Jessica Moreland, M.D.

Associate Dean for Faculty Development

Thomas Fariss Marsh, Jr. Chair in Pediatrics

Pediatrics - Critical Care

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Biography

Download Curriculum Vitae

Jessica Moreland received her bachelor’s degree in zoology from Duke University. She obtained her M.D. from Vanderbilt University in Nashville, Tennessee, in 1992. Dr. Moreland remained at Vanderbilt University for her residency training in pediatrics and her fellowship training in pediatric critical care. After completion of all of her postgraduate training, she was recruited to join the faculty at the University of Iowa.

Dr. Moreland was appointed as an Assistant Professor on the tenure track in 1998 and rose to the rank of Professor with Tenure in 2013. Her research focus has centered broadly on the theme of neutrophil-based inflammation. While on faculty at the University of Iowa, Dr. Moreland served initially as the Fellowship Director for Pediatric Critical Care and served as the Division Director prior to joining UT Southwestern.

Dr. Moreland took over as the Division Chief of Pediatric Critical Care at UT Southwestern in January of 2014. She is currently the Professor of Pediatrics and Microbiology and the Thomas Fariss Marsh, Jr. Chair in Pediatrics.

Dr. Moreland was included in D Magazine's Best Doctors list for 2018 and 2022 and its Best Pediatric Specialists list for 2020 and 2021.

Education & Training

Fellowship - Vanderbilt University Medical Center (1995-1998), Pediatric Critical Care Medicine
Residency - Vanderbilt University Medical Center (1992-1995), Pediatrics
Medical School - Vanderbilt University School of Medicine (1988-1992)

Professional Associations & Affiliations

Society for Pediatric Research
Society for Leukocyte Biology
Society for Critical Care Medicine
American Pediatric Society
American Academy of Pediatrics

Honors & Awards

D Magazine Best Doctor, 2018, 2022
D Magazine Best Pediatric Specialist, 2015, 2020-2021
Election to American Pediatric Society 2013
Best Doctors in America 2012-2013, Best Doctors, Inc.
Above and Beyond Award 2005-2006, University of Iowa Health Care
Election to Society for Pediatric Research 2001
Elliot V. Newman Award 1997, Vanderbilt University Medical Center Research Forum
House Officer Research Award 1995, Society for Pediatric Research
David Karzon Award 1995, Vanderbilt University, Department of Pediatrics
Amos Christie Award in Pediatrics 1995, Vanderbilt University Medical School
1992 Alpha Omega Alpha 1992, Alpha Omega Alpha Honor Medical Society

Books & Publications

Publications
- Nox2 Regulates Platelet Activation and NET Formation in the Lung.
  Hook JS, Cao M, Potera RM, Alsmadi NZ, Schmidtke DW, Moreland JG, Frontiers in immunology 2019 10 1472
- Alveolar Macrophage Chemokine Secretion Mediates Neutrophilic Lung Injury in Nox2-Deficient Mice.
  Potera RM, Cao M, Jordan LF, Hogg RT, Hook JS, Moreland JG Inflammation 2018 Oct
- Neutrophil Phenotype Correlates With Postoperative Inflammatory Outcomes in Infants Undergoing Cardiopulmonary Bypass.
  Huber JN, Hilkin BM, Hook JS, Brophy PD, Davenport TL, Davis JE, Colaizy TT, Moreland JG Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2017 Oct
- Correction: Interferon Regulatory Factor 6 Has a Protective Role in the Host Response to Endotoxic Shock.
  Joly S, Rhea L, Volk P, Moreland JG, Dunnwald M PloS one 2017 12 1 e0171459
- Craniectomy and Traumatic Brain Injury in Children on Extracorporeal Membrane Oxygenation Support: Case Report and Review of the Literature.
  Anton-Martin P, Braga B, Megison S, Journeycake J, Moreland J Pediatric emergency care 2016 Oct
- Neutrophil azurophilic granule exocytosis is primed by TNF-a and partially regulated by NADPH oxidase.
  Potera RM, Jensen MJ, Hilkin BM, South GK, Hook JS, Gross EA, Moreland JG Innate immunity 2016 Sep
- A Common Genetic Variant in TLR1 Enhances Human Neutrophil Priming and Impacts Length of Intensive Care Stay in Pediatric Sepsis.
  Whitmore LC, Hook JS, Philiph AR, Hilkin BM, Bing X, Ahn C, Wong HR, Ferguson PJ, Moreland JG Journal of immunology (Baltimore, Md. : 1950) 2016 Feb 196 3 1376-86
- Interferon Regulatory Factor 6 Has a Protective Role in the Host Response to Endotoxic Shock.
  Joly S, Rhea L, Volk P, Moreland JG, Dunnwald M PloS one 2016 11 4 e0152385
- Evaluation of hematologic composition in newborn C57/BL6 mice up to day 35.
  White JR, Gong H, Colaizy TT, Moreland JG, Flaherty H, McElroy SJ Veterinary clinical pathology / American Society for Veterinary Clinical Pathology 2015 Dec
- NOX2 protects against progressive lung injury and multiple organ dysfunction syndrome.
  Whitmore LC, Goss KL, Newell EA, Hilkin BM, Hook JS, Moreland JG American journal of physiology. Lung cellular and molecular physiology 2014 May
- ROS-containing endosomal compartments: implications for signaling.
  Davis Volk AP, Moreland JG Methods in enzymology 2014 535 201-24
- NOX2 Protects against Prolonged Inflammation, Lung Injury, and Mortality following Systemic Insults.
  Whitmore LC, Hilkin BM, Goss KL, Wahle EM, Colaizy TT, Boggiatto PM, Varga SM, Miller FJ, Moreland JG Journal of innate immunity 2013 Apr
- Transepithelial migration of neutrophils into the lung requires TREM-1.
  Klesney-Tait J, Keck K, Li X, Gilfillan S, Otero K, Baruah S, Meyerholz DK, Varga SM, Knudson CJ, Moninger TO, Moreland J, Zabner J, Colonna M The Journal of clinical investigation 2013 Jan 123 1 138-49
- Endotoxin priming of neutrophils requires endocytosis and NADPH oxidase-dependent endosomal reactive oxygen species.
  Lamb FS, Hook JS, Hilkin BM, Huber JN, Volk AP, Moreland JG The Journal of biological chemistry 2012 Apr 287 15 12395-404
- Priming of neutrophils and differentiated PLB-985 cells by pathophysiological concentrations of TNF-a is partially oxygen dependent.
  Volk AP, Barber BM, Goss KL, Ruff JG, Heise CK, Hook JS, Moreland JG Journal of innate immunity 2011 3 3 298-314
- Multiple mechanisms of NADPH oxidase inhibition by type A and type B Francisella tularensis.
  McCaffrey RL, Schwartz JT, Lindemann SR, Moreland JG, Buchan BW, Jones BD, Allen LA Journal of leukocyte biology 2010 Oct 88 4 791-805
- Activation of swelling-activated chloride current by tumor necrosis factor-alpha requires ClC-3-dependent endosomal reactive oxygen production.
  Matsuda JJ, Filali MS, Moreland JG, Miller FJ, Lamb FS The Journal of biological chemistry 2010 Jul 285 30 22864-73
- Francisella tularensis directly interacts with the endothelium and recruits neutrophils with a blunted inflammatory phenotype.
  Moreland JG, Hook JS, Bailey G, Ulland T, Nauseef WM American journal of physiology. Lung cellular and molecular physiology 2009 Jun 296 6 L1076-84
- Electrophysiology of reactive oxygen production in signaling endosomes.
  Lamb FS, Moreland JG, Miller FJ Antioxidants & redox signaling 2009 Jun 11 6 1335-47
- ZEB1 enhances transendothelial migration and represses the epithelial phenotype of prostate cancer cells.
  Drake JM, Strohbehn G, Bair TB, Moreland JG, Henry MD Molecular biology of the cell 2009 Apr 20 8 2207-17
- ClC-3 and IClswell are required for normal neutrophil chemotaxis and shape change.
  Volk AP, Heise CK, Hougen JL, Artman CM, Volk KA, Wessels D, Soll DR, Nauseef WM, Lamb FS, Moreland JG The Journal of biological chemistry 2008 Dec 283 49 34315-26
- Overexpression of CLC-3 in HEK293T cells yields novel currents that are pH dependent.
  Matsuda JJ, Filali MS, Volk KA, Collins MM, Moreland JG, Lamb FS American journal of physiology. Cell physiology 2008 Jan 294 1 C251-62
- Endotoxin priming of neutrophils requires NADPH oxidase-generated oxidants and is regulated by the anion transporter ClC-3.
  Moreland JG, Davis AP, Matsuda JJ, Hook JS, Bailey G, Nauseef WM, Lamb FS The Journal of biological chemistry 2007 Nov 282 47 33958-67
- Pre-surgical evaluation of interrupted aortic arch with 3-dimensional reconstruction of CT images.
  Morriss J, Moreland J, Burkhart H, Kao S The Annals of thoracic surgery 2007 Jul 84 1 299
- The antibacterial activity of human neutrophils and eosinophils requires proton channels but not BK channels.
  Femling JK, Cherny VV, Morgan D, Rada B, Davis AP, Czirják G, Enyedi P, England SK, Moreland JG, Ligeti E, Nauseef WM, DeCoursey TE The Journal of general physiology 2006 Jun 127 6 659-72
- Anion channels, including ClC-3, are required for normal neutrophil oxidative function, phagocytosis, and transendothelial migration.
  Moreland JG, Davis AP, Bailey G, Nauseef WM, Lamb FS The Journal of biological chemistry 2006 May 281 18 12277-88
- Neutrophil transendothelial migration in vitro to Streptococcus pneumoniae is pneumolysin dependent.
  Moreland JG, Bailey G American journal of physiology. Lung cellular and molecular physiology 2006 May 290 5 L833-40
- Organism-specific neutrophil-endothelial cell interactions in response to Escherichia coli, Streptococcus pneumoniae, and Staphylococcus aureus.
  Moreland JG, Bailey G, Nauseef WM, Weiss JP Journal of immunology (Baltimore, Md. : 1950) 2004 Jan 172 1 426-32
- CD11b and intercellular adhesion molecule-1 are involved in pulmonary neutrophil recruitment in lipopolysaccharide-induced airway disease.
  Moreland JG, Fuhrman RM, Pruessner JA, Schwartz DA American journal of respiratory cell and molecular biology 2002 Oct 27 4 474-80

Research

Translational analysis of neutrophil activation state during cardiopulmonary bypass and during chronic inflammatory disease
Neutrophil priming
NADPH oxidase and reactive oxygen species signaling
Inflammation and the resolution of inflammation
Granule and vesicle exocytosis

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