- Society for Pediatric Research
- Society for Leukocyte Biology
- Society for Critical Care Medicine
- American Pediatric Society
- American Academy of Pediatrics
Jessica Moreland, M.D.
Associate Dean for Faculty Development
- Thomas Fariss Marsh, Jr. Chair in Pediatrics
- Pediatrics - Critical Care
Biography
Jessica Moreland received her bachelor’s degree in zoology from Duke University. She obtained her M.D. from Vanderbilt University in Nashville, Tennessee, in 1992. Dr. Moreland remained at Vanderbilt University for her residency training in pediatrics and her fellowship training in pediatric critical care. After completion of all of her postgraduate training, she was recruited to join the faculty at the University of Iowa.
Dr. Moreland was appointed as an Assistant Professor on the tenure track in 1998 and rose to the rank of Professor with Tenure in 2013. Her research focus has centered broadly on the theme of neutrophil-based inflammation. While on faculty at the University of Iowa, Dr. Moreland served initially as the Fellowship Director for Pediatric Critical Care and served as the Division Director prior to joining UT Southwestern.
Dr. Moreland took over as the Division Chief of Pediatric Critical Care at UT Southwestern in January of 2014. She is currently the Professor of Pediatrics and Microbiology and the Thomas Fariss Marsh, Jr. Chair in Pediatrics.
Dr. Moreland was included in D Magazine's Best Doctors list for 2018 and 2022-2025 and its Best Pediatric Specialists list for 2020 and 2021.
Education & Training
- Fellowship - Vanderbilt University Medical Center (1995-1998), Pediatric Critical Care Medicine
- Residency - Vanderbilt University Medical Center (1992-1995), Pediatrics
- Medical School - Vanderbilt University School of Medicine (1988-1992)
Professional Associations & Affiliations
Honors & Awards
- D Magazine Best Doctor, 2018, 2022-2025
- D Magazine Best Pediatric Specialist, 2015, 2020-2021
- Election to American Pediatric Society 2013
- Best Doctors in America 2012-2013, Best Doctors, Inc.
- Above and Beyond Award 2005-2006, University of Iowa Health Care
- Election to Society for Pediatric Research 2001
- Elliot V. Newman Award 1997, Vanderbilt University Medical Center Research Forum
- House Officer Research Award 1995, Society for Pediatric Research
- David Karzon Award 1995, Vanderbilt University, Department of Pediatrics
- Amos Christie Award in Pediatrics 1995, Vanderbilt University Medical School
- 1992 Alpha Omega Alpha 1992, Alpha Omega Alpha Honor Medical Society
Books & Publications
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Publications
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Role for IRAK-4 and p38 in Neutrophil Signaling in Response to Bacterial Lipoproteins from Staphylococcus aureus
Hook JS, Matheis AD, Kavanaugh JS, Horswill AR, Moreland JG Inflammation 2025 Aug 48 1704-1715 -
Does serial procalcitonin monitoring predict clinical outcomes in children with sepsis? A diagnostic stewardship study
Rubbab B, Davila S, Moreland J, Firmani S, Most Z Antimicrobial Stewardship and Healthcare Epidemiology 2025 Jun 5 -
Granular Insights: Neutrophil Predominance and Elastase Release in Severe Asthma Exacerbations in a Pediatric Cohort
Henley K, Tresselt E, Hook JS, Patel PA, Gill MA, Moreland JG Cells 2024 Mar 13 -
Quantifying neutrophil extracellular trap release in a combined infection-inflammation NET-array device
Datla US, Vundurthy B, Hook JS, Menon N, Razmi Bagtash H, Shihabeddin T, Schmidtke DW, Moreland JG, Radic MZ, Jones CN Lab on a Chip 2024 Jan 24 615-628 -
Neutrophil metabolomics in severe COVID-19 reveal GAPDH as a suppressor of neutrophil extracellular trap formation
Li Y, Hook JS, Ding Q, Xiao X, Chung SS, Mettlen M, Xu L, Moreland JG, Agathocleous M Nature communications 2023 Dec 14 -
Itaconate-producing neutrophils regulate local and systemic inflammation following trauma
Crossley JL, Ostashevskaya-Gohstand S, Comazzetto S, Hook JS, Guo L, Vishlaghi N, Juan C, Xu L, Horswill AR, Hoxhaj G, Moreland JG, Tower RJ, Levi B JCI Insight 2023 Oct 8 -
Evaluation of an association between RANKL and OPG with bone disease in people with cystic fibrosis
Abid S, Lee MJ, Rodich B, Hook JS, Moreland JG, Towler D, Maalouf NM, Keller A, Ratti G, Jain R Journal of Cystic Fibrosis 2023 Jan 22 140-145 -
Neutrophil Extracellular Trap Formation Potential Correlates with Lung Disease Severity in COVID-19 Patients
Kinnare N, Hook JS, Patel PA, Monson NL, Moreland JG Inflammation 2022 Apr 45 800-811 -
Novel neutrophil phenotypic signature in pediatric patients with type 1 diabetes and diabetic ketoacidosis
Nichols BE, Hook JS, Weng K, Ahn C, Moreland JG Journal of Leukocyte Biology 2022 Apr 111 849-856 -
Lipoproteins from staphylococcus aureus drive neutrophil extracellular trap formation in a TLR2/1- And PAD-dependent manner
Hook JS, Patel PA, O'Malley A, Xie L, Kavanaugh JS, Horswill AR, Moreland JG Journal of Immunology 2021 Aug 207 :966-973 -
Mycobacterium tuberculosis lipoarabinomannan activates human neutrophils via a TLR2/1 mechanism distinct from Pam3CSK4
Hook JS, Cao M, Weng K, Kinnare N, Moreland JG Journal of Immunology 2020 Feb 204 671-681 -
Alveolar Macrophage Chemokine Secretion Mediates Neutrophilic Lung Injury in Nox2-Deficient Mice
Potera RM, Cao M, Jordan LF, Hogg RT, Hook JS, Moreland JG Inflammation 2019 Feb 42 185-198 -
Nox2 regulates platelet activation and net formation in the lung
Hook JS, Cao M, Potera RM, Alsmadi NZ, Schmidtke DW, Moreland JG Frontiers in immunology 2019 10 -
Neutrophil Phenotype Correlates with Postoperative Inflammatory Outcomes in Infants Undergoing Cardiopulmonary Bypass
Huber JN, Hilkin BM, Hook JS, Brophy PD, Davenport TL, Davis JE, Colaizy TT, Moreland JG Pediatric Critical Care Medicine 2017 Dec 18 1145-1152 -
Neutrophil azurophilic granule exocytosis is primed by TNF-α and partially regulated by NADPH oxidase
Potera RM, Jensen MJ, Hilkin BM, South GK, Hook JS, Gross EA, Moreland JG Innate Immunity 2016 Nov 22 635-646 -
Craniectomy and Traumatic Brain Injury in Children on Extracorporeal Membrane Oxygenation Support: Case Report and Review of the Literature
Anton-Martin P, Braga B, Megison S, Journeycake J, Moreland J Pediatric Emergency Care 2016 Oct -
Interferon Regulatory factor 6 has a protective role in the host response to endotoxic shock
Joly S, Rhea L, Volk P, Moreland JG, Dunnwald M PloS one 2016 Apr 11 -
Evaluation of hematologic variables in newborn C57/BL6 mice up to day 35
White JR, Gong H, Colaizy TT, Moreland JG, Flaherty H, Mcelroy SJ Veterinary Clinical Pathology 2016 Mar 45 87-95 -
A common genetic variant in TLR1 enhances human neutrophil priming and impacts length of intensive care stay in pediatric sepsis
Whitmore LC, Hook JS, Philiph AR, Hilkin BM, Bing X, Ahn C, Wong HR, Ferguson PJ, Moreland JG Journal of Immunology 2016 Feb 196 1376-1386 -
NOX2 protects against progressive lung injury and multiple organ dysfunction syndrome
Whitmore LC, Goss KL, Newell EA, Hilkin BM, Hook JS, Moreland JG American Journal of Physiology - Lung Cellular and Molecular Physiology 2014 Jul 307 L71-L82 -
The immune system in critical illness and injury
Moreland JG 2014 Jan 421-429 -
ROS-containing endosomal compartments: Implications for signaling
Paige Davis Volk A, Moreland JG 2014 201-224 -
NOX2 protects against prolonged inflammation, lung injury, and mortality following systemic insults
Whitmore LC, Hilkin BM, Goss KL, Wahle EM, Colaizy TT, Boggiatto PM, Varga SM, Miller FJ, Moreland JG Journal of innate immunity 2013 Nov 5 565-580 -
Transepithelial migration of neutrophils into the lung requires TREM-1
Klesney-Tait J, Keck K, Li X, Gilfillan S, Otero K, Baruah S, Meyerholz DK, Varga SM, Knudson CJ, Moninger TO, Moreland J, Zabner J, Colonna M Journal of Clinical Investigation 2013 Jan 123 138-149 -
Endotoxin priming of neutrophils requires endocytosis and NADPH oxidase-dependent endosomal reactive oxygen species
Lamb FS, Hook JS, Hilkin BM, Huber JN, Volk AP, Moreland JG Journal of Biological Chemistry 2012 Apr 287 12395-12404 -
Priming of neutrophils and differentiated PLB-985 cells by pathophysiological concentrations of TNF-α is partially oxygen dependent
Volk AP, Barber BM, Goss KL, Ruff JG, Heise CK, Hook JS, Moreland JG Journal of innate immunity 2011 Apr 3 298-314 -
The Accreditation Council for Graduate Medical Education proposed work hour regulations
Goodman DM, Winkler MK, Fiser RT, Abd-Allah S, Mathur M, Rivero N, Weiss IK, Peterson B, Cornfield DN, Mink R, Nozik Grayck E, McCabe ME, Schuette J, Nares MA, Totapally B, Petrillo-Albarano T, Wolfson RK, Moreland JG, Potter KE, Fackler J, Garber N, Burns JP, Shanley TP, Lieh-Lai MW, Steiner M, Tieves KS, Goldsmith M, Asuncion A, Ross SL, Howell JD, Biagas K, Ognibene K, Joshi P, Rubenstein JS, Kocis KC, Cheifetz IM, Turner DA, Doughty L, Hall MW, Mason K, Penfil S, Morrison W, Hoehn KS, Watson RS, Garcia RL, Storgion SA, Fleming GM, Castillo L, Tcharmtchi MH, Taylor RP, Ul Haque I, Crain N, Baden HP, Lee KJ Pediatric Critical Care Medicine 2011 Jan 12 120-121 -
Multiple mechanisms of NADPH oxidase inhibition by type A and type B Francisella tularensis
McCaffrey RL, Schwartz JT, Lindemann SR, Moreland JG, Buchan BW, Jones BD, Allen LA Journal of Leukocyte Biology 2010 Oct 88 791-805 -
Activation of swelling-activated chloride current by tumor necrosis factor-α requires ClC-3-dependent endosomal reactive oxygen production
Matsuda JJ, Filali MS, Moreland JG, Miller FJ, Lamb FS Journal of Biological Chemistry 2010 Jul 285 22864-22873 -
Electrophysiology of reactive oxygen production in signaling endosomes
Lamb FS, Moreland JG, Miller FJ Antioxidants and Redox Signaling 2009 Jun 11 1335-1347 -
Francisella tularensis directly interacts with the endothelium and recruits neutrophils with a blunted inflammatory phenotype
Moreland JG, Hook JS, Bailey G, Ulland T, Nauseef WM American Journal of Physiology - Lung Cellular and Molecular Physiology 2009 Jun 296 L1076-L1084 -
ZEB1 enhances transendothelial migration and represses the epithelial phenotype of prostate cancer cells
Drake JM, Strohbehn G, Bair TB, Moreland JG, Henry MD Molecular Biology of the Cell 2009 Apr 20 2207-2217 -
ClC-3 and IClswell are required for normal neutrophil chemotaxis and shape change
Volk AP, Heise CK, Hougen JL, Artman CM, Volk KA, Wessels D, Soll DR, Nauseef WM, Lamb FS, Moreland JG Journal of Biological Chemistry 2008 Dec 283 34315-34326 -
Overexpression of CLC-3 in HEK293T cells yields novel currents that are pH dependent
Matsuda JJ, Filali MS, Volk KA, Collins MM, Moreland JG, Lamb FS American Journal of Physiology - Cell Physiology 2008 Jan 294 C251-C262 -
Endotoxin priming of neutrophils requires NADPH oxidase-generated oxidants and is regulated by the anion transporter ClC-3
Moreland JG, Davis AP, Matsuda JJ, Hook JS, Bailey G, Nauseef WM, Lamb FS Journal of Biological Chemistry 2007 Nov 282 33958-33967 -
Pre-Surgical Evaluation of Interrupted Aortic Arch With 3-Dimensional Reconstruction of CT Images
Morriss J, Moreland J, Burkhart H, Kao S Annals of Thoracic Surgery 2007 Jul 84 299 -
The antibacterial activity of human neutrophils and eosinophils requires proton channels but not BK channels
Femling JK, Cherny VV, Morgan D, Rada B, Davis AP, Czirják G, Enyedi P, England SK, Moreland JG, Ligeti E, Nauseef WM, DeCoursey TE Journal of General Physiology 2006 Jun 127 659-672 -
Anion channels, including ClC-3, are required for normal neutrophil oxidative function, phagocytosis, and transendothelial migration
Moreland JG, Davis AP, Bailey G, Nauseef WM, Lamb FS Journal of Biological Chemistry 2006 May 281 12277-12288 -
Neutrophil transendothelial migration in vitro to Streptococcus pneumoniae is pneumolysin dependent
Moreland JG, Bailey G American Journal of Physiology - Lung Cellular and Molecular Physiology 2006 May 290 L833-L840 -
Organism-Specific Neutrophil-Endothelial Cell Interactions in Response to Escherichia coli, Streptococcus pneumoniae, and Staphylococcus aureus
Moreland JG, Bailey G, Nauseef WM, Weiss JP Journal of Immunology 2004 Jan 172 426-432 -
CD11b and intercellular adhesion molecule-1 are involved in pulmonary neutrophil recruitment in lipopolysaccharide-induced airway disease
Moreland JG, Fuhrman RM, Pruessner JA, Schwartz DA American journal of respiratory cell and molecular biology 2002 Oct 27 474-480 -
TNF-α and IL-1β are not essential to the inflammatory response in LPS-induced airway disease
Moreland JG, Fuhrman RM, Wohlford-Lenane CL, Quinn TJ, Benda E, Pruessner JA, Schwartz DA American Journal of Physiology - Lung Cellular and Molecular Physiology 2001 Jan 280 L173-L180
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Role for IRAK-4 and p38 in Neutrophil Signaling in Response to Bacterial Lipoproteins from Staphylococcus aureus
Research
- Translational analysis of neutrophil activation state during cardiopulmonary bypass and during chronic inflammatory disease
- Neutrophil priming
- NADPH oxidase and reactive oxygen species signaling
- Inflammation and the resolution of inflammation
- Granule and vesicle exocytosis
Results: 1 Locations
Children's Medical Center of Dallas
1935 Medical District DriveDallas, Texas 75235 214-730-5437 Directions to Children's Medical Center of Dallas at Children's Medical Center of Dallas, Dallas