E. Sherwood Brown, M.D., Ph.D.

Distinguished Teaching Professor

Peter O'Donnell Jr. Brain Institute

Lou and Ellen McGinley Distinguished Chair in Psychiatric Research
Aradine S. Ard Chair in Brain Science

Psychiatry

Biography

E. Sherwood Brown, M.D., Ph.D., M.B.A., is a Professor of Psychiatry with Tenure, Vice Chair for Clinical Research, Chief of the Division of Clinical Neuroscience, and Director of the Psychoneuroendocrine Research Program at UT Southwestern Medical Center. Dr. Brown received his B.A. and Ph.D. degrees in chemistry from Texas Christian University. He earned his M.D. degree at the University of Texas Medical School at Houston, and completed a psychiatry residency on the research track at UT Southwestern Medical Center, followed by a research fellowship. He also received an M.B.A. (Healthcare Leadership Concentration) from UT Dallas.

Dr. Brown is board certified in psychiatry and consultation-liaison psychiatry.

He serves on the editorial boards of several journals, including Journal of Affective Disorders, and is Editor-in-Chief of the Journal of Dual Diagnosis. He also serves as Treasurer and as a member of the board of directors and executive committee of the Academy of Consultation Liaison Psychiatry.

Dr. Brown’s research focuses on comorbidities of mood disorders including medical illness and substance abuse. He has received numerous grants from both the National Institutes of Health and private foundations, including grants from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) and the National Institute on Drug Abuse (NIDA) examining the treatment of patients with bipolar disorder and substance use disorders, grants from the National Heart, Lung, and Blood Institute (NHLBI) examining the treatment of depressed asthma patients, grants from the National Institute of Mental Health (NIMH) exploring interventions to protect the brain from the effects of corticosteroid excess, and grants from the National Center for Complementary and Integrative Health (NCCIH) examining a novel supplements.

Dr. Brown has published well over 200 research papers, books, chapters, reviews and editorials.

Education & Training

Fellowship - UT Southwestern Medical Center (1997-1998), Research
Residency - UT Southwestern Medical Center (1994-1997), Psychiatry
Internship - UT Southwestern Medical Center (1993-1994), Psychiatry
Medical School - UT Health Science Center McGovern Medical School (1989-1993)

Professional Associations & Affiliations

Society of Biological Psychiatry
Research Society on Alcoholism
American Psychiatric Association
American College of Neuropsychopharmacology
Texas Medical Association (1993)
Academy of Consultation-Liaison Psychiatry (2005)

Honors & Awards

Lilly Fellowship Travel Award 1998, to Society of Biological Psychiatry Annual Convention
New Investigator Award 1997, from New Clinical Drug Evaluation Unit (NCDEU)
Bristol-Myers Squibb Travel Fellowship 1999, to American College of Neuropsychopharmacology (ACNP) Annual Meeting
Gerald L. Klerman Award 2002, for clinical research from National Alliance for Research in Schizophrenia and Depression (NARSAD)

Books & Publications

Publications
- The Relationship Between Cumulative Exogenous Corticosteroid Exposure and Volumes of Hippocampal Subfields and Surrounding Structures.
  Nguyen DM, Yassa MA, Tustison NJ, Roberts JM, Kulikova A, Nakamura A, Ivleva EI, Van Enkevort E, Brown ES, Journal of clinical psychopharmacology 2019 Nov/Dec 39 6 653-657
- Trust in Physicians and Regional Brain Volumes: A Population-Based Study.
  Sadhu M, Jalalizadeh B, Fritz A, Nicholson TF, Garcia R, Lampley S, Rain M, Van Enkevort E, Brown ES, The primary care companion for CNS disorders 2019 Oct 21 5
- Subcortical gray matter volumes in asthma: associations with asthma duration, control, and anxiety.
  Ritz T, Kroll JL, Aslan S, Janssens T, Khan DA, Pinkham AE, Brown ES, Brain imaging and behavior 2019 Sep
- Effect of Selective Serotonin Reuptake Inhibitors on Healthcare Utilization in Patients with Post-Traumatic Stress Disorder and Alcohol Use Disorder.
  Naglich AC, Bozeman S, Brown ES, Adinoff B, Alcohol and alcoholism (Oxford, Oxfordshire) 2019 Jun
- A randomized trial of an NMDA receptor antagonist for reversing corticosteroid effects on the human hippocampus.
  Brown ES, Kulikova A, Van Enkevort E, Nakamura A, Ivleva EI, Tustison NJ, Roberts J, Yassa MA, Choi C, Frol A, Khan DA, Vazquez M, Holmes T, Malone K, Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2019 Jun
- Cortisol awakening response and fractional exhaled nitric oxide in asthma.
  Kroll JL, Brown ES, Ritz T, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2019 Jun
- Relationship between trust in neighbors and regional brain volumes in a population-based study.
  Sadhu M, Nicholson TF, Garcia R, Lampley S, Rain M, Fritz A, Jalalizadeh B, Van Enkevort E, Palka J, Brown ES, Psychiatry research. Neuroimaging 2019 Apr 286 11-17
- Central Nervous System Signatures of Affect in Asthma: Associations with Emotion-Induced Bronchoconstriction, Airway Inflammation, and Asthma Control.
  Ritz T, Kroll JL, Patel SV, Chen JR, Yezhuvath US, Aslan S, Khan DA, Pinkham AE, Rosenfield D, Brown ES, Journal of applied physiology (Bethesda, Md. : 1985) 2019 Mar
- From the Editors.
  Green AI, Brown ES, Journal of dual diagnosis 2019 Mar 1
- Association between telomere length and cognitive ability in a community-based sample.
  Kaja R, Reyes SM, Rossetti HC, Brown ES Neurobiology of aging 2019 Mar 75 51-53
- A pilot study of brexpiprazole for bipolar depression.
  Brown ES, Khaleghi N, Van Enkevort E, Ivleva E, Nakamura A, Holmes T, Mason BL, Escalante C Journal of affective disorders 2019 Feb 249 315-318
- A Randomized, Double-Blind, Placebo-Controlled Trial of Citicoline in Patients with Alcohol Use Disorder.
  Brown ES, Van Enkevort E, Kulikova A, Escalante C, Nakamura A, Ivleva EI, Holmes T Alcoholism, clinical and experimental research 2019 Feb 43 2 317-323
- A randomized, double-blind, placebo-controlled trial of lamotrigine for prescription corticosteroid effects on the human hippocampus.
  Brown ES, Sayed N, Choi C, Tustison N, Roberts J, Yassa MA, Van Enkevort E, Nakamura A, Ivleva EI, Sunderajan P, Khan DA, Vazquez M, McEwen B, Kulikova A, Frol AB, Holmes T European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2019 Jan
- Gabapentin Enacarbil Extended-Release for Alcohol Use Disorder: A Randomized, Double-Blind, Placebo-Controlled, Multisite Trial Assessing Efficacy and Safety.
  Falk DE, Ryan ML, Fertig JB, Devine EG, Cruz R, Brown ES, Burns H, Salloum IM, Newport DJ, Mendelson J, Galloway G, Kampman K, Brooks C, Green AI, Brunette MF, Rosenthal RN, Dunn KE, Strain EC, Ray L, Shoptaw S, Ait-Daoud Tiouririne N, Gunderson EW, Ransom J, Scott C, Leggio L, Caras S, Mason BJ, Litten RZ Alcoholism, clinical and experimental research 2019 Jan 43 1 158-169
- Relationship between depressive symptom severity and amygdala volume in a large community-based sample.
  Daftary S, Van Enkevort E, Kulikova A, Legacy M, Brown ES Psychiatry research. Neuroimaging 2019 Jan 283 77-82
- Systematic review of preclinical, clinical, and post-marketing evidence of bupropion misuse potential.
  Naglich AC, Brown ES, Adinoff B The American journal of drug and alcohol abuse 2019 Jan 1-14
- Megestrol Acetate Induces Declarative Memory Changes and Cortisol Suppression in Healthy Volunteers.
  Mason BL, Ivleva EI, Van Enkevort E, Nakamura A, Brown ES Dementia and geriatric cognitive disorders 2018 Oct 46 3-4 186-192
- The Effects of Caregiver Depression on Childhood Asthma: Pathways and Mechanisms.
  Wood BL, Brown ES, Lehman HK, Khan DA, Lee MJ, Miller BD Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2018 Jul
- Association of Biological Markers of Alcohol Consumption and Self-Reported Drinking with Hippocampal Volume in a Population-Based Sample of Adults.
  Naglich A, Van Enkevort E, Adinoff B, Brown ES Alcohol and alcoholism (Oxford, Oxfordshire) 2018 Jun
- A Randomized, Double-Blind, Placebo-Controlled Trial of Escitalopram in Patients with Asthma and Major Depressive Disorder.
  Brown ES, Sayed N, Van Enkevort E, Kulikova A, Nakamura A, Khan DA, Ivleva EI, Sunderajan P, Bender BG, Holmes T The journal of allergy and clinical immunology. In practice 2018 Feb
- The relationship between asthma and depression in a community-based sample.
  Akula M, Kulikova A, Khan DA, Brown ES The Journal of asthma : official journal of the Association for the Care of Asthma 2018 Jan 1-7
- Neurosteroid Levels in Patients With Bipolar Disorder and a History of Cannabis Use Disorders.
  Mason BL, Van Enkevort E, Filbey F, Marx CE, Park J, Nakamura A, Sunderajan P, Brown ES Journal of clinical psychopharmacology 2017 Oct
- Relationship Between Current Depressive Symptoms and Telomere Length in a Large, Multiethnic Sample.
  Wignall ND, Deschner M, Evans HM, Brown ES The Journal of clinical psychiatry 2017 Mar
- Evaluation of the value of team-based psychiatric consultation in a general hospital setting.
  Orsak C, Thomas A, Bush P, Brown ES International journal of psychiatry in medicine 2017 Jan 91217417749798
- Expanded conceptualization of multimorbidity to encompass substance use disorders and other psychiatric illness.
  North CS, Brown ES, Pollio DE Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists 2016 Aug 28 3 182-8
- Factitious angioedema: a mimic of refractory "angioedema".
  Feldman MF, Khan DA, Brown ES, Bernstein JA The journal of allergy and clinical immunology. In practice 2014 Nov-Dec 2 6 795-7
- Hippocampal Volume in Healthy Controls Given 3-Day Stress Doses of Hydrocortisone.
  Brown ES, Jeon-Slaughter H, Lu H, Jamadar R, Issac S, Shad M, Denniston D, Tamminga C, Nakamura A, Thomas BP Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2014 Nov
- Adverse consequences of glucocorticoid medication: psychological, cognitive, and behavioral effects.
  Judd LL, Schettler PJ, Brown ES, Wolkowitz OM, Sternberg EM, Bender BG, Bulloch K, Cidlowski JA, Ronald de Kloet E, Fardet L, Joëls M, Leung DY, McEwen BS, Roozendaal B, Van Rossum EF, Ahn J, Brown DW, Plitt A, Singh G The American journal of psychiatry 2014 Oct 171 10 1045-51
- The effect of cognitive functioning on treatment attendance and adherence in comorbid bipolar disorder and cocaine dependence.
  Fagan CS, Carmody TJ, McClintock SM, Suris A, Nakamura A, Jeon-Slaughter H, Lo A, Brown ES Journal of substance abuse treatment 2014 Jul
- Citicoline in addictive disorders: a review of the literature.
  Wignall ND, Brown ES The American journal of drug and alcohol abuse 2014 Jul 40 4 262-8
- A Randomized, Double-Blind, Placebo-Controlled Trial of Pregnenolone for Bipolar Depression.
  Brown ES, Park J, Marx CE, Hynan LS, Gardner C, Davila D, Nakamura A, Sunderajan P, Lo A, Holmes T Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2014 Jun
- Asthma and depression: the Cooper Center Longitudinal Study.
  Trojan TD, Khan DA, Defina LF, Akpotaire O, Goodwin RD, Brown ES Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2014 Mar
- Association of Depressive Symptoms with Hippocampal Volume in 1936 Adults.
  Brown ES, Hughes CW, McColl R, Peshock R, King KS, Rush AJ Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2013 Oct
- The relationship between asthma and self-reported anxiety in a predominantly healthy adult population.
  Gada E, Khan DA, Defina LF, Brown ES Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2013 Sep
- A comparison of clinician-rated neuropsychological and self-rated cognitive assessments in patients with asthma and rheumatologic disorders.
  Frol AB, Vasquez A, Getahun Y, Pacheco M, Khan DA, Brown ES Allergy and asthma proceedings : the official journal of regional and state allergy societies 2013 Mar 34 2 170-5
- Relationship between asthma and cognition: the Cooper Center Longitudinal Study.
  Caldera-Alvarado G, Khan DA, Defina LF, Pieper A, Brown ES Allergy 2013 Feb
- A randomized, placebo-controlled proof-of-concept, crossover trial of phenytoin for hydrocortisone-induced declarative memory changes.
  Brown ES, Lu H, Denniston D, Uh J, Thomas BP, Carmody TJ, Auchus RJ, Diaz-Arrastia R, Tamminga C Journal of affective disorders 2013 Feb
- A randomized, double-blind, placebo-controlled trial of citicoline for bipolar and unipolar depression and methamphetamine dependence.
  Brown ES, Gabrielson B Journal of affective disorders 2012 Dec 143 1-3 257-60
- A randomized, double-blind, placebo-controlled, trial of lamotrigine therapy in bipolar disorder, depressed or mixed phase and cocaine dependence.
  Brown ES, Sunderajan P, Hu LT, Sowell SM, Carmody TJ Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2012 Oct 37 11 2347-54
- An epidemiological approach to "steroid psychosis".
  Brown ES The American journal of psychiatry 2012 May 169 5 447-9
- Relationship between serum homocysteine levels and depressive symptoms: the Cooper Center Longitudinal Study.
  Gu P, DeFina LF, Leonard D, John S, Weiner MF, Brown ES The Journal of clinical psychiatry 2012 May 73 5 691-5
- T2 measurement of J-coupled metabolites in the human brain at 3T.
  Ganji SK, Banerjee A, Patel AM, Zhao YD, Dimitrov IE, Browning JD, Brown ES, Maher EA, Choi C NMR in biomedicine 2012 Apr 25 4 523-9
- Depression, anxiety, and COPD: the unexamined role of nicotine dependence.
  Goodwin RD, Lavoie KL, Lemeshow AR, Jenkins E, Brown ES, Fedoronko DA Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 2012 Feb 14 2 176-83
- Escitalopram for severe asthma and major depressive disorder: a randomized, double-blind, placebo-controlled proof-of-concept study.
  Brown ES, Howard C, Khan DA, Carmody TJ Psychosomatics 2012 Jan-Feb 53 1 75-80
- Association between low serum 25-hydroxyvitamin D and depression in a large sample of healthy adults: the Cooper Center longitudinal study.
  Hoang MT, Defina LF, Willis BL, Leonard DS, Weiner MF, Brown ES Mayo Clinic proceedings. Mayo Clinic 2011 Nov 86 11 1050-5
- Effects of lamotrigine on hippocampal activation in corticosteroid-treated patients.
  Brown ES, Zaidel L, Allen G, McColl R, Vazquez M, Ringe WK Journal of affective disorders 2010 Nov 126 3 415-9
- A double-blind, placebo-controlled study with quetiapine as adjunct therapy with lithium or divalproex in bipolar I patients with coexisting alcohol dependence.
  Stedman M, Pettinati HM, Brown ES, Kotz M, Calabrese JR, Raines S Alcoholism, clinical and experimental research 2010 Oct 34 10 1822-31
- Pregnenolone for cognition and mood in dual diagnosis patients.
  Osuji IJ, Vera-Bolaños E, Carmody TJ, Brown ES Psychiatry research 2010 Jul 178 2 309-12
- A randomized, double-blind, placebo-controlled pilot study of naltrexone in outpatients with bipolar disorder and alcohol dependence.
  Brown ES, Carmody TJ, Schmitz JM, Caetano R, Adinoff B, Swann AC, John Rush A Alcoholism, clinical and experimental research 2009 Nov 33 11 1863-9
- Effects of glucocorticoids on mood, memory, and the hippocampus. Treatment and preventive therapy.
  Brown ES Annals of the New York Academy of Sciences 2009 Oct 1179 41-55
- Attenuation of amygdala atrophy with lamotrigine in patients receiving corticosteroid therapy.
  Desai S, Khanani S, Shad MU, Brown ES Journal of clinical psychopharmacology 2009 Jun 29 3 284-7
- A randomized, double-blind, placebo-controlled add-on trial of quetiapine in outpatients with bipolar disorder and alcohol use disorders.
  Brown ES, Garza M, Carmody TJ The Journal of clinical psychiatry 2008 May 69 5 701-5
- A randomized, placebo-controlled trial of citicoline add-on therapy in outpatients with bipolar disorder and cocaine dependence.
  Brown ES, Gorman AR, Hynan LS Journal of clinical psychopharmacology 2007 Oct 27 5 498-502
- A randomized trial of citalopram versus placebo in outpatients with asthma and major depressive disorder: a proof of concept study.
  Brown ES, Vigil L, Khan DA, Liggin JD, Carmody TJ, Rush AJ Biological psychiatry 2005 Dec 58 11 865-70
- Hippocampal volume, spectroscopy, cognition, and mood in patients receiving corticosteroid therapy.
  Brown ES, J Woolston D, Frol A, Bobadilla L, Khan DA, Hanczyc M, Rush AJ, Fleckenstein J, Babcock E, Cullum CM Biological psychiatry 2004 Mar 55 5 538-45
- Association of depression with medical illness: does cortisol play a role?
  Brown ES, Varghese FP, McEwen BS Biological psychiatry 2004 Jan 55 1 1-9

Research

Treatment of patients with bipolar disorder and substance abuse
Treatment of bipolar depression
Effects of corticosteroids on the hippocampus
Depression in asthma patients