- Medical School - Baylor College of Medicine (1974-1977)
- Residency - Duke University School of Medicine (1977-1980), Internal Medicine
- Fellowship - UT Southwestern Medical School (1980-1983), Gastroenterology & Liver Diseases
Dwain Thiele, M.D.
- Jan and Henri Bromberg Chair in Internal Medicine
- Internal Medicine - Digestive and Liver Diseases
- Liver Disease
- Liver Transplant Medicine
Biography
Dr. Thiele joined the Department of Internal Medicine in 1983, and the Graduate Program in Immunology in the Graduate School of Biomedical Sciences in 1986. He served as Chief of Hepatology from 1998-2005, Interim Chief of the Division of Digestive and Liver Diseases from 2002-2005, Vice Chair for Financial Affairs, Department of Internal Medicine from 2005-2010 and as Interim Chair, Department of Internal Medicine, 2009-2010 before assuming his current position as Vice Provost and Senior Associate Dean.
Dr. Thiele has broad interests in clinical hepatology, with special interests in acute viral hepatitis, autoimmune hepatitis and acute hepatitis of unknown etiology. Research conducted in Dr. Thiele’s laboratory focuses on delineating mechanisms of cytotoxic lymphocyte activation, differentiation and effector function, and exploring the role of these immune effector mechanisms in clearance of viral infections from the liver.
Dr. Thiele was included in D Magazine's Best Doctors list for 2018 and 2020.
Education & Training
Professional Associations & Affiliations
- American Association for Immunologists
- American Association for the Study of Liver Diseases
- American Gastroenterological Association
Honors & Awards
- D Magazine Best Doctor, (2018, 2020)
- American Association of Physicians 2004
- American Society for Clinical Investigation 1997
- Best Doctors in America 1996
- Teacher of the Year, UT Southwestern Gastroenterology Training Program 1994
Books & Publications
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Publications
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The role of serpinB9 / serine protease inhibitor 6 in preventing granzyme B dependent hepatotoxicity
Stout-Delgado HW, Y Getachew, TE Rogers, BC Miller and DL Thiele Hepatology 2007 45 In Press -
Intrahepatic Lymphocyte Expression of Dipeptidyl Peptidase I Processed Granzyme B and Perforin Induces Hepatocyte Expression of Serine Proteinase Inhibitor 6 (Serpinb9/SPI-6).
74. Stout-Delgado HW, Y Getachew, BC Miller and DL Thiele J. Immunol. 2007 179 6561-6567 -
Fas and TNFR1 but not cytolytic granule dependent mechanisms mediate clearance of liver adenovirus infection
Abougergi MC, SJ Gidner, DK Spady, BC Miller and DL Thiele Hepatology 2004 41 97-102 -
Anti-viral cytokines induce hepatic expression of the granzyme B inhibitors proteinase inhibitor 9 and serine proteinase inhibitor 6
Barrie MB, HW Stout, MS Abougergi, BC Miller and DL Thiele J Immunol 2004 172 6453-6459 -
Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivo
Miller BC, Eckman EA, Sambamurti K, Dobbs N, Chow KM, Eckman CB, Hersh LB and Thiele DL Proc Natl Acad Sci U S A 2003 100 6221-6226 -
A selective inhibitor of dipeptidyl peptidase I impairs generation of CD8(+) T cell cytotoxic effector function
Thiele DL, McGuire MJ and Lipsky PE J. Immunol. 1997 158 5200-5210 -
Generation of active myeloid and lymphoid granule serine proteases requires processing by the granule thiol protease dipeptidyl peptidase I
McGuire MJ, Lipsky PE and Thiele DL J. Biol. Chem. 1993 268 2458-2467 -
The action of leucyl-leucine methyl ester on cytotoxic lymphocytes requires uptake by a novel dipeptide-specific facilitated transport system and dipeptidyl peptidase I mediated conversion to membranolytic products
Thiele DL and Lipsky PE J. Exp. Med. 1990 172 183-194 -
Intestinal graft versus-host disease is initiated by donor T cells distinct from classic cytotoxic T lymphocytes
Thiele DL, Eigenbrodt ML, Bryde SE, Eigenbrodt EH and Lipsky PE J. Clin. Invest. 1989 84 1947-1956 -
Regulation of cellular function by products of lysosomal enzyme activity: Elimination of human natural killer cells by a dipeptide methyl ester generated from L-leucine methyl ester by monocytes or polymorphonuclear leukocytes
Thiele DL and Lipsky PE Proc. Natl. Acad. Sci. USA 1985 82 2468-2472
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The role of serpinB9 / serine protease inhibitor 6 in preventing granzyme B dependent hepatotoxicity
Research
- Transplantation immunology
- Cytotoxic lymphocyte function
- Antiviral immune responses
Clinical Focus
- Liver Disease
- Liver Transplant Medicine
- Gastroenterology
Results: 1 Locations
Parkland Memorial Hospital
5200 Harry Hines Blvd.Dallas, Texas 75235 214-590-8000 Directions to Parkland Memorial Hospital