Pai EL, Wu K, Matcham AC, Yin L, Dang EJ, Marciano DK, Rubenstein JL, Wang F, Ullian EM, Duan X, Nature neuroscience 2022 May 25 5 659-674
Loss of diacylglycerol kinase epsilon in mice causes endothelial distress and impairs glomerular Cox-2 and PGE2 production.
Zhu J, Chaki M, Lu D, Ren C, Wang SS, Rauhauser AA, Li B, Zimmerman S, Jun B, Du Y, Vadnagara K, Wang H, Elhadi S, Quigg RJ, Topham MK, Mohan C, Ozaltin F, Zhou XJ, Marciano DK, Bazan NG, Attanasio M American journal of physiology. Renal physiology 2016 Feb ajprenal.00431.2015
An aqueous channel for filamentous phage export.
Marciano DK, Russel M, Simon SM Science (New York, N.Y.) 1999 May 284 5419 1516-9
The Bloody Mystery of Glomerular Tuft Development.
Marciano DK, Journal of the American Society of Nephrology : JASN 2021 Sep 32 9 2104-2106
Uromodulin regulates renal magnesium homeostasis through the ion channel transient receptor potential melastatin 6 (TRPM6).
Nie M, Bal MS, Liu J, Yang Z, Rivera C, Wu XR, Hoenderop JGJ, Bindels RJM, Marciano DK, Wolf MTF The Journal of biological chemistry 2018 Aug
Microfold Cells Actively Translocate Mycobacterium tuberculosis to Initiate Infection.
Nair VR, Franco LH, Zacharia VM, Khan HS, Stamm CE, You W, Marciano DK, Yagita H, Levine B, Shiloh MU Cell reports 2016 Jul
Methods for identifying novel integrin ligands.
Marciano DK, Denda S, Reichardt LF Methods in enzymology 2007 426 223-37
Disruption of the beclin 1-BCL2 autophagy regulatory complex promotes longevity in mice.
Fernández ÁF, Sebti S, Wei Y, Zou Z, Shi M, McMillan KL, He C, Ting T, Liu Y, Chiang WC, Marciano DK, Schiattarella GG, Bhagat G, Moe OW, Hu MC, Levine B Nature 2018 May
Mesangial Cells: The Tuft Guys of Glomerular Development.
Marciano DK, Journal of the American Society of Nephrology : JASN 2019 Sep 30 9 1551-1553
- Assembling filamentous phage occlude pIV channels.
- Kidney development and disease
- Cell polarity