- American Association for the Advancement of Science
- American Association for the Study of Liver Diseases
- American Gastroenterological Association
- American Pediatric Society
- American Society for Clinical Investigation
- Association of American Physicians
- North American Society for Pediatric Gastroenterology and Nutrition
- Society for Pediatric Research
Jorge Bezerra, M.D.
- Robert L. Moore Chair in Pediatrics
- Pediatrics - Gastroenterology
- Liver Disease
- Transplant Hepatology
Biography
Jorge A. Bezerra, M.D., is Professor and Chair of the Department of Pediatrics at UT Southwestern Medical Center. He specializes in pediatric gastroenterology and holds the Robert L. Moore Chair in Pediatrics.
Dr. Bezerra earned his medical degree from the Federal University of Rio Grande do Norte School of Medicine in Brazil. After a pediatrics residency at the University of Arizona Health Sciences, he completed clinical and research fellowships in pediatric gastroenterology, hepatology, and nutrition at Cincinnati Children’s Hospital Medical Center. There, he would also serve as Director of the Division of Pediatric Gastroenterology, Hepatology, and Nutrition; Medical Director of the Pediatric Liver Care Center; and Director of the Digestive Health Center.
Certified by the American Board of Pediatrics in pediatric gastroenterology and pediatric transplant hepatology, he joined UT Southwestern in 2022.
As department Chair and a practicing pediatric gastroenterologist, Dr. Bezerra provides strategic vision and operational leadership for the pediatric clinical, research, and training programs at UT Southwestern. He also serves as Pediatrician-in-Chief for Children’s Medical Center Dallas, overseeing the quality of pediatric patient care and the integration of clinical and academic activities.
Dr. Bezerra is the principal investigator of multiple grants from the National Institutes of Health that are focused on preclinical and translational research on biliary atresia, the most common cause of chronic liver disease in children. His scientific achievements include the discovery of a key immunologic signature in the liver of children with biliary atresia. This discovery led to a test, now transitioning to clinical use, that facilitates diagnosis of biliary atresia and shortens the time to surgical treatment.
A prolific author and lecturer, he has published more than 100 peer-reviewed articles and scores of book chapters, invited papers, and abstracts. He is a Co-Editor of Liver Disease in Children, 5th Edition, and he serves as a reviewer for numerous scholarly journals.
Dr. Bezerra is an elected member of the American Society for Clinical Investigation and the Association of American Physicians. He is also a Fellow of the American Gastroenterological Association and in 2020 served as the seventy-first President of the American Association for the Study of Liver Diseases. In addition, he served as Chairman of the Board of Scientific Counselors of the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases in 2021-2022.
Education & Training
- Medical School - Federal University of Rio Grande Do Sul - Brazil (1978-1984)
- Residency - University of Arizona Health Sciences Center (1987-1989), Pediatrics
- Fellowship - Cincinnati Children's Hospital Medical Center (1990-1993), Pediatric Gastroenterology
Professional Associations & Affiliations
Honors & Awards
- Chairman 2021, Board of Scientific Councilors, Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases
- Honorary Member 2021, Academy of Medicine, Federal University of Rio Grande do Norte School of Medicine, Natal, Brazil
- The Klatskin Lecturer 2021, Yale University
- President 2020, American Association for the Study of Liver Diseases
- The Best Doctors in America, 2005, 2008-2021
- Castle Conolly Top Doctors in America 2018-2021
- Top Doctor, Pediatrics, 2014-2015, 2017-2021, Cincinnati Magazine
- Chairman 2017, National Institute of Diabetes and Digestive and Kidney Diseases Special Emphasis Panel, ZRG1 DKUS-P (03)
- Trustee 2016-2018, Foundation of the American Association for the Study of Liver Diseases
- Councilor and Governing Board Member 2016, American Association for the Study of Liver Diseases
- Fellow 2015, American Gastroenterological Association
- Fellow 2014, American Association for the Study of Liver Diseases
- Award for distinguished scientific accomplishments 2014, 15th Brazilian Congress of Pediatric Gastroenterology, Hepatology, and Nutrition, Natal, Brazil
- Mentorship Achievement Award 2014, Cincinnati Children’s Hospital Medical Center
- Associate Editor 2012, Hepatology
- William and Rebecca Balistreri Chair of Pediatric Hepatology 2009-2022, Cincinnati Children’s Hospital Medical Center
- Pediatric Resident Research Award 1989, American Academy of Pediatrics
- Graduating Resident Award for Excellence in Research 1989, Department of Pediatrics, University of Arizona Health Sciences Center, Tucson, AZ
- Graduating Resident Award for Excellence in Clinical Service 1989, Department of Pediatrics, University of Arizona Health Sciences Center, Tucson, AZ
- Graduating Resident Award for Excellence in Teaching 1989, Department of Pediatrics, University of Arizona Health Sciences Center, Tucson, AZ
- Best Graduating Student, Merit Medal 1984, Federal University of Rio Grande do Norte School of Medicine
Books & Publications
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Books
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Cirrhosis in Current Pediatric Therapy. Vol 14
Bezerra JA, Balistreri W (1993), Philadelphia, W.B. Saunders Co. -
Transplantation for cholestatic liver disease in Transplantation of the Liver
Bezerra JA, Balistreri W (1996), Philadelphia, W.B. Saunders Co. -
Metabolic diseases in children in Liver Diseases
D’Agata I, Bezerra JA (2001), Brazil, Editora Atheneu -
Biliary atresia in National Organization of Rare Disorders: A Guide to Rare Disorders
Bezerra JA (2002) -
Gastrointestinal evaluation in immunodeficient children in Endoscopia Pediatrica (Pediatric Endoscopy)
Guthery S, Bezerra JA (2004), Rio de Janeiro, Brazil, Guanabara Koogan -
Biliary atresia in Textbook of Pediatric Gastrointestinal Disease
Campbell K, Bezerra JA (2004), Lewiston, NY, BC Decker -
Biliary atresia in Textbook of Pediatric Gastrointestinal Disease
Bezerra JA (2008), BC Decker Inc -
Biliary atresia in Molecular Pathology of Liver Diseases
Bezerra JA (2011), Springer -
Textbook of Clinical Pediatrics
Vitolla B, Bezerra JA (2011), Springer -
Disorders of protein metabolism in Gastroenterologia e Hepatologia em Pediatria: Diagnostico e Tratamento
Bezerra JA (2012), Sao Paulo, Brazil, Editora Manole -
Congenital disorders of glycosylation in Gastroenterologia e Hepatologia em Pediatria: Diagnostico e Tratamento
Bezerra JA (2012), Sao Paulo, Brazil, Editora Manole -
Biliary atresia in Pediatric Liver Disease
Balistreri WF, Bezerra JA, Ryckman FR -
Biliary atresia in Textbook of Pediatric Gastrointestinal Disease
Bezerra JA (Submitted), BC Decker Inc -
Biliary atresia in National Organization of Rare Disorders: A Guide to Rare Disorders
Bezerra JA (2015) -
Transplantation for cholestatic liver disease in children in Transplantation of the Liver
Ibrahim SH, Bezerra JA, Balistreri WF (2015), Elsevier -
Biliary atresia in National Organization of Rare Disorders: A Guide to Rare Disorders
Bezerra JA (2016) -
Biliary atresia – An Update 2019 in National Organization of Rare Disorders: A Guide to Rare Disorders
Bezerra JA (2019) -
Biliary atresia in Liver Disease in Children
Bezerra JA, Asai A, Mulappadi B, Tiao G, Balistreri WF (2019)
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Cirrhosis in Current Pediatric Therapy. Vol 14
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Publications
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Cellular crosstalk mediated by TGF-β drives epithelial-mesenchymal transition in patient-derived multi-compartment biliary organoids
Ayabe H, DePasquale EA, Amarachintha SP, Mourya R, Li W, Nalluri S, Fox SR, Konishi K, Shivakumar P, Bezerra JA Nature communications 2025 Dec 16 -
Cellular crosstalk mediated by TGF-β drives epithelial-mesenchymal transition in patient-derived multi-compartment biliary organoids
Ayabe H, DePasquale EA, Amarachintha SP, Mourya R, Li W, Nalluri S, Fox SR, Konishi K, Shivakumar P, Bezerra JA Nature communications 2025 Dec 16 -
Increased serum GM-CSF at diagnosis of biliary atresia is associated with improved biliary drainage
Author Collaboration ft, Taylor SA, Harpavat S, Gromer KD, Andreev V, Loomes KM, Bezerra JA, Jarasvaraparn C, Wang K, Horslen S, Rosenthal P, Teckman J, Valentino PL, Ng VL, Karpen SJ, Sokol RJ, Alonso EM, Mack CL Pediatric Research 2025 Oct 98 1386-1394 -
Diagnostic accuracy of serum matrix metalloproteinase-7 as a biomarker of biliary atresia in a large North American cohort
Author Collaboration TC, Pandurangi S, Mourya R, Nalluri S, Fei L, Dong S, Harpavat S, Guthery SL, Molleston JP, Rosenthal P, Sokol RJ, Wang KS, Ng V, Alonso EM, Hsu EK, Karpen SJ, Loomes KM, Magee JC, Shneider BL, Horslen SP, Teckman JH, Bezerra JA Hepatology 2024 Jul 80 152-162 -
Plasticity between type 2 innate lymphoid cell subsets and amphiregulin expression regulates epithelial repair in biliary atresia
Russi AE, Shivakumar P, Luo Z, Bezerra JA Hepatology 2023 Oct 78 1035-1049 -
Recent Increase in Incidence of Severe Acute Hepatitis of Unknown Etiology in Children is Associated with Infection with Adenovirus and Other Nonhepatotropic Viruses
Peters AL, Kim S, Mourya R, Asai A, Taylor A, Rogers M, Campbell K, Fei L, Miethke A, Balistreri WF, Bezerra JA Journal of Pediatrics 2023 Aug 259 -
Customized Postoperative Therapy Improves Bile Drainage in Biliary Atresia: A Single Center Preliminary Report
Pandurangi S, Kim S, Asai A, Bondoc A, Balistreri W, Campbell K, Miethke A, Peters A, Rogers M, Taylor A, Attia SL, Gibbons T, Mullapudi B, Sheridan R, Tiao G, Bezerra JA Journal of Pediatric Surgery 2023 Aug 58 1483-1488 -
Clinical spectrum and genetic causes of mitochondrial hepatopathy phenotype in children
Author Collaboration tC, Squires JE, Miethke AG, Alexander Valencia C, Hawthorne K, Henn L, Van Hove JL, Squires RH, Bove K, Horslen S, Kohli R, Molleston JP, Romero R, Alonso EM, Bezerra JA, Guthery SL, Hsu E, Karpen SJ, Loomes KM, Ng VL, Rosenthal P, Mysore K, Wang KS, Friederich MW, Magee JC, Sokol RJ Hepatology Communications 2023 Jun 7 -
Serum bile acids as a prognostic biomarker in biliary atresia following Kasai portoenterostomy
Harpavat S, Hawthorne K, Setchell KD, Rivas MN, Henn L, Beil CA, Karpen SJ, Ng VL, Alonso EM, Bezerra JA, Guthery SL, Horslen S, Loomes KM, McKiernan P, Magee JC, Merion RM, Molleston JP, Rosenthal P, Thompson RJ, Wang KS, Sokol RJ, Shneider BL Hepatology 2023 Mar 77 862-873 -
Serum biomarkers correlated with liver stiffness assessed in a multicenter study of pediatric cholestatic liver disease
Author Collaboration TC, Leung DH, Devaraj S, Goodrich NP, Chen X, Rajapakshe D, Ye W, Andreev V, Minard CG, Guffey D, Molleston JP, Bass LM, Karpen SJ, Kamath BM, Wang KS, Sundaram SS, Rosenthal P, McKiernan P, Loomes KM, Jensen MK, Horslen SP, Bezerra JA, Magee JC, Merion RM, Sokol RJ, Shneider BL, Alonso E, Bass L, Kelly S, Riordan M, Melin-Aldana H, Bezerra J, Bove K, Heubi J, Miethke A, Tiao G, Denlinger J, Chapman E, Sokol R, Feldman A, Mack C, Narkewicz M, Suchy F, Sundaram SS, Van Hove J, Garcia B, Kauma M, Kocher K, Steinbeiss M, Lovell M, Loomes KM Hepatology 2023 Feb 77 530-545 -
Genotype-phenotype relationships of truncating mutations, p.E297G and p.D482G in bile salt export pump deficiency
Author Collaboration tN, Felzen A, van Wessel DB, Gonzales E, Thompson RJ, Jankowska I, Shneider BL, Sokal E, Grammatikopoulos T, Kadaristiana A, Jacquemin E, Spraul A, Lipiński P, Czubkowski P, Rock N, Shagrani M, Broering D, Nicastro E, Kelly D, Nebbia G, Arnell H, Fischler B, Hulscher JB, Serranti D, Arikan C, Polat E, Debray D, Lacaille F, Goncalves C, Hierro L, Muñoz Bartolo G, Mozer-Glassberg Y, Azaz A, Brecelj J, Dezsőfi A, Calvo PL, Grabhorn E, Hartleif S, van der Woerd WJ, Kamath BM, Wang JS, Li L, Durmaz Ö, Kerkar N, Jørgensen MH, Fischer R, Jimenez-Rivera C, Alam S, Cananzi M, Laverdure N, Bezerra JA JHEP Reports 2023 Feb 5 -
Maternal regulation of biliary disease in neonates via gut microbial metabolites
Jee JJ, Yang L, Shivakumar P, Xu Pp, Mourya R, Thanekar U, Yu P, Zhu Y, Pan Y, Wang H, Duan X, Ye Y, Wang B, Jin Z, Liu Y, Cao Z, Watanabe-Chailland M, Romick-Rosendale LE, Wagner M, Fei L, Luo Z, Ollberding NJ, Tang St, Bezerra JA Nature communications 2022 Dec 13 -
Risk of variceal hemorrhage and pretransplant mortality in children with biliary atresia
Author Collaboration C, Bass LM, Ye W, Hawthorne K, Leung DH, Murray KF, Molleston JP, Romero R, Karpen S, Rosenthal P, Loomes KM, Wang KS, Squires RH, Miethke A, Ng VL, Horslen S, Kyle Jensen M, Sokol RJ, Magee JC, Shneider BL, Alonso E, Bass L, Kelly S, Riordan M, Melin-Aldana H, Bezerra J, Bove K, Heubi J, Tiao G, Denlinger J, Chapman E, Sokol R, Feldman A, Mack C, Narkewicz M, Suchy F, Sundaram S, Van Hove J, Garcia B, Kauma M, Kocher K, Steinbeiss M, Lovell M, Loomes K, Piccoli D, Rand E, Russo P, Spinner N, Erlichman J, Stalford S, Pakstis D Hepatology 2022 Sep 76 712-726 -
Use of funded multicenter prospective longitudinal databases to inform clinical trials in rare diseases—Examination of cholestatic liver disease in Alagille syndrome
Author Collaboration ft, Shneider BL, Kamath BM, Magee JC, Goodrich NP, Loomes KM, Ye W, Spino C, Alonso EM, Molleston JP, Bezerra JA, Wang KS, Karpen SJ, Horslen SP, Guthery SL, Rosenthal P, Squires RH, Sokol RJ Hepatology Communications 2022 Aug 6 1910-1921 -
Serum Proteomics Uncovers Biomarkers of Clinical Portal Hypertension in Children With Biliary Atresia
Osborn J, Mourya R, Thanekar U, Su W, Fei L, Shivakumar P, Bezerra JA Hepatology Communications 2022 May 6 995-1004 -
The Liver Biopsy in Neonatal Cholestasis: Just a Cherry on Top?
Russi AE, Pandurangi S, Bezerra JA Clinical Liver Disease 2022 Mar 19 111-113 -
Biliary organoids uncover delayed epithelial development and barrier function in biliary atresia
Amarachintha SP, Mourya R, Ayabe H, Yang L, Luo Z, Li X, Thanekar U, Shivakumar P, Bezerra JA Hepatology 2022 Jan 75 89-103 -
The 2020 Nobel Prize for Medicine or Physiology for the Discovery of Hepatitis C Virus: A Triumph of Curiosity and Persistence
Ghany MG, Lok AS, Dienstag JL, Feinstone SM, Hoofnagle JH, Jake Liang T, Seeff LB, Cohen DE, Bezerra JA, Chung RT Hepatology 2021 Nov 74 2813-2823 -
Presentation and Outcomes of Infants With Idiopathic Cholestasis: A Multicenter Prospective Study
Author Collaboration tC, Hertel PM, Hawthorne K, Kim S, Finegold MJ, Shneider BL, Squires JE, Gupta NA, Bull LN, Murray KF, Kerkar N, Ng VL, Molleston JP, Bezerra JA, Loomes KM, Taylor SA, Schwarz KB, Turmelle YP, Rosenthal P, Magee JC, Sokol RJ Journal of pediatric gastroenterology and nutrition 2021 Oct 73 478-484 -
High Mobility Group Box 1 Release by Cholangiocytes Governs Biliary Atresia Pathogenesis and Correlates With Increases in Afflicted Infants
Mohanty SK, Donnelly B, Temple H, Ortiz-Perez A, Mowery S, Lobeck I, Dupree P, Poling HM, McNeal M, Mourya R, Jenkins T, Bansal R, Bezerra J, Tiao G Hepatology 2021 Aug 74 864-878 -
A single-cell view of biliary atresia
Russi AE, Bezerra JA Nature Reviews Gastroenterology and Hepatology 2021 Apr 18 219-220 -
Autoimmune Hepatitis: Predictors of Native Liver Survival in Children and Adolescents
Author Collaboration BG, Porta G, de Carvalho E, Santos JL, Gama J, Bezerra JA, Borges CV, Seixas RB, Ferreira A, Miura IK, Silveira TR, Silva LR, Fagundes ED, de Carvalho Trevizoli I, Brandão MA, Sawamura R, Vieira SM, Melere M, Ferreira CD, Porta A, Ferreira CT, Pugliese RP, Danesi VL, Marsilac M, Valadares MA, Vasconcelos JR, Meneses DG, de Paula M, Maia J Journal of Pediatrics 2021 Feb 229 95-101.e3 -
Longitudinal Outcomes in Young Patients with Alpha-1-Antitrypsin Deficiency with Native Liver Reveal that Neonatal Cholestasis is a Poor Predictor of Future Portal Hypertension
Author Collaboration C(, Teckman J, Rosenthal P, Hawthorne K, Spino C, Bass LM, Murray KF, Kerkar N, Magee JC, Karpen S, Heubi JE, Molleston JP, Squires RH, Kamath BM, Guthery SL, Loomes KM, Sherker AH, Sokol RJ, Alonso E, Bass L, Kelly S, Riordan M, Melin-Aldana H, Bezerra J, Bove K, Heubi J, Miethke A, Tiao G, Denlinger J, Chapman E, Sokol R, Feldman A, Mack C, Narkewicz M, Suchy F, Sundaram S, Van Hove J, Garcia B, Kauma M, Kocher K, Steinbeiss M, Lovell M, Loomes K, Piccoli D, Rand E, Russo P, Spinner N, Erlichman J, Stalford S, Pakstis D, King S Journal of Pediatrics 2020 Dec 227 81-86.e4 -
Modeling Outcomes in Children With Biliary Atresia With Native Liver After 2 Years of Age
Author Collaboration ft, Venkat V, Ng VL, Magee JC, Ye W, Hawthorne K, Harpavat S, Molleston JP, Murray KF, Wang KS, Soufi N, Bass LM, Alonso EM, Bezerra JA, Jensen MK, Kamath BM, Loomes KM, Mack CL, Rosenthal P, Shneider BL, Squires RH, Sokol RJ, Karpen SJ Hepatology Communications 2020 Dec 4 1824-1834 -
Nonfasted Liver Stiffness Correlates with Liver Disease Parameters and Portal Hypertension in Pediatric Cholestatic Liver Disease
Author Collaboration ft, Shneider BL, Goodrich NP, Ye W, Sawyers C, Molleston JP, Merion RM, Leung DH, Karpen SJ, Kamath BM, Cavallo L, Wang K, Teckman JH, Squires JE, Sundaram SS, Rosenthal P, Romero R, Murray KF, Loomes KM, Jensen MK, Bezerra JA, Bass LM, Sokol RJ, Magee JC Hepatology Communications 2020 Nov 4 1694-1707 -
Natural Course of Pediatric Portal Hypertension
Kassam AF, Goddard GR, Johnston ME, Cortez AR, Trout AT, Jenkins TM, Miethke AG, Campbell KM, Bezerra JA, Balistreri WF, Nathan JD, Alonso MH, Tiao GM, Bondoc AJ Hepatology Communications 2020 Sep 4 1346-1352 -
Clinical Best Practice Advice for Hepatology and Liver Transplant Providers During the COVID-19 Pandemic: AASLD Expert Panel Consensus Statement
Fix OK, Hameed B, Fontana RJ, Kwok RM, McGuire BM, Mulligan DC, Pratt DS, Russo MW, Schilsky ML, Verna EC, Loomba R, Cohen DE, Bezerra JA, Reddy KR, Chung RT Hepatology 2020 Jul 72 287-304 -
Regulation of bile duct epithelial injury by hepatic CD71+ erythroid cells
Yang L, Shivakumar P, Kinder J, Way SS, Donnelly B, Mourya R, Luo Z, Bezerra JA JCI Insight 2020 Jun 5 -
Congenital Portosystemic Shunts in Children: Associations, Complications, and Outcomes
DiPaola F, Trout AT, Walther AE, Gupta A, Sheridan R, Campbell KM, Tiao G, Bezerra JA, Bove KE, Patel M, Nathan JD Digestive Diseases and Sciences 2020 Apr 65 1239-1251 -
Neurodevelopmental Outcomes in Preschool and School Aged Children with Biliary Atresia and Their Native Liver
Squires JE, Ng VL, Hawthorne K, Henn LL, Sorensen LG, Fredericks EM, Alonso EM, Murray KF, Loomes KM, Karpen SJ, Cavallo LA, Molleston JP, Bezerra JA, Rosenthal P, Squires RH, Wang KS, Schwarz KB, Arnon R, Magee JC, Sokol RJ Journal of pediatric gastroenterology and nutrition 2020 Jan 70 79-86 -
Gene Expression Signatures Associated With Survival Times of Pediatric Patients With Biliary Atresia Identify Potential Therapeutic Agents
Luo Z, Shivakumar P, Mourya R, Gutta S, Bezerra JA Gastroenterology 2019 Oct 157 1138-1152.e14 -
Identification of Polycystic Kidney Disease 1 Like 1 Gene Variants in Children With Biliary Atresia Splenic Malformation Syndrome
Author Collaboration ft, Berauer JP, Mezina AI, Okou DT, Sabo A, Muzny DM, Gibbs RA, Hegde MR, Chopra P, Cutler DJ, Perlmutter DH, Bull LN, Thompson RJ, Loomes KM, Spinner NB, Rajagopalan R, Guthery SL, Moore B, Yandell M, Harpavat S, Magee JC, Kamath BM, Molleston JP, Bezerra JA, Murray KF, Alonso EM, Rosenthal P, Squires RH, Wang KS, Finegold MJ, Russo P, Sherker AH, Sokol RJ, Karpen SJ Hepatology 2019 Sep 70 899-910 -
Prospective Assessment of Ultrasound Shear Wave Elastography for Discriminating Biliary Atresia from other Causes of Neonatal Cholestasis
Dillman JR, DiPaola FW, Smith SJ, Barth RA, Asai A, Lam S, Campbell KM, Bezerra JA, Tiao GM, Trout AT Journal of Pediatrics 2019 Sep 212 60-65.e3 -
Visualizing structures in confocal microscopy datasets through clusterization: A case study on bile ducts
Beltran LA, Cruz CU, Dos Santos JL, Shivakumar P, Bezerra J, Dal Sasso Freitas CM 2019 Jun 405-410 -
Correlation of Immune Markers With Outcomes in Biliary Atresia Following Intravenous Immunoglobulin Therapy
Author Collaboration TC, Kim S, Moore J, Alonso E, Bednarek J, Bezerra JA, Goodhue C, Karpen SJ, Loomes KM, Magee JC, Ng VL, Sherker AH, Smith C, Spino C, Venkat V, Wang K, Sokol RJ, Mack CL Hepatology Communications 2019 May 3 685-696 -
A Phase I/IIa Trial of Intravenous Immunoglobulin Following Portoenterostomy in Biliary Atresia
Author Collaboration TC, Mack CL, Spino C, Alonso EM, Bezerra JA, Moore J, Goodhue C, Ng VL, Karpen SJ, Venkat V, Loomes KM, Wang K, Sherker AH, Magee JC, Sokol RJ Journal of pediatric gastroenterology and nutrition 2019 Apr 68 495-501 -
Single cell RNA sequencing reveals regional heterogeneity of hepatobiliary innate lymphoid cells in a tissue-enriched fashion
Peters AL, Luo Z, Li J, Mourya R, Wang Y, Dexheimer P, Shivakumar P, Aronow B, Bezerra JA PloS one 2019 Apr 14 -
Diagnostic Accuracy of Serum Matrix Metalloproteinase-7 for Biliary Atresia
Yang L, Zhou Y, Xu Pp, Mourya R, Lei Hy, Cao Gq, Xiong Xl, Xu H, Duan Xf, Wang N, Fei L, Chang Xp, Zhang X, Jiang M, Bezerra JA, Tang St Hepatology 2018 Dec 68 2069-2077 -
Impact of Steroid Therapy on Early Growth in Infants with Biliary Atresia: The Multicenter Steroids in Biliary Atresia Randomized Trial
Author Collaboration CN, Alonso EM, Ye W, Hawthorne K, Venkat V, Loomes KM, Mack CL, Hertel PM, Karpen SJ, Kerkar N, Molleston JP, Murray KF, Romero R, Rosenthal P, Schwarz KB, Shneider BL, Suchy FJ, Turmelle YP, Wang KS, Sherker AH, Sokol RJ, Bezerra JA, Magee JC Journal of Pediatrics 2018 Nov 202 179-185.e4 -
Regulation of epithelial injury and bile duct obstruction by NLRP3, IL-1R1 in experimental biliary atresia
Yang L, Mizuochi T, Shivakumar P, Mourya R, Luo Z, Gutta S, Bezerra JA Journal of Hepatology 2018 Nov 69 1136-1144 -
Biliary Atresia: Clinical and Research Challenges for the Twenty-First Century
Bezerra JA, Wells RG, Mack CL, Karpen SJ, Hoofnagle JH, Doo E, Sokol RJ Hepatology 2018 Sep 68 1163-1173 -
Neurodevelopmental Outcome of Young Children with Biliary Atresia and Native Liver: Results from the ChiLDReN Study
Author Collaboration CL, Ng VL, Sorensen LG, Alonso EM, Fredericks EM, Ye W, Moore J, Karpen SJ, Shneider BL, Molleston JP, Bezerra JA, Murray KF, Loomes KM, Rosenthal P, Squires RH, Wang K, Arnon R, Schwarz KB, Turmelle YP, Haber BH, Sherker AH, Magee JC, Sokol RJ, Hertel PM, Harpavat S, Brandt ML, Leung DH, Karnsakul W, Torrance R, Hall S, Doo E, Hoofnagle JH, Whitington P, Bass L, Miethke AG, Heubi JE, Setchell K, Bove KE, Tiao G, Mack CL, Narkewicz MR, Feldman AG, Sundaram SS, Suchy FJ, Karrer FM, Lovell M, Van Hove JL, Rand EB, Squires JE, Venkat VL, Sindhi R Journal of Pediatrics 2018 May 196 139-147.e3 -
Gene-disease associations identify a connectome with shared molecular pathways in human cholangiopathies
Luo Z, Jegga AG, Bezerra JA Hepatology 2018 Feb 67 676-689 -
A novel pkhd1 mutation interacts with the nonobese diabetic genetic background to cause autoimmune cholangitis
Huang W, Rainbow DB, Wu Y, Adams D, Shivakumar P, Kottyan L, Karns R, Aronow B, Bezerra J, Gershwin ME, Peterson LB, Wicker LS, Ridgway WM Journal of Immunology 2018 Jan 200 147-162 -
Large-scale proteomics identifies MMP-7 as a sentinel of epithelial injury and of biliary atresia
Lertudomphonwanit C, Mourya R, Fei L, Zhang Y, Gutta S, Yang L, Bove KE, Shivakumar P, Bezerra JA Science translational medicine 2017 Nov 9 -
Cxcr2 signaling and the microbiome suppress inflammation, bile duct injury, and the phenotype of experimental biliary atresia
Jee J, Mourya R, Shivakumar P, Fei L, Wagner M, Bezerra JA PloS one 2017 Aug 12 -
Initial assessment of the infant with neonatal cholestasis-Is this biliary atresia?
Author Collaboration CL, Shneider BL, Moore J, Kerkar N, Magee JC, Ye W, Karpen SJ, Kamath BM, Molleston JP, Bezerra JA, Murray KF, Loomes KM, Whitington PF, Rosenthal P, Squires RH, Guthery SL, Arnon R, Schwarz KB, Turmelle YP, Sherker AH, Sokol RJ, Hertel PM, Alonso EM, Fredericks EM, Haber BH, Wang KS, Sorensen LG, Ng VL, Bass L, Lin H, Goodrich NP, Hawthorne K, Heubi JE, Sheridan R, Fei L, Teckman J, Spino CA PloS one 2017 May 12 -
Paracrine signals regulate human liver organoid maturation from induced pluripotent stem cells
Asai A, Aihara E, Watson C, Mourya R, Mizuochi T, Shivakumar P, Phelan K, Mayhew C, Helmrath M, Takebe T, Wells J, Bezerra JA Development (Cambridge) 2017 Mar 144 1056-1064 -
Preferential TNFα signaling via TNFR2 regulates epithelial injury and duct obstruction in experimental biliary atresia
Shivakumar P, Mizuochi T, Mourya R, Gutta S, Yang L, Luo Z, Bezerra JA JCI Insight 2017 2 -
Pediatric Cholestatic Syndromes
Squires JE, Balistreri WF, Bezerra JA 2017 Jan 976-994 -
Novel approaches to the treatment of biliary atresia
Li Y, Bezerra JA Clinical Liver Disease 2016 Dec 8 145-149 -
Biliary atresia and other cholestatic childhood diseases: Advances and future challenges
Verkade HJ, Bezerra JA, Davenport M, Schreiber RA, Mieli-Vergani G, Hulscher JB, Sokol RJ, Kelly DA, Ure B, Whitington PF, Samyn M, Petersen C Journal of Hepatology 2016 Sep 65 631-642 -
MDR3 mutation analysis: A step closer to precision medicine
Bezerra JA Hepatology 2016 May 63 1421-1423 -
Increased frequency of double and triple heterozygous gene variants in children with intrahepatic cholestasis
Goldschmidt ML, Mourya R, Connor J, Dexheimer P, Karns R, Miethke A, Sheridan R, Zhang K, Bezerra JA Hepatology Research 2016 Apr 46 306-311 -
Total Serum Bilirubin within 3 Months of Hepatoportoenterostomy Predicts Short-Term Outcomes in Biliary Atresia
Author Collaboration CL, Shneider BL, Magee JC, Karpen SJ, Rand EB, Narkewicz MR, Bass LM, Schwarz K, Whitington PF, Bezerra JA, Kerkar N, Haber B, Rosenthal P, Turmelle YP, Molleston JP, Murray KF, Ng VL, Wang KS, Romero R, Squires RH, Arnon R, Sherker AH, Moore J, Ye W, Sokol RJ Journal of Pediatrics 2016 Mar 170 211-217.e2 -
Pathogenesis of biliary atresia: Defining biology to understand clinical phenotypes
Asai A, Miethke A, Bezerra JA Nature Reviews Gastroenterology and Hepatology 2015 Jun 12 342-352 -
IL-33 facilitates oncogene-induced cholangiocarcinoma in mice by an interleukin-6-sensitive mechanism
Yamada D, Rizvi S, Razumilava N, Bronk SF, Davila JI, Champion MD, Borad MJ, Bezerra JA, Chen X, Gores GJ Hepatology 2015 May 61 1627-1642 -
Natural killer cells promote long-term hepatobiliary inflammation in a low-dose rotavirus model of experimental biliary atresia
Squires JE, Shivakumar P, Mourya R, Bessho K, Walters S, Bezerra JA PloS one 2015 May 10 -
Reply
Mourya R, Bessho K, Shivakumar P, Bezerra JA Hepatology 2015 Feb 61 732-733 -
Transplantation for Cholestatic Liver Disease in Children
Ibrahim SH, Bezerra JA, Balistreri WF 2015 Jan 288-304 -
Total serum bilirubin predicts fat-soluble vitamin deficiency better than serum bile acids in infants with biliary atresia
Author Collaboration CL, Venkat VL, Shneider BL, Magee JC, Turmelle Y, Arnon R, Bezerra JA, Hertel PM, Karpen SJ, Kerkar N, Loomes KM, Molleston J, Murray KF, Ng VL, Raghunathan T, Rosenthal P, Schwartz K, Sherker AH, Sokol RJ, Teckman J, Wang K, Whitington PF, Heubi JE Journal of pediatric gastroenterology and nutrition 2014 Dec 59 702-707 -
Biliary repair and carcinogenesis are mediated by IL-33-dependent cholangiocyte proliferation
Li J, Razumilava N, Gores GJ, Walters S, Mizuochi T, Mourya R, Bessho K, Wang YH, Glaser SS, Shivakumar P, Bezerra JA Journal of Clinical Investigation 2014 Jul 124 3241-3251 -
Gene expression signature for biliary atresia and a role for interleukin-8 in pathogenesis of experimental disease
Bessho K, Mourya R, Shivakumar P, Walters S, Magee JC, Rao M, Jegga AG, Bezerra JA Hepatology 2014 Jul 60 211-223 -
Use of corticosteroids after hepatoportoenterostomy for bile drainage in infants with biliary atresia the start randomized clinical trial
Bezerra JA, Spino C, Magee JC, Shneider BL, Rosenthal P, Wang KS, Erlichman J, Haber B, Hertel PM, Karpen SJ, Kerkar N, Loomes KM, Molleston JP, Murray KF, Romero R, Schwarz KB, Shepherd R, Suchy FJ, Turmelle YP, Whitington PF, Moore J, Sherker AH, Robuck PR, Sokol RJ JAMA 2014 May 311 1750-1759 -
Replication of a GWAS signal in a Caucasian population implicates ADD3 in susceptibility to biliary atresia
Tsai EA, Grochowski CM, Loomes KM, Bessho K, Hakonarson H, Bezerra JA, Russo PA, Haber BA, Spinner NB, Devoto M Human genetics 2014 Feb 133 235-243 -
Perforin and granzymes work in synergy to mediate cholangiocyte injury in experimental biliary atresia
Shivakumar P, Mourya R, Bezerra JA Journal of Hepatology 2014 Feb 60 370-376 -
Extrahepatic anomalies in infants with biliary atresia: Results of a Large prospective North American multicenter study
Schwarz KB, Haber BH, Rosenthal P, Mack CL, Moore J, Bove K, Bezerra JA, Karpen SJ, Kerkar N, Shneider BL, Turmelle YP, Whitington PF, Molleston JP, Murray KF, Ng VL, Romero R, Wang KS, Sokol RJ, Magee JC Hepatology 2013 Nov 58 1724-1731 -
Integrative genomics identifies candidate microRNAs for pathogenesis of experimental biliary atresia
Bessho K, Shanmukhappa K, Sheridan R, Shivakumar P, Mourya R, Walters S, Kaimal V, Dilbone E, Jegga AG, Bezerra JA BMC Systems Biology 2013 Oct 7 -
Identification of intramural epithelial networks linked to peribiliary glands that express progenitor cell markers and proliferate after injury in mice
Dipaola F, Shivakumar P, Pfister J, Walters S, Sabla G, Bezerra JA Hepatology 2013 Oct 58 1486-1496 -
Efficacy of fat-soluble vitamin supplementation in infants with biliary atresia
Shneider BL, Magee JC, Bezerra JA, Haber B, Karpen SJ, Raghunathan T, Rosenthal P, Schwarz K, Suchy FJ, Kerkar N, Turmelle Y, Whitington PF, Robuck PR, Sokol RJ Pediatrics 2012 Sep 130 e607-e614 -
50 years ago in the journal of pediatrics: Persistent jaundice in infancy
Dipaola F, Bezerra JA Journal of Pediatrics 2012 Jul 161 164 -
The beneficial impact of revision of kasai portoenterostomy for biliary atresia: An institutional study
Bondoc AJ, Taylor JA, Alonso MH, Nathan JD, Wang Y, Balistreri WF, Bezerra JA, Ryckman FC, Tiao GM Annals of surgery 2012 Mar 255 570-576 -
Th2 signals induce epithelial injury in mice and are compatible with the biliary atresia phenotype
Li J, Bessho K, Shivakumar P, Mourya R, Mohanty SK, Dos Santos JL, Miura IK, Porta G, Bezerra JA Journal of Clinical Investigation 2011 Nov 121 4244-4256 -
Dendritic cells regulate natural killer cell activation and epithelial injury in experimental biliary atresia
Saxena V, Shivakumar P, Sabla G, Mourya R, Chougnet C, Bezerra JA Science translational medicine 2011 Sep 3 -
Biliary Atresia: Will blocking inflammation tame the disease?
Bessho K, Bezerra JA Annual review of medicine 2011 Feb 62 171-185 -
Biliary atresia and other disorders of the extrahepatic bile ducts
Balistreri WF, Bezerra JA, Ryckman FC 2011 Jan 155-176 -
Lampe1: An ENU-germline mutation causing spontaneous hepatosteatosis identified through targeted exon-enrichment and next-generation sequencing
Sheridan R, Lampe K, Shanmukhappa SK, Putnam P, Keddache M, Divanovic S, Bezerra J, Hoebe K PloS one 2011 6 -
Biliary atresia in Brazil: Where we are and where we are going
Bezerra JA Jornal de Pediatria 2010 Nov 86 445-447 -
Analysis of gene mutations in children with cholestasis of undefined etiology
Matte U, Mourya R, Miethke A, Liu C, Kauffmann G, Moyer K, Zhang K, Bezerra JA Journal of pediatric gastroenterology and nutrition 2010 Oct 51 488-493 -
Analysis of gene mutations in children with cholestasis of undefined etiology
Matte U, Mourya R, Miethke A, Liu C, Kauffmann G, Moyer K, Zhang K, Bezerra JA Journal of pediatric gastroenterology and nutrition 2010 Oct 51 488-493 -
Advances in biliary atresia: From patient care to research
Santos JL, Carvalho E, Bezerra JA Brazilian Journal of Medical and Biological Research 2010 Jun 43 522-527 -
Staging of biliary atresia at diagnosis by molecular profiling of the liver
Moyer K, Kaimal V, Pacheco C, Mourya R, Xu H, Shivakumar P, Chakraborty R, Rao M, Magee JC, Bove K, Aronow BJ, Jegga AG, Bezerra JA Genome Medicine 2010 May 2 -
Macrophages are targeted by rotavirus in experimental biliary atresia and induce neutrophil chemotaxis by Mip2/Cxcl2
Mohanty SK, Ivantes CA, Mourya R, Pacheco C, Bezerra JA Pediatric Research 2010 Apr 67 345-351 -
Cholestatic liver disease in children
Santos JL, Choquette M, Bezerra JA Current gastroenterology reports 2010 Feb 12 30-39 -
Neonatal NK cells target the mouse duct epithelium via Nkg2d and drive tissue-specific injury in experimental biliary atresia
Shivakumar P, Sabla GE, Whitington P, Chougnet CA, Bezerra JA Journal of Clinical Investigation 2009 Aug 119 2281-2290 -
Plasmin-mediated proteolysis is required for hepatocyte growth factor activation during liver repair
Shanmukhappa K, Matte U, Degen JL, Bezerra JA Journal of Biological Chemistry 2009 May 284 12917-12923 -
Cholestasis: Current issues and plan for the future
Haber B, Ferreira CT, Aw M, Bezerra J, Sturm E, Thompson R, D'Agostino D, McKiernan P Journal of pediatric gastroenterology and nutrition 2008 Aug 47 220-224 -
Temporal-spatial activation of apoptosis and epithelial injury in murine experimental biliary atresia
Erickson N, Mohanty SK, Shivakumar P, Sabla G, Chakraborty R, Bezerra JA Hepatology 2008 May 47 1567-1577 -
Growth failure and outcomes in infants with biliary atresia: A report from the biliary atresia research consortium
DeRusso PA, Ye W, Shepherd R, Haber BA, Shneider BL, Whitington PF, Schwarz KB, Bezerra JA, Rosenthal P, Karpen S, Squires RH, Magee JC, Robuck PR, Sokol RJ Hepatology 2007 Nov 46 1632-1638 -
Screening and outcomes in biliary atresia: Summary of a national institutes of health workshop
Sokol RJ, Shepherd RW, Superina R, Bezerra JA, Robuck P, Hoofnagle JH Hepatology 2007 Aug 46 566-581 -
Effector Role of Neonatal Hepatic CD8+ Lymphocytes in Epithelial Injury and Autoimmunity in Experimental Biliary Atresia
Shivakumar P, Sabla G, Mohanty S, McNeal M, Ward R, Stringer K, Caldwell C, Chougnet C, Bezerra JA Gastroenterology 2007 Jun 133 268-277 -
Reply
Shneider BL, Bezerra JA, Sokol RJ, Whitington PF Journal of Pediatrics 2007 Jun 150 e89-e90 -
Extrahepatic biliary atresia: Current concepts and future directions
De Carvalho E, Pontes Ivantes CA, Bezerra JA Jornal de Pediatria 2007 Mar 83 105-120 -
Effect of rotavirus strain on the murine model of biliary atresia
Allen SR, Jafri M, Donnelly B, McNeal M, Witte D, Bezerra J, Ward R, Tiao GM Journal of virology 2007 Feb 81 1671-1679 -
Biliary atresia and other disorders of the extrahepatic bile ducts
Balistreri WF, Balistreri WF, Bezerra JA, Bezerra JA, Ryckman FC, Ryckman FC 2007 Jan 247-269 -
Novel Resequencing Chip Customized to Diagnose Mutations in Patients With Inherited Syndromes of Intrahepatic Cholestasis
Liu C, Aronow BJ, Jegga AG, Wang N, Miethke A, Mourya R, Bezerra JA Gastroenterology 2007 Jan 132 119-126 -
High prevalence of α-1-antitrypsin heterozygosity in children with chronic liver disease
Campbell KM, Arya G, Ryckman FC, Alonso M, Tiao G, Balistreri WF, Bezerra JA Journal of pediatric gastroenterology and nutrition 2007 Jan 44 99-103 -
Urokinase-type plasminogen activator supports liver repair independent of its cellular receptor
Shanmukhappa K, Sabla GE, Degen JL, Bezerra JA BMC Gastroenterology 2006 Nov 6 -
Pancreas Recovery Following Cerulein-Induced Pancreatitis Is Impaired in Plasminogen-Deficient Mice
Lugea A, Nan L, French SW, Bezerra JA, Gukovskaya AS, Pandol SJ Gastroenterology 2006 Sep 131 885-899 -
The next challenge in pediatric cholestasis: Deciphering the pathogenesis of biliary atresia
Bezerra JA Journal of pediatric gastroenterology and nutrition 2006 Jul 43 S23-S29 -
Biliary atresia - Translational research on key molecular processes regulating biliary injury and obstruction
Bezerra JA Chang Gung Medical Journal 2006 May 29 222-230 -
Loss of interleukin-12 modifies the pro-inflammatory response but does not prevent duct obstruction in experimental biliary atresia
Mohanty SK, Shivakumar P, Sabla G, Bezerra JA BMC Gastroenterology 2006 Apr 6 -
A multicenter study of the outcome of biliary atresia in the United States, 1997 to 2000
Shneider BL, Brown MB, Haber B, Whitington PF, Schwarz K, Squires R, Bezerra J, Shepherd R, Rosenthal P, Hoofnagle JH, Sokol RJ Journal of Pediatrics 2006 Apr 148 467-467.e -
Whatever happened to "neonatal hepatitis"?
Balistreri WF, Bezerra JA Clinics in Liver Disease 2006 Feb 10 27-53 -
Pediatric hepatology: Progress in deciphering mechanisms and advancing therapy
Bezerra JA, Balistreri WF Clinics in Liver Disease 2006 Feb 10 ix-xii -
Genetic modifiers of cholestatic liver disease: An evolving field
Bezerra J, Shneider BL Journal of pediatric gastroenterology and nutrition 2006 Jan 42 7-8 -
Potential etiologies of biliary atresia
Bezerra JA Pediatric Transplantation 2005 Oct 9 646-651 -
Analysis of the biliary transcriptome in experimental biliary atresia
Carvalho E, Liu C, Shivakumar P, Sabla G, Aronow B, Bezerra JA Gastroenterology 2005 Aug 129 713-717 -
Hepatic to pancreatic switch defines a role for hemostatic factors in cellular plasticity in mice
Shanmukhappa K, Mourya R, Sabla GE, Degen JL, Bezerra JA Proceedings of the National Academy of Sciences of the United States of America 2005 Jul 102 10182-10187 -
Intrahepatic cholestasis: Summary of an American Association for the Study of Liver Diseases Single-Topic Conference
Balistreri WF, Bezerra JA, Jansen P, Karpen SJ, Shneider BL, Suchy FJ Hepatology 2005 Jul 42 222-235 -
A challenge on the use of the words Embryonic and Perinatal in the context of biliary atresia [3] (multiple letters)
Davenport M, Bezerra JA, Sokol RJ Hepatology 2005 Feb 41 403-404 -
Liver transplantation in children younger than 1 year-the Cincinnati experience
Tiao GM, Alonso M, Bezerra J, Yazigi N, Heubi J, Balistreri W, Bucuvalas J, Ryckman F Journal of Pediatric Surgery 2005 Jan 40 268-273 -
Transplantation for Cholestatic Liver Disease in the Pediatric Patient
Choe BH, Bezerra JA, Balistreri WF 2005 Jan 303-321 -
Obstruction of extrahepatic bile ducts by lymphocytes is regulated by IFN-γ in experimental biliary atresia
Shivakumar P, Campbell KM, Sabla GE, Miethke A, Tiao G, McNeal MM, Ward RL, Beserra JA Journal of Clinical Investigation 2004 Aug 114 322-329 -
Biliary atresia and Th1 function: Linking lymphocytes and bile ducts
Shivakumar P, Bezerra JA Pediatric Research 2004 Jul 56 9-10 -
Coordinate Expression of Regulatory Genes Differentiates Embryonic and Perinatal Forms of Biliary Atresia
Zhang DY, Sabla G, Shivakumar P, Tiao G, Sokol RJ, Mack C, Shneider BL, Aronow B, Bezerra JA Hepatology 2004 Apr 39 954-962 -
Transcriptional reprogramming in murine liver defines the physiologic consequences of biliary obstruction
Campbell KM, Sabla GE, Bezerra JA Journal of Hepatology 2004 Jan 40 14-23 -
Gene expression profiling in biliary atresia [6] (multiple letters)
Smith MJ, Coffey JC, Wang JH, Cotter TG, Redmond HP, Bezerra JA, Aronow BJ Lancet 2003 Mar 361 971-972 -
Plasminogen directs the pleiotropic effects of uPA in liver injury and repair
Currier AR, Sabla G, Locaputo S, Melin-Aldana H, Degen JL, Bezerra JA American Journal of Physiology - Gastrointestinal and Liver Physiology 2003 Mar 284 G508-G515 -
Genetic induction of proinflammatory immunity in children with biliary atresia
Bezerra JA, Tiao G, Ryckman FC, Alonso M, Sabla GE, Shneider B, Sokol RJ, Aronow BJ Lancet 2002 Nov 360 1653-1659 -
Novel genes and functional relationships in the adult mouse gastrointestinal tract identified by microarray analysis
Bates MD, Erwin CR, Philip SL, Wiginton D, Bezerra JA, Schatzman LC, Jegga AG, Ley-Ebert C, Williams SS, Steinbrecher KA, Warner BW, Cohen MB, Aronow BJ Gastroenterology 2002 122 1467-1482 -
Hepatocytes and endothelial cells: Joining forces to conquer development
Bezerra JA Pediatric Research 2002 51 413 -
Independent and overlapping transcriptional activation during liver development and regeneration in mice
Kelley-Loughnane N, Sabla GE, Ley-Ebert C, Aronow BJ, Bezerra JA Hepatology 2002 35 525-534 -
Plasminogen deficiency leads to impaired lobular reorganization and matrix accumulation after chronic liver injury
Pohl JF, Melin-Aldana H, Sabla G, Degen JL, Bezerra JA American Journal of Pathology 2001 Dec 159 2179-2186 -
Cholestatic syndromes of infancy and childhood
Bezerra JA, Balistreri WF Seminars in Gastrointestinal Disease 2001 12 54-65 -
Plasminogen activators direct reorganization of the liver lobule after acute injury
Bezerra JA, Currier AR, Melin-Aldana H, Sabla G, Bugge TH, Kombrinck KW, Degen JL American Journal of Pathology 2001 158 921-929 -
Genetic manipulation of fibrinogen and fibrinolysis in mice
Degen JL, Drew AF, Palumbo JS, Kombrinck KW, Bezerra JA, Danton MJ, Holmbäck K, Suh TT Annals of the New York Academy of Sciences 2001 936 276-290 -
Plasminogen deficiency results in poor clearance of non-fibrin matrix and persistent activation of hepatic stellate cells after an acute injury
Ng VL, Sabla GE, Melin-Aldana H, Kelley-Loughnane N, Degen JL, Bezerra JA Journal of Hepatology 2001 35 781-789 -
Long-term outcome after partial external biliary diversion for intractable pruritus in patients with intrahepatic cholestasis
Ng VL, Ryckman FC, Porta G, Miura IK, De Carvalho E, Servidoni MF, Bezerra JA, Balistreri WF Journal of pediatric gastroenterology and nutrition 2000 Feb 30 152-156 -
The unique nature of the pediatric liver
Bezerra JA, Balistreri WF Clinics in Liver Disease 2000 4 xi-xv -
Hepatocyte transplantation: Advancing biology and treating children
Ng VL, Alonso M, Bezerra JA Clinics in Liver Disease 2000 4 929-945 -
Plasminogen deficiency leads to impaired remodeling after a toxic injury to the liver
Bezerra JA, Bugge TH, Melin-Aldana H, Sabla G, Kombrinck KW, Witte DP, Degen JL Proceedings of the National Academy of Sciences of the United States of America 1999 Dec 96 15143-15148 -
Zonal regulation of gene expression during liver regeneration of urokinase transgenic mice
Locaputo S, Carrick TL, Bezerra JA Hepatology 1999 29 1106-1113 -
Image of the month
Rudolph JA, Bezerra J, Alonso M Gastroenterology 1999 116 788 -
Pylephlebitis
Pohl JF, Murarka P, Farrell MK, Bezerra J Journal of Pediatrics 1999 135 529 -
Intrahepatic cholestasis: Order out of chaos
Bezerra JA, Balistreri WE Gastroenterology 1999 117 1496-1498 -
Molecular and enzymatic analyses of lysosomal acid lipase in cholesteryl ester storage disease
Du H, Sheriff S, Bezerra J, Leonova T, Grabowski GA Molecular genetics and metabolism 1998 Jun 64 126-134 -
Biological effects of targeted inactivation of hepatocyte growth factor- like protein in mice
Bezerra JA, Carrick TL, Degen JL, Witte D, Degen SJ Journal of Clinical Investigation 1998 Mar 101 1175-1183 -
Hepatobiliary disorders of childhood pathophysiology, clinical features and treatment: Foreword
Bezerra JA, Balistreri WF Seminars in liver disease 1998 18 193 -
Liver development: A paradigm for hepatobiliary disease in later life
Bezerra JA Seminars in liver disease 1998 18 203-216 -
Differential expression of liver growth factors in tyrosinemic transgenic livers: 47
Bezerra JA, Carrick TL, Pavlus JE, Grompe M Journal of pediatric gastroenterology and nutrition 1997 Oct 25 454 -
Effects of protein malnutrition on liver cytochrome P450s
Lee PC, Struve MF, Bezerra JA, Duncan B Nutrition Research 1997 Oct 17 1577-1587 -
Expansion of transplanted hepatocytes during liver regeneration
Yazigi NA, Carrick TL, Bucuvalas JC, Schmidt CS, Balistreri WF, Bezerra JA Transplantation 1997 Sep 64 816-820 -
Hepatocyte growth factor (HGF) mrna expression is increased in diseased liver and decreased in regenerating liver nodules in urokinase transgenic mice
Carrick TL, Chen T, Bezerra JA Journal of pediatric gastroenterology and nutrition 1996 Oct 23 351 -
Hepatocyte transplantation: 'only the strong survive'
Bezerra JA, Balistreri WF Hepatology 1996 24 1321-1323 -
Progress in pediatric hepatology
Bezerra JA, Balistreri WF Current Opinion in Gastroenterology 1996 12 237-245 -
Use of a single solution for oral rehydration and maintenance therapy of infants with diarrhea and mild to moderate dehydration
Cohen MB, Mezoff AG, Laney DW, Bezerra JA, Beane BM, Drazner D, Baker R, Moran JR Pediatrics 1995 95 639-645 -
Increased expression of mRNA for hepatocyte growth factor-like protein during liver regeneration and inflammation
Bezerra JA, Laney DW, Degen SJ Biochemical and Biophysical Research Communications 1994 Aug 203 666-673 -
Upregulation of Escherichia coli heat-stable enterotoxin receptor in regenerating rat liver
Laney DW, Bezerra JA, Kosiba JL, Degen SJ, Cohen MB American Journal of Physiology - Gastrointestinal and Liver Physiology 1994 266 G899-G906 -
Hepatocyte‐specific expression of the mouse hepatocyte growth factor–like protein
Bezerra JA, Witte DP, Arono BJ, Friezner SJ Hepatology 1993 Aug 18 394-399 -
Are hepatocyte growth factor‐like protein and macrophage stimulating protein the same protein?
Bezerra JA, Han S, Danton MJ, Friezner Degen SJ Protein Science 1993 Apr 2 666-668 -
Treatment of infants with acute diarrhea: What's recommended and what's practiced
Bezerra JA, Stathos TH, Duncan B, Gaines JA, Udall JN Pediatrics 1992 90 1-4 -
A one-month-old infant who had a 'double bubble'
Bezerra JA, Duncan B, Anderson F Hospital Practice 1992 27 255+257-258 -
Age-related changes in sucrase and lactase activity in the small intestine of 3- and 10-week-old obese mice (C57bl/6jobob)
Flores CA, Bezerra J, Bustamante SA, Goda T, Macdonal P, Kaplan ML, Koldovsky O Journal of the American College of Nutrition 1990 Jun 9 255-260 -
Diagnosis and management of acute diarrhea in children
Bezerra JA, Cohen MB Current opinion in pediatrics 1990 2 1134-1140 -
Dietary management of acute diarrhea: Fast or feed?
Bezerra JA, Duncan B, Udall J International Pediatrics 1990 5 30-36 -
Intestinal permeability to intact lactose in newborns and adults
Bezerra JA, Thompson SH, Morse M, Koldovský O, Udall JN Neonatology 1990 58 334-342 -
Assessment of lactose absorption by measurement of urinary galactose
Grant JD, Bezerra JA, Thompson SH, Lemen RJ, Koldovsky O, Udall JN Gastroenterology 1989 Oct 97 895-899 -
Effect of diet on intestinal and pancreatic enzyme activities in the pig
Flores CA, Brannon PM, Bustamante SA, Bezerra J, Butler KT, Goda T, Koldovsky O Journal of pediatric gastroenterology and nutrition 1988 7 914-921 -
Chronic effects of an α-glucosidase inhibitor (Bay o 1248) on intestinal disaccharidase activity in normal and diabetic mice
Lee SM, Bustamante S, Flores C, Bezerra J, Goda T, Koldovský O Journal of Pharmacology and Experimental Therapeutics 1987 240 132-137 -
Effect of a high-dextrose diet on sucrase and lactase activity in jejunum of obese mice (C57bL/6J obob)
Flores CA, Bezerra J, Goda T, Bustamante S, MaCdonald MP, Kaplan M, Koldovsky O Journal of the American College of Nutrition 1986 Jan 5 565-575 -
Postweaning changes of jejunal protein and activity of disaccharidases in obese mice and lean littermates
Goda T, Bezerra J, Bustamante S Federation Proceedings 1985 44 No.4407 -
Effect of a high dextrose diet on sucrase and lactase activity in jejunum of obese mice (C57 BL/6J-ob)
Koldovsky O, Bezerra J, Bustamante S Federation Proceedings 1985 44 No. 1161
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Cellular crosstalk mediated by TGF-β drives epithelial-mesenchymal transition in patient-derived multi-compartment biliary organoids
Research
- Biliary atresia
- Inherited liver diseases
- Viral hepatitis
- Cholestatic liver diseases
Clinical Focus
- Liver Disease
- Transplant Hepatology