John Minna, M.D.

Harold C. Simmons Comprehensive Cancer Center

Max L. Thomas Distinguished Chair in Molecular Pulmonary Oncology
Sarah M. and Charles E. Seay Distinguished Chair in Cancer Research

Internal Medicine - Hematology/Oncology
Lung Cancer

Biography

John Minna, M.D., is a Professor in the Department of Internal Medicine and Department of Pharmacology at UT Southwestern Medical Center. He specializes in lung cancer.

Dr. Minna earned his medical degree at Stanford Medical School. He completed a residency in internal medicine at Massachusetts General Hospital and received advanced training in biochemical genetics through a fellowship at the National Institutes of Health.

Certified by the American Board of Internal Medicine in medical oncology, he joined the UT Southwestern faculty in 1991.

Dr. Minna is Director of the Hamon Center for Therapeutic Oncology Research at UT Southwestern. He holds the Max L. Thomas Distinguished Chair in Molecular Pulmonary Oncology and the Sarah M. and Charles E. Seay Distinguished Chair in Cancer Research.

Prior to joining UT Southwestern, he was Chief of the Section of Somatic Cell Genetics, Chief of the National Cancer Institute (NCI)-VA, and Chief of the NCI-Navy Medical Oncology Branch.

Dr. Minna’s research has focused on understanding the molecular pathogenesis of lung cancer and translating his findings into the clinic. As part of this, he has trained many investigators in lung cancer research. He leads a joint Lung Cancer NCI Special Program of Research Excellence (SPORE) grant between UT Southwestern and MD Anderson Cancer Center and is part of several NCI and State of Texas Cancer Prevention and Research Institute (CPRIT) multi-investigator grants to discover new therapeutic approaches and personalized medicine for lung cancer.

He co-leads the Experimental Therapeutics Program at UT Southwestern’s Harold C. Simmons Comprehensive Cancer Center. Currently, he is working with a team of UT Southwestern and MD Anderson scientists to discover all of the “acquired vulnerabilities” in lung cancer and their associated predictive molecular signatures to provide a new functional classification of lung cancer and rationale therapeutics for all new lung cancer patients.

Dr. Minna has served on the scientific advisory boards for several cancer centers and cancer research foundations, including the V Foundation and the NCI. Additionally, he has served on the board of directors for the American Association for Cancer Research and the American Society of Clinical Oncology. Currently, he is on the external advisory boards of the cancer centers at UC San Diego and the University of California, Los Angeles.

He has earned numerous awards, including the United Against Lung Cancer Caine Halter Hope Now Award for Lung Cancer Research in 2013, the Giants of Cancer Care award in 2015, and the Abbott ISOBM Award in 2016.

Education & Training

Fellowship - National Institutes of Health (1969-1973), Biochemical Genetics
Residency - Massachusetts General Hospital (1968-1969), Medicine
Internship - Massachusetts General Hospital (1967-1968), Medicine
Medical School - Stanford University Medical Center (1963-1967)

Professional Associations & Affiliations

American Association for Cancer Research
American College of Physicians (Fellow)
American Federation for Clinical Research
American Society for Biochemistry and Molecular Biology
American Society of Clinical Oncology
American Society for Clinical Investigation
American Society of Hematology
American Thoracic Society
Association of American Physicians
International Association for the Study of Lung Cancer

Honors & Awards

Abbott ISOBM Award 2016
Giants of Cancer Care 2015
Caine Halter Hope Now Award for Lung Cancer Research 2013, United Against Lung Cancer
Asclepios Award 2012, Addario Lung Cancer Foundation
Helis Foundation Award for Lifetime Achievement in Lung Cancer Research 2010, Baylor College of Medicine
ASCO Statesman Award 2007
Pfizer Visiting Professor Oncology 2006, Vanderbilt
ASCO Award 2005, Lifetime Scientific Achievement
Ochsner Award 2004, Award for Smoking Related Research
NCI SPORE Program Award for Leadership 2003
Moran Award 2000, University of Michigan
Bristol Myers Squibb Award 1997, Award for Lung Cancer Research
Chester Stock Award 1992, Memorial Sloan Kettering Cancer Center
Award for Scientific Excellence in Clinical Research 1989, Milken Foundation
Rosenthal Prize 1984, Prize for Cancer Research
Unit Commendation Medal 1991
Meritorious Service Medical 1986
PHS Commendation Medal 1979

Books & Publications

Publications
- SLC43A3 is a Biomarker of Sensitivity to the Telomeric DNA Damage Mediator 6-Thio-2'-Deoxyguanosine.
  Mender I, Batten K, Peyton M, Vemula A, Cornelius C, Girard L, Gao B, Minna JD, Shay JW, Cancer research 2020 Jan
- UCHL1 has prognostic relevance and is a therapeutic target for high-grade neuroendocrine lung cancers.
  Shimada Y, Kudo Y, Maehara S, Matsubayashi J, Otaki Y, Kajiwara N, Ohira T, Minna JD, Ikeda N, Cancer science 2019 Dec
- From clinical specimens to human cancer preclinical models-a journey the NCI-cell line database-25 years later.
  Mulshine JL, Ujhazy P, Antman M, Burgess CM, Kuzmin I, Bunn PA, Johnson BE, Roth JA, Pass HI, Ross SM, Aldige CR, Wistuba II, Minna JD, Journal of cellular biochemistry 2019 Dec
- A Proteomic Connectivity Map for Characterizing the Tumor Adaptive Response to Small Molecule Chemical Perturbagens.
  Zi Z, Zhang Y, Zhang P, Ding Q, Chu M, Chen Y, Minna JD, Yu Y, ACS chemical biology 2019 Dec
- RUVBL1/RUVBL2 ATPase Activity Drives PAQosome Maturation, DNA Replication and Radioresistance in Lung Cancer.
  Yenerall P, Das AK, Wang S, Kollipara RK, Li LS, Villalobos P, Flaming J, Lin YF, Huffman K, Timmons BC, Gilbreath C, Sonavane R, Kinch LN, Rodriguez-Canales J, Moran C, Behrens C, Hirasawa M, Takata T, Murakami R, Iwanaga K, Chen BPC, Grishin NV, Raj GV, Wistuba II, Minna JD, Kittler R, Cell chemical biology 2019 Dec
- ConvPath: A software tool for lung adenocarcinoma digital pathological image analysis aided by a convolutional neural network.
  Wang S, Wang T, Yang L, Yang DM, Fujimoto J, Yi F, Luo X, Yang Y, Yao B, Lin S, Moran C, Kalhor N, Weissferdt A, Minna J, Xie Y, Wistuba II, Mao Y, Xiao G, EBioMedicine 2019 Nov
- Artificial Intelligence in Lung Cancer Pathology Image Analysis.
  Wang S, Yang DM, Rong R, Zhan X, Fujimoto J, Liu H, Minna J, Wistuba II, Xie Y, Xiao G, Cancers 2019 Oct 11 11
- Unbiased peptoid combinatorial cell screen identifies plectin protein as a potential biomarker for lung cancer stem cells.
  Raymond AC, Gao B, Girard L, Minna JD, Gomika Udugamasooriya D, Scientific reports 2019 Oct 9 1 14954
- Metabolic Diversity in Human Non-Small Cell Lung Cancer Cells.
  Chen PH, Cai L, Huffman K, Yang C, Kim J, Faubert B, Boroughs L, Ko B, Sudderth J, McMillan EA, Girard L, Chen D, Peyton M, Shields MD, Yao B, Shames DS, Kim HS, Timmons B, Sekine I, Britt R, Weber S, Byers LA, Heymach JV, Chen J, White MA, Minna JD, Xiao G, DeBerardinis RJ, Molecular cell 2019 Sep
- AIF: an acquired metabolic liability in lung cancer.
  Faubert B, DeBerardinis RJ, Minna JD, Cell research 2019 Aug 29 8 607-608
- p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas.
  Hsieh MH, Choe JH, Gadhvi J, Kim YJ, Arguez MA, Palmer M, Gerold H, Nowak C, Do H, Mazambani S, Knighton JK, Cha M, Goodwin J, Kang MK, Jeong JY, Lee SY, Faubert B, Xuan Z, Abel ED, Scafoglio C, Shackelford DB, Minna JD, Singh PK, Shulaev V, Bleris L, Hoyt K, Kim J, Inoue M, DeBerardinis RJ, Kim TH, Kim JW, Cell reports 2019 Aug 28 7 1860-1878.e9
- Subtype-specific secretomic characterization of pulmonary neuroendocrine tumor cells.
  Wang XD, Hu R, Ding Q, Savage TK, Huffman KE, Williams N, Cobb MH, Minna JD, Johnson JE, Yu Y, Nature communications 2019 Jul 10 1 3201
- Systematic Analysis of Gene Expression in Lung Adenocarcinoma and Squamous Cell Carcinoma with a Case Study of FAM83A and FAM83B.
  Cai L, Luo D, Yao B, Yang DM, Lin S, Girard L, DeBerardinis RJ, Minna JD, Xie Y, Xiao G, Cancers 2019 Jun 11 6
- Molecular subtypes of small cell lung cancer: a synthesis of human and mouse model data.
  Rudin CM, Poirier JT, Byers LA, Dive C, Dowlati A, George J, Heymach JV, Johnson JE, Lehman JM, MacPherson D, Massion PP, Minna JD, Oliver TG, Quaranta V, Sage J, Thomas RK, Vakoc CR, Gazdar AF, Nature reviews. Cancer 2019 May 19 5 289-297
- Development and Validation of a Pathology Image Analysis-based Predictive Model for Lung Adenocarcinoma Prognosis - A Multi-cohort Study.
  Luo X, Yin S, Yang L, Fujimoto J, Yang Y, Moran C, Kalhor N, Weissferdt A, Xie Y, Gazdar A, Minna J, Wistuba II, Mao Y, Xiao G, Scientific reports 2019 May 9 1 6886
- LKB1 and KEAP1/NRF2 pathways cooperatively promote metabolic reprogramming with enhanced glutamine dependence in KRAS-mutant lung adenocarcinoma.
  Galan-Cobo A, Sitthideatphaiboon P, Qu X, Poteete A, Pisegna MA, Tong P, Chen PH, Boroughs LK, Rodriguez MLM, Zhang W, Parlati F, Wang J, Gandhi V, Skoulidis F, DeBerardinis RJ, Minna JD, Heymach JV, Cancer research 2019 Apr
- Checkpoint Inhibitor Pneumonitis: Too Clinically Serious For Benefit?
  Le T, Minna JD, Gerber DE Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2019 Mar 14 3 332-335
- Small cell lung cancers made from scratch.
  Gazdar AF, Minna JD The Journal of experimental medicine 2019 Feb
- ClickGene: an open cloud-based platform for big pan-cancer data genome-wide association study, visualization and exploration.
  Bi JH, Tong YF, Qiu ZW, Yang XF, Minna J, Gazdar AF, Song K, BioData mining 2019 12 12
- Inhibition of Thioredoxin/Thioredoxin Reductase Induces Synthetic Lethality in Lung Cancers with Compromised Glutathione Homeostasis.
  Yan X, Zhang X, Wang L, Zhang R, Pu X, Wu S, Li L, Tong P, Wang J, Meng QH, Jensen VB, Girard L, Minna JD, Roth JA, Swisher SG, Heymach JV, Fang B Cancer research 2019 Jan 79 1 125-132
- Elucidating synergistic dependencies in lung adenocarcinoma by proteome-wide signaling-network analysis.
  Bansal M, He J, Peyton M, Kustagi M, Iyer A, Comb M, White M, Minna JD, Califano A PloS one 2019 14 1 e0208646
- LCE: an open web portal to explore gene expression and clinical associations in lung cancer.
  Cai L, Lin S, Girard L, Zhou Y, Yang L, Ci B, Zhou Q, Luo D, Yao B, Tang H, Allen J, Huffman K, Gazdar A, Heymach J, Wistuba I, Xiao G, Minna J, Xie Y Oncogene 2018 Dec
- Transmembrane Protease TMPRSS11B Promotes Lung Cancer Growth by Enhancing Lactate Export and Glycolytic Metabolism.
  Updegraff BL, Zhou X, Guo Y, Padanad MS, Chen PH, Yang C, Sudderth J, Rodriguez-Tirado C, Girard L, Minna JD, Mishra P, DeBerardinis RJ, O'Donnell KA Cell reports 2018 Nov 25 8 2223-2233.e6
- Different Originating Cells Underlie Intertumoral Heterogeneity in Lung Neuroendocrine Tumors.
  Pozo K, Kelenis DP, Minna JD, Johnson JE Cancer discovery 2018 Oct 8 10 1216-1218
- Validation of the 12-gene predictive signature for Adjuvant Chemotherapy Response in Lung Cancer.
  Xie Y, Lu W, Wang S, Tang X, Tang H, Zhou Y, Moran C, Behrens C, Roth JA, Zhou Q, Johnson DH, Swisher SG, Heymach JV, Papadimitrakopoulou VA, Xiao G, Minna JD, Wistuba II Clinical cancer research : an official journal of the American Association for Cancer Research 2018 Oct
- HORMAD1 is a negative prognostic indicator in lung adenocarcinoma and specifies resistance to oxidative and genotoxic stress.
  Nichols BA, Oswald NW, McMillan EA, McGlynn K, Yan J, Kim MS, Saha J, Mallipeddi PL, LaDuke SA, Villalobos PA, Rodriguez-Canales J, Wistuba II, Posner BA, Davis AJ, Minna JD, MacMillan JB, Whitehurst AW Cancer research 2018 Sep
- -altered non-small cell lung cancer.
  Ruder D, Papadimitrakopoulou V, Shien K, Behrens C, Kalhor N, Chen H, Shen L, Lee JJ, Hong WK, Tang X, Girard L, Minna JD, Diao L, Wang J, Mino B, Villalobos P, Rodriguez-Canales J, Hanson NE, Sun J, Miller V, Greenbowe J, Frampton G, Herbst RS, Baladandayuthapani V, Wistuba II, Izzo JG Oncotarget 2018 Sep 9 74 33995-34008
- Retraction notice to "Sun exposure related methylation in malignant and non-malignant skin lesions" [Cancer Letters 245/1-2 (2007) 112-120].
  Sathyanarayana UG, Moore AY, Li L, Padar A, Majmudar K, Stastny V, Makarla P, Suzuki M, Minna JD, Feng Z, Gazdar AF Cancer letters 2018 Sep 432 272
- Corrigendum: Identifying a missing lineage driver in a subset of lung neuroendocrine tumors.
  Pozo K, Minna JD, Johnson JE Genes & development 2018 09 32 17-18 1266
- Kub5-Hera RPRD1B deficiency promotes "BRCAness" and vulnerability to PARP inhibition in BRCA-proficient Breast Cancers.
  Motea EA, Fattah FJ, Xiao L, Girard L, Rommel A, Morales JC, Patidar P, Zhou Y, Porter A, Xie Y, Minna JD, Boothman DA Clinical cancer research : an official journal of the American Association for Cancer Research 2018 Aug
- Telomerase-Mediated Strategy for Overcoming Non-Small Cell Lung Cancer Targeted Therapy and Chemotherapy Resistance.
  Mender I, LaRanger R, Luitel K, Peyton M, Girard L, Lai TP, Batten K, Cornelius C, Dalvi MP, Ramirez M, Du W, Wu LF, Altschuler SJ, Brekken R, Martinez ED, Minna JD, Wright WE, Shay JW Neoplasia (New York, N.Y.) 2018 Aug 20 8 826-837
- A quantitative method for assessing smoke associated molecular damage in lung cancers.
  Song K, Bi JH, Qiu ZW, Felizardo R, Girard L, Minna JD, Gazdar AF Translational lung cancer research 2018 Aug 7 4 439-449
- LMO1 functions as an oncogene by regulating TTK expression and correlates with neuroendocrine differentiation of lung cancer.
  Du L, Zhao Z, Suraokar M, Shelton SS, Ma X, Hsiao TH, Minna JD, Wistuba I, Pertsemlidis A Oncotarget 2018 Jul 9 51 29601-29618
- Inosine Monophosphate Dehydrogenase Dependence in a Subset of Small Cell Lung Cancers.
  Huang F, Ni M, Chalishazar MD, Huffman KE, Kim J, Cai L, Shi X, Cai F, Zacharias LG, Ireland AS, Li K, Gu W, Kaushik AK, Liu X, Gazdar AF, Oliver TG, Minna JD, Hu Z, DeBerardinis RJ Cell metabolism 2018 Jun
- TNF-driven adaptive response mediates resistance to EGFR inhibition in lung cancer.
  Gong K, Guo G, Gerber DE, Gao B, Peyton M, Huang C, Minna JD, Hatanpaa KJ, Kernstine K, Cai L, Xie Y, Zhu H, Fattah FJ, Zhang S, Takahashi M, Mukherjee B, Burma S, Dowell J, Dao K, Papadimitrakopoulou VA, Olivas V, Bivona TG, Zhao D, Habib AA The Journal of clinical investigation 2018 Jun 128 6 2500-2518
- Diagnosis and management of pulmonary toxicity associated with cancer immunotherapy.
  Rashdan S, Minna JD, Gerber DE The Lancet. Respiratory medicine 2018 Jun 6 6 472-478
- Chemistry-First Approach for Nomination of Personalized Treatment in Lung Cancer.
  McMillan EA, Ryu MJ, Diep CH, Mendiratta S, Clemenceau JR, Vaden RM, Kim JH, Motoyaji T, Covington KR, Peyton M, Huffman K, Wu X, Girard L, Sung Y, Chen PH, Mallipeddi PL, Lee JY, Hanson J, Voruganti S, Yu Y, Park S, Sudderth J, DeSevo C, Muzny DM, Doddapaneni H, Gazdar A, Gibbs RA, Hwang TH, Heymach JV, Wistuba I, Coombes KR, Williams NS, Wheeler DA, MacMillan JB, Deberardinis RJ, Roth MG, Posner BA, Minna JD, Kim HS, White MA Cell 2018 Apr
- eIF2ß, a Subunit of Translation-Initiation Factor EIF2, Is a Potential Therapeutic Target for Non-Small Cell Lung Cancer.
  Tanaka I, Sato M, Kato T, Goto D, Kakumu T, Miyazawa A, Yogo N, Hase T, Morise M, Sekido Y, Girard L, Minna JD, Byers LA, Heymach JV, Coombes KR, Kondo M, Hasegawa Y Cancer science 2018 Apr
- Evaluating tumor-suppressor gene combinations.
  Kim J, Minna JD Nature genetics 2018 Apr 50 4 480-482
- Small cell lung cancer tumors and preclinical models display heterogeneity of neuroendocrine phenotypes.
  Zhang W, Girard L, Zhang YA, Haruki T, Papari-Zareei M, Stastny V, Ghayee HK, Pacak K, Oliver TG, Minna JD, Gazdar AF Translational lung cancer research 2018 Feb 7 1 32-49
- Silencing the Snail-dependent RNA splice regulator ESRP1 drives malignant transformation of human pulmonary epithelial cells.
  Walser TC, Jing Z, Tran LM, Lin YQ, Yakobian N, Wang G, Krysan K, Zhu LX, Sharma S, Lee MH, Belperio JA, Ooi AT, Gomperts BN, Shay JW, Larsen JE, Minna JD, Hong LS, Fishbein MC, Dubinett SM Cancer research 2018 Feb
- The Epithelial Sodium Channel (aENaC) Is a Downstream Therapeutic Target of ASCL1 in Pulmonary Neuroendocrine Tumors.
  He M, Liu S, Gallolu Kankanamalage S, Borromeo MD, Girard L, Gazdar AF, Minna JD, Johnson JE, Cobb MH Translational oncology 2018 Feb 11 2 292-299
- Estrogen Receptor Beta-Mediated Modulation of Lung Cancer Cell Proliferation by 27-Hydroxycholesterol.
  Hiramitsu S, Ishikawa T, Lee WR, Khan T, Crumbley C, Khwaja N, Zamanian F, Asghari A, Sen M, Zhang Y, Hawse JR, Minna JD, Umetani M Frontiers in endocrinology 2018 9 470
- The Impact of Smoking and TP53 mutations in lung adenocarcinoma patients with targetable mutations - the Lung Cancer Mutation Consortium (LCMC2).
  Aisner DL, Sholl LM, Berry L, Rossi M, Chen H, Fujimoto J, Moreira AL, Ramalingam S, Villaruz LC, Otterson GA, Haura EB, Politi K, Glisson BS, Cetnar J, Garon E, Schiller J, Waqar S, Sequist LV, Brahmer JR, Shyr Y, Kugler K, Wistuba II, Johnson BE, Minna JD, Kris MG, Bunn PA, Kwiatkowski DJ Clinical cancer research : an official journal of the American Association for Cancer Research 2017 Dec
- Small-cell lung cancer: what we know, what we need to know and the path forward.
  Gazdar AF, Bunn PA, Minna JD Nature reviews. Cancer 2017 Oct
- Quantitative Proteomic Analysis of Optimal Cutting Temperature (OCT) Embedded Core-Needle Biopsy of Lung Cancer.
  Zhao X, Huffman KE, Fujimoto J, Canales JR, Girard L, Nie G, Heymach JV, Wistuba II, Minna JD, Yu Y Journal of the American Society for Mass Spectrometry 2017 Jul
- JAK1/STAT3 activation through a proinflammatory cytokine pathway leads to resistance to molecularly targeted therapy in non-small cell lung cancer.
  Shien K, Papadimitrakopoulou VA, Ruder D, Behrens C, Shen L, Kalhor N, Song J, Lee JJ, Wang J, Tang X, Herbst RS, Toyooka S, Girard L, Minna JD, Kurie JM, Wistuba II, Izzo JG Molecular cancer therapeutics 2017 Jul
- Identification of a human airway epithelial cell subpopulation with altered biophysical, molecular, and metastatic properties.
  Pagano PC, Tran LM, Bendris N, O'Byrne S, Tse HT, Sharma S, Hoech JW, Park SJ, Liclican EL, Jing Z, Li R, Krysan K, Paul MK, Fontebasso Y, Larsen JE, Hakimi S, Seki A, Fishbein MC, Gimzewski JK, Di Carlo D, Minna JD, Walser TC, Dubinett SM Cancer prevention research (Philadelphia, Pa.) 2017 Jul
- CHK1 Inhibition in Small-Cell Lung Cancer Produces Single-Agent Activity in Biomarker-Defined Disease Subsets and Combination Activity with Cisplatin or Olaparib.
  Sen T, Tong P, Stewart CA, Cristea S, Valliani A, Shames DS, Redwood AB, Fan YH, Li L, Glisson BS, Minna JD, Sage J, Gibbons DL, Piwnica-Worms H, Heymach JV, Wang J, Byers LA Cancer research 2017 Jul 77 14 3870-3884
- CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells.
  Kim J, Hu Z, Cai L, Li K, Choi E, Faubert B, Bezwada D, Rodriguez-Canales J, Villalobos P, Lin YF, Ni M, Huffman KE, Girard L, Byers LA, Unsal-Kacmaz K, Peña CG, Heymach JV, Wauters E, Vansteenkiste J, Castrillon DH, Chen BPC, Wistuba I, Lambrechts D, Xu J, Minna JD, DeBerardinis RJ Nature 2017 Jun 546 7656 168-172
- The distinct metabolic phenotype of lung squamous cell carcinoma defines selective vulnerability to glycolytic inhibition.
  Goodwin J, Neugent ML, Lee SY, Choe JH, Choi H, Jenkins DMR, Ruthenborg RJ, Robinson MW, Jeong JY, Wake M, Abe H, Takeda N, Endo H, Inoue M, Xuan Z, Yoo H, Chen M, Ahn JM, Minna JD, Helke KL, Singh PK, Shackelford DB, Kim JW Nature communications 2017 May 8 15503
- Taxane-Platin-Resistant Lung Cancers Co-develop Hypersensitivity to JumonjiC Demethylase Inhibitors.
  Dalvi MP, Wang L, Zhong R, Kollipara RK, Park H, Bayo J, Yenerall P, Zhou Y, Timmons BC, Rodriguez-Canales J, Behrens C, Mino B, Villalobos P, Parra ER, Suraokar M, Pataer A, Swisher SG, Kalhor N, Bhanu NV, Garcia BA, Heymach JV, Coombes K, Xie Y, Girard L, Gazdar AF, Kittler R, Wistuba II, Minna JD, Martinez ED Cell reports 2017 May 19 8 1669-1684
- Combination Therapy Targeting BCL6 and Phospho-STAT3 Defeats Intratumor Heterogeneity in a Subset of Non-Small Cell Lung Cancers.
  Deb D, Rajaram S, Larsen JE, Dospoy PD, Marullo R, Li LS, Avila K, Xue F, Cerchietti L, Minna JD, Altschuler SJ, Wu LF Cancer research 2017 Apr
- Genetic variations in cancer-related significantly mutated genes and lung cancer susceptibility.
  Zhang Y, Zhang L, Li R, Chang DW, Ye Y, Minna JD, Roth JA, Han B, Wu X Annals of oncology : official journal of the European Society for Medical Oncology 2017 Apr
- Identification of Proteasomal Catalytic Subunit PSMA6 as a Therapeutic Target for Lung Cancer.
  Kakumu T, Sato M, Goto D, Kato T, Yogo N, Hase T, Morise M, Fukui T, Yokoi K, Sekido Y, Girard L, Minna JD, Byers LA, Heymach JV, Coombes KR, Kondo M, Hasegawa Y Cancer science 2017 Feb
- Comprehensive evaluation of published gene expression prognostic signatures for biomarker-based lung cancer clinical studies.
  Tang H, Wang S, Xiao G, Schiller J, Papadimitrakopoulou V, Minna J, Wistuba II, Xie Y Annals of oncology : official journal of the European Society for Medical Oncology 2017 Feb
- Characterization of Human Cancer Cell Lines by Reverse-phase Protein Arrays.
  Li J, Zhao W, Akbani R, Liu W, Ju Z, Ling S, Vellano CP, Roebuck P, Yu Q, Eterovic AK, Byers LA, Davies MA, Deng W, Gopal YN, Chen G, von Euw EM, Slamon D, Conklin D, Heymach JV, Gazdar AF, Minna JD, Myers JN, Lu Y, Mills GB, Liang H Cancer cell 2017 Feb 31 2 225-239
- Proportion of Never-Smoker Non-Small Cell Lung Cancer Patients at Three Diverse Institutions.
  Pelosof L, Ahn C, Gao A, Horn L, Madrigales A, Cox J, McGavic D, Minna JD, Gazdar AF, Schiller J Journal of the National Cancer Institute 2017 Jan 109 7
- SMARCA4-inactivating mutations increase sensitivity to Aurora kinase A inhibitor VX-680 in non-small cell lung cancers.
  Tagal V, Wei S, Zhang W, Brekken RA, Posner BA, Peyton M, Girard L, Hwang T, Wheeler DA, Minna JD, White MA, Gazdar AF, Roth MG Nature communications 2017 Jan 8 14098
- Non-malignant respiratory epithelial cells preferentially proliferate from resected non-small cell lung cancer specimens cultured under conditionally reprogrammed conditions.
  Gao B, Huang C, Kernstine K, Pelekanou V, Kluger Y, Jiang T, Peters-Hall JR, Coquelin M, Girard L, Zhang W, Huffman K, Oliver D, Kinose F, Haura E, Teer JK, Rix U, Le AT, Aisner DL, Varella-Garcia M, Doebele RC, Covington KR, Hampton OA, Doddapaneni HV, Jayaseelan JC, Hu J, Wheeler DA, Shay JW, Rimm DL, Gazdar A, Minna JD Oncotarget 2016 Dec
- Leveraging an NQO1 Bioactivatable Drug for Tumor-Selective Use of Poly(ADP-ribose) Polymerase Inhibitors.
  Huang X, Motea EA, Moore ZR, Yao J, Dong Y, Chakrabarti G, Kilgore JA, Silvers MA, Patidar PL, Cholka A, Fattah F, Cha Y, Anderson GG, Kusko R, Peyton M, Yan J, Xie XJ, Sarode V, Williams NS, Minna JD, Beg M, Gerber DE, Bey EA, Boothman DA Cancer cell 2016 Dec 30 6 940-952
- PROTOCADHERIN 7 Acts through SET and PP2A to Potentiate MAPK Signaling by EGFR and KRAS during Lung Tumorigenesis.
  Zhou X, Updegraff BL, Guo Y, Peyton M, Girard L, Larsen JE, Xie XJ, Zhou Y, Hwang TH, Xie Y, Rodriguez-Canales J, Villalobos P, Behrens C, Wistuba II, Minna JD, O'Donnell KA Cancer research 2016 Nov
- Developing New, Rational Therapies for Recalcitrant Small Cell Lung Cancer.
  Gazdar AF, Minna JD Journal of the National Cancer Institute 2016 Oct 108 10
- XPO1-dependent nuclear export is a druggable vulnerability in KRAS-mutant lung cancer.
  Kim J, McMillan E, Kim HS, Venkateswaran N, Makkar G, Rodriguez-Canales J, Villalobos P, Neggers JE, Mendiratta S, Wei S, Landesman Y, Senapedis W, Baloglu E, Chow CB, Frink RE, Gao B, Roth M, Minna JD, Daelemans D, Wistuba II, Posner BA, Scaglioni PP, White MA Nature 2016 Sep 538 7623 114-117
- ZEB1 drives epithelial-to-mesenchymal transition in lung cancer.
  Larsen JE, Nathan V, Osborne JK, Farrow RK, Deb D, Sullivan JP, Dospoy PD, Augustyn A, Hight SK, Sato M, Girard L, Behrens C, Wistuba II, Gazdar AF, Hayward NK, Minna JD The Journal of clinical investigation 2016 Sep 126 9 3219-3235
- Developing EZH2-Targeted Therapy for Lung Cancer.
  Frankel AE, Liu X, Minna JD Cancer discovery 2016 Sep 6 9 949-52
- Functional polyesters enable selective siRNA delivery to lung cancer over matched normal cells.
  Yan Y, Liu L, Xiong H, Miller JB, Zhou K, Kos P, Huffman KE, Elkassih S, Norman JW, Carstens R, Kim J, Minna JD, Siegwart DJ Proceedings of the National Academy of Sciences of the United States of America 2016 Sep 113 39 E5702-10
- Fatty Acid Oxidation Mediated by Acyl-CoA Synthetase Long Chain 3 Is Required for Mutant KRAS Lung Tumorigenesis.
  Padanad MS, Konstantinidou G, Venkateswaran N, Melegari M, Rindhe S, Mitsche M, Yang C, Batten K, Huffman KE, Liu J, Tang X, Rodriguez-Canales J, Kalhor N, Shay JW, Minna JD, McDonald J, Wistuba II, DeBerardinis RJ, Scaglioni PP Cell reports 2016 Aug 16 6 1614-28
- Opening a Chromatin Gate to Metastasis.
  Minna JD, Johnson JE Cell 2016 Jul 166 2 275-6
- ASCL1 and NEUROD1 Reveal Heterogeneity in Pulmonary Neuroendocrine Tumors and Regulate Distinct Genetic Programs.
  Borromeo MD, Savage TK, Kollipara RK, He M, Augustyn A, Osborne JK, Girard L, Minna JD, Gazdar AF, Cobb MH, Johnson JE Cell reports 2016 Jul
- An Expression Signature as an Aid to the Histologic Classification of Non-Small Cell Lung Cancer.
  Girard L, Rodriguez-Canales J, Behrens C, Thompson DM, Botros IW, Tang H, Xie Y, Rekhtman N, Travis WD, Wistuba II, Minna JD, Gazdar AF Clinical cancer research : an official journal of the American Association for Cancer Research 2016 Jun
- Monitoring drug induced apoptosis and treatment sensitivity in non-small cell lung carcinoma using dielectrophoresis.
  Taruvai Kalyana Kumar R, Liu S, Minna JD, Prasad S Biochimica et biophysica acta 2016 Jun 1860 9 1877-1883
- Torin2 Suppresses Ionizing Radiation-Induced DNA Damage Repair.
  Udayakumar D, Pandita RK, Horikoshi N, Liu Y, Liu Q, Wong KK, Hunt CR, Gray NS, Minna JD, Pandita TK, Westover KD Radiation research 2016 May 185 5 527-38
- Telomerase inhibitor imetelstat has preclinical activity across the spectrum of non-small cell lung cancer oncogenotypes in a telomere length dependent manner.
  Frink RE, Peyton M, Schiller JH, Gazdar AF, Shay JW, Minna JD Oncotarget 2016 May
- Identification of lipid-phosphatidylserine (PS) as the target of unbiasedly selected cancer specific peptide-peptoid hybrid PPS1.
  Desai TJ, Toombs JE, Minna JD, Brekken RA, Udugamasooriya DG Oncotarget 2016 Apr
- Small Cell Lung Cancer: Can Recent Advances in Biology and Molecular Biology Be Translated into Improved Outcomes?
  Bunn PA, Minna JD, Augustyn A, Gazdar AF, Ouadah Y, Krasnow MA, Berns A, Brambilla E, Rekhtman N, Massion PP, Niederst M, Peifer M, Yokota J, Govindan R, Poirier JT, Byers LA, Wynes MW, McFadden DG, MacPherson D, Hann CL, Farago AF, Dive C, Teicher BA, Peacock CD, Johnson JE, Cobb MH, Wendel HG, Spigel D, Sage J, Yang P, Pietanza MC, Krug LM, Heymach J, Ujhazy P, Zhou C, Goto K, Dowlati A, Christensen CL, Park K, Einhorn LH, Edelman MJ, Giaccone G, Gerber DE, Salgia R, Owonikoko T, Malik S, Karachaliou N, Gandara DR, Slotman BJ, Blackhall F, Goss G, Thomas R, Rudin CM, Hirsch FR Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2016 Apr 11 4 453-74
- MiRNA-Related Genetic Variations Associated with Radiotherapy-Induced Toxicities in Patients with Locally Advanced Non-Small Cell Lung Cancer.
  Li R, Pu X, Chang JY, Ye Y, Komaki R, Minna JD, Roth JA, Han B, Wu X PloS one 2016 11 3 e0150467
- Quantitative Secretomic Analysis Identifies Extracellular Protein Factors That Modulate the Metastatic Phenotype of Non-Small Cell Lung Cancer.
  Hu R, Huffman KE, Chu M, Zhang Y, Minna JD, Yu Y Journal of proteome research 2016 Jan
- Computational Discovery of Pathway-Level Genetic Vulnerabilities in Non-Small-Cell Lung Cancer.
  Young JH, Peyton M, Kim HS, McMillan E, Minna JD, White MA, Marcotte EM Bioinformatics (Oxford, England) 2016 Jan
- Identification of Gene Expression Differences between Lymphangiogenic and Non-Lymphangiogenic Non-Small Cell Lung Cancer Cell Lines.
  Regan E, Sibley RC, Cenik BK, Silva A, Girard L, Minna JD, Dellinger MT PloS one 2016 11 3 e0150963
- Selecting Reliable mRNA Expression Measurements Across Platforms Improves Downstream Analysis.
  Tong P, Diao L, Shen L, Li L, Heymach JV, Girard L, Minna JD, Coombes KR, Byers LA, Wang J Cancer informatics 2016 15 81-9
- Validation of SCT Methylation As a Hallmark Biomarker for Lung Cancers.
  Zhang YA, Ma X, Sathe A, Fujimoto J, Wistuba II, Lam S, Yatabe Y, Wang YW, Stastny V, Gao B, Larsen JE, Girard L, Liu X, Song K, Behrens C, Kalhor N, Xie Y, Zhang MQ, Minna JD, Gazdar AF Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2015 Dec
- Modulation of EZH2 expression by MEK-ERK or PI3K-AKT signaling in lung cancer is dictated by different KRAS oncogene mutations.
  Riquelme E, Behrens C, Lin HY, Simon GR, Papadimitrakopoulou VA, Izzo J, Moran C, Kalhor N, Lee JJ, Minna JD, Wistuba II Cancer research 2015 Dec
- From Mice to Men and Back: An Assessment of Preclinical Model Systems for the Study of Lung Cancers.
  Gazdar AF, Hirsch FR, Minna JD Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2015 Dec
- Auranofin-mediated inhibition of PI3K/AKT/mTOR axis and anticancer activity in non-small cell lung cancer cells.
  Li H, Hu J, Wu S, Wang L, Cao X, Zhang X, Dai B, Cao M, Shao R, Zhang R, Majidi M, Ji L, Heymach JV, Wang M, Pan S, Minna J, Mehran RJ, Swisher SG, Roth JA, Fang B Oncotarget 2015 Dec
- Epithelial-Mesenchymal Transition Predicts Polo-Like Kinase 1 Inhibitor-Mediated Apoptosis in Non-Small Cell Lung Cancer.
  Ferrarotto R, Goonatilake R, Yoo SY, Tong P, Giri U, Peng S, Minna JD, Girard L, Wang Y, Wang L, Li L, Diao L, Peng DH, Gibbons DL, Glisson BS, Heymach JV, Wang J, Byers LA, Johnson FM Clinical cancer research : an official journal of the American Association for Cancer Research 2015 Nov
- Nicotinic acetylcholine receptor expression in human airway correlates with lung function.
  Lam DC, Luo SY, Fu KH, Lui MM, Chan KH, Wistuba II, Gao B, Tsao SW, Ip MS, Minna JD American journal of physiology. Lung cellular and molecular physiology 2015 Nov ajplung.00101.2015
- NRF2 regulates serine biosynthesis in non-small cell lung cancer.
  DeNicola GM, Chen PH, Mullarky E, Sudderth JA, Hu Z, Wu D, Tang H, Xie Y, Asara JM, Huffman KE, Wistuba II, Minna JD, DeBerardinis RJ, Cantley LC Nature genetics 2015 Oct
- Unbiased Selection of Peptide-Peptoid Hybrids Specific for Lung Cancer Compared to Normal Lung Epithelial Cells.
  Matharage JM, Minna JD, Brekken RA, Udugamasooriya DG ACS chemical biology 2015 Oct
- Cancer-specific production of N-acetylaspartate via NAT8L overexpression in non-small cell lung cancer and its potential as a circulating biomarker.
  Lou TF, Sethuraman D, Dospoy P, Srivastva P, Kim HS, Kim J, Ma X, Chen PH, Huffman KE, Frink RE, Larsen JE, Lewis CM, Um SW, Kim DH, Ahn JM, DeBerardinis RJ, White M, Minna JD, Yoo H Cancer prevention research (Philadelphia, Pa.) 2015 Oct
- LZTFL1 suppresses lung tumorigenesis by maintaining differentiation of lung epithelial cells.
  Wei Q, Chen ZH, Wang L, Zhang T, Duan L, Behrens C, Wistuba II, Minna JD, Gao B, Luo JH, Liu ZP Oncogene 2015 Sep
- A systematic analysis reveals heterogeneous changes in the endocytic activities of cancer cells.
  Elkin SR, Bendris N, Reis C, Zhou Y, Xie Y, Huffman KE, Minna JD, Schmid SL Cancer research 2015 Sep
- Co-occurring genomic alterations define major subsets of KRAS - mutant lung adenocarcinoma with distinct biology, immune profiles, and therapeutic vulnerabilities.
  Skoulidis F, Byers LA, Diao L, Papadimitrakopoulou VA, Tong P, Izzo J, Behrens C, Kadara H, Parra ER, Rodriguez-Canales J, Zhang J, Giri U, Gudikote J, Cortez MA, Yang C, Fan YH, Peyton M, Girard L, Coombes KR, Toniatti C, Heffernan TP, Choi M, Frampton GM, Miller V, Weinstein JN, Herbst RS, Wong KK, Zhang J, Sharma P, Mills GB, Hong WK, Minna JD, Allison JP, Futreal A, Wang J, Wistuba II, Heymach JV Cancer discovery 2015 Jun
- Small cell lung cancer: will recent progress lead to improved outcomes?
  Pietanza MC, Byers LA, Minna JD, Rudin CM Clinical cancer research : an official journal of the American Association for Cancer Research 2015 May 21 10 2244-55
- An integrated molecular analysis of lung adenocarcinomas identifies potential therapeutic targets among TTF1-negative tumors including DNA repair proteins and Nrf2.
  Cardnell RJ, Behrens C, Diao L, Fan YH, Tang X, Tong P, Minna JD, Mills GB, Heymach JV, Wistuba II, Wang J, Byers LA Clinical cancer research : an official journal of the American Association for Cancer Research 2015 Apr
- Differential expression of cell cycle regulators in CDK5-dependent medullary thyroid carcinoma tumorigenesis.
  Pozo K, Hillmann A, Augustyn A, Plattner F, Hai T, Singh T, Ramezani S, Sun X, Pfragner R, Minna JD, Cote GJ, Chen H, Bibb JA, Nwariaku FE Oncotarget 2015 Apr
- Multi-institutional oncogenic driver mutation analysis in lung adenocarcinoma: The Lung Cancer Mutation Consortium experience.
  Sholl LM, Aisner DL, Varella-Garcia M, Berry LD, Dias-Santagata D, Wistuba II, Chen H, Fujimoto J, Kugler K, Franklin WA, Iafrate AJ, Ladanyi M, Kris MG, Johnson BE, Bunn PA, Minna JD, Kwiatkowski DJ Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2015 Feb
- Systematic siRNA Screen Unmasks NSCLC Growth Dependence by Palmitoyltransferase DHHC5.
  Tian H, Lu JY, Shao C, Huffman KE, Carstens RM, Larsen JE, Girard L, Liu H, Rodriguez-Canales J, Frenkel EP, Wistuba II, Minna JD, Hofmann SL Molecular cancer research : MCR 2015 Jan
- Genetic mutation of p53 and suppression of the miR-17~92 cluster are synthetic lethal in non-small cell lung cancer due to upregulation of vitamin D signaling.
  Borkowski R, Du L, Zhao Z, McMillan E, Kosti A, Yang C, Suraokar M, Wistuba II, Gazdar AF, Minna JD, White M, Pertsemlidis A Cancer research 2014 Dec
- On comparing heterogeneity across biomarkers.
  Steininger RJ, Rajaram S, Girard L, Minna JD, Wu LF, Altschuler SJ Cytometry. Part A : the journal of the International Society for Analytical Cytology 2014 Nov
- Clinicopathologic features and outcomes of patients with lung adenocarcinomas harboring BRAF mutations in the Lung Cancer Mutation Consortium.
  Villaruz LC, Socinski MA, Abberbock S, Berry LD, Johnson BE, Kwiatkowski DJ, Iafrate AJ, Varella-Garcia M, Franklin WA, Camidge DR, Sequist LV, Haura EB, Ladanyi M, Kurland BF, Kugler K, Minna JD, Bunn PA, Kris MG Cancer 2014 Oct
- ASCL1 is a lineage oncogene providing therapeutic targets for high-grade neuroendocrine lung cancers.
  Augustyn A, Borromeo M, Wang T, Fujimoto J, Shao C, Dospoy PD, Lee V, Tan C, Sullivan JP, Larsen JE, Girard L, Behrens C, Wistuba II, Xie Y, Cobb MH, Gazdar AF, Johnson JE, Minna JD Proceedings of the National Academy of Sciences of the United States of America 2014 Sep
- Selective antitumor activity of ibrutinib in EGFR-mutant non-small cell lung cancer cells.
  Gao W, Wang M, Wang L, Lu H, Wu S, Dai B, Ou Z, Zhang L, Heymach JV, Gold KA, Minna J, Roth JA, Hofstetter WL, Swisher SG, Fang B Journal of the National Cancer Institute 2014 Sep 106 9
- Ras transformation uncouples the kinesin-coordinated cellular nutrient response.
  Zaganjor E, Weil LM, Gonzales JX, Minna JD, Cobb MH Proceedings of the National Academy of Sciences of the United States of America 2014 Jul 111 29 10568-73
- Loss of miR-125a expression in a model of K-ras-dependent pulmonary premalignancy.
  Liclican EL, Walser TC, Hazra S, Krysan K, Park SJ, Pagano PC, Gardner B, Larsen JE, Minna JD, Dubinett SM Cancer prevention research (Philadelphia, Pa.) 2014 Jun
- Essential role of aldehyde dehydrogenase 1A3 (ALDH1A3) for the maintenance of non-small cell lung cancer stem cells is associated with the STAT3 pathway.
  Shao C, Sullivan JP, Girard L, Augustyn A, Yenerall P, Rodriguez J, Liu H, Behrens C, Shay JW, Wistuba II, Minna JD Clinical cancer research : an official journal of the American Association for Cancer Research 2014 Jun
- A search for novel cancer/testis antigens in lung cancer identifies VCX/Y genes expanding the repertoire of potential immunotherapeutic targets.
  Taguchi A, Taylor AD, Rodriguez J, Celiktas M, Liu H, Ma X, Zhang Q, Wong CH, Chin A, Girard L, Behrens C, Lam WL, Lam S, Minna JD, Wistuba II, Gazdar AF, Hanash SM Cancer research 2014 Jun
- Branching morphogenesis of immortalized human bronchial epithelial cells in three-dimensional culture.
  Kaisani A, Delgado O, Fasciani G, Kim SB, Wright WE, Minna JD, Shay JW Differentiation; research in biological diversity 2014 May
- VEGF/VEGFR-2 upregulates EZH2 expression in lung adenocarcinoma cells and EZH2 depletion enhances the response to platinum-based and VEGFR-2-targeted therapy.
  Riquelme E, Suraokar M, Behrens C, Lin HY, Girard L, Nilsson M, Simon G, Wang J, Coombes K, Lee JJ, Hong WK, Heymach JV, Minna JD, Wistuba II Clinical cancer research : an official journal of the American Association for Cancer Research 2014 May
- Using multiplexed assays of oncogenic drivers in lung cancers to select targeted drugs.
  Kris MG, Johnson BE, Berry LD, Kwiatkowski DJ, Iafrate AJ, Wistuba II, Varella-Garcia M, Franklin WA, Aronson SL, Su PF, Shyr Y, Camidge DR, Sequist LV, Glisson BS, Khuri FR, Garon EB, Pao W, Rudin C, Schiller J, Haura EB, Socinski M, Shirai K, Chen H, Giaccone G, Ladanyi M, Kugler K, Minna JD, Bunn PA JAMA : the journal of the American Medical Association 2014 May 311 19 1998-2006
- Aiolos Promotes Anchorage Independence by Silencing p66(Shc) Transcription in Cancer Cells.
  Li X, Xu Z, Du W, Zhang Z, Wei Y, Wang H, Zhu Z, Qin L, Wang L, Niu Q, Zhao X, Girard L, Gong Y, Ma Z, Sun B, Yao Z, Minna JD, Terada LS, Liu Z Cancer cell 2014 May 25 5 575-89
- Inflammation-related Genetic Variations and Survival for Advanced Non-Small Cell Lung Cancer Receiving First-line Chemotherapy.
  Pu X, Hildebrandt MA, Lu C, Roth JA, Stewart DJ, Zhao Y, Heist RS, Ye Y, Chang DW, Su L, Minna JD, Lippman SM, Spitz MR, Christiani DC, Wu X Clinical pharmacology and therapeutics 2014 Apr
- NeuroD1 mediates nicotine-induced migration and invasion via regulation of the nicotinic acetylcholine receptor subunits in a subset of neural and neuroendocrine carcinomas.
  Osborne JK, Guerra ML, Gonzales JX, McMillan EA, Minna JD, Cobb MH Molecular biology of the cell 2014 Apr
- Radiation-Enhanced Lung Cancer Progression in a Transgenic Mouse Model of Lung Cancer Is Predictive of Outcomes in Human Lung and Breast Cancer.
  Delgado O, Batten KG, Richardson JA, Xie XJ, Gazdar AF, Kaisani AA, Girard L, Behrens C, Suraokar M, Fasciani G, Wright WE, Story MD, Wistuba II, Minna JD, Shay JW Clinical cancer research : an official journal of the American Association for Cancer Research 2014 Feb
- Adaptive prediction model in prospective molecular signature-based clinical studies.
  Xiao G, Ma S, Minna J, Xie Y Clinical cancer research : an official journal of the American Association for Cancer Research 2014 Feb 20 3 531-9
- Comparison between concurrent and sequential chemoradiation for non-small cell lung cancer in vitro.
  Song SY, DAS AK, Minna JD Oncology letters 2014 Feb 7 2 307-310
- Integrative analysis of two cell lines derived from a non-small-lung cancer patient--a panomics approach.
  Mayba O, Gnad F, Peyton M, Zhang F, Walter K, Du P, Huntley MA, Jiang Z, Liu J, Haverty PM, Gentleman RC, Li R, Minna JD, Li Y, Shames DS, Zhang Z Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing 2014 75-86
- Identification and characterization of a suite of tumor targeting peptides for non-small cell lung cancer.
  McGuire MJ, Gray BP, Li S, Cupka D, Byers LA, Wu L, Rezaie S, Liu YH, Pattisapu N, Issac J, Oyama T, Diao L, Heymach JV, Xie XJ, Minna JD, Brown KC Scientific reports 2014 4 4480
- Genes suppressed by DNA methylation in non-small cell lung cancer reveal the epigenetics of epithelial-mesenchymal transition.
  Lin SH, Wang J, Saintigny P, Wu CC, Giri U, Zhang J, Menju T, Diao L, Byers L, Weinstein JN, Coombes KR, Girard L, Komaki R, Wistuba II, Date H, Minna JD, Heymach JV BMC genomics 2014 15 1079
- A pan-cancer proteomic perspective on The Cancer Genome Atlas.
  Akbani R, Ng PK, Werner HM, Shahmoradgoli M, Zhang F, Ju Z, Liu W, Yang JY, Yoshihara K, Li J, Ling S, Seviour EG, Ram PT, Minna JD, Diao L, Tong P, Heymach JV, Hill SM, Dondelinger F, Städler N, Byers LA, Meric-Bernstam F, Weinstein JN, Broom BM, Verhaak RG, Liang H, Mukherjee S, Lu Y, Mills GB Nature communications 2014 5 3887
- A novel molecular pathway for snail-dependent, SPARC-mediated invasion in non-small cell lung cancer pathogenesis.
  Grant JL, Fishbein MC, Hong LS, Krysan K, Minna JD, Shay JW, Walser TC, Dubinett SM Cancer prevention research (Philadelphia, Pa.) 2014 Jan 7 1 150-60
- A reevaluation of CD22 expression in human lung cancer.
  Pop LM, Barman S, Shao C, Poe JC, Venturi GM, Shelton JM, Pop IV, Gerber DE, Girard L, Liu XY, Behrens C, Rodriguez-Canales J, Liu H, Wistuba II, Richardson JA, Minna JD, Tedder TF, Vitetta ES Cancer research 2014 Jan 74 1 263-71
- IGFBP2/FAK pathway is causally associated with dasatinib resistance in non-small cell lung cancer cells.
  Lu H, Wang L, Gao W, Meng J, Dai B, Wu S, Minna J, Roth JA, Hofstetter WL, Swisher SG, Fang B Molecular cancer therapeutics 2013 Dec 12 12 2864-73
- Ras regulates kinesin 13 family members to control cell migration pathways in transformed human bronchial epithelial cells.
  Zaganjor E, Osborne JK, Weil LM, Diaz-Martinez LA, Gonzales JX, Singel SM, Larsen JE, Girard L, Minna JD, Cobb MH Oncogene 2013 Nov
- Molecular biology of lung cancer.
  Cooper WA, Lam DC, O'Toole SA, Minna JD Journal of thoracic disease 2013 Oct 5 Suppl 5 S479-S490
- Systematic identification of molecular subtype-selective vulnerabilities in non-small-cell lung cancer.
  Kim HS, Mendiratta S, Kim J, Pecot CV, Larsen JE, Zubovych I, Seo BY, Kim J, Eskiocak B, Chung H, McMillan E, Wu S, De Brabander J, Komurov K, Toombs JE, Wei S, Peyton M, Williams N, Gazdar AF, Posner BA, Brekken RA, Sood AK, Deberardinis RJ, Roth MG, Minna JD, White MA Cell 2013 Oct 155 3 552-66
- miR-93-directed downregulation of DAB2 defines a novel oncogenic pathway in lung cancer.
  Du L, Zhao Z, Ma X, Hsiao TH, Chen Y, Young E, Suraokar M, Wistuba I, Minna JD, Pertsemlidis A Oncogene 2013 Sep
- EGFR-Mediated Beclin 1 Phosphorylation in Autophagy Suppression, Tumor Progression, and Tumor Chemoresistance.
  Wei Y, Zou Z, Becker N, Anderson M, Sumpter R, Xiao G, Kinch L, Koduru P, Christudass CS, Veltri RW, Grishin NV, Peyton M, Minna J, Bhagat G, Levine B Cell 2013 Sep 154 6 1269-84
- Proteomic markers of DNA repair and PI3K pathway activation predict response to the PARP inhibitor BMN 673 in small cell lung cancer.
  Cardnell RJ, Feng Y, Diao L, Fan YH, Masrorpour F, Wang J, Shen Y, Mills GB, Minna JD, Heymach JV, Byers LA Clinical cancer research : an official journal of the American Association for Cancer Research 2013 Sep
- Precision Medicine for Cancer Patients: Lessons Learned and the Path Forward.
  Gazdar AF, Minna JD Journal of the National Cancer Institute 2013 Aug
- KEAP1-dependent synthetic lethality induced by AKT and TXNRD1 inhibitors in lung cancer.
  Dai B, Yoo SY, Bartholomeusz G, Graham RA, Majidi M, Yan S, Meng J, Ji L, Coombes K, Minna JD, Fang B, Roth JA Cancer research 2013 Jul
- Pathway-based serum microRNA profiling and survival in patients with advanced non-small cell lung cancer.
  Wang Y, Gu J, Roth JA, Hildebrandt MA, Lippman SM, Ye Y, Minna JD, Wu X Cancer research 2013 Jun
- Genome-wide association study of genetic predictors of overall survival for non-small cell lung cancer in never smokers.
  Wu X, Wang L, Ye Y, Aakre JA, Pu X, Chang GC, Yang PC, Roth JA, Marks RS, Lippman SM, Chang JY, Lu C, Deschamps C, Su WC, Wang WC, Huang MS, Chang DW, Li Y, Pankratz VS, Minna JD, Hong WK, Hildebrandt MA, Hsiung CA, Yang P Cancer research 2013 May
- NeuroD1 regulates survival and migration of neuroendocrine lung carcinomas via signaling molecules TrkB and NCAM.
  Osborne JK, Larsen JE, Shields MD, Gonzales JX, Shames DS, Sato M, Kulkarni A, Wistuba II, Girard L, Minna JD, Cobb MH Proceedings of the National Academy of Sciences of the United States of America 2013 Apr 110 16 6524-9
- Endobronchial miRNAs as Biomarkers in Lung Cancer Chemoprevention.
  Mascaux C, Feser WJ, Lewis MT, Barón AE, Coldren CD, Merrick DT, Kennedy TC, Eckelberger JI, Rozeboom LM, Franklin WA, Minna JD, Bunn PA, Miller YE, Keith RL, Hirsch FR Cancer prevention research (Philadelphia, Pa.) 2013 Feb 6 2 100-8
- MicroRNA-Related Genetic Variants Associated with Clinical Outcomes in Early Stage Non-Small Cell Lung Cancer Patients.
  Pu X, Roth JA, Hildebrandt MA, Ye Y, Wei H, Minna JD, Lippman SM, Wu X Cancer research 2013 Feb
- TIMELESS is overexpressed in lung cancer and its expression correlates with poor patient survival.
  Yoshida K, Sato M, Hase T, Elshazley M, Yamashita R, Usami N, Taniguchi T, Yokoi K, Nakamura S, Kondo M, Girard L, Minna JD, Hasegawa Y Cancer science 2013 Feb 104 2 171-7
- Human lung epithelial cells progressed to malignancy through specific oncogenic manipulations.
  Sato M, Larsen JE, Lee W, Sun H, Shames DS, Dalvi MP, Ramirez RD, Tang H, Dimaio JM, Gao B, Xie Y, Wistuba II, Gazdar AF, Shay JW, Minna JD Molecular cancer research : MCR 2013 Feb
- Systems approaches to modeling chronic mucosal inflammation.
  Kalita M, Tian B, Gao B, Choudhary S, Wood TG, Carmical JR, Boldogh I, Mitra S, Minna JD, Brasier AR BioMed research international 2013 2013 505864
- Distinct transcriptome profiles identified in normal human bronchial epithelial cells after exposure to ?-rays and different elemental particles of high Z and energy.
  Ding LH, Park S, Peyton M, Girard L, Xie Y, Minna JD, Story MD BMC genomics 2013 14 372
- The tumor suppressor gene TUSC2 (FUS1) sensitizes NSCLC to the AKT inhibitor MK2206 in LKB1-dependent manner.
  Meng J, Majidi M, Fang B, Ji L, Bekele BN, Minna JD, Roth JA PloS one 2013 8 10 e77067
- An epithelial-mesenchymal transition gene signature predicts resistance to EGFR and PI3K inhibitors and identifies Axl as a therapeutic target for overcoming EGFR inhibitor resistance.
  Byers LA, Diao L, Wang J, Saintigny P, Girard L, Peyton M, Shen L, Fan Y, Giri U, Tumula PK, Nilsson MB, Gudikote J, Tran H, Cardnell RJ, Bearss DJ, Warner SL, Foulks JM, Kanner SB, Gandhi V, Krett N, Rosen ST, Kim ES, Herbst RS, Blumenschein GR, Lee JJ, Lippman SM, Ang KK, Mills GB, Hong WK, Weinstein JN, Wistuba II, Coombes KR, Minna JD, Heymach JV Clinical cancer research : an official journal of the American Association for Cancer Research 2013 Jan 19 1 279-90
- GWAS Meets TCGA to Illuminate Mechanisms of Cancer Predisposition.
  Kim HS, Minna JD, White MA Cell 2013 Jan 152 3 387-9
- Pre-Clinical Studies of Epigenetic Therapies Targeting Histone Modifiers in Lung Cancer.
  Huffman K, Martinez ED Frontiers in oncology 2013 3 235
- A 12-Gene Set Predicts Survival Benefits from Adjuvant Chemotherapy in Non-Small-Cell Lung Cancer Patients.
  Tang H, Xiao G, Behrens C, Schiller J, Allen J, Chow CW, Suraokar M, Corvalan A, Mao JH, White M, Wistuba II, Minna JD, Xie Y Clinical cancer research : an official journal of the American Association for Cancer Research 2013 Jan
- NeuroD1 regulation of migration accompanies the differential sensitivity of neuroendocrine carcinomas to TrkB inhibition.
  Osborne JK, Larsen JE, Gonzales JX, Shames DS, Sato M, Wistuba II, Girard L, Minna JD, Cobb MH Oncogenesis 2013 2 e63
- Genome and transcriptome sequencing of lung cancers reveal diverse mutational and splicing events.
  Liu J, Lee W, Jiang Z, Chen Z, Jhunjhunwala S, Haverty PM, Gnad F, Guan Y, Gilbert HN, Stinson J, Klijn C, Guillory J, Bhatt D, Vartanian S, Walter K, Chan J, Holcomb T, Dijkgraaf P, Johnson S, Koeman J, Minna JD, Gazdar AF, Stern HM, Hoeflich KP, Wu TD, Settleman J, de Sauvage FJ, Gentleman RC, Neve RM, Stokoe D, Modrusan Z, Seshagiri S, Shames DS, Zhang Z Genome research 2012 Dec 22 12 2315-27
- The circadian clock gene BMAL1 is a novel therapeutic target for malignant pleural mesothelioma.
  Elshazley M, Sato M, Hase T, Yamashita R, Yoshida K, Toyokuni S, Ishiguro F, Osada H, Sekido Y, Yokoi K, Usami N, Shames DS, Kondo M, Gazdar AF, Minna JD, Hasegawa Y International journal of cancer. Journal international du cancer 2012 Dec 131 12 2820-31
- Defining molecular and cellular responses after low and high linear energy transfer radiations to develop biomarkers of carcinogenic risk or therapeutic outcome.
  Story M, Ding LH, Brock WA, Ang KK, Alsbeih G, Minna J, Park S, Das A Health physics 2012 Nov 103 5 596-606
- Predictors of survival in never-smokers with non-small cell lung cancer: a large-scale, two-phase genetic study.
  Pu X, Ye Y, Spitz MR, Wang L, Gu J, Lippman SM, Hildebrandt MA, Hong WK, Minna JD, Roth JA, Yang P, Wu X Clinical cancer research : an official journal of the American Association for Cancer Research 2012 Nov 18 21 5983-91
- Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer.
  Rudin CM, Durinck S, Stawiski EW, Poirier JT, Modrusan Z, Shames DS, Bergbower EA, Guan Y, Shin J, Guillory J, Rivers CS, Foo CK, Bhatt D, Stinson J, Gnad F, Haverty PM, Gentleman R, Chaudhuri S, Janakiraman V, Jaiswal BS, Parikh C, Yuan W, Zhang Z, Koeppen H, Wu TD, Stern HM, Yauch RL, Huffman KE, Paskulin DD, Illei PB, Varella-Garcia M, Gazdar AF, de Sauvage FJ, Bourgon R, Minna JD, Brock MV, Seshagiri S Nature genetics 2012 Oct 44 10 1111-6
- Proteomic profiling identifies dysregulated pathways in small cell lung cancer and novel therapeutic targets including PARP1.
  Byers LA, Wang J, Nilsson MB, Fujimoto J, Saintigny P, Yordy J, Giri U, Peyton M, Fan YH, Diao L, Masrorpour F, Shen L, Liu W, Duchemann B, Tumula P, Bhardwaj V, Welsh J, Weber S, Glisson BS, Kalhor N, Wistuba II, Girard L, Lippman SM, Mills GB, Coombes KR, Weinstein JN, Minna JD, Heymach JV Cancer discovery 2012 Sep 2 9 798-811
- Oncogenic KRAS-induced epiregulin overexpression contributes to aggressive phenotype and is a promising therapeutic target in non-small-cell lung cancer.
  Sunaga N, Kaira K, Imai H, Shimizu K, Nakano T, Shames DS, Girard L, Soh J, Sato M, Iwasaki Y, Ishizuka T, Gazdar AF, Minna JD, Mori M Oncogene 2012 Sep
- Probe mapping across multiple microarray platforms.
  Allen JD, Wang S, Chen M, Girard L, Minna JD, Xie Y, Xiao G Briefings in bioinformatics 2012 Sep 13 5 547-54
- Global evaluation of Eph receptors and ephrins in lung adenocarcinomas identifies EphA4 as an inhibitor of cell migration and invasion.
  Saintigny P, Peng S, Zhang L, Sen B, Wistuba II, Lippman SM, Girard L, Minna JD, Heymach JV, Johnson FM Molecular cancer therapeutics 2012 Sep 11 9 2021-32
- Research resource: Diagnostic and therapeutic potential of nuclear receptor expression in lung cancer.
  Jeong Y, Xie Y, Lee W, Bookout AL, Girard L, Raso G, Behrens C, Wistuba II, Gadzar AF, Minna JD, Mangelsdorf DJ Molecular endocrinology (Baltimore, Md.) 2012 Aug 26 8 1443-54
- Transient but not stable ZEB1 knockdown dramatically inhibits growth of malignant pleural mesothelioma cells.
  Horio M, Sato M, Takeyama Y, Elshazley M, Yamashita R, Hase T, Yoshida K, Usami N, Yokoi K, Sekido Y, Kondo M, Toyokuni S, Gazdar AF, Minna JD, Hasegawa Y Annals of surgical oncology 2012 Jul 19 Suppl 3 S634-45
- Antitumor activity of a novel STAT3 inhibitor and redox modulator in non-small cell lung cancer cells.
  Liu X, Guo W, Wu S, Wang L, Wang J, Dai B, Kim ES, Heymach JV, Wang M, Girard L, Minna J, Roth JA, Swisher SG, Fang B Biochemical pharmacology 2012 May 83 10 1456-64
- A lung cancer molecular prognostic test ready for prime time.
  Xie Y, Minna JD Lancet 2012 Mar 379 9818 785-7
- Effect of KRAS oncogene substitutions on protein behavior: implications for signaling and clinical outcome.
  Ihle NT, Byers LA, Kim ES, Saintigny P, Lee JJ, Blumenschein GR, Tsao A, Liu S, Larsen JE, Wang J, Diao L, Coombes KR, Chen L, Zhang S, Abdelmelek MF, Tang X, Papadimitrakopoulou V, Minna JD, Lippman SM, Hong WK, Herbst RS, Wistuba II, Heymach JV, Powis G Journal of the National Cancer Institute 2012 Feb 104 3 228-39
- Divergent genomic and epigenomic landscapes of lung cancer subtypes underscore the selection of different oncogenic pathways during tumor development.
  Lockwood WW, Wilson IM, Coe BP, Chari R, Pikor LA, Thu KL, Solis LM, Nunez MI, Behrens C, Yee J, English J, Murray N, Tsao MS, Minna JD, Gazdar AF, Wistuba II, MacAulay CE, Lam S, Lam WL PloS one 2012 7 5 e37775
- Functional characterization of CLPTM1L as a lung cancer risk candidate gene in the 5p15.33 locus.
  James MA, Wen W, Wang Y, Byers LA, Heymach JV, Coombes KR, Girard L, Minna J, You M PloS one 2012 7 6 e36116
- miR-337-3p and its targets STAT3 and RAP1A modulate taxane sensitivity in non-small cell lung cancers.
  Du L, Subauste MC, DeSevo C, Zhao Z, Baker M, Borkowski R, Schageman JJ, Greer R, Yang CR, Suraokar M, Wistuba II, Gazdar AF, Minna JD, Pertsemlidis A PloS one 2012 7 6 e39167
- Molecular biology of lung cancer: clinical implications.
  Larsen JE, Minna JD Clinics in chest medicine 2011 Dec 32 4 703-40
- SMAC mimetic (JP1201) sensitizes non-small cell lung cancers to multiple chemotherapy agents in an IAP-dependent but TNF-a-independent manner.
  Greer RM, Peyton M, Larsen JE, Girard L, Xie Y, Gazdar AF, Harran P, Wang L, Brekken RA, Wang X, Minna JD Cancer research 2011 Dec 71 24 7640-8
- From mice and men to earth and space: joint NASA-NCI workshop on lung cancer risk resulting from space and terrestrial radiation.
  Shay JW, Cucinotta FA, Sulzman FM, Coleman CN, Minna JD Cancer research 2011 Nov 71 22 6926-9
- Targeted therapies for lung cancer: clinical experience and novel agents.
  Larsen JE, Cascone T, Gerber DE, Heymach JV, Minna JD Cancer journal (Sudbury, Mass.) 2011 Nov-Dec 17 6 512-27
- How do we safely get people to stop smoking?
  Lam DC, Minna JD Cancer prevention research (Philadelphia, Pa.) 2011 Nov 4 11 1724-7
- Robust Gene Expression Signature from Formalin-Fixed Paraffin-Embedded Samples Predicts Prognosis of Non-Small-Cell Lung Cancer Patients.
  Xie Y, Xiao G, Coombes K, Behrens C, Solis LM, Raso MG, Girard L, Erickson HS, Roth JA, Heymach JV, Moran C, Danenberg KD, Minna JD, Wistuba II Clinical cancer research : an official journal of the American Association for Cancer Research 2011 Jul 5705-14
- Oncogenic KRAS-induced interleukin-8 overexpression promotes cell growth and migration and contributes to aggressive phenotypes of non-small cell lung cancer.
  Sunaga N, Imai H, Shimizu K, Shames DS, Kakegawa S, Girard L, Sato M, Kaira K, Ishizuka T, Gazdar AF, Minna JD, Mori M International journal of cancer. Journal international du cancer 2011 May
- Knockdown of oncogenic KRAS in non-small cell lung cancers suppresses tumor growth and sensitizes tumor cells to targeted therapy.
  Sunaga N, Shames DS, Girard L, Peyton M, Larsen JE, Imai H, Soh J, Sato M, Yanagitani N, Kaira K, Xie Y, Gazdar AF, Mori M, Minna JD Molecular cancer therapeutics 2011 Feb 10 2 336-46
- ALK inhibition for non-small cell lung cancer: from discovery to therapy in record time.
  Gerber DE, Minna JD Cancer cell 2010 Dec 18 6 548-51
- Aldehyde dehydrogenase activity selects for lung adenocarcinoma stem cells dependent on notch signaling.
  Sullivan JP, Spinola M, Dodge M, Raso MG, Behrens C, Gao B, Schuster K, Shao C, Larsen JE, Sullivan LA, Honorio S, Xie Y, Scaglioni PP, DiMaio JM, Gazdar AF, Shay JW, Wistuba II, Minna JD Cancer research 2010 Dec 70 23 9937-48
- Non-small-cell lung cancer mRNA expression signature predicting response to adjuvant chemotherapy.
  Xie Y, Minna JD Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2010 Oct 28 29 4404-7
- Lung cancer cell lines as tools for biomedical discovery and research.
  Gazdar AF, Girard L, Lockwood WW, Lam WL, Minna JD Journal of the National Cancer Institute 2010 Sep 102 17 1310-21
- Steroid receptor coactivator-3 expression in lung cancer and its role in the regulation of cancer cell survival and proliferation.
  Cai D, Shames DS, Raso MG, Xie Y, Kim YH, Pollack JR, Girard L, Sullivan JP, Gao B, Peyton M, Nanjundan M, Byers L, Heymach J, Mills G, Gazdar AF, Wistuba I, Kodadek T, Minna JD Cancer research 2010 Aug 70 16 6477-85
- Radiogenomics predicting tumor responses to radiotherapy in lung cancer.
  Das AK, Bell MH, Nirodi CS, Story MD, Minna JD Seminars in radiation oncology 2010 Jul 20 3 149-55
- Tumor oncogenotypes and lung cancer stem cell identity.
  Sullivan JP, Minna JD Cell stem cell 2010 Jul 7 1 2-4
- Lung cancer cell lines: Useless artifacts or invaluable tools for medical science?
  Gazdar AF, Gao B, Minna JD Lung cancer (Amsterdam, Netherlands) 2010 Jun 68 3 309-18
- Evidence for self-renewing lung cancer stem cells and their implications in tumor initiation, progression, and targeted therapy.
  Sullivan JP, Minna JD, Shay JW Cancer metastasis reviews 2010 Mar 29 1 61-72
- Nuclear receptor expression defines a set of prognostic biomarkers for lung cancer.
  Jeong Y, Xie Y, Xiao G, Behrens C, Girard L, Wistuba II, Minna JD, Mangelsdorf DJ PLoS medicine 2010 7 12 e1000378
- MFSD2A is a novel lung tumor suppressor gene modulating cell cycle and matrix attachment.
  Spinola M, Falvella FS, Colombo F, Sullivan JP, Shames DS, Girard L, Spessotto P, Minna JD, Dragani TA Molecular cancer 2010 9 62
- Cancer stem cells.
  Rudin C, Minna J Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2009 Nov 4 11 Suppl 3 S1079-81
- Multifocal lung cancers--clonality vs field cancerization and does it matter?
  Gazdar AF, Minna JD Journal of the National Cancer Institute 2009 Apr 101 8 541-3
- Small-cell lung cancer: translational research enroute to therapeutic advances.
  Dowell J, Minna JD Oncology (Williston Park, N.Y.) 2008 Nov 22 13 1493, 1495
- Deregulated EGFR signaling during lung cancer progression: mutations, amplicons, and autocrine loops.
  Gazdar AF, Minna JD Cancer prevention research (Philadelphia, Pa.) 2008 Aug 1 3 156-60
- ASPP1, a common activator of TP53, is inactivated by aberrant methylation of its promoter in acute lymphoblastic leukemia.
  Agirre X, Román-Gómez J, Jiménez-Velasco A, Garate L, Montiel-Duarte C, Navarro G, Vázquez I, Zalacain M, Calasanz MJ, Heiniger A, Torres A, Minna JD, Prósper F Oncogene 2006 Mar 25 13 1862-70

Research

Molecular Pathogenesis of Human Cancer
Molecular Biomarkers of Response to Cancer Therapy
Lung Cancer
Genome-Wide mRNA, Protein, and DNA Analysis
Breast Cancer

Clinical Focus

Lung Cancer