John Battaile, M.D.

Associate Program Director, Pulmonary and Critical Care Fellowship Program

Internal Medicine - Pulmonary and Critical Care Medicine
Hereditary Hemorrhagic Telangiectasia
Lung (Pulmonary) Disorders

New Patient Appointment Accepting Virtual Visits or 214-645-6616

Biography

John Turbeville Battaile, M.D., is a Professor in the Department of Internal Medicine at UT Southwestern Medical Center, where he also serves as Medical Director of the Hereditary Hemorrhagic Telangiectasia Center of Excellence and Director of the Pulmonary and Critical Care Medicine Fellowship Program. He specializes in hereditary hemorrhagic telangiectasia.

Dr. Battaile earned his medical degree at the University of Tennessee. He completed both his residency in internal medicine and fellowship in pulmonary diseases and critical care medicine at Washington University in St. Louis. He also holds a master’s degree in clinical investigation from Washington University School of Medicine.

Certified by the American Board of Internal Medicine, Dr. Battaile joined the UT Southwestern faculty in 2009.

Dr. Battaile’s research interests focus on improving care for patients with hereditary hemorrhagic telangiectasia, a rare disorder characterized by malformations of various blood vessels, potentially resulting in bleeding. He is the author of numerous book chapters and scholarly articles and has presented his work worldwide.

He is a member of the American College of Chest Physicians, the American Thoracic Society, the Texas Medical Association, and the Dallas County Medical Society.

Education & Training

Medical School - University of Tennessee Health Science Center (1995-1999)
Graduate School - Washington University School of Medicine (2007-2009)
Fellowship - Washington University School of Medicine (2003-2006), Pulmonary Diseases & Critical Care Medicine
Residency - Washington University in St. Louis School of Medicine (1999-2002), Internal Medicine
Other Post Graduate Training - Washington University School of Medicine (2007-2009)

Professional Associations & Affiliations

American College of Chest Physicians
American Thoracic Society
Dallas County Medical Society
Texas Medical Association

Honors & Awards

Multidisciplinary Clinical Research Career Development Award 2007
Knowlton Award for Clinical Excellence 2004
Clinicopathologic Conference 2002, Elected by fellow residents as discussant for year-end conference

Books & Publications

Publications
- Retrospective Comparison of Pulmonary Arteriovenous Malformation Embolization with the Polytetrafluoroethylene-Covered Nitinol Microvascular Plug, AMPLATZER Plug, and Coils in Patients with Hereditary Hemorrhagic Telangiectasia.
  Ratnani R, Sutphin PD, Koshti V, Park H, Chamarthy M, Battaile J, Kalva SP, Journal of vascular and interventional radiology : JVIR 2019 Jul 30 7 1089-1097
- Triggering Receptor Expressed on Myeloid Cells-2 (TREM-2) expression tracks with M2-like macrophage activity and disease severity in COPD.
  Byers DE, Wu K, Dang-Vu G, Jin X, Agapov E, Zhang X, Battaile JT, Schechtman K, Yusen R, Pierce RA, Holtzman MJ Chest 2017 Oct
- Primary Outcomes in Acute Respiratory Distress Syndrome Research.
  Adams TN, Battaile JT Critical care medicine 2017 Oct 45 10 e1096
- Pro-inflammatory phenotype of COPD fibroblasts not compatible with repair in COPD lung.
  Zhang J, Wu L, Qu JM, Bai CX, Merrilees MJ, Black PN, Journal of cellular and molecular medicine 2012 Jul 16 7 1522-32
- CD46 protects against chronic obstructive pulmonary disease.
  Grumelli S, Lu B, Peterson L, Maeno T, Gerard C, PloS one 2011 May 6 5 e18785
- Cigarette smoke induces nucleic-acid oxidation in lung fibroblasts.
  Deslee G, Adair-Kirk TL, Betsuyaku T, Woods JC, Moore CH, Gierada DS, Conradi SH, Atkinson JJ, Toennies HM, Battaile JT, Kobayashi DK, Patterson GA, Holtzman MJ, Pierce RA American journal of respiratory cell and molecular biology 2010 Nov 43 5 576-84
- Macrophage chitinase 1 stratifies chronic obstructive lung disease.
  Agapov E, Battaile JT, Tidwell R, Hachem R, Patterson GA, Pierce RA, Atkinson JJ, Holtzman MJ American journal of respiratory cell and molecular biology 2009 Oct 41 4 379-84
- Elastin expression in very severe human COPD.
  Deslee G, Woods JC, Moore CM, Liu L, Conradi SH, Milne M, Gierada DS, Pierce J, Patterson A, Lewit RA, Battaile JT, Holtzman MJ, Hogg JC, Pierce RA The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2009 Aug 34 2 324-31
- Oxidative damage to nucleic acids in severe emphysema.
  Deslee G, Woods JC, Moore C, Conradi SH, Gierada DS, Atkinson JJ, Battaile JT, Liu L, Patterson GA, Adair-Kirk TL, Holtzman MJ, Pierce RA Chest 2009 Apr 135 4 965-74
- Immune pathways for translating viral infection into chronic airway disease.
  Holtzman MJ, Byers DE, Benoit LA, Battaile JT, You Y, Agapov E, Park C, Grayson MH, Kim EY, Patel AC Advances in immunology 2009 102 245-76
- Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease.
  Kim EY, Battaile JT, Patel AC, You Y, Agapov E, Grayson MH, Benoit LA, Byers DE, Alevy Y, Tucker J, Swanson S, Tidwell R, Tyner JW, Morton JD, Castro M, Polineni D, Patterson GA, Schwendener RA, Allard JD, Peltz G, Holtzman MJ Nature medicine 2008 Jun 14 6 633-40
- Matrix metalloproteinase expression by human alveolar macrophages in relation to emphysema.
  Wallace AM, Sandford AJ, English JC, Burkett KM, Li H, Finley RJ, Müller NL, Coxson HO, Paré PD, Abboud RT, COPD 2008 Feb 5 1 13-23
- Induction of high-affinity IgE receptor on lung dendritic cells during viral infection leads to mucous cell metaplasia.
  Grayson MH, Cheung D, Rohlfing MM, Kitchens R, Spiegel DE, Tucker J, Battaile JT, Alevy Y, Yan L, Agapov E, Kim EY, Holtzman MJ The Journal of experimental medicine 2007 Oct 204 11 2759-69
- Influenza virus receptor specificity and cell tropism in mouse and human airway epithelial cells.
  Ibricevic A, Pekosz A, Walter MJ, Newby C, Battaile JT, Brown EG, Holtzman MJ, Brody SL Journal of virology 2006 Aug 80 15 7469-80
- Blocking airway mucous cell metaplasia by inhibiting EGFR antiapoptosis and IL-13 transdifferentiation signals.
  Tyner JW, Kim EY, Ide K, Pelletier MR, Roswit WT, Morton JD, Battaile JT, Patel AC, Patterson GA, Castro M, Spoor MS, You Y, Brody SL, Holtzman MJ The Journal of clinical investigation 2006 Feb 116 2 309-21

Research

Airway Inflammation in COPD and Asthma
Alternative Macrophage Activation
Hereditary Hemorrhagic Telangiectasia
Immune Mechanisms of Acute and Chronic Lung Injury
Role of Infection in the Development of Chronic Inflammation Lung Disease

Clinical Focus

Hereditary Hemorrhagic Telangiectasia
Lung (Pulmonary) Disorders
Critical Care Medicine