- Residency - UT Southwestern Medical Center (2018-2021), Dermatology
- Internship - UT Southwestern Medical Center (2017-2018), Internal Medicine
- Medical School - UT Southwestern Medical School (2012-2017)

Jack O'Brien, M.D.
- Dermatology - General
- Hidradenitis Suppurativa
- Skin Cancer
New Patient Appointment Accepting Virtual Visits or 214-645-2400
Biography
Jack O’Brien, M.D., is an Assistant Professor in the Department of Dermatology at UT Southwestern Medical Center. He specializes in hidradenitis suppurativa, general dermatology, and skin cancer.
Dr. O’Brien earned his medical degree at UT Southwestern Medical School, where he also completed a residency in dermatology, serving as Chief Resident.
Certified by the American Board of Dermatology, he joined the UT Southwestern faculty in 2021.
At UT Southwestern, Dr. O’Brien is the Medical Director of the Dermatology Clinic, the Director of the Hidradenitis Suppurativa Clinic, and the Associate Program Director of the Dermatology Residency.
Dr. O’Brien is a Fellow of the American Academy of Dermatology. He serves as Secretary-Treasurer of the Dallas Dermatological Society and is a member of the Society for Investigative Dermatology. In addition, he is a faculty volunteer at the Agape Dermatology Clinic in Dallas.
He has delivered presentations and published peer-reviewed academic articles related to his areas of expertise. He also contributed to the book Treatment of Skin Disease.
Personal Note
When he’s not at work, Dr. O’Brien enjoys spending time with his family, running, hiking, and playing sports.
Education & Training
Professional Associations & Affiliations
- American Academy of Dermatology
- Dallas Dermatological Society
- Society for Investigative Dermatology
Books & Publications
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Books
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Treatment of Skin Disease (5th ed.)
O’Brien JC, Morphea, JH (2018), London, Elsevier
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Treatment of Skin Disease (5th ed.)
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Publications
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The Use of Complementary and Alternative Medicine in Management of Hidradenitis Suppurativa
Jain S, O’Brien JC, Harris-Tryon T Current Dermatology Reports 2024 Dec 13 315-323 -
When handed lemons, beware of squeezing them
Zhu CS, Trickett J, O'Brien J, Cruz PD Contact Dermatitis 2024 Mar 90 327-328 -
Gene Expression Signatures in Inflammatory and Sclerotic Morphea Skin and Sera Distinguish Morphea from Systemic Sclerosis
Chen HW, Zhu JL, Martyanov V, Tsoi LC, Johnson ME, Barber G, Popovich D, O'Brien JC, Coias J, Cyrus N, Malviya N, Florez-Pollack S, Kunzler E, Hosler GA, Gudjonsson JE, Khanna D, Whitfield M, Jacobe HT Journal of Investigative Dermatology 2023 Oct 143 1886-1895.e10 -
Elevated serum levels of C-X-C motif chemokine ligand 10 can distinguish systemic lupus erythematosus patients from cutaneous lupus erythematosus patients
Zhu JL, O'Brien JC, Barber G, Saxena R, Chong BF Journal of the American Academy of Dermatology 2021 Oct 85 1051-1054 -
Changes in Disease Activity and Damage over Time in Patients with Morphea
O'Brien JC, Nymeyer H, Green A, Jacobe HT JAMA Dermatology 2020 May 156 513-520 -
A Cross-sectional Comparison of Magnetic Resonance Imaging Findings and Clinical Assessment in Patients with Morphea
Abbas LF, O'Brien JC, Goldman S, Pezeshk P, Chalian M, Chhabra A, Jacobe HT JAMA Dermatology 2020 May 156 590-592 -
Linear morphea: Clinical characteristics, disease course, and treatment of the Morphea in Adults and Children cohort
Kunzler E, Florez-Pollack S, Teske N, O'Brien J, Prasad S, Jacobe H Journal of the American Academy of Dermatology 2019 Jun 80 1664-1670.e1 -
Not Just Skin Deep: Systemic Disease Involvement in Patients With Cutaneous Lupus
O'Brien JC, Chong BF Journal of Investigative Dermatology Symposium Proceedings 2017 Oct 18 S69-S74 -
Transcriptional and Cytokine Profiles Identify CXCL9 as a Biomarker of Disease Activity in Morphea
O'Brien JC, Rainwater YB, Malviya N, Cyrus N, Auer-Hackenberg L, Hynan LS, Hosler GA, Jacobe HT Journal of Investigative Dermatology 2017 Aug 137 1663-1670 -
Changes in T cell and B cell composition in discoid lupus erythematosus skin at different stages
O'Brien JC, Hosler GA, Chong BF Journal of Dermatological Science 2017 Mar 85 247-249 -
Changes in T cell and B cell composition in discoid lupus erythematosus skin at different stages
O'Brien JC, Hosler GA, Chong BF Journal of Dermatological Science 2017 Mar 85 247-249 -
Morphea
O’Brien JC, Jacobe HT 2017 Jan 512-514 -
Reducing outpatient dermatology clinic wait times in a safety net health system in Dallas, Texas
O'Brien JC, Chong BF Journal of the American Academy of Dermatology 2016 Sep 75 631-632 -
Autoantibodies and disease activity in patients with discoid lupus erythematosus
Kim A, O'Brien J, Tseng LC, Zhang S, Chong BF JAMA Dermatology 2014 Jun 150 651-654
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The Use of Complementary and Alternative Medicine in Management of Hidradenitis Suppurativa
Clinical Focus
- Hidradenitis Suppurativa
- Skin Cancer
- General Dermatology
New Patient Appointment Accepting Virtual Visits or 214-645-2400